Cancer research made in Tuebingen
iFIT Cluster of Excellence

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iFIT Junior Research Groups

Systems Immunology Lab

The junior research group around Dr. Florian Wimmers answers questions in basic and translational immunology using systems biology tools. Their goal is to understand how the immune system fights cancer and infection and what happens when it is forced to fight both at the same time. Cancer patients are at high risk of infection and often respond poorly to vaccinations. In the Wimmers Lab, researchers are working to understand how cancer manipulates the immune system to cause dysregulation and how this influences the response to vaccines.

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Structural Immuno-Oncology Lab

Inflammation is our body’s early response to infection and danger. It is triggered by a series of specialized proteins called pattern recognition receptors, which trigger downstream signals and activate cellular programs to clear the infection and repair the damaged tissue. While controlled inflammation protects us from pathogens, "errors" in its regulation caused by mutations, environmental factors or our lifestyle lead to chronic inflammation - a cause of numerous diseases plaguing modern society, including autoinflammation and cancer. The group around Dr. Liudmila Andreeva is interested in studying inflammatory processes in health and disease at the molecular level.

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Dr. Zizmare during her research visit and training at the Maastricht MultiModal Molecular Imaging Institute – M4i, the Netherlands.

Spatial Immuno-Oncology Metabolomics Lab

The research of Dr. Laimdota Zizmare focuses on unraveling and elucidating metabolic events taking place in cancer progression, cellular microenvironment and metastasis by employing spatial metabolomics approaches and MALDI imaging. With her background spanning from chemical engineering to medicinal chemistry and physical sciences for health, Dr. Zizmare aims to employ metabolomics and spatial omics workflows to advance the understanding of cancer biology. 

Her doctoral research has been instrumental in elucidating the intricate metabolic pathways underlying immunology, neurology, and oncology-related disease progression. Her expertise in NMR spectroscopy, MALDI imaging mass spectrometry and omics sciences, coupled with extensive experience in biomarker discovery and systems biology experience and interdisciplinary approach, empowers her to unravel the complexities highly relevant for future personalized medicine and improved targeted therapies.

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