Here you will find all relevant publications that are directly related to the iFIT Cluster of Excellence sorted by year.
Publications
2019
Publications from 2019
- Zelba, H. et al. PD-1 and LAG-3 Dominate Checkpoint Receptor-Mediated T-cell Inhibition in Renal Cell Carcinoma. Cancer Immunol Res 7, 1891-1899 (2019). https://doi.org:10.1158/2326-6066.CIR-19-0146
- Weiss, J. et al. Assessment of Hepatic Perfusion Using GRASP MRI: Bringing Liver MRI on a New Level. Invest Radiol 54, 737-743 (2019). https://doi.org:10.1097/RLI.0000000000000586
- Schmied, B. J. et al. An Fc-Optimized CD133 Antibody for Induction of Natural Killer Cell Reactivity against Colorectal Cancer. Cancers (Basel) 11 (2019). https://doi.org:10.3390/cancers11060789
- Schmied, B. J. et al. Induction of NK Cell Reactivity against B-Cell Acute Lymphoblastic Leukemia by an Fc-Optimized FLT3 Antibody. Cancers (Basel) 11 (2019). https://doi.org:10.3390/cancers11121966
- Roerden, M. et al. The role of autologous stem cell transplantation in peripheral T cell lymphoma: a long-term follow-up single-center experience. J Cancer Res Clin Oncol 145, 2595-2604 (2019). https://doi.org:10.1007/s00432-019-02999-9
- Rammensee, H. G. et al. A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer. J Immunother Cancer 7, 307 (2019). https://doi.org:10.1186/s40425-019-0796-5
- Paczulla, A. M. et al. Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature 572, 254-259 (2019). https://doi.org:10.1038/s41586-019-1410-1
- Paczulla, A. M. et al. Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature 572, E19 (2019). https://doi.org:10.1038/s41586-019-1475-x
- Moya, I. M. et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science 366, 1029-1034 (2019). https://doi.org:10.1126/science.aaw9886
- Mannheim, J. G. et al. Reproducibility and Comparability of Preclinical PET Imaging Data: A Multicenter Small-Animal PET Study. J Nucl Med 60, 1483-1491 (2019). https://doi.org:10.2967/jnumed.118.221994
- Lorscheid, S. et al. Keratinocyte-derived IkappaBzeta drives psoriasis and associated systemic inflammation. JCI Insight 4 (2019). https://doi.org:10.1172/jci.insight.130835
- Loffler, M. W. et al. A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer. Front Immunol 10, 2526 (2019). https://doi.org:10.3389/fimmu.2019.02526
- Kauer, J. et al. CD105 (Endoglin) as negative prognostic factor in AML. Sci Rep 9, 18337 (2019). https://doi.org:10.1038/s41598-019-54767-x
- Kandabarau, S. et al. Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival. Cancers (Basel) 12 (2019). https://doi.org:10.3390/cancers12010006
- Jiang, X. et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun 10, 431 (2019). https://doi.org:10.1038/s41467-018-08054-4
- Jiang, X. et al. Publisher Correction: Shared heritability and functional enrichment across six solid cancers. Nat Commun 10, 4386 (2019). https://doi.org:10.1038/s41467-019-12095-8
- Hoffmann, S. H. L. et al. Visualization and quantification of in vivo homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer. Theranostics 9, 5869-5885 (2019). https://doi.org:10.7150/thno.33275
- Hilf, N. et al. Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature 565, 240-245 (2019). https://doi.org:10.1038/s41586-018-0810-y
- Hilf, N. et al. Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature 566, E13 (2019). https://doi.org:10.1038/s41586-019-0959-z
- Fiz, F. et al. Automated Definition of Skeletal Disease Burden in Metastatic Prostate Carcinoma: A 3D Analysis of SPECT/CT Images. Cancers (Basel) 11 (2019). https://doi.org:10.3390/cancers11060869
