Das Klinikum

Prof. Dr. Michael Schindler

Prof. Dr. Michael Schindler

Universitätsprofessor

Leiter der Forschungssektion Molekulare Virologie
Head of Department Molecular Virology

Kontakt

Telefonnummer: +49 7071 29-87459 / Sekretariat: +49 7071 29-80247

Faxnummer: +49 7071 29-5790

E-Mail-Adresse: michael.schindler@med.uni-tuebingen.de

  • Viral immune evasion mechanisms and viral pathogenesis (HIV, HCMV, Ebola virus).
  • Intracellular trafficking and viral morphogenesis (HCV, HIV).
  • Identification and inhibition of viral protein interactions.
  • Novel immunotherapeutic approaches against viral infections.
  • Reviewer for various funding agencies including the DFG, MRC, FWO, NWO and various scientific journals (e.g. Nature Communications, Traffic, Journal of Virology, Retrovirology, Scientific Reports, PlosONE, Journal of Hepatology etc.)
    Editorial board PlosONE.
  • Since 2018W3-Univ. Professor for Medical Virology, Head of Research Section Molecular Virology, Institute of Medical Virology and Epidemiology, University Hospital Tübingen, Germany
  • 2014 - 2018W2-Univ. Professor for Molecular Virology of Human Infectious Diseases, Institute of Medical Virology and Epidemiology, University Hospital Tübingen, Germany
  • 2011 – 2014Group leader “HIV Immune Activation and Morphogenesis”, Institute of Virology, Helmholtz Zentrum Munich, Germany
  • 2007 – 2011Independent Junior Group leader “Virus Pathogenesis” Heinrich Pette Institute – Leibniz Institute for Experimental Virology, Hamburg, Germany
  • 2006 – 2007Postdoc at the Institute of Virology, University of Ulm, Prof. Frank Kirchhoff
  • 2003 - 2006Dissertation (PhD), Institute of Virology, University of Ulm, Prof. Frank Kirchhoff; Title: Evolution of the lentiviral Nef Protein; Graduation with "summa cum laude".
  • 1998 - 2003Course of studies biology, Degree "Dipl. Biol." (Masters equivalent), Institute of Virology, University of Ulm, Prof. Frank Kirchhoff; Graduation with "distinction".
  • 2017: Received a call as “Chair of Infectious Diseases” (Full Professorship), Imperial College London, UK, declined
  • 2015: Teaching Award, University Hospital Tübingen, Medical Faculty
  • 2013: Eva and Klaus Grohe-Prize (Berlin-Brandenb. Akademie d. Wissensch.)
  • 2010 - 2011: Fellow of the Young Leaders in Science Program (Schering Foundation)
  • 2010: Robert Koch Postdoc Prize (Robert-Koch-Stiftung)
  • 2007: Laureate of the Lindau Nobel Prize Meeting
  • 2007: Paul Ehrlich and Ludwig Darmstädter Young Researcher Award
  • 2007: CROI, Los Angeles, USA, Young Investigator Award
  • 2007: Novartis Prize for therapeutic research
  • 2007: AIDS-Award of the DAIG (Deutsche AIDS-Gesellschaft)
  • 2006: Award for excellent PhD thesis (University of Ulm)
  • 2003: Award for excellent Diploma (Masters equivalent) thesis (University of Ulm)
  • Businger R, Deutschmann J, Gruska I, Milbradt J, Wiebusch L, Gramberg T, Schindler M. (2019) Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97. Nat Microbiol. 2019 Sep 23. doi: 10.1038/s41564-019-0557-8.
  • Deutschmann J, Schneider A, Gruska I, Vetter B, Thomas D, Kießling M, Wittmann S, Herrmann A, Schindler M, Milbradt J, Ferreirós N, Winkler TH, Wiebusch L, Gramberg T. (2019) A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1. Nat Microbiol. 2019 Sep 23. doi: 10.1038/s41564-019-0529-z.
  • Winkler M, Wrensch F, Bosch P, Knoth M, Schindler M, Gärtner S, Pöhlmann S. (2019) Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay. Int J Mol Sci. 2019 Aug 8;20(16). pii: E3859. doi: 10.3390/ijms20163859.
