Institute of Medical Psychology and Behavioural Neurobiology

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568

Address: Otfried-Müller-Straße 25
72076 Tübingen

Phone number: +49 7071 29-88923

Fax number: 07071 29-25016

E-mail address: anja.​otterbein@​uni-​tuebingen.​de

Directions

Sleep and immune functions

Research Aims

In our group, we investigate the impact of sleep on the immune system. We are especially interested to study how sleep modulates the development of immunological memory, e.g., after vaccination. We are also investigating the underlying mechanisms of the influence of sleep on the immune system and focus hereby on the role of various hormones that are released in a sleep-dependent fashion.

Contact

Head of research group:

frontend.sr-only_#{element.contextual_1.children.icon}: Dr. Luciana Besedovsky

More about

Current projects

  • Role of sleep in vaccination responses and T-cell function
  • Hormonal regulation and circadian aspects of T-cell function
  • Strengthening sleep to promote its endocrine and immune-regulatory functions
  • Impact of an immune activation on sleep and memory processes

Key publications

  • Besedovsky, L., Lange, T., Haack, M. (2019). The sleep-immune crosstalk in health and disease. Physiol Rev, 99, 1325-1380.
  • Dimitrov, S., Lange, T., Gouttefangeas, C., Jensen, A. T. R., Szczepanski, M., Lehnnolz, J., Soekadar, S., Rammensee, H.G., Born, J., Besedovsky, L. (2019). Gαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells. J Exp Med, 216, 517-526. 
  • Dimitrov, S., Gouttefangeas, C., Besedovsky, L., Jensen, A. T. R., Chandran, P. A., Rusch, E., Businger, R., Schindler, M., Lange, T., Born, J., Rammensee, H. G. (2018). Activated integrins identify functional antigen-specific CD8(+) T cells within minutes after antigen stimulation. Proc Natl Acad Sci U S A, 115, E5536-5545.
  • Besedovsky, L., Ngo, H.V., Dimitrov, S., Gassenmaier, C., Lehmann, R., Born, J. (2017). Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function. Nat Commun., 8, 1984.
  • Besedovsky, L., Born, J., Lange, T. (2014). Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4. FASEB J., 28, 67-75
  • Lange, T., Dimitrov, S., Bollinger, T., Diekelmann, S., Born, J. (2011). Sleep after vaccination boosts immunological memory.J Immunol., 187, 283-290.
  • Dimitrov, S., Benedict C., Heutling, D., Westermann, J., Born, J., Lange, T. (2009). Cortisol and epinephrine control opposing circadian rhythms in T cell subsets. Blood, 21, 113, 5134-5143.