- Figlioli, G. et al. The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer. NPJ Breast Cancer 5, 38 (2019). https://doi.org:10.1038/s41523-019-0127-5
- El Maadidi, S. et al. Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells. Sci Rep 9, 13168 (2019). https://doi.org:10.1038/s41598-019-49017-z
- Dork, T. et al. Two truncating variants in FANCC and breast cancer risk. Sci Rep 9, 12524 (2019). https://doi.org:10.1038/s41598-019-48804-y
- Dimitrov, S. et al. Galpha(s)-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells. J Exp Med 216, 517-526 (2019). https://doi.org:10.1084/jem.20181169
- Brauch, H., Schroth, W., Murdter, T. & Schwab, M. Tamoxifen Pharmacogenetics and Metabolism: The Same Is Not the Same. J Clin Oncol 37, 1981-1982 (2019). https://doi.org:10.1200/JCO.19.00507
- Bowden, G. D., Pichler, B. J. & Maurer, A. A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated (18)F-Fluorination Reactions of Arylstannanes. Sci Rep 9, 11370 (2019). https://doi.org:10.1038/s41598-019-47846-6
- Bilich, T. et al. The HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy. Blood 133, 550-565 (2019). https://doi.org:10.1182/blood-2018-07-866830
- Bichmann, L. et al. MHCquant: Automated and Reproducible Data Analysis for Immunopeptidomics. J Proteome Res 18, 3876-3884 (2019). https://doi.org:10.1021/acs.jproteome.9b00313
- Belnoue, E. et al. Targeting self and neo-epitopes with a modular self-adjuvanting cancer vaccine. JCI Insight 5 (2019). https://doi.org:10.1172/jci.insight.127305
2020
Publications from 2020
- Zhang, H. et al. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses. Nat Genet 52, 572-581 (2020). https://doi.org:10.1038/s41588-020-0609-2
- Zbinden, A. et al. Fluorescence lifetime metabolic mapping of hypoxia-induced damage in pancreatic pseudo-islets. J Biophotonics 13, e202000375 (2020). https://doi.org:10.1002/jbio.202000375
- Xiao, Q. et al. Germline variant burden in multidrug resistance transporters is a therapy-specific predictor of survival in breast cancer patients. Int J Cancer 146, 2475-2487 (2020). https://doi.org:10.1002/ijc.32898
- Wormann, B. et al. Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper. Oncol Res Treat 43, 628-636 (2020). https://doi.org:10.1159/000510258
- Wolter, K. & Zender, L. Therapy-induced senescence - an induced synthetic lethality in liver cancer? Nat Rev Gastroenterol Hepatol 17, 135-136 (2020). https://doi.org:10.1038/s41575-020-0262-3
- Wojtyniak, J. G., Britz, H., Selzer, D., Schwab, M. & Lehr, T. Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling. CPT Pharmacometrics Syst Pharmacol 9, 322-331 (2020). https://doi.org:10.1002/psp4.12511
- Wistuba-Hamprecht, K., Gouttefangeas, C., Weide, B. & Pawelec, G. Immune Signatures and Survival of Patients With Metastatic Melanoma, Renal Cancer, and Breast Cancer. Front Immunol 11, 1152 (2020). https://doi.org:10.3389/fimmu.2020.01152
- Wenzel, T. et al. Trans-Mucosal Efficacy of Non-Thermal Plasma Treatment on Cervical Cancer Tissue and Human Cervix Uteri by a Next Generation Electrosurgical Argon Plasma Device. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12020267
- Weissinger, M. et al. Correlation of C-arm CT acquired parenchymal blood volume (PBV) with 99mTc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up. PLoS One 15, e0244235 (2020). https://doi.org:10.1371/journal.pone.0244235
- Weber, A. N. R. et al. Recent insights into the regulatory networks of NLRP3 inflammasome activation. J Cell Sci 133 (2020). https://doi.org:10.1242/jcs.248344