  • Herster F, Bittner Z, Cordrea MS, Archer N, Heister M, Löffler MW, Heumos S, Wegner J, Businger R, Schindler M, Stegner D, Schäkel K, Grabbe S, Ghoreschi K, Miller L, Weber ANR. (2019) Platelets aggregate with neutrophils and promote skin pathology in psoriasis. Frontiers in Immunology; 2019 Aug 16;10:1867. doi: 10.3389/fimmu.2019.01867.
  • Trümper V, von Knethen A, Preuß A, Ermilov E, Hackbarth S, Kuchler S, Gunne S, Schäfer A, Bornhütter T, Brüne B, Röder B, Schindler M, Parnham MJ, Knape T. (2019) Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells. Theranostics online date 2019-5-8; doi:10.7150/thno.29367.
  • Nehls J, Businger R, Hoffmann M, Brinkmann C, Fehrenbacher B, Schaller M, Maurer B, Schönfeld C, Kramer D, Hailfinger S, Pöhlmann S, Schindler M. (2019) Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles is Suppressed by Tetherin in a Species-Specific Manner. Cell Reports 26, 1-13 Feb 12, 2019.
  • Hoffmann M, Nehlmeier I, Brinkmann C, Krähling V, Behner L, Moldenhauer AS, Krüger N, Nehls J, Schindler M, Hoenen T, Maisner A, Becker S, Pöhlmann S. (2018) Tetherin inhibits Nipah virus but not Ebola virus replication in fruit bat cells. J Virol. 2018 Nov 14. pii: JVI.01821-18. doi: 10.1128/JVI.01821-18.
  • Dimitrov S, Gouttefangeas C, Besedovsky L, Jensen ATR, Chandran PA, Rusch E, Businger R, Schindler M, Lange T, Born J, Rammensee HG. (2018) Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5536-E5545
  • Barbosa NS, Mendonça LR, Dias MVS, Pontelli MC, da Silva EZM, Criado MF, da Silva-Januário ME, Schindler M, Jamur MC, Oliver C, Arruda E, daSilva LLP. (2018) ESCRT machinery components are required for Orthobunyavirus particle production in Golgi compartments. PLoS Pathog. 2018 May 3;14(5):e1007047. doi: 10.1371/journal.ppat.1007047
  • González-Hernández M, Hoffmann M, Brinkmann C, Nehls J, Winkler M, Schindler M, Pöhlmann S. (2018) A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism. J Virol. 2018 Jun 13;92(13). pii: e00403-18. doi: 10.1128/JVI.00403-18.
  • Suffner S, Gerstenberg N, Patra M, Ruibal P, Orabi A, Schindler M, Bruss V. (2018) Domains of the Hepatitis B Virus Small Surface Protein S Mediating Oligomerization. J Virol. 2018 May 14;92(11). pii: e02232-17. doi: 10.1128/JVI.02232-17
  • Bolduan S, Koppensteiner H, Businger R, Rebensburg S, Kunze C, Brack-Werner R, Draenert R, Schindler M (2017) T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naive chronic HIV-1 patients. JIAS, 2017 Sep 19;20(1):21865.
  • Hofmann S, Dehn S, Businger R, Bolduan S, Schneider M, Debyser Z, Brack-Werner R, Schindler M. (2017) Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication. Open Biology, 2017 Oct;7(10).
  • Zhernov Y, Kremb S, Helfer M, Schindler M, Harir M, Mueller C, Hertkorn N, Avvakumova N, Konstantinov A, Brack-Werner R, Schmitt-Kopplin P, Perminova I (2017) Supramolecular combinations of humic polyanions as potent microbicides with polymodal anti-HIV-activities. New J. Chem., 2017,41, 212-224.
  • Brinkmann C, Nehlmeier I, Walendy-Gnirß K, Nehls J, González Hernández M, Hoffmann M, Qiu X, Takada A, Schindler M, Pöhlmann S. (2016) Tetherin antagonism by the Ebola virus glycoprotein requires an intact receptor-binding domain and can be blocked by GP1-specific antibodies. J Virol. 2016 Oct 5. pii: JVI.01563-16.
  • Bayer K, Banning C, Bruss V, Wiltzer-Bach L, Schindler M. (2016) Hepatitis C virus is released via a non-canonical secretory route. J Virol. 2016 Sep 14. pii: JVI.01615-16.
  • Höhne K, Businger R, van Nuffel A, Bolduan S, Koppensteiner H, Baeyens A, Vermeire J, Malatinkova E, Verhasselt B, Schindler M. (2016) Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection. Open Biology, 2016 Jul;6(7).
