Clinical trial unit
Tübingen Eye and Ear Ophthalmology and Otolaryngology

Sicherheit und Wirksamkeit einer beidseitigen, einmaligen subretinalen Injektion von rAAV. hCNGA3 in Erwachsenen und Kindern, die an CNGA3 verursachter Achromatopsie leiden, untersucht in einer randomisierten, Untersucher maskierten Studie mit Wartegruppendesign; Akronym: Colour Bridge.

Peters, T., Ziegler, M., Kinkl, N., & Zrenner, E. Link zur Publikation

Subretinal injection in the USH1CR31∗ pig model leads to chorioretinal atrophy that limits evaluation of efficacy of an AAV-mediated gene therapy

Ruslan Nyshchuk, Joshua Klein, Immanuel P. Seitz, Tobias Peters, Matthias Mai, Taras Ardan, Saskia Drutovič, Božena Levinská Bohuslavová, Štefan Juhás, Jana Juhásová, Yesim Tütüncü, Yaroslav Nemesh, Lienne M. Reifferscheid, Kathryn Post DeMott, Jennifer J. Klein, Kerstin Nagel-Wolfrum, Nikolai Klymiuk, Ashley R. Winslow, Jan Motlik, Zdenka Ellederova, M. Dominik Fischer, Uwe Wolfrum Link zur Publikation

MyopiaX-1 Safety and Efficacy of a Novel Approach to Slow Juvenile Myopia Progression: A Multicenter, Randomized, Controlled Trial

James Loughman, Gareth Lingham, Hakan Kaymak, Katrin Lorenz, Jan Roelof Polling, Anna Beck, Gonzalo Carracedo, Annegret H. Dahlmann-Noor, Philipp L. Müller, Ian Flitcroft, Ana Amorim-de-Sousa, Cristina Arroyo del Arroyo, Laura Batres, Carlos Carpena Torres, Christoph Deuter, Machteld Devenijn, Paulo R.B. Fernandes, Roxana Folga, Mariya Gosheva, Enrique Jimenez Gañan, Timea Katona, Caroline Klaver, Kübra Liman, Jose Manuel González-Meijome, Ann-Isabel Mattern, Marta Morales Ballús, Birte Neller, Cristina Pastrana Robles, Sofia C. Peixoto-de-Matos, Tobias Peters, Paloma Porras Ángel, María Serramito Blanco, Sara Silva-Leite, Julia Bodas Romero Link zur Publikation

Surgical Approach for the Implantation of a Ring Electrode into the Sulcus in a Phakic Non-human Primate

Kortuem FC, Seitz I, Kaltenstadler S, Schumayer S, Sigdel B, Peters T, Rothermel A, Bucher V, Zrenner E, Bartz-Schmidt KU, Straßer T. Link zur Publikation

Safety and vision outcomes of subretinal gene supplementation therapy in PDE6A-associated retinitis pigmentosa: a non-randomised controlled trial

Reichel FF, Fischer MD, Stingl K, Kuehlewein L, Seitz I, Peters T, Ziegler M, Wilhelm B, Kohl S, Weisschuh N, Martus P, Seeliger M, Muehlfriedel R, Paquet-Durand F, Tsang SH, Bartz-Schmidt KU, Ueffing M, Zrenner E, Biel M, Wissinger B, Michalakis S; RD-Cure Consortium Link zur Publikation

Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD

Frank G Holz 1,✉, Yannick Le Mer 2, Mahiul MK Muqit 3, Lars-Olof Hattenbach 4, Andrea Cusumano 5, Salvatore Grisanti 6, Laurent Kodjikian 7, Marco Andrea Pileri 8, Frederic Matonti 9, Eric Souied 10, Boris V Stanzel 11, Peter Szurman 12, Michel Weber 13, Karl Ulrich Bartz-Schmidt 14, Nicole Eter 15, Marie Noelle Delyfer 16, Jean François Girmens 17, Koen A van Overdam 18, Armin Wolf 19, Ralf Hornig 20, Martina Corazzol 20, Frank Brodie 21, Lisa Olmos de Koo 22, Daniel Palanker 23,*, José-Alain Sahel 2,17,24,* Link zur Publikation

Safety of Human USH1C Transgene Expression Following Subretinal Injection in Wild-Type Pigs

Kiraly, P., Klein, J., Seitz, I. P., Reichel, F. F., Peters, T., Ardan, T., Juhasova, J., Juhás, S., Ellederova, Z., Nemesh, Y., Nyshchuk, R., Klymiuk, N., Nagel-Wolfrum, K., Winslow, A. R., Wolfrum, U., Motlik, J., & Fischer, M. D. Link zur Publikation

Ocular Safety and Toxicology of Subretinal Gene Therapy With rAAV.hPDE6A in Nonhuman Primates

Seitz, I. P., Wozar, F., Ochakovski, G. A., Reichel, F. F., Korte, S., Korbmacher, B., Wilhelm, B., Süsskind, D., Bartz-Schmidt, K. U., Fischer, M. D., Peters, T., & RD Cure Consortium Link zur Publikation

DB-OTO Gene Therapy for Inherited Deafness.

Vassili Valayannopoulos  1 , Manohar Bance  2 , Daniela S Carvalho  3 , John H Greinwald Jr  4 , Steven A Harvey  5 , Akira Ishiyama  6 , Evie C Landry  7 , Hubert Löwenheim  8 , Lawrence R Lustig  9 , Manuel Manrique  10 , Robert Nash  11 , Rubén Polo  12 , Cedric V Pritchett  13 , Jay T Rubinstein  14 , A Eliot Shearer  15 , Ignacio Del Castillo  16   17 , Jeffery J Anderson  1 , C Eduardo Corrales  1   18 , Tera M Quigley  1 , William J Riggs  1 , Peter Weber  1 , Gary Wilson  1 , Susan C Irvin  1 , Hazem E Hassan  1 , Yanping Chen  1 , Rong Liu  1 , Meghan C Drummond  1 , Leah R Sabin  1 , Bret J Musser  1 , George D Yancopoulos  1 , Christos A Kyratsous  1 , Gary A Herman  1 , Aris Baras  1 , Jonathon P Whitton  1 ; CHORD Study Group Link zur Publikation

Transkorneale Elektrostimulation bei Retinitis pigmentosa : Prüfplan einer multizentrischen, prospektiven, randomisierten, kontrollierten und doppelblinden Studie im Auftrag des Gemeinsamen Bundesausschusses (G-BA-Erprobungsrichtlinie) [Transcorneal electrostimulation in retinitis pigmentosa : Protocol of a multicentric prospective, randomized, controlled and double-masked trial on behalf of the Joint Federal Committee (G-BA pilot regulation)]

Kahle N, Peters T, Braun A, Franklin J, Michalik C, Gekeler F, Wilhelm B; retina.net e. V.; TES-RP-Studiengruppe Link zur Publikation