- Wang, J. et al. HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell 183, 1264-1281 e1220 (2020). https://doi.org:10.1016/j.cell.2020.09.054
- Walter, A. et al. Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon. Front Phys-Lausanne 8 (2020). https://doi.org:ARTN 47
- 10.3389/fphy.2020.00047
- Volpato, M. et al. Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERalpha-positive breast cancer. Explor Target Antitumor Ther 1, 355-371 (2020). https://doi.org:10.37349/etat.2020.00021
- Vogel, M. M. E. et al. Prognostic risk classification for biochemical relapse-free survival in patients with oligorecurrent prostate cancer after [(68)Ga]PSMA-PET-guided metastasis-directed therapy. Eur J Nucl Med Mol Imaging 47, 2328-2338 (2020). https://doi.org:10.1007/s00259-020-04760-8
- Urbanczyk, M., Zbinden, A., Layland, S. L., Duffy, G. & Schenke-Layland, K. Controlled Heterotypic Pseudo-Islet Assembly of Human beta-Cells and Human Umbilical Vein Endothelial Cells Using Magnetic Levitation. Tissue Eng Part A 26, 387-399 (2020). https://doi.org:10.1089/ten.TEA.2019.0158
- Urbanczyk, M., Layland, S. L. & Schenke-Layland, K. The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues. Matrix Biol 85-86, 1-14 (2020). https://doi.org:10.1016/j.matbio.2019.11.005
- Unger, M. S. et al. Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs. Anal Chem 92, 11851-11859 (2020). https://doi.org:10.1021/acs.analchem.0c02186
- Tremmel, R. et al. Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression. Hum Genet 139, 137-149 (2020). https://doi.org:10.1007/s00439-019-02093-7
- Teck, A. T. et al. Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo. Cancer Immunol Immunother 69, 1217-1227 (2020). https://doi.org:10.1007/s00262-020-02519-6
- Tandler, C. et al. Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12102725
- Stotz, S., Bleher, D., Kalbacher, H. & Maurer, A. Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D. Biochem Biophys Res Commun 527, 238-241 (2020). https://doi.org:10.1016/j.bbrc.2020.04.070
- Spenle, C. et al. Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma. Cancer Immunol Res 8, 1122-1138 (2020). https://doi.org:10.1158/2326-6066.CIR-20-0074
- Seitz, C. M. et al. GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells. Oncoimmunology 9, 1683345 (2020). https://doi.org:10.1080/2162402X.2019.1683345
- Seith, F. et al. Is there a link between very early changes of primary and secondary lymphoid organs in (18)F-FDG-PET/MRI and treatment response to checkpoint inhibitor therapy? J Immunother Cancer 8 (2020). https://doi.org:10.1136/jitc-2020-000656
- Schwenck, J. et al. Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo(18)F-FDG-PET. Theranostics 10, 925-937 (2020). https://doi.org:10.7150/thno.35989
- Schuhmacher, J. et al. Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial. J Immunother Cancer 8 (2020). https://doi.org:10.1136/jitc-2020-001157
- Schroth, W. et al. Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor-Positive Breast Cancer Patients. Clin Cancer Res 26, 6523-6534 (2020). https://doi.org:10.1158/1078-0432.CCR-20-1923
- Schmidt-Hegemann, N. S. et al. Influence of localization of PSMA-positive oligo-metastases on efficacy of metastasis-directed external-beam radiotherapy-a multicenter retrospective study. Eur J Nucl Med Mol Imaging 47, 1852-1863 (2020). https://doi.org:10.1007/s00259-020-04708-y
