The Clinical Cooperation Unit Translational Immunology is a multidisciplinary unit that develops and applies novel immunotherapeutics for cancer patients. It draws on experience obtained in decades of research regarding the development of optimized antitumor antibodies and vaccination strategies, combined with our expertise in the treatment of malignant diseases and the clinical evaluation of new therapeutic concepts. We work closely together with the specialists at the other Departments at University Hospital Tübingen that treat cancer patients as well as the Department of Immunology.
Acute myeloid leukemia (AML)
First in man study to evaluate the safety, tolerability and preliminary efficacy of the Fc-optimized FLT3 antibody FLYSYN for the treatment of acute myeloid leukemia patients with minimal residual disease.
Chronic lymphocytic leukemia (CLL)
Patient-individualized peptide vaccination after first line therapy of CLL
Personalized peptide vaccination in combination with the TLR2 ligand XS15 for CLL patients under ibrutinib treatment.
First in human study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration resistant prostate carcinoma
Start of recruitment planned Q4/2019
Patient individual immunotherapy concepts
The direct link between research and patient care enables us to offer our patients newly developed and personalized immunotherapic concepts for tumor diseases.
Please note that for enquiries regarding participation in our clinical trials or for medical consulation on cancer immunotherapy concepts, it is mandatory that the treating physician beforehand provides your treatment documents (current doctor's letter, imaging findings, etc.), ideally via e-mail:
E-mail address: KKETI@med.uni-tuebingen.de
Office for clinical studies:
+49 7071 29-82834
Novel vaccine trial to activate T-cell responses against SARS-CoV-2
University Hospital Tübingen starts clinical studies with an in-house developed vaccine for COVID-19Learn more
The challenges of
Commentary in EMBO Molecular MedicineLearn more
Making cancer stem cells visible for the immune system
Publication in NatureLearn more
The increasing understanding of the mechanisms underlying host-tumor interaction led to development of strategies that harness antitumor immunity for cancer treatment. However, while immunotherapy meanwhile has become a mainstay of tumor therapy, there is still ample room for improvement. Some patients do not respond to presently available approaches at all, others for limited time only, and for many cancer entities so far no immunotherapeutic strategies are available. In our view, this calls for efforts to more rapidly translate promising results from research to clinical application. To achieve this superordinate goal, our work focusses on the following key aspects:
Molecular mechanisms influencing tumor-immune interaction and escape
Here we investigate the role of various immunoregulatory molecules involved in host-tumor interaction, in particular with putative tumor stem cells. Beyond improving the understanding of tumor biology per se, these studies aim to identify new target molecules for immunotherapeutic approaches and to identify prognostic markers for disease progression and response in patients. We further investigate how "conventional" systemic tumor therapeutics influence the immune response to enable rational combinations with immunotherapy. In addition, the development of valid model systems for testing novel strategies prior to application in humans is an important basis to develop rational immunotherapeutics.
Development and clinical evaluation of optimized anti-tumor antibodies and peptide vaccination strategies
The "preclinical" work mentioned above provides the basis for the second focus of our work, which is clearly focused on clinical application. This includes the development of optimized mono- and bispecific antibodies, novel immunocytokines and personalized peptide vaccination strategies. Our efforts cover the entire process, from conception and manufacture to clinical application in patients. This enables the rapid translation of results from basic research to novel therapies for cancer patients ("bench to bedside"). The feasibility of our approach is reflected by our various clinical studies with in-house developed immunotherapeutics.
Education and Career
The rapid developments in tumor immunology and immunotherapy during the recent years call for a greater focus on this topic during academic education. Therefore, the CCU Translational Immunology participates in numerous classes and curricula in human medicine, biochemistry, biology and molecular medicine. In addition to strengthening basic immunological education, in our view it is particularly important to inspire students of human medicine for research for tumor immunology. Likewise it is equally important to illustrate the potential, but also the difficulties of translation in the field of immunotherapy to students of non-clinical natural sciences. Accordingly, we consider an early involvement of students and later also resident physicians and PhD students in translational research as a very important aspect of academic education. The various research groups within the CCU Translational Immunology offer the opportunity to gain insights into basic research and translational projects during internships, bachelor's and master's theses as well as medical and scientific doctoral dissertations. We provide numerous opportunities for further education within the framework of the iFIT excellence cluster, the National Center for Tumor Diseases (NCT) Southwest and by attending national and international meetings as well as workshops and courses for career development.
The CCU Translational Immunology offers resident physicians and specialists of the various disciplines involved in treatment of cancer patients the opportunity to gain experience in the development and conduct of clinical trials within the scope of a rotation. With support of our experienced lab staff, this also provides a chance to conduct research projects with the aim to publish scientific work, which enables the application for internal and external research funds as well as research scholarships for stays abroad. For a rotation to the CCU Translational Immunology, a minimum of 2 years clinical experience is mandatory.
Applications from motivated students for a position to conduct a master's thesis or a medical or scientific doctoral thesis are welcome. The same applies to Ph.D. scientists interested in our field.
+49 7071 29-83275
+49 7071 29-4391
E-mail address: Sabrina.email@example.com
Certificates and Associations
Focus: Top Nationales Krankenhaus 2020
Kooperation für Transparenz und Qualität im Gesundheitswesen
Qualitätspartnerschaft mit der PKV
Die Altersvorsorge für den Öffentlichen Dienst