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Clinical Microbiology Team

Main topic

The emerge of highly virulent and multidrug-resistant Gram-negative pathogens jeopardizes successful treatment of severe infections. Increasing incidence rates reported from various countries drive health care systems into an international crisis of antimicrobial failure. At the same time, the understanding of the underlying mechanisms and spread of multidrug-resistance as well as of the optimal diagnostic approach and clinical management is still limited and needs to be widened. One example is the rising appearance of metallo-ß-lactamases (MBLs) that confer resistance to all ß-lactam antimicrobials except aztreonam. MBLs present a particular thread since their genes can be located on plasmids or integron structures that could be transferred between pathogens. These mechanisms could be an explanation for the rapid spread and reservoir formation within the hospital setting. To fight this development, efficient infection control measures are urgently needed. Our group aims to investigate the association between hospital environment, antimicrobial treatment, clinical parameters and the isolation of multidrug-resistant Gram-negative pathogens. We furthermore focus on the diagnostic and therapeutic potential of recently discovered virulence factors to give credit to new clinical management strategies that are of a major interest in the absence of sufficient antimicrobial treatment regimes.

Objectives

1. Quantification of antimicrobial selection pressure and clinical score derivation.

 

2. Effect of molecular resistance mechanisms on clinical outcomes in patients with severe infection by Gram-negative rods.

 

3. Simulation of hospital-wide antibiotic restriction on the incidence of multidrug-resistant pathogens for the design of custom-made antibiotic stewardship programs.

 

4. Investigation of the relative diagnostic merit of bacterial virulence properties.

 

5. Evaluation of different diagnostic approaches to develop fast, reliable and efficient diagnostic tools.

 

6. Characterization of genetic resistance elements to understand their relevance in transmission of resistance within the individual patient and the hospital setting.

Group leader
 
 

Peter_90x90

CV PD. Dr. med. Silke Peter

Tel. +49 7071 29-81527
 

 

Year Academic career
2013 Consultant in medical microbiology and infection epidemiology
Since 2011 Group leader Clinical Microbiology and Epidemiology of Infectious Diseases, Institute of Medical Microbiology and Hygiene (Chair: Prof. Dr. I. B. Autenrieth), University of Tübingen, Germany
2008 Clinical microbiology specialist (FAMH)
2005 - 2009 Training in Medical Microbiology, Institute of Medical Microbiology (Chair: Prof. Dr. E. C. Böttger), University of Zürich, Switzerland
1999 - 2000 MD thesis: "Mechanisms of serum resistance of Neisseria meningitidis serogroup A", Prof. Dr. U. Vogel, Institute of Hygiene and Microbiology, University of Würzburg, Germany
2000 Stipend of the graduate college "Immunmodulation", Institute of Immunology, University of Würzburg, Germany
2000 Research stay at the Department of Infectious Diseases, Boston University, Medical Center, Boston, USA

 

 

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