- Sahbai, S. et al. Influence of 99m-Tc-Nanocolloid Activity Concentration on Sentinel Lymph Node Detection in Endometrial Cancer: A Quantitative SPECT/CT Study. Diagnostics (Basel) 10 (2020). https://doi.org:10.3390/diagnostics10090700
- Rudesheim, S. et al. Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and alpha-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions. Pharmaceutics 12 (2020). https://doi.org:10.3390/pharmaceutics12121200
- Rohm, S. et al. Selective targeting of the alphaC and DFG-out pocket in p38 MAPK. Eur J Med Chem 208, 112721 (2020). https://doi.org:10.1016/j.ejmech.2020.112721
- Roerden, M. et al. Outcome after autologous stem cell transplantation in primary refractory or relapsed Hodgkin lymphoma-a long-term follow-up single center experience. Ann Hematol 99, 265-276 (2020). https://doi.org:10.1007/s00277-019-03900-x
- Roerden, M. et al. HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12071835
- Reustle, A. et al. Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy. Genome Med 12, 32 (2020). https://doi.org:10.1186/s13073-020-00731-8
- Reinert, C. P. et al. Clinical and prognostic value of tumor volumetric parameters in melanoma patients undergoing (18)F-FDG-PET/CT: a comparison with serologic markers of tumor burden and inflammation. Cancer Imaging 20, 44 (2020). https://doi.org:10.1186/s40644-020-00322-1
- Rammensee, H. G. et al. [Tumor vaccines-therapeutic vaccination against cancer]. Internist (Berl) 61, 690-698 (2020). https://doi.org:10.1007/s00108-020-00814-z
- Rammensee, H. G. & Loffler, M. W. [Individualized immunotherapy for malignant tumors using peptide vaccines-maybe it does work after all?]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63, 1380-1387 (2020). https://doi.org:10.1007/s00103-020-03227-3
- Perl, R. M., Haring, A., Horger, M. S., Pfannenberg, C. & Gatidis, S. Paraneoplastic syndrome in undifferentiated embryonic sarcoma of the liver. EJNMMI Res 10, 11 (2020). https://doi.org:10.1186/s13550-020-0602-x
- Pedreira, J. G. B. et al. Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38alpha MAP Kinase Inhibitors. J Med Chem 63, 7347-7354 (2020). https://doi.org:10.1021/acs.jmedchem.0c00508
- Pedersen, N. W. et al. Optimization in Detection of Antigen-Specific T Cells Through Differentially Labeled MHC Multimers. Cytometry A 97, 955-964 (2020). https://doi.org:10.1002/cyto.a.23942
- Okkelman, I. A. et al. Extracellular Ca(2+)-Sensing Fluorescent Protein Biosensor Based on a Collagen-Binding Domain. ACS Appl Bio Mater 3, 5310-5321 (2020). https://doi.org:10.1021/acsabm.0c00649
- Oehus, A. K. et al. Efficacy of PSMA ligand PET-based radiotherapy for recurrent prostate cancer after radical prostatectomy and salvage radiotherapy. BMC Cancer 20, 362 (2020). https://doi.org:10.1186/s12885-020-06883-5
- Neveu, M. A. et al. Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study. Mol Imaging Biol 22, 1324-1332 (2020). https://doi.org:10.1007/s11307-020-01510-y
- Neef, S. K. et al. Optimized protocol for metabolomic and lipidomic profiling in formalin-fixed paraffin-embedded kidney tissue by LC-MS. Anal Chim Acta 1134, 125-135 (2020). https://doi.org:10.1016/j.aca.2020.08.005
- Neef, S. K. et al. Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS. Metabolites 10 (2020). https://doi.org:10.3390/metabo10120494
- Nardin, J. M. et al. The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer. Clin Transl Sci 13, 284-292 (2020). https://doi.org:10.1111/cts.12707
- Muller, A. et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest 130, 5765-5781 (2020). https://doi.org:10.1172/JCI134217