  • Rebensburg S, Helfer M, Schneider M, Koppensteiner H, Eberle J, Schindler M, Gürtler L, Brack-Werner R. (2016) Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins. Sci Rep. 2016 Feb 2;6:20394.
  • Nowicka AM, Häuselmann I, Borsig L, Bolduan S, Schindler M, Schraml P, Heikenwalder M, Moch H. (2015) A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization. Oncogene. 2015 Oct 26. doi: 10.1038/onc.2015.400.
  • Matheson NJ, Sumner J, Wals K, Rapiteanu R, Weekes MP, Vigan R, Weinelt J, Schindler M, Antrobus R, Costa AS, Frezza C, Clish CB, Neil SJ, Lehner PJ. (2015) Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. Cell Host Microbe. 2015 Oct 14;18(4):409-23.
  • Gondim MV, Wiltzer-Bach L, Maurer B, Banning C, Arganaraz E, Schindler M. (2015) AP-2 is the crucial clathrin adaptor protein for CD4 downmodulation by HIV-1 Nef in primary infected CD4+ T cells. J Virol. 2015 Sep 30. pii: JVI.01838-15.
  • Gnirß K, Zmora P, Blazejewska P, Winkler M, Lins A, Nehlmeier I, Gärtner S, Moldenhauer AS, Hofmann-Winkler H, Wolff T, Schindler M, Pöhlmann S. (2015) Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase. J Virol. 2015 Sep 15;89(18):9178-88.
  • Graessel A, Hauck SM, von Toerne C, Kloppmann E, Goldberg T, Koppensteiner H, Schindler M, Knapp B, Krause L, Dietz K, Schmidt-Weber CB, Suttner K. (2015) A Combined Omics Approach to Generate the Surface Atlas of Human Naive CD4+ T Cells during Early T-Cell Receptor Activation. Mol Cell Proteomics. 2015 Aug;14(8):2085-102.
  • Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. (2015) HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. J Virol. 2015 May 15;89(10):5687-700.
  • Lambelé M, Koppensteiner H, Symeonides M, Roy NH, Chan J, Schindler M, Thali M. (2015) Vpu Is the Main Determinant for Tetraspanin Downregulation in HIV-1-Infected Cells. J Virol. 2015 Mar 15;89(6):3247-55.
  • Nehls J, Koppensteiner H, Brack-Werner R, Floss T, Schindler M. (2014) HIV-1 Replication in Human Immune Cells Is Independent of TAR DNA Binding Protein 43 (TDP-43) Expression. PLoS One. 2014 Aug 15;9(8):e105478
  • Bolduan S, Reif T, Schindler M*, Schubert U*. (2014) HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain. Virology. 2014 Sep;464-465C:375-384. *Equal last authors
  • Hagen N, Bayer K, Rösch K, Schindler M. (2014) The intraviral protein interaction network of hepatitis C virus. Mol Cell Proteomics. 2014 Jul;13(7):1676-89.
  • Gnirß K, Fiedler M, Krämer-Kühl A, Bolduan S, Mittler E, Becker S, Schindler M, Pöhlmann S. (2014) Analysis of determinants in filovirus glycoproteins required for tetherin antagonism. Viruses. 2014 Apr 9;6(4):1654-71.
  • Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. (2014) Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014 Mar 14;343(6176):1221-8.
  • Helfer M, Koppensteiner H, Schneider M, Rebensburg S, Forcisi S, Müller C, Schmitt-Kopplin P, Schindler M, Brack-Werner R. (2014) The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor. PLoS One. 2014 Jan 29;9(1):e87487.
  • Koppensteiner H, Höhne K, Gondim MV, Gobert FX, Gundlach S, Heigele A, Kirchhoff F, Winkler M, Benaroch P, Schindler M. (2014) Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis. Retrovirology. 2014 Jan 2;11:1.
  • Van Nuffel A, Ariën KK, Stove V, Schindler M, O'Neill E, Schmökel J, Van de Walle I, Naessens E, Vanderstraeten H, Van Landeghem K, Taghon T, Pulkkinen K, Saksela K, Garcia JV, Fackler OT, Kirchhoff F (2013) Verhasselt B. Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms. Retrovirology. 2013 Nov 15;10:137.
  • Gaudin R, Berre S, Cunha de Alencar B, Decalf J, Schindler M, Gobert FX, Jouve M, Benaroch P. (2013) Dynamics of HIV-Containing Compartments in Macrophages Reveal Sequestration of Virions and Transient Surface Connections. PLoS One. 2013 Jul 29;8(7):e69450. doi: 10.1371/journal.pone.0069450.
