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AG Wolz

In vivo adaptation of Staphylococcus aureus

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Apl. Prof. Dr. rer. nat. Christiane Wolz
Phone: +49 7071 29-80187
Fax: +49 7071 29-5165
 

 

 

Academic career

2010 - present APL Professor at the Faculty of Medicine of the University of Tübingen,

Department of Medical Microbiology and Hygiene

2006-2011 Associate Professor at the Institute of Microbiology and Hygiene, Tübingen
2004-2006 "Oberassistentin" at Institute of Microbiology and Hygiene, Tübingen
2002-2004  Assistant professor (Oberassistentin) at the Institute of General and Environmental Hygiene, Tübingen
2002 Postdoctoral thesis (Habilitation) in "Experimental Microbiology and Hygiene" at the Medical Faculty of the University of Tübingen
1994-1996 Postdoctoral Research Fellow in the laboratory of Prof. Dr. Vincent Fischetti/A.Cheung at the Rockefeller University, New York. DFG-Fellowship.
1992 - 1994 Assistant professor at the Institute of General and Environmental Hygiene, Tübingen (Main Research topic Pseudomonas aeruginosa and cystic fibrosis).
1987-1991 PhD thesis in the laboratory of Prof. Dr. Gerd Döring, Institute of General and Environmental Hygiene (Subject: Pseudomonas aeruginosa and cystic fibrosis).

 

Main Topic: S. aureus Adaptation during infection and colonisation

The major human pathogen S. aureus asymptomatically colonizes the anterior nares of humans, but also causes a wide spectrum of diseases ranging from simple skin infections to major life-threatening acute infections. Additionally, S. aureus can cause chronic infections (osteomyelitis, device-related infections, and lung infections in patients with cystic fibrosis) that require successful adaptation of the pathogen to the human host. In the short term, regulatory mechanisms allow the pathogen to quickly change its phenotype in response to the micro-environment. In the long term, mutation or recombination together with purging selection enforced by the changing environment leads to inheritable shifts in the bacterial population.

Generally, we are interested in the regulatory mechanisms and selective forces, which are important for the in vivo survival, virulence and adaptation of S. aureus. For this purpose we use molecular approaches to study prototypic strains as well as a subset of a well-defined strain collection from patients and healthy individuals. The insights gained by in vitro experiments are linked to actual infectious processes by the analysis of in vivo grown bacteria.

 

 

 

Funding
 
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DFG - Collaborative Research Center SFB 766 - The Bacterial Cell Envelope: Structure, Function and Infection Interface

 

 

 
 
DFG - Transregional Collaborative Research Center TR-SFB 34 -Pathophysiology of Staphylococci

 

DFG - Transregional Collaborative Research Center TR-SFB 34 -Pathophysiology of Staphylococci

 

 

 

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