Core Facility
Genomics

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Address: Calwerstraße 772076 Tübingen

Phone number: +49 7071 29-72298

E-mail address: ncct@med.uni-tuebingen.de

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News

Our Core Facility Genomics is pleased to announce a special sequencing offer! For a limited time, we provide bacterial hybrid whole‑genome sequencing combining Illumina and Oxford Nanopore, together with bioinformatic genome assembly, at a special price of 200 € per sample.
This offer is restricted tto scientists affiliated with UKT or the University of Tübingen. Interested researchers are invited to register by 31 July 2026 by contacting ncct@med.uni‑tuebingen.de.

Details on sample requirements can be found in the guidelines 

About us

The Core Facility Genomics provides a wide range of next generation sequencing (NGS) methodologies for short- and long-read sequencing, along with tailored solutions for specific research needs. Our services prioritize expertise, reliability, and reproducibility, aiming to streamline functional genomics studies. Combining expertise from two specialized labs - human genetics (eukaryotes) and microbial genomics (prokaryotes) - we offer complementary resources, including biosafety and automation capabilities. Beyond sequencing, we support genomic research, microbial studies, model systems, and data science, focusing on custom solutions and advanced support for projects of all sizes.

Further Information

The Deutsche Forschungsgemeinschaft (DFG) offers funding for high-throughput sequencing projects in a range of 100 k – 1 Mio €. You can find more information here. If you are interested to apply, please contact us.

News

Services

  • For newcomers:
    Which tool / which question
  • For experts:
    Latest methods & benchmarking
  • For optimization:
    Experimental design


  • DNA/RNA
  • Diverse sample sources


  • Whole genome sequencing 
    Short/long read
  • Single cell sequencing: 
    Gene expression, immune profiling, chromatin, antibody tag-based proteomics
  • Targeted sequencing: 
    Whole exome, panels, amplicon
  • RNA sequencing:
    TotalRNA, mRNA, smallRNA, low input, RNA isoform, directRNA
  • Metagenomics:
    Shotgun, amplicons 16S, ITS
  • Circulating DNA
  • Epigenomics:
    Methylation
  • Metatranscriptomics
  • Illumina and ONT sequencing options
  • QC and flow cells for ready-to-sequence libraries/pools
  • Sequencing QC
  • Demultiplexing
  • Based on research collaboration:
    - Mapping in reference genomes
    - Variant calling
    - Gene expression
  • Further analyses and data storage options are available via QBiC

Teams

Human Genetics Group

Address: Calwerstraße 7
72076 Tübingen

Phone number: +49 7071 29-72298

E-mail address: ncct@med.uni-tuebingen.de

Institution: How to find us

Dr. Nicolas Casadei

Head of Core Facility Genomics


Dr. Elena Buena Atienza

Scientist Long Reads

Dr. Sabine Fraschka

Scientist Single Cell

Michaela Pogoda, M.Sc

Scientist Short Reads, Automation

Jakob Admard, M.Sc

Scientist Bioinformatics

Mehmet Direnc Mungan

Scientist Bioinformatics

Sven Poths

Laboratory Manager

Jessica Klaus

Technician Short Reads

Noella Ansorge

Technician Long Reads

Antje Schulze-Selting

Technician Single Cell

Microbial Genomics Group

Address: Elfriede-Aulhorn-Straße 6
72076 Tübingen

Phone number: +49 7071 29-61951

E-mail address: ncct@med.uni-tuebingen.de

Institution: How to find us

Dr. Janina Geißert-Janek

Deputy Head of Core Facility Genomics
Scientist


Dr. Janina Vogt

Team leader microbiology lab, Scientist

Dr. Oleksandra Karpiuk

Scientist

Dr. Miriam Lucke

Scientist

Jennifer Müller, M.Sc

Scientist Bioinformatics

Manuela Löffler

Technician

Chukwunonso Nnabude

Technician

Teams 2

Sven Dobler

Finance Management

Equipment

Small scale, medium scale and high-throughput sequencers are available from Illumina and Oxford Nanopore Technologies, supporting short-read and long-read technology.

