Institute of Medical Psychology and Behavioural Neurobiology


Address: Otfried-Müller-Straße 25
72076 Tübingen

Phone number: +49 7071 29-88923

Fax number: 07071 29-25016

E-mail address: anja.​otterbein@​uni-​tuebingen.​de


Research Aims

This area of our research deals with metabolic processes in humans and animals and how they are influenced or controlled by cognition, sleep/wake rhythms and neuroendocrine signals. We are interested in central nervous processes that establish cognitive control of food intake and are investigating the impact of hormones like insulin and oxytocin on central nervous and peripheral metabolic functions. Of particular interest for our research is the dual role of neuropeptides as modulators of metabolic and cognitive processes, and how sleep interacts with both functions. We are also investigating the impact of nutrients on sleep-dependent processes of memory formation and metabolic adaptation.


Head of research group{element.contextual_1.children.icon}: Prof. Manfred Hallschmid

More about

Laufende Projekte

Current topics

  • Cognitive control of eating behavior
  • Fetal and neonatal aspects of eating behavior
  • Insulin effects on the human brain
  • Oxytocin and metabolic function in health and disease
  • Sleep-dependent neuronal processes and metabolic control
  • Sucrose and fat in the regulation of CNS function and sleep physiology

Key publications

  • Feld GB, Wilhem I, Benedict C, Rüdel B, Klameth C, Born J, Hallschmid M (2016) Central nervous insulin signaling in sleep-associated memory formation and neuroendocrine regulation. Neuropsychopharmacology 41(6):1540-1550; doi: 10.1038/npp.2015.312.
  • Klement J, Ott V, Rapp K, Brede S, Piccinini F, Cobelli C, Lehnert H, Hallschmid M (2017) Oxytocin improves beta-cell responsivity and glucose tolerance in healthy men. Diabetes 66(2):264-271; doi: 10.2337/db16-0569.
  • Kohl SH, Veit R, Spetter MS, Günther A, Rina A, Lührs M, Birbaumer N, Preissl H, Hallschmid M (2019) Real-time fMRI neurofeedback training to improve eating behavior by self-regulation of the dorsolateral prefrontal cortex: A randomized controlled trial in overweight and obese subjects. NeuroImage 191:596-609; doi: 10.1016/j.neuroimage.2019.02.033.
  • Krug R, Mohwinkel L, Drotleff B, Born J, Hallschmid M (2018) Insulin and estrogen independently and differentially reduce macronutrient intake in healthy men. J Clin Endocrinol Metab 103(4):1393-1401; doi: 10.1210/jc.2017-01835.
  • Ritze Y, Kern W, Ebner EM, Jahn S, Benedict C, Hallschmid M (2018) Metabolic and cognitive outcomes of subchronic once-daily intranasal insulin administration in healthy men. Front Endocrinol (Lausanne) 9:663. doi: 10.3389/fendo.2018.00663.