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FOR 2715 - Epileptogenesis of genetic epilepsies

Objective

In this research group, we want to clarify whether and how genetic mutations trigger a cascade of multidimensional epileptogenic processes and how these interact with brain development so that age-related epilepsy syndromes manifest themselves.
We will combine the following studies to this end:

...which should further decipher the "lack of heredity" in the rare epileptic encephalopathies and the frequent genetic generalised epilepsies in the largest data sets available worldwide;

...of cell-specific, secondary transcriptional changes (single cell RNA sequencing);

...which integrate primary genetic and transcriptional data to identify epileptogenic gene networks and signalling pathways

...which determine the consequences of genetic mutations at different developmental stages:
(a) the biophysical and neuronal behaviour in heterologous and neuronal expression systems,
(b) the neurophysiological changes in specific neuronal cell populations and compartments, and(c)
the behaviour of entire networks in vivo.

Speaker and coordinator

Holger Lark

Professor Dr. med.

Institution: Centre for Neurology Hertie Institute for Clinical Brain Research
Department of Neurology with focus on Epileptology

Address: Hoppe-Seyler-Strasse 3
72076 Tübingen

E-mail address: Holger.Lerche@med.uni-tuebingen.de

Subprojects

Overview of the subprojects

P4 + Z1: Additional funding from the FNR/Luxembourg

Prof. Dr. Yvonne Weber

Leading consultant and research group leader

Department of Neurology and Epileptology and Hertie Institute for Clinical Brain Research

University of Tübingen, Tübingen, Germany

E-mail address: Yvonne.Weber@med.uni-tuebingen.de

Prof. Dr. med. Ingo Helbig

Research group leader

Department of Neuropediatrics
University Medical Center Schleswig-Holstein (UKSH)
University of Kiel, Kiel, Germany

Prof. Dr. Michael Nothnagel

Department of Statistical Genetics and Bioinformatics, Cologne Center for Genomics (CCG)
University of Cologne, Cologne, Germany

Dr. Roland Krause

Bioinformatics Core, Luxembourg Centre for Systems Biomedicine
University of Luxembourg, Esch-Belval, Luxembourg

Prof. Dr. Holger Lerche

Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research
University of Tübingen, Tübingen, Germany

MD habil. Thomas Sander

Epilepsy Genetics Group, Cologne Center for Genomics
University of Cologne, Cologne, Germany

Prof. Dr. med. Albert J. Becker

Translational Epileptology, Dept. of Neuropathology
University of Bonn Medical School, Bonn, Germany

Dr. Camila V. Esguerra

Principal Investigator, Chemical Neuroscience Group

Centre for Molecular Medicine Norway (NCMM)
University of Oslo, Oslo, Norway

Dr. Alexander Skupin

Principal Investigator, Integrative Cell Signalling Group

Luxembourg Centre for Systems Biomedicine (LCSB)
University of Luxembourg, Belval, Luxembourg

Prof. Dr. Holger Lerche

Department of Neurology and Epileptology
Hertie Institutes for Clinical Brain Research
University of Tübingen

Dr. Henner Koch

Department of Neurology and Epileptology
Hertie Institutes for Clinical Brain Research
University of Tübingen

E-mail address: henner.koch@uni-tuebingen.de

Prof. Dr. Olga Garaschuk

Professor of Physiology (W3)

Department of Neurophysiology, Institute of Physiology
University of Tübingen, Germany

E-mail address: olga.garaschuk@uni-tuebingen.de

Dr. Ulrike Hedrich-Klimosch

postdoctoral researcher

Department of Neurology and Epileptology / HIH
University of Tübingen, Germany

E-mail address: ulrike.hedrich-klimosch@uni-tuebingen.de

Prof. Dr. med. Dirk Isbrandt

Research Group Experimental Neurophysiology

German Center for Neurodegenerative Diseases, Bonn & Institute for Molecular and Behavioral Neuroscience, University of Cologne

Prof. Dr. Heinz Beck

Laboratory of Experimental Epileptology
Dept. of Epileptology
University of Bonn
Bonn, Germany D-53127

Dr. Tony Kelly

Laboratory of Experimental Epileptology
Dept. of Epileptology
University of Bonn
Bonn, Germany D-53127

Dr. Roland Krause

Bioinformatics Core
Luxembourg Centre for Systems Biomedicine
University of Luxembourg, Luxembourg

Prof. Dr. Peter Nuremberg

Cologne Center for Genomics & Center for Molecular Medicine Cologne
University of Cologne, Germany

Prof. Dr. Achim Tresch

Institute of Medical Statistics, Informatics and Epidemiology
University of Cologne, Germany

PD Dr Thomas Ott

Core Facility Transgenic Animals, FORS/HIH
Institute of Medical Genetics and Applied

Prof. Holger Lerche

Department of Neurology and Epileptology
Hertie Institutes for Clinical Brain Research
University of Tübingen

Dr. Ulrike Hedrich-Klimosch

Department of Neurology and Epileptology
Hertie Institutes for Clinical Brain Research
University of Tübingen, Germany

Dr. Henner Koch

Department of Neurology and Epileptology
Hertie Institutes for Clinical Brain Research
University of Tübingen

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