Images are courtesy of Illumina, Inc. and Oxford Nanopore Technologies.

Ilumina MiSeq

Illumina MiSeq

  • Flexible low-output sequencer
  • Read length: 50-600 bp
  • Output: 0.54 - 15 Gb

Illumina NextSeq 500/550

  • Mid-output sequencer
  • Read length: 75 -300 bp
  • Output: 16.25 - 120 Gb

Illumina NovaSeq 6000

  • High-output sequencer
  • Read length: 35 - 500 bp
  • Output: 80 - 6,000 Gb

Illumina NovaSeq X Plus

  • High-output sequencer
  • Read length: 50 - 300 bp
  • Output: 165 - 16,000 Gb

Oxford Nanopore MinION

  • Low-throughput long-read sequencer
  • Output: application dependent 300 Mb - 10 Gb / flow cell

Oxford Nanopore PromethION

  • High-throughput long-read sequencer
  • Output: application dependent 30 - 120 Gb / flow cell

Liquid handling systems help to increase reproducibility and scale up production. Several platforms for nucleic acid extraction and library preparation are implemented.

Tecan Fluent 780

High-throughput liquid handler 
Implemented on site for bacterial genomic applications

Beckman i5

High-throughput liquid handler
Implemented on site for pre-PCR eukaryotic applications

Beckman i7

High-throughput liquid handler
Implemented on site for pre-PCR and post-PCR eukaryotic applications

QIAsymphony

High-throughput nucleic acid extraction
DNA & RNA isolation

QIAcube HT

High-throughput nucleic acid extraction
DNA & RNA isolation

Qubit

Fluorometer for DNA/RNA quantification

Bioanalyzer

Microfluidic device for DNA/RNA quantification and quality control  

FemtoPulse

Automated pulse-field capillary electrophoresis system to assess quality and quantity of
high molecular weight DNA, as well as very low input DNA

TapeStation

Automated capillary electrophoresis system to assess quality and quantity of DNA or RNA samples

10x ChromiumX

High-throughput automated single-cell partitioning

10x CytAssist (for Visium HD)

Automated diffusion system to improve the resolution of spatial transcriptomics

FAQ

Please contact us if we can support you in the planning of your sequencing project. 

Before reaching out, please collect the following data:

  • What is the aim of your project?
  • How many samples do you have?
  • How many replicates are planned?
  • What is your sample type? (e.g. library, DNA/RNA, blood, stool, etc.)
  • Are your samples genetically modified organisms (GMOs), do they present a biosafety risk?
  • Which species are you working on? (e.g. human, mouse, etc.)
  • Is bioinformatics analysis needed? If yes, to what degree?

You can provide your sample details in our Metadata Sheet.
Please enter your contact and sample details and submit in digital form and in printed version together with your samples.

Sample guidelines, shipment address and other useful information can be found on this page under resources.

Yes, it is possible. Please contact us beforehand to coordinate date and time. Even if the travel time is short, please ensure that the samples are stored properly during transportation (e.g., they are frozen or kept on ice).

The quality of RNA and subsequent RNA-seq is strongly dependent on its storage and transportation conditions, so we strongly encourage using dry ice for RNA shipment. If you are shipping samples for RNA isolation, they also have to be shipped on dry ice. Important note: samples in RNA stabilizing solutions (e.g., RNAlater) can be shipped chilled or frozen at -20°C. Please notify us beforehand if your samples contain RNA stabilizing solution.

Without prior information about your project it is very difficult to estimate the time required for it. The turnaround time depends on sample number, exact sample prep workflow, equipment and personnel availability. Please contact us for more details. Please note, during winter and summer holidays, the turnaround time is slower due to personnel availability.

The standard output from a sequencing project is demultiplexed FASTQ files. If further bioinformatics support is needed, please contact us.

Please contact us to receive a quote for your project.