- Michelotti, F. C. et al. PET/MRI enables simultaneous in vivo quantification of beta-cell mass and function. Theranostics 10, 398-410 (2020). https://doi.org:10.7150/thno.33410
- Meraz-Torres, F., Ploger, S., Garbe, C., Niessner, H. & Sinnberg, T. Disulfiram as a Therapeutic Agent for Metastatic Malignant Melanoma-Old Myth or New Logos? Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12123538
- Maurer, S., Kopp, H. G., Salih, H. R. & Kropp, K. N. Modulation of Immune Responses by Platelet-Derived ADAM10. Front Immunol 11, 44 (2020). https://doi.org:10.3389/fimmu.2020.00044
- Marzec, J. et al. (68)Ga-PSMA-PET/CT-directed IGRT/SBRT for oligometastases of recurrent prostate cancer after initial surgery. Acta Oncol 59, 149-156 (2020). https://doi.org:10.1080/0284186X.2019.1669816
- Marklin, M. et al. CD105 (endoglin) as risk marker in AML patients undergoing stem cell transplantation. Int J Hematol 112, 57-64 (2020). https://doi.org:10.1007/s12185-020-02875-0
- Marklin, M. et al. Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis. Exp Biol Med (Maywood) 245, 1254-1259 (2020). https://doi.org:10.1177/1535370220931043
- Lubke, M. et al. Identification of HCMV-derived T cell epitopes in seropositive individuals through viral deletion models. J Exp Med 217 (2020). https://doi.org:10.1084/jem.20191164
- Liu, J. et al. Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk. Sci Rep 10, 9688 (2020). https://doi.org:10.1038/s41598-020-65665-y
- Kramer, I. et al. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk. Am J Hum Genet 107, 837-848 (2020). https://doi.org:10.1016/j.ajhg.2020.09.001
- Kosnopfel, C. et al. Tumour Progression Stage-Dependent Secretion of YB-1 Stimulates Melanoma Cell Migration and Invasion. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12082328
- Kaufmann, S. et al. Simultaneous whole-body PET/MRI with integrated multiparametric MRI for primary staging of high-risk prostate cancer. World J Urol 38, 2513-2521 (2020). https://doi.org:10.1007/s00345-019-03066-1
- Kauer, J. et al. Tocilizumab, but not dexamethasone, prevents CRS without affecting antitumor activity of bispecific antibodies. J Immunother Cancer 8 (2020). https://doi.org:10.1136/jitc-2020-000621
- Jodicke, L., Zender, L. & Malek, N. P. [Personalized treatment of cholangiocellular carcinoma (CCA)]. Internist (Berl) 61, 170-174 (2020). https://doi.org:10.1007/s00108-019-00723-w
- Jensen, O. et al. Variability and Heritability of Thiamine Pharmacokinetics With Focus on OCT1 Effects on Membrane Transport and Pharmacokinetics in Humans. Clin Pharmacol Ther 107, 628-638 (2020). https://doi.org:10.1002/cpt.1666
- Jaeckle, E. et al. Towards automation in biologics production via Raman micro-spectroscopy, laser-induced forward cell transfer and surface-enhanced Raman spectroscopy. J Biotechnol 323, 313-321 (2020). https://doi.org:10.1016/j.jbiotec.2020.09.001
- Ilhan, H., la Fougere, C. & Krause, B. J. [PSMA-based theranostics for prostate cancer : From imaging to treatment]. Urologe A 59, 617-625 (2020). https://doi.org:10.1007/s00120-020-01193-x
- Hilke, F. J. et al. Distinct Mutation Patterns Reveal Melanoma Subtypes and Influence Immunotherapy Response in Advanced Melanoma Patients. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12092359
- Heitmann, J. S. et al. Protocol of a prospective, multicentre phase I study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration-resistant prostate carcinoma. BMJ Open 10, e039639 (2020). https://doi.org:10.1136/bmjopen-2020-039639
