The University Hospital

PhD Kristina Hopfensperger

PhD Kristina Hopfensperger

Postdoctoral researcher

HIV researcher in the 'Mechanisms of innate antiviral immunity' research group.

I investigate how HIV manipulates our immune system to replicate successfully. Specifically, I am interested in ubiquitination and how this post translational modification regulates innate antiviral immune responses.

Contact

Phone number: 07071 29-80285

E-mail address: kristina.hopfensperger@med.uni-tuebingen.de

Clinic / Institute / Center

  • seit 2021Postdoctoral researcher
  • 2017-2021Doctorate - Dr. rer. nat.
  • 2015-2017Master of Science- Molecular Medicine, University of Ulm
  • 2012-2015Bachelor of Science - Molecular Medicine, University of Ulm
  • Zhao Z, Fagerlund R, Tossavainen H, Hopfensperger K, Lotke R, Srinivasachar Badarinarayan S, Kirchhoff F, Permi P, Sato K, Sauter D, Saksela K. Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage. PLoS Pathog. 2021 Nov 15;17(11):e1009728. doi: 10.1371/journal.ppat.1009728
  • Kimura I, Konno Y, Uriu K, Hopfensperger K, Sauter D, Nakagawa S, Sato K. Sarbecovirus ORF6 proteins hamper induction of interferon signaling. Cell Rep. 2021 Mar 30;34(13):108916. doi: 10.1016/j.celrep.2021.108916. Epub 2021 Mar 12.
  • Hopfensperger K, Richard J, Stürzel CM, et al. Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2. Mbio. 2020 Jul;11(4). DOI: 10.1128/mbio.00782-20
  • Hopfensperger K, Sauter D. Decreased, Deformed, Defective-How HIV-1 Vpu Targets Peroxisomes. Mbio. 2020 May;11(3). DOI: 10.1128/mbio.00967-20
  • Langer S, Hammer C, Hopfensperger K, et al. HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses. Elife. 2019 Feb;8. DOI: 10.7554/elife.41930
  • Yamada E, Nakaoka S, Klein L, et al. Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo. Cell Host Microbe. 2018 Jan 10;23(1):110-120.e7. doi: 10.1016/j.chom.2017.12.009
  • Langer SM, Hopfensperger K, Iyer SS, et al. A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1. Plos one. 2015 ;10(11):e0142118. DOI: 10.1371/journal.pone.0142118
  • Further publications