  • Bolduan S, Hubel P, Reif T, Hoehne K, Fritz J, Sauter D, Kirchhoff F, Fackler OT, Schindler M, Schubert U. (2013) HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A. Virology, 2013 Jun 5;440(2):190-203. doi: 10.1016/j.virol.2013.02.021.
  • Gaudin R, Cunha de Alencar B, Jouve M, Bèrre S, Le Bouder E, Schindler M, Varthaman A, Gobert FX, Benaroch P. (2012) Critical role for the kinesin KIF3A in the HIV life cycle in primary human macrophages. J Cell Biol. 2012 Oct 22.
  • Hoffmann D, Schwarck D, Banning C, Brenner M, Krepstakies M, Schindler M, Millar DP, Hauber J. (2012) Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains. PLoS One. 2012;7(6):e38305.
  • Koppensteiner H, Brack-Werner R, Schindler M. (2012) Macrophages and their Relevance in Human Immunodeficiency Virus Type I Infection. Retrovirology, 2012, 9:82.
  • Koppensteiner H, Banning C, Schneider C, Hohenberg H, Schindler M. (2012) Macrophage Internal HIV-1 Is Protected from Neutralizing Antibodies. J Virol. 2012 Mar;86(5):2826.
  • Kühl A, Banning C, Marzi A, Votteler J, Steffen I, Bertram S, Glowacka I, Konrad A, Stürzl M, Guo JT, Schubert U, Feldmann H, Behrens G, Schindler M, Pöhlmann S. (2011) The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin. J Infect Dis. 2011 Nov;204 Suppl 3:S850-60.
  • Ghiglione Y, Rodríguez AM, De Candia C, Carobene M, Benaroch P, Schindler M, Salomón H, Turk G (2011) HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects. Virus Res. 2011 Sep 16.
  • Stieler K, Schindler S, Schlomm T, Hohn O, Bannert N, Simon R, Minner S, Schindler M, Fischer N (2011) No Detection of XMRV in Blood Samples and Tissue Sections from Prostate Cancer Patients in Northern Europe. PLoS One. 2011;6(10):e25592. Epub 2011 Oct 12.
  • Heigele A, Schindler M, Gnanadurai CW, Leonard JA, Collins KL, Kirchhoff (2011) F.Down-modulation of CD8{alpha}ss is a fundamental activity of primate lentiviral Nef proteins. J Virol. 2011 Oct 19.
  • Bolduan S, Votteler J, Lodermeyer V, Greiner T, Koppensteiner H, Schindler M, Thiel G, Schubert U. (2011) Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317. Virology. 2011 Jul 20;416(1-2):75-85. Epub 2011 May 23.
  • Tschulena U, Sanzenbacher R, Mühlebach MD, Berger A, Münch J, Schindler M, Kirchhoff F, Plesker R, Coulibaly C, Panitz S, Prüfer S, Muckenfuss H, Hamdorf M, Schweizer M, Cichutek K, Flory E. (2011) Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease. Retrovirology. 2011 Mar 2;8:14.
  • Schmökel J, Sauter D, Schindler M, Leendertz FH, Bailes E, Dazza MC, Saragosti S, Bibollet-Ruche F, Peeters M, Hahn BH, Kirchhoff F. (2011) The presence of a vpu gene and lack of Nef-mediated down-modulation of TCR-CD3 are not always linked in primate lentiviruses. J Virol. 2011 Jan;85(2):742-52. Epub 2010 Nov 10
  • Benaroch P, Billard E, Gaudin R, Schindler M, Jouve M. (2010) HIV-1 assembly in macrophages. Retrovirology, 2010 Apr 7;7:29.
  • Banning C, Votteler J, Hoffmann D, Koppensteiner H, Warmer M, Reimer R, Kirchhoff F, Schubert U, Hauber J, Schindler M. (2010) A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells. PLoS ONE 5(2): e9344.
  • Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T and Kirchhoff F. (2010) Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue. Retrovirology 2010, 7:1doi:10.1186/1742-4690-7-1.