- Heitmann, J. S. et al. Identification of CD318 (CDCP1) as novel prognostic marker in AML. Ann Hematol 99, 477-486 (2020). https://doi.org:10.1007/s00277-020-03907-9
- Heitmann, J. S. et al. Fc gamma receptor expression serves as prognostic and diagnostic factor in AML. Leuk Lymphoma 61, 2466-2474 (2020). https://doi.org:10.1080/10428194.2020.1775208
- Haller, V., Nahidino, P., Forster, M. & Laufer, S. A. An updated patent review of p38 MAP kinase inhibitors (2014-2019). Expert Opin Ther Pat 30, 453-466 (2020). https://doi.org:10.1080/13543776.2020.1749263
- Haen, S. P., Loffler, M. W., Rammensee, H. G. & Brossart, P. Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire. Nat Rev Clin Oncol 17, 595-610 (2020). https://doi.org:10.1038/s41571-020-0387-x
- Guo, S. et al. Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study. Anal Chem 92, 15745-15756 (2020). https://doi.org:10.1021/acs.analchem.0c02696
- Grimm, J., Kiessling, F. & Pichler, B. J. Quo Vadis, Molecular Imaging? J Nucl Med 61, 1428-1434 (2020). https://doi.org:10.2967/jnumed.120.241984
- Ghosh, M. et al. The Impact of Biomaterial Cell Contact on the Immunopeptidome. Front Bioeng Biotechnol 8, 571294 (2020). https://doi.org:10.3389/fbioe.2020.571294
- Gehringer, M. Covalent inhibitors: back on track? Future Med Chem 12, 1363-1368 (2020). https://doi.org:10.4155/fmc-2020-0118
- Forster, M. et al. Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK. Int J Mol Sci 21 (2020). https://doi.org:10.3390/ijms21239269
- Feng, H. et al. Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. Genet Epidemiol 44, 442-468 (2020). https://doi.org:10.1002/gepi.22288
- Fachal, L. et al. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat Genet 52, 56-73 (2020). https://doi.org:10.1038/s41588-019-0537-1
- Ewels, P. A. et al. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol 38, 276-278 (2020). https://doi.org:10.1038/s41587-020-0439-x
- Escala-Garcia, M. et al. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Nat Commun 11, 312 (2020). https://doi.org:10.1038/s41467-019-14100-6
- Daum, R. et al. Fibronectin Adsorption on Electrospun Synthetic Vascular Grafts Attracts Endothelial Progenitor Cells and Promotes Endothelialization in Dynamic In Vitro Culture. Cells 9 (2020). https://doi.org:10.3390/cells9030778
- Chenoweth, M. J. et al. Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities. Clin Pharmacol Ther 107, 57-61 (2020). https://doi.org:10.1002/cpt.1664
- Chen, M. et al. Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1. Clin Pharmacol Ther 107, 227-237 (2020). https://doi.org:10.1002/cpt.1588
- Busche, M. et al. HepaChip-MP - a twenty-four chamber microplate for a continuously perfused liver coculture model. Lab Chip 20, 2911-2926 (2020). https://doi.org:10.1039/d0lc00357c
- Bucher, P. et al. Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma. Blood 135, 121-132 (2020). https://doi.org:10.1182/blood.2019001866
- Bresnahan, E., Ramadori, P., Heikenwalder, M., Zender, L. & Lujambio, A. Novel patient-derived preclinical models of liver cancer. J Hepatol 72, 239-249 (2020). https://doi.org:10.1016/j.jhep.2019.09.028
- Brenner, E. et al. Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun 11, 1335 (2020). https://doi.org:10.1038/s41467-020-14987-6
- Brendle, C. et al. Determinants of activity of brown adipose tissue in lymphoma patients. Sci Rep 10, 21802 (2020). https://doi.org:10.1038/s41598-020-78419-7
- Bilich, T. et al. Mass spectrometry-based identification of a B-cell maturation antigen-derived T-cell epitope for antigen-specific immunotherapy of multiple myeloma. Blood Cancer J 10, 24 (2020). https://doi.org:10.1038/s41408-020-0288-3
