Institute of Medical Psychology and Behavioural Neurobiology

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568

Address: Otfried-Müller-Straße 25
72076 Tübingen

Phone number: +49 7071 29-88923

Fax number: 07071 29-25016

E-mail address: anja.​otterbein@​uni-​tuebingen.​de

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Neuroprosthetics

Research Aims

In the neuroprosthetics group we work on open and closed loop systems for cognitive or motor impairments restoration. We use mainly brain (invasive and non-invasive) and muscle activity (non-invasive) as main control signals for the different devices. The final goal of our group is to combine state of the art techniques in signal processing, skill learning and clinical impairment related neurophysiology know-how to construct, use, optimise and test rehabilitation and assisstive neuroprostheses in specifics cognitive or motor impairments.

We study multisensory integration neurophysiology and psychophysiscs to improve efficacy of our systems. CNS electrical and magnetic stimulation techniques and effects are also studied and used.

Technologies used: EEG, MEG, fNIRS, fMRI, EMG, ECoG, Intracortical electrodes, Robotics (exoskeletons), FES, TMS, tDCS, haptic feedback.

Laufende Projekte

Current projects

  • Decoding of EEG, EMG and hybrid EEG-EMG in paralyzed patients (Andrea Sarasola, Nerea Irastorza, Carlos Bibian, Andreas Ray, Florian Helmhold, Ainhoa Insausti, Eduardo Lopez-Larraz, Ander Ramos-Murguialday)
  • EMG synergies in chronic stroke (Nerea Irastorza, Ander Ramos-Murguialday)
  • Factors influencing neural plasticity during motor rehabilitation (Wala Mahmoud, Ander Ramos-Murguialday)
  • Neurophysiologcial correlates of functional electrical stimulation during motor rehabilitation using FES-BCI (Ainhoa Insausti, Eduardo Lopez-Larraz Ander Ramos-Murguialday)
  • Motivational and psychological factors and gamification during motor rehabilitation (Doris Broetz, Wala Mahmoud, Andreas Ray, Florian Helmhold, Ander Ramos-Murguialday)
  • Improvement of non-invasive BCIs during motor rehabilitation (Carlos Bibian, Eduardo Lopez Larraz, Andrea Sarasola, Nerea Irastorza, Florian Helmhold, Wala Mahmoud, Iñaki Ortego-Isasa, Andreas Ray, Ainhoa Insausti-Delgado, Ander Ramos-Murguialday)
  • Biomarkers of stroke and motor recovery (Andreas Ray, Florian Helmhold, Eduardo Lopez)
  • Multi-scale information flow and predictability of neural activity during movement preparation, attempt and execution in chronic stroke (Florian Helmhold, Nerea Irastorza, Andreas Ray, Ander Ramos-Murguialday)
  • EEG-based BCI for the volitional control of spinal magnetic stimulation to rehabilitate lower limb paralysis (Ainhoa Insausti-Delgado, Eduardo Lopez-Larraz Ander Ramos-Murguialday)
  • Electromagnetic Simulation and Modeling of neurotechnology devices such as: TMS and FES (Iñaki Ortego-Isasa)
  • Optimization of stimulation parameters of TMS, NMES and FES for assistive and rehabilitation purposes (Iñaki Ortego-Isasa, Florian Helmhold, Ander Ramos-Murguialday)
  • Ultrasonic neural stimulation (Florian Helmhold, Ander Ramos-Murguialday)

Key publications

  • N. Birbaumer, A. Ramos-Murguialday and L. Cohen, Brain-Computer-Interface (BCI) in paralysis. In: Current opininon in Neurology Vol. 21(6):634-638, 2008
  • Ramos-Murguialday A, Schürholz M, Caggiano V, Wilgrüber M, Caria A, Hammer EM, Halder S, Birbaumer N. Proprioceptive feedback and brain computer interface (BCI) based neuroprostheses. PLoS ONE. 2012; 7(10):e47048.doi:10.1371/journal.pone.0047048
  • Walter A, Ramos-Murguialday A, Rosenstiel W, Birbaumer N, Bogdan M. Coupling BCI and cortical stimulation for brain-state-dependent stimulation: methods for spectral estimation in the presence of stimulation after-effects. Frontiers in Neural Circuits 2012; 6:87. doi: 10.3389/fncir.2012.00087
  • Ramos-Murguialday A, Broetz D, Rea M, Laeer L, Yilmaz O, Brasil FL, Liberati G, Curado MR, Garcia-Cossio E, Vyziotis A, Cho W, Agostini M, Soares E, Soekadar S, Caria A, Cohen LG, Bibaumer N. Brain-Machine-Interface in Chronic Stroke Rehabilitation: A Controlled Study. Annals of Neurology (2013). DOI: 10.1002/ana.23879
  • Vidaurre C, Pascual J, Ramos-Murguialday A, Blankertz B, Birbaumer N, Mueller KR. Neuromuscular electrical stimulation induced brain patterns to decode motor imagery. ClinNeurophysiol.2013; doi:10.1016/j.clinph.2013.03.009