The University Hospital

Dr. rer. nat. Birte Zurek

Dr. rer. nat. Birte Zurek

Research manager

Project management of "Solve-RD - solving the unsolved rare diseases" and the Ataxia Global Initiative

Contact

Phone number: 07071 29-72285

Fax number: 07071 29-25061

E-mail address: birte.zurek@med.uni-tuebingen.de

Clinic / Institute / Center

  • 10/2001 - 11/2006Study of Biochemistry, University of Bielefeld
  • 11/2007 - 10/2011Doctoral studies, Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne
  • 10/2011Dr. rer. nat., University Hospital Cologne
  • 02/2012 - 06/2012KoWi (Eurpean Liaison Office of the German Research Organisations), Bonn
  • seit 07/2012Institute for Medical Genetics and Applied Genomics, University Hospital Tübingen
  • Denommé-Pichon A-S et al. A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing. Genet Med. 2023 Apr;25(4):100018.doi: 10.1016/j.gim.2023.100018.
  • Graessner H, Zurek B, Hoischen A, Beltran S. Solving the unsolved rare diseases in Europe. Editorial: Eur J Hum Genet. 2021 Sep;29(9):1319-1320.doi: 10.1038/s41431-021-00924-8.
  • Zurek B et al. Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases. Eur J Hum Genet. 2021 Sep;29(9):1325-1331.doi: 10.1038/s41431-021-00859-0. Epub 2021 Jun 1.
  • Atalaia A et al. A guide to writing systematic reviews of rare disease treatments to generate FAIR-compliant datasets: building a Treatabolome. Orphanet J Rare Dis. 2020 Aug 12;15(1):206.doi: 10.1186/s13023-020-01493-7.
  • Zurek B, Graessner H, Lerche H, IonNeurONet Consortium. IonNeurONet - German Network for Neurological and Ophthalmological Ion Channel Diseases. medgen 2013 25: 501-505.
  • Bielig H, Lautz K, Braun PR, Menning M, Machuy N, Brügmann C, Barisic S, Eisler SA, Andree M, Zurek B, Kashkar H, Sansonetti PJ, Hausser A, Meyer TF, Kufer TA. The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling. PLoS Pathog. 2014 Sep 4;10(9):e1004351. doi: 10.1371/journal.ppat.1004351.
  • Mayle S, Boyle JP, Sekine E, Zurek B, Kufer TA, Monie TP. Engagement of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) by receptor-interacting protein 2 (RIP2) is insufficient for signal transduction. J Biol Chem. 2014 Aug 15;289(33):22900-14. doi: 10.1074/jbc.M114.557900.
  • Zurek B, Schoultz I, Neerincx A, Napolitano LM, Birkner K, Bennek E, Sellge G, Lerm M, Meroni G, Söderholm JD, Kufer TA. TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation. PLoS One. 2012;7(7):e41255. doi: 10.1371/journal.pone.0041255.
  • Bielig H, Dongre M, Zurek B, Wai SN, Kufer TA. A role for quorum sensing in regulating innate immune responses mediated by Vibrio cholerae outer membrane vesicles (OMVs). Gut Microbes. 2011 Sep 1;2(5):274-9. doi: 10.4161/gmic.2.5.18091.
  • Zurek B, Bielig H, Kufer TA. Cell-based reporter assay to analyze activation of Nod1 and Nod2. Methods Mol Biol. 2011;748:107-19. doi: 10.1007/978-1-61779-139-0_7.
  • Zurek B, Proell M, Wagner RN, Schwarzenbacher R, Kufer TA. Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation. Innate Immun. 2012 Feb;18(1):100-11. doi: 10.1177/1753425910394002.
  • Bielig H, Rompikuntal PK, Dongre M, Zurek B, Lindmark B, Ramstedt M, Wai SN, Kufer TA. NOD-like receptor activation by outer membrane vesicles from Vibrio cholerae non-O1 non-O139 strains is modulated by the quorum-sensing regulator HapR. Infect Immun. 2011 Apr;79(4):1418-27. doi: 10.1128/IAI.00754-10.
  • Bielig H, Zurek B, Kutsch A, Menning M, Philpott DJ, Sansonetti PJ, Kufer TA. A function for AAMP in Nod2-mediated NF-kappaB activation. Mol Immunol. 2009 Aug;46(13):2647-54. doi: 10.1016/j.molimm.2009.04.022.
  • Publications