GRTC Lecture Series
Enhanced strategies for safe human cell editing: novel genome editing tools and epigenetic modulators
Dear colleagues,
It is our pleasure to invite you to the upcoming talk in the GRTC Lecture Series, featuring Dr. Claudio Mussolino from the Institute for Transfusion Medicine and Gene Therapy at the Center for Translational Cell Research (ZTZ), University of Freiburg.
🗓 Date: 09.02.2026
🕒 Time: 4-5pm (CET)
📍Location: Med. Klinik E2R101
Title: Enhanced strategies for safe human cell editing: novel genome editing tools and epigenetic modulators
Abstract: Advancing safe and precise human cell engineering requires innovations at both the genome and epigenome levels. Recent strategies enhance CRISPR-mediated homology-directed repair to boost precise editing in diverse human cells while minimizing unwanted mutations. Complementing this, epigenetic editing in CAR T cells enables durable, multiplexed modulation of inhibitory receptors, improving cell function without altering the genome. Together, these approaches highlight novel avenues to optimize human cell therapies through both precise genome and targeted epigenome engineering
Speaker Bio: Dr. Claudio Mussolino is a group leader at the Institute for Transfusion Medicine and Gene Therapy in Freiburg (Germany) since 2012. He received his PhD in 2009 at the TIGEM, Telethon Institute of Genetics and Medicine, in Napoli (Italy) where he established a mutation-independent approach to treat dominant forms of the blindness disorder Retinitis Pigmentosa using zinc finger-based designer transcription factors. Currently, Dr Mussolino research focuses on the development of novel and long-term therapeutic strategies for HIV patients. Using TALE- or CRISPR-based effectors Dr. Mussolino explores the potential of editing the genome or the epigenome of hematopoietic stem cells or T cells to render them resistant to HIV infection. Additional current projects include the adaptation of these methodologies to other acquired and congenital disorders of the immune system. (https://www.aiche.org/community/bio/claudio-mussolino)
Feel free to share this invitation with colleagues or others who may be interested in attending.