- Berchtold, S. et al. Assessing and Overcoming Resistance Phenomena against a Genetically Modified Vaccinia Virus in Selected Cancer Cell Lines. Int J Mol Sci 21 (2020). https://doi.org:10.3390/ijms21207618
- Armanious, K. et al. Independent attenuation correction of whole body [(18)F]FDG-PET using a deep learning approach with Generative Adversarial Networks. EJNMMI Res 10, 53 (2020). https://doi.org:10.1186/s13550-020-00644-y
2021
Publications from 2021
- Zhou, Y. et al. Regulation of Platelet-Derived ADAM17: A Biomarker Approach for Breast Cancer? Diagnostics (Basel) 11 (2021). https://doi.org:10.3390/diagnostics11071188
- Zhou, Y. et al. Platelet-expressed immune checkpoint regulator GITRL in breast cancer. Cancer Immunol Immunother 70, 2483-2496 (2021). https://doi.org:10.1007/s00262-021-02866-y
- Zhang, Y. et al. A T(2ex) MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach. Dalton Trans 50, 2014-2017 (2021). https://doi.org:10.1039/d0dt03734f
- Zekri, L. et al. An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer. EMBO Mol Med 13, e11902 (2021). https://doi.org:10.15252/emmm.201911902
- Zbinden, A. et al. Collagen and Endothelial Cell Coculture Improves beta-Cell Functionality and Rescues Pancreatic Extracellular Matrix. Tissue Eng Part A 27, 977-991 (2021). https://doi.org:10.1089/ten.TEA.2020.0250
- Zbinden, A. et al. Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration. Adv Sci (Weinh) 8, 2002500 (2021). https://doi.org:10.1002/advs.202002500
- Yurttas, C., Konigsrainer, A. & Loffler, M. W. ASO Author Reflections: First Do No Harm-Revisiting Adjuvant Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Trials to Reduce the Risk of Peritoneal Metastasis. Ann Surg Oncol 28, 9096-9097 (2021). https://doi.org:10.1245/s10434-021-10263-z
- Yurttas, C. et al. A Prospective, Phase I/II, Open-Label Pilot Trial to Assess the Safety of Hyperthermic Intraperitoneal Chemotherapy After Oncological Resection of Pancreatic Adenocarcinoma. Ann Surg Oncol 28, 9086-9095 (2021). https://doi.org:10.1245/s10434-021-10187-8
- Wydra, V. et al. N-(6-Chloro-3-nitropyridin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine. Molbank 2021 (2021). https://doi.org:10.3390/m1181
- Wojtyniak, J. G., Selzer, D., Schwab, M. & Lehr, T. Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis. Clin Pharmacol Ther 109, 201-211 (2021). https://doi.org:10.1002/cpt.2111
- Weissinger, M. et al. Lymph Node Staging with a Combined Protocol of (18)F-FDG PET/MRI and Sentinel Node SPECT/CT: A Prospective Study in Patients with FIGO I/II Cervical Carcinoma. J Nucl Med 62, 1062-1067 (2021). https://doi.org:10.2967/jnumed.120.255919
- Weigelin, B. et al. Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity. Nat Commun 12, 5217 (2021). https://doi.org:10.1038/s41467-021-25282-3
- Weber, A. N. R. Targeting the NLRP3 Inflammasome via BTK. Front Cell Dev Biol 9, 630479 (2021). https://doi.org:10.3389/fcell.2021.630479
- Walter, B. et al. Argyrin F Treatment-Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma. Adv Ther-Germany 4 (2021). https://doi.org:ARTN 2100078
- 10.1002/adtp.202100078
- Wagner, T. R. & Rothbauer, U. Nanobodies - Little helpers unravelling intracellular signaling. Free Radic Biol Med 176, 46-61 (2021). https://doi.org:10.1016/j.freeradbiomed.2021.09.005
- Wagner, T. R. et al. NeutrobodyPlex-monitoring SARS-CoV-2 neutralizing immune responses using nanobodies