  • Sauter D,* Schindler M,* Specht A, Landford W, Munch J, Kim KA, Votteler J, Schubert U, Bibollet-Ruche F, Keele BF, Takehisa J, Ogando Y, Ochsenbauer C, Kappes JC, Ayouba A, Peeters M, Learn GH, Shaw G, Sharp PM, Bieniasz P, Hahn BH, Hatziioannou T, Kirchhoff F. (2009) Tetherin-Driven Adaptation of Vpu and Nef Function during the Evolution of Pandemic and Nonpandemic HIV-1 strain. Cell Host&Microbe 2009, Nov 19;6(5):409-21. *Equal contribution
  • Rudolph JM, Eickel N, Haller C, Schindler M, Fackler OT. (2009) Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins. J Virol. 2009 Nov;83(22):11528-39.
  • Schmokel J, Li H, Bailes E, Schindler M, Silvestri G, Hahn BH, Apetrei C, Kirchhoff F. (2009) Conservation of Nef function across highly diverse lineages of SIVsmm. Retrovirology. 2009 Apr 9;6(1):36.
  • Turk G, Gundlach S, Carobene M, Schindler M, Salomon H, Benaroch P. Single Nef proteins from HIV type 1 subtypes C and F fail to upregulate invariant chain cell surface expression but are active for other functions. (2009) AIDS Res Hum Retroviruses. 2009 Mar;25(3):285-96.
  • Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalod M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F. (2008) Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+ T cells in natural SIV infection. PLoS Pathog 4(7): e1000107.
  • Toussaint H, Gobert FX, Schindler M, Banning C, Kozik Patrycja, Jouve M, Kirchhoff F, Benaroch P. (2008) HIV-1 Nef expression prevents AP-2-mediated internalization of the MHC II-associated invariant chain. J Virol. 2008 Sep;82(17):8373-82.
  • Kirchhoff F, Schindler M, Specht A, Arhel N, Münch J. (2008) Role of Nef in primate lentiviral immunopathogenesis. Cell Mol Life Sci. 2008 Sep;65(17):2621-36.
  • Specht A, Degottardi MQ, Schindler M, Hahn B, Evans DT, Kirchhoff F. (2008) Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses. Virology. 2008 Mar 30;373(1):229-37. Epub 2007 Dec 21.
  • Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F. (2007) Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection. Cell. Dec 14;131(6):1059-71.
  • Münch J,* Rajan D,* Schindler M,* Specht A,* Rücker E, Novembre FJ, Nerrienet E, Müller-Trutwin MC, Peeters M, Hahn BH, Kirchhoff F. (2007) Nef-mediated Enhancement of Virion Infectivity and Stimulation of Viral Replication are Fundamental Properties of Primate Lentiviruses. J Virol. 2007 Dec;81(24):13852-64. Epub 2007 Oct 10. *Equal contribution
  • Schindler M, Rajan D, Specht A, Ritter C, Pulkkinen K, Saksela K, Kirchhoff F. (2007) Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue. J Virol. Dec;81(23):13005-14.
  • Schindler, M., Wildum, S., Casartelli, N., Doria, M. and Kirchhoff, F. (2007) Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progressors. AIDS. May 31;21(9):1103-7.
  • Münch, J., Ständker, L., Adermann, K., Schulz, A., Schindler, M., Chinnadurai, R., Pöhlmann, S., Chaipan, C., Biet, T., Peters, T., Meyer, B., Wilhelm, D., Lu, H., Jing, W., Jiang, S., Forssmann, WG., Kirchhoff, F. (2007) Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell. Apr 20;129(2)
  • Priceputu, E., Hanna, Z., Simard MC., Vincent, P., Hu, C., Wildum S., Schindler M., Kirchhoff, F., Jolicoeur. P. (2007) Primary HIV-1 Nef Alleles Show Major Differences in Pathogenicity in Transgenic Mice. J Virol. 2007 May;81(9):4677-93.
  • Wildum, S., Schindler, M., Munch, J., Kirchhoff, F. (2006) Contribution of Vpu, Env and Nef to CD4 down-modulation and resistance of HIV-1 infected T-cells to superinfection. J Virol. 80: 8047-59.
  • Schindler, M., Münch, J., Kutsch, O., Li, H., Santiago, M., Bibollet-Ruche, F., Müller-Trutwin, M., Novembre, F., Peeters, M., Courgnaud, V., Bailes, E., Roques, P., Sodora, D., Silvestri, G., Sharp, P., Hahn, B., Kirchhoff, F., (2006) Nef-mediated suppression of T cell activation is a fundamental property of primate lentiviruses. Cell 125: 10.
  • Brenner, M., Münch, J., Schindler, M., Wildum, S., Stolte, N., Stahl-Hennig, C., Fuchs, D., Mätz-Rensing, K., Franz, M., Heeney, J., Haaft, P., Swigut, T., Hrecka, K., Skowronski, J., Kirchhoff, F. (2006) Importance of the N-distal AP-2 binding element in Nef for Simian Immunodeficiency Virus replication and pathogenicity in rhesus macaques. J Virol. 80: 4469.
  • Rajan, D., Wildum, S., Rucker, E., Schindler, M., Kirchhoff, F. (2006) Effect of R77Q, R77A and R80A changes in Vpr on HIV-1 replication and CD4 T cell depletion in human lymphoid tissue ex vivo. AIDS 20: 831-6.
  • Hrecka, K., Swigut, T., Schindler, M., Kirchhoff, F., Skowronski, J. (2005) Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. J Virol. 79:10650-9.
  • Münch, J.,* Schindler, M.,* Wildum, S., Rucker, E., Bailer, N., Knoop, V., Novembre, F.J., and Kirchhoff, F. (2005). Primary SIVsm and HIV-2 Nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication. J. Virol. 79: 10547-10560. *Equal contribution
  • van 't Wout, A.B., Swain, J.V., Schindler, M., Rao, U., Pathmajeyan, M.S., Mullins, J.I., Kirchhoff, F. (2005). Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. J. Virol. 79
  • Schindler, M., Münch, J., Kirchhoff, F. (2005). HIV-1 inhibits DNA damage triggered apoptosis by a Nef-independent mechanism. J. Virol. 79: 5489-5498.
  • Schindler, M., Munch, J., Brenner, M., Stahl-Hennig, C., Skowronski, J. & Kirchhoff, F. (2004). Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques. J.Virol. 78: 10588-10597.
  • Kirchhoff, F., Schindler, M., Bailer, N., Renkema, G.H., Saksela, K., Knoop, V., Muller-Trutwin, M.C., Santiago, M.L., Bibollet-Ruche, F., Dittmar, M.T., Heeney, J.L., Hahn, B.H., Münch J. (2004). Nef proteins from SIVcpz-infected Chimpanzees and HIV-1 group N and O -infected Humans Interact with the p21-activated Kinase 2 and Modulate Cell Surface Expression of Various Human Receptors. J. Virol. 78: 6864-6874.
  • Hiebenthal-Millow, K., Greenough, T.C., Bretttler, D.B., Schindler, M., Wildum, S., Sullivan, J.L., Kirchhoff, F. (2003) Alterations in HIV-1 LTR promoter activity during AIDS progression. Virology 317: 109-18.
  • Schindler, M., Wurfl, S., Benaroch, P., Greenough, T. C., Daniels, R., Easterbrook, P., Brenner, M., Munch, J., Kirchhoff, F. (2003). Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J.Virol. 77: 10548-10556.
  • Arganaraz, E.R., Schindler, M., Kirchhoff, F., Cortes, M.J., Lama, J. (2003) Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. J Biol Chem. 278: 33912-9.
  • Pruchner, D., Nassal, B., Schindler, M., Knoop, V. (2001) Mosses share mitochondrial group II introns with flowering plants, not with liverworts. Mol Genet Genomics. 266: 608-13.
  • Patents:
  • German Patent 10 2016 105 069.5; ImmuVir: HIV-1 IMMUNETHERAPY THROUGH MEMBRANE RECEPTOR LIGATION; PCT Patent submitted
  • Other publications (Textbook contributions, monographs):
  • Schindler M, Banning C (2010), Analyse von Proteininteraktionen durch FRET und FACS. Biospektrum 03/2010
  • Banning, C., Schindler, M. (2010). Mit FRET und FACS auf Partnersuche. Laborjournal 04/2010
  • Schindler M, Banning C, Holstermann B, Hohenberg H. (2009). Virologische Fährtensuche: Kombinierte Mikroskopietechniken zur Abbildung von Virusinfektionen. Bioforum 03/2009
  • Schindler M. (2008) Evolution des lentiviralen Nef Proteins. VDM 2008, ISBN978-3-63901822-6
  • Schindler M, Kirchhoff F (2006) AIDS – Ein Unfall der viralen Evolution? Retrovirus Bulletin 04/2006
  • GfV - German Society for Virology
  • ESV - European Society for Virology
  • ASM - American Society for Microbiology