312

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iFIT Junior Research Groups

Systems Immunology Lab

The junior research group around Dr. Florian Wimmers answers questions in basic and translational immunology using systems biology tools. Their goal is to understand how the immune system fights cancer and infection and what happens when it is forced to fight both at the same time. Cancer patients are at high risk of infection and often respond poorly to vaccinations. In the Wimmers Lab, researchers are working to understand how cancer manipulates the immune system to cause dysregulation and how this influences the response to vaccines.

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Structural Immuno-Oncology Lab

Inflammation is our body’s early response to infection and danger. It is triggered by a series of specialized proteins called pattern recognition receptors, which trigger downstream signals and activate cellular programs to clear the infection and repair the damaged tissue. While controlled inflammation protects us from pathogens, "errors" in its regulation caused by mutations, environmental factors or our lifestyle lead to chronic inflammation - a cause of numerous diseases plaguing modern society, including autoinflammation and cancer. The group around Dr. Liudmila Andreeva is interested in studying inflammatory processes in health and disease at the molecular level.

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