Das Klinikum

apl. Prof. Dr. Sandra Beer-Hammer

apl. Prof. Dr. Sandra Beer-Hammer

Stellvertretende Abteilungsleiterin

Wissenschaftliche Schwerpunkte:

Funktion und biologische Relevanz von Gai-Proteinen für kardiovaskuläre Erkrankungen und SLy-Adaptorproteinen im Immunsystem

Kontakt

Telefonnummer: 07071 29-74594

Faxnummer: 07071 29-4942

E-Mail-Adresse: sandra.beer-hammer@uni-tuebingen.de

Klinik / Institut / Zentrum

  • Fachimmunologin der DGfi
  • Koordinatorin und Leiterin (ab 2019) der Herbstschule der DGfI (seit 2008)
  • Mitglied des Beirats der DGfI (seit 2019)
  • seit Oktober 2016Stellvertretende Abteilungsleiterin Abteilung für Pharmakologie, Experimentelle Therapie und Toxikologie, UKT
  • 02/2016Ernennung zur APL-Professorin für Pharmakologie und Immunologie, UKT
  • 05/2012Umhabilitation in den Fächern Pharmakologie und Immunologie, UKT
  • seit 2010Leiterin der IeEPhA-Mausklinik, UKT
  • 10/2010Habilitation im Fach Immunologie, HHU Düsseldorf
  • seit 09/2009Gruppenleiterin am Institut für Pharmakologie und Toxikologie, UKT
  • 2008-2009Elternzeit
  • 2002-2009Gruppenleiterin am Institut für Medizinische Mikrobiologie und Krankenhaushygiene, HHU Düsseldorf
  • 1999-2002PostDoc am Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, TU München
  • 1996-1999Promotion, DKFZ, Heidelberg
  • 1995-1996Diplomarbeit, Institut für Tropenmedizin, Uniklinikum Tübingen (UKT)
  • 1990-1995Biologie-Studium, Universität Tübingen
  • Beer, S., Simins, A., Schuster, A., Holzmann, B. (2001) Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells. Bioch Biophys Acta 1520: 89-93.
  • Astoul, E., Laurence, A.D., Totty, N., Beer, S., Alexander, D.R., Cantrell, D.A. (2003) Approaches to define antigen receptor induced serine kinase signal transduction pathways. J Biol Chem 278: 9267-9275.
  • Semmrich, M., Smith, A., Feterowski, C., Beer, S., Engelhardt, B., Busch, D.H.,Bartsch, B., Laschinger M., Hogg, N., Pfeffer, K., Holzmann, B. (2005) Importance of LFA-1 deactivation for the generation of immune responses. J Exp Med 20: 1987-1998.
  • Beer, S., Scheikl, T., Reis, B., Hüser, N., Pfeffer, K., Holzmann, B. (2005) Impaired immune responses and prolonged allograft survival in SLY- mutant mice. Mol Cell Biol 25: 9646-9660.
  • Reis, B., Pfeffer, K., Beer-Hammer, S. (2009) The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development. BMC Immunol 10: 38-51. doi:10.1186/1471-2172-10-38.
  • Brandt, S., Beuter-Gunia, C., Schuster, M., Hausser, A., Schmitz, I., Beer-Hammer, S. (2010) The nucleo-cytoplasmic protein SLy2 targets the SAP30/HDAC1 complex. Int J Biochem Cell Biol 42: 1472-1481.
  • von Holleben, M., Gohla, A., Janssen, K.-P., Iritani, B., Beer-Hammer, S. (2011) The immunoinhibitory adapter protein SRC homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading. J Biol Chem 286: 13489-13501.
  • Autenrieth, S.E., Warnke, P., Wabnitz, G.H., Lucero Estrada, C., Pasquevich, K.A., Drechsler, D., Günter, M., Hochweller, K., Novakovic, A., Beer-Hammer, S., Samstag, Y., Hämmerling, G.J., Garbi, N., Autenrieth, I.B. (2012) Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis. PLOS Pathogen 8, e1002552.
  • Wiege, K., Le, D.D., Syed, S.N., Ali, S.R., Novakovic, A., Pexa, K., Beer-Hammer, S., Piekorz, R.P., Schmidt, R.E., Nürnberg, B., Gessner, J.E. (2012) Defective macrophage migration in Gαi2- but not Gαi3-deficient mice. J Immunol 189: 980-987.
  • Gogishvili, T., Lühder, F., Göbbels, S., Beer-Hammer, S., Nave, K.-A., Pfeffer, K., Reuter, S., Taube, C., Hünig, T. (2012) Interruption of CD28-mediated costimulation protects mice from allergic airway disease by reprogramming the T-cell response. J Allergy Clin Invest, 130: 1394-1403.
  • Wiege, K., Ali, S.R., Gewecke, B., Novakovic, A., Pexa, K., Beer-Hammer, S., Piekorz, R.P., Schmidt, R.E., Nürnberg, B., Gessner, J.E. (2013) Gαi2 is the essential Gαi protein in immune complex-induced lung disease. J Immunol, 190(1): 324-333.
  • Degrandi, D., Kravets, E., Konermann, C., Beuter-Gunia, C., Beer-Hammer, S., Pfeffer, K. (2013) Toxoplasma gondii replication is controlled by the murine guanylate binding protein 2 (mGBP2). Proc Natl Aacad Sci USA, 110(1): 294-299.
  • Mays, L.E., Ammon-Treiber, S., Mothes, B., Müller-Hermelink, E.S., Grimm, M., Mezger, M., Beer-Hammer, S., Nürnberg, B., Schwab, M., Handgretinger, R., Idzko, M., Hartl, D., Kormann, M.S.D. (2013) Modified mRNA encoding Foxp3 protects against allergic asthma in mice through an IL-23/IL-17A-dependent mechanism. J Clin Invest, 123(3): 1216-1228.
  • Ezan, J., Lasvaux, L., Gezer, A., Novakovic, A., May-Simera, H., Belotti, E., Lhoumeau, A.-C., Birnbaumer, L., Beer-Hammer, S., Borg, J.-P., Le Bivic, A., Nürnberg, B., Sans, N., Montcouquiol, M. (2013) Primary cilia migration depends on G-protein signaling in mammalian epithelium. Nat Cell Biol, 15(9): 1107-15. doi: 10.1038/ncb2819. Epub 2013 Aug 11.
  • Köhler, D., Devanathan, V., Bernardo de Oliveira Franz, C., Eldh, T., Novakovic, A., Roth, J.M., Granja, T., Birnbaumer, L., Rosenberger, P., Beer-Hammer, S., Nürnberg, B. (2013) Gαi2- and Gαi3-deficient mice display converse severity of myocardial ischemia reperfusion injury. PLOSOne 9(5): e98325. doi:10.1371/journal.pone.0098325.
  • Danielyan, D., Beer-Hammer, S., Stolzing, A., Schäfer, R., Siegel, G., Fabian, C., Kahle, P., Biedermann, T., Lourhmati, A., Buadze, M., Novakovic, A., Proksch, B., Gleiter, C.H., Frey II, W.H., Schwab, M. (2014) Intranasal delivery of bone marrow derived mesenchymal stem cells, macrophages and microglia to the brain in mouse models of Alzheimer’s and Parkinson’s disease. Cell Transpl 23 Suppl 1: 123-39. doi: 10.3727/ 096368914X684970. Epub 2014 Oct 9.
  • Schmitt, F., Schäll, D., Bucher, K., Schindler, T.I., Hector, A., Biedermann, T., Zemlin, M., Hartl, D., Beer-Hammer, S. (2015) SLy2 controls the antibody response to pneumococcal vaccine through an IL5-R-dependent mechanism in B-1 cells. Eur J Immunol 45(1): 60-70. doi: 10.1002/eji.201444882. Epub 2014 Nov 13.
  • Devanathan, V., Hagedorn, I., Köhler, D., Pexa, K., Cherpokova, D., Kraft, P., Singh, M., Rosenberger, P., Stoll, G., Birnbaumer, L., Piekorz, R.P., Beer-Hammer, S.*, Nieswandt, B.*, Nürnberg, B.* (2015) Platelet Gi protein Gi2 is an essential mediator of thrombo-inflammatory organ damage in mice. PNAS 112(20): 6491-6496. doi/10.1073 *shared last author
  • Mahiny, A.J., Dewerth, A., Alkhaled, M., Mothes, B., Malaeksefat, E., Loretz, B., Mays, L.E., Rottenberger, J., Brosch, D.M., Reautschnig, P., Surapolchai, P., Zeyer, F., Dulay, G., Zhang, L., Schams, A., Carevic, M., Bakele, M., Griese, M., Schwab, M., Nürnberg, B., Beer-Hammer, S., Handgretinger, R., Hartl, D., Cost, G.J., Lehr, C.-M., Kormann, M.S.D. (2015) Lung phenotypic disease correction by in vivo genome editing using nucleaseencoding chemically modified mRNA. Nat Biotechnology 33(6): 584-6. doi:10.1038/nbt.3241.
  • Schäll, D., Schmitt, F., Reis, B., Brandt, S., Beer-Hammer, S. (2015) SLy1 regulates proliferation of T cells during Listeria monocytogenes infection in a Foxo1 dependent manner. Eur J Immunol 45(11): 3087-97. doi: 10.1002/eji.201545609. Epub 2015 Sep 21.
  • Arefanian, S., Schäll, D., Chang, S., Ghasemi, R., Higashikubo, R., Zheleznyak, A., Guo, Y., Yu, J., Asgharian, H., Li, W., Gelman, A.E., Kreisel, D., French, A.R., Zaher, H., Plougastel-Douglas, B., Maggi, L., Yokoyama, W., Beer-Hammer, S.*, Krupnick, A.S.* (2016) Deficiency of the Adaptor Protein SLy1 Results in a Natural Killer Cell Ribosomopathy Affecting Tumor Clearance. OncoImmunology 5(12): e1238543. *shared last author
  • Mauriac, S.A., Hien, E.Y., Bird, J., Dos-Santos Carvalho, S., Peyroutou, R., Moreau, M.M., Geyser, A., Medina, C., Thoumine, O., Beer-Hammer, S., Friedman, T., Rüttiger, L., Forge, A., Nürnberg, B., Sans, N., Montcouquiol, M. (2017) Identification of the molecular mechanism behind the Chudley McCullough syndrome reveals new function for mPins and Gi3 in cytoskeleton regulation. Nat Communications 7: 8:14907. doi: 10.1038/ncomms14907.
  • Beer-Hammer, S., Lee, S.C., Mauriac, S.A., Leiss, V., Groh, I.A.M., Novakovic, A., Piekorz, R.P., Bucher, K., Chen, C., Ni, K., Singer, W., Harasztosi, C., Schimmang, T., Zimmermann, U., Pfeffer, K., Birnbaumer, L., Forge, A., Montcouquiol, M., Knipper, M., Nürnberg, B., Rüttiger, L. (2018) Gi Proteins are indispensable for Hearing. Cell Physiol Biochem 47(4): 1509-1532.
  • Lian, X., Beer-Hammer, S., König, G.M., Kostenis, E., Nürnberg, B., Gollasch, M. (2018) RXFP Receptor activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway Front Physiol. 9:1234. doi: 10.3389/fphys.2018.01234.
  • Kukuk, L., Dingley, A.J., Granzin, J., Nagel-Steger, L., Thiagarajan-Rosenkranz, P., Ciupka, D., Hänel, K., Batra-Safferling, R., Pacheco, V., Stoldt, M., Pfeffer, K., Beer-Hammer, S., Willbold, D., Koenig, BW. (2019) Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association. Sci Rep. 9(1): 54. doi: 10.1038/s41598-018-37185-3.
  • Hansen, M., Peltier, J., Killy, B., Amin, B., Bodendorfer, B., Härtlova, A., Uebel, S., Bosmann, M., Hofmann, J., Büttner, C., Ekici, A.B., Kuttke, M., Franzyk, H., Foged, C., Beer-Hammer, S., Schabbauer, G., Trost, M., Lang, R. (2019) Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling. Mol Cell Proteomics doi: 10.1074/mcp.RA118.000929.
  • Nürnberg, B., Beer-Hammer, S. (2019) Function, Regulation and Biological Roles of PI3Kg Variants. Review. Biomolecules 9(9):E427. doi 10.3390/biom9090427.
  • Jaufmann, J., Lelis, F.J.N., Teschner, A.A., Fromm, K., Rieber, N., Hartl, D., Beer-Hammer, S. (2020) Human monocytic myeloid-suppressor cells impair B-cell phenotype and function in vitro. Eur J Immunol 50(1): 33-47. doi:10.1002/eji.201948240.Epub 2019 Oct 2.
  • Vega, S.C., Leiss, V., Piekorz, R., Calaminus, C., Pexa, K., Vuozzo, M., Schmid, A.M., Devanathan, V., Kesenheimer, C., Pichler, B.J., Beer-Hammer, S., Nürnberg, B. (2020) Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin. J Mol Med 98(1): 97-110. doi: 10.1007/s00109-019-01854-1. Epub 2019 Dec 6.
  • Danielyan, L., Schwab, M., Siegel, G., Brawek, B., Garaschuk, O., Asavapanumas, N., Buadze, M., Lourhmati, A., Wendel, H.P., Avci-Adali, M., Krueger, M.A., Calaminus, C., Naumann, U., Winter, S., Schaeffeler, E., Spogis, A., Beer-Hammer, S., Neher, J,J., Spohn, G., Kretschmer, A., Krämer-Albers, E.M., Barth, K., Lee, H.J., Kim, S.U., Frey, W.H. 2nd, Claussen, C.D., Hermann, D.M., Doeppner, T.R., Seifried, E., Gleiter, C.H., Northoff, H., Schäfer, R. (2020) Cell motility and migration as determinants of stem cell efficacy. EBioMedicine 60: 102989. doi: 10.1016/j.ebiom.2020.102989. Epub 2020 Sep 10.
  • Jaufmann, J., Tümen, L., Schmitt, F., von Holleben, M., Beer-Hammer S. (2020) SLy2-deficiency promotes B-1 cell immunity and triggers enhanced production of IgM and IgG2 antibodies against pneumococcal vaccine. Immun Inflamm Dis 8(4): 736-752. doi: 10.1002/iid3.365. Epub 2020 Oct 24.
  • Publikationen
  • Mitglied der Kommission "Fachimmunologe der DGfI" (seit 2014)
  • Mitglied der Deutschen Gesellschaft für Pharmakologie (seit 2013)
  • Mitglied der Gesellschaft für Signaltransduktion (seit 2006)
  • Mitglied der Deutschen Gesellschaft für Immunologie (DGfI; seit 1999)