Contact

Telefonnummer: +49-7071-29 87623

E-Mail-Adresse: alexander.weber@uni-tuebingen.de

Adresse: Auf der Morgenstelle 15, 72076 Tübingen

About us

Welcome to the webpages of the Department of Innate Immunity at the University of Tübingen. The department is led by Prof. Alexander Weber, PhD and emerged out of his research group which has existed at the University’s Medical Faculty since 2011. 

Our research focus is the human innate immune system, especially so-called pattern recognition receptors (PRRs). Although the major focus is basic research the lab is also involved in clinical and translational studies with partners at the University Hospital Tübingen. The department is also affiliated with the Clusters of Excellence iFIT & CMFI,  the German Cancer Consortium (DKTK) and multiple DFG-funded research networks. Our scope spans from the molecular level (where it is mostly focused on pattern recognition receptors as primary danger sensors of the immune system) via subcellular aspects of signaling and cellular responses to the intercellular context and the interactions of immune cells with various tissue cells. A particular emphasis is on the control of inflammation and on imaging but other state-of-the-art methods are also employed in our well-funded laboratory.

Our team is dynamic and highly international and enjoys a very positive working atmosphere. We are strongly dedicated to Good Scientific Practice and committed to continuing professional development of which annual appraisals and retreats are a hallmark.

The department also seeks to nucleate new local and international initiatives in the area of immunology, e.g. via the network Innate Immunity @Tübingen. Via the bi-annual Novel Concepts of Innate Immunity (NCII) conference series the department seeks to continue the long tradition of Tübingen in the discovery of mediators of Innate Immunity, most notably the discovery of the Toll receptor.

Our Team

Prof. Alexander Weber

Prof. Alexander Weber

W3/Full Professor and Head of the Department of Innate Immunity

Telefonnummer: 07071 29-87623

Faxnummer: 07071029-4759

E-Mail-Adresse: alexander.weber@uni-tuebingen.de

Publikationen: Pubmed

Publikationen: ORCID

Publikationen: Research Gate

Personenprofil: Mehr zur Person

Our Team members

Innate Immunity in Tübingen Network

Our goal has been to bring together different local researchers with interests in the expanding field of innate immunity via joint events and the internet platform “Innate Immunity in Tübingen”. Further details can be found here: Click here

Novel Concepts in Innate Immunity” (NCII) conference series

The  “Novel Concepts in Innate Immunity” (NCII) conference series started in 2015 to commemorate the discovery of the Toll receptor in Tübingen (Anderson et al Cell 1985), a milestone in the exploration of innate immunity. Typically held on the beautiful Tübingen University campus the biannual conference seeks to bring together researchers in the the various disciplines of innate immunity to share the latest results and discuss the latest trends in the field. The 2015, 2017, 2021 (online) and 2023 (hybrid) conferences hosted notable keynote speakers like Nobel laureates Christiane Nüsslein-Vollhard, Jules Hoffmann, and Bruce Beutler, was well as other internationally renowned experts like Yasmine Belkaid, Giorgio Trinchieri, Louis Staudt, Richard Flavell, Ruth Ley, Mihai Netea, James Chen, Vishva Dixit, Luke O’Neill and Hao Wu to nbame but a few. Moreover,t he editors of Science, J Exp Med, J Leukoc Res and EMBO Reports have been joining the conferences and have held workshops to advise especially junior researchers on how best to publicize their work. The conference is heavily attended by students and is the ideal event for exposure to the exciting field of innate immunity. Social events showcase the beauty of Tübingen and provide valuable networking opportunities.

Further information, including the dates and details of the next NCII, can be found at www.innate-immunity-conference.de

We would be glad to welcome you in Tübingen at a future NCII conference!

Publications

  • 2024Bork F, Greve CL, Youn C, Chen S, Leal VNC, Wang Y, Fischer B, Nasri  M, Focken J, Scheurer J, Engels P, Dubbelaar M, Hipp K, Zalat B, Szolek A, Wu MJ, Schittek B, Bugl S, Kufer TA, Löffler MW, Chamaillard M, Skokowa J, Kramer D, Archer NK, Weber ANR. naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation. EMBO Rep 2024;  May 23;10.1038/s44319-024-00150-5
  • 2021Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. J Exp Med. 2021;218(11):e20201656.
  • 2020Herster F, Bittner Z, Archer NK, Dickhöfer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Löffler MW, Kalbacher H, Vierbuchen T, Heine H, Miller LS, Hartl D, Freund L, Schäkel K, Heister M, Ghoreschi K, Weber ANR. Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. Nat Commun 2020, 8;11(1):105.
  • 2018Fuchs K*, Cardona Gloria Y*, Wolz OO, Herster F, Sharma L, Dillen C, Täumer C, Dickhöfer D, Bittner Z, Dang TM, Singh A, Haischer D, Schlöffel MA, Koymans KJ, Sanmuganantham T, Krach M, Schilling NA, Frauhammer F, Miller L, Nürnberger N, LeibundGut-Landmann S, Gust AA, Macek B, Frank M, Gouttefangeas C, Dela Cruz CS, Hartl DH, Weber AN. The fungal ligand chitin directly binds and signals inflammation dependent on oligomer size and TLR2. EMBO Rep 2018. pii: e201846065. doi: 10.15252/embr.201846065.
  • 2017Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber AN. Human NLRP3 inflammasome activity is regulated by and therapeutically targetable via BTK. J Allergy Clin Immunol. 2017. pii: S0091-6749(17)30232-4.

News

NLRP3 inflammasome seminar

First virtual NLRP3 inflammasome seminar

research on the NLRP3 Inflammasome

New research on the NLRP3 Inflammasome

PhD students defend their thesis

Congratulations to Sangeetha Shankar and Pujan Engels