iFIT Lunch & Learn Session with Dr. Liudmila Andreeva
Structural biology of inflammation: unraveling biology and acrobatics of the higher-order innate immune signalosomes
On behalf of the iFIT spokespersons Lars Zender, Juliane Walz and Bernd Pichler, it is our pleasure to inform you about and invite you to the next episode of our iFIT Lunch & Learn 2025 that will take place
on Wednesday, November 5th at 12:00 pm (CET)
at Lecture Hall in the Psychiatric Clinic.
Our speaker and member, Dr. Liudmila Andreeva (Department of Medical Oncology and Pneumology, Tübingen) will give a talk on
“Structural biology of inflammation: unraveling biology and acrobatics of the higher-order innate immune signalosomes ”.
Innate immunity is an inherited first-line defense against microbial threats, represented by pattern recognition receptors (PRRs) that detect pathogen- or damage-derived molecules and trigger inflammation. To fulfil their role in organism protection, PRRs must be highly specific to their trigger and activate a quick and powerful response to outpace rapidly multiplying pathogens. Mechanistically, this is achieved by oligomerization and formation of higher-ordered supramolecular complexes on the level of sensing and signal transduction. Dysregulation of any stage of this complex process leads to chronic inflammation and multiple autoinflammatory and systemic disease. Thus, understanding of the mechanisms of inflammation on molecular level is critical for development of novel anti-inflammatory therapies. In the talk we will discuss the major principles governing innate immunity uncovered by structural biology, as well as look in detail at one class of innate immune sensors called inflammasomes
As a special feature of this program, iFIT will sponsor free lunch packages! (First come, first serve)
All members of the University Hospital and University of Tübingen are invited to participate!
We look forward to this Lunch & Learn Session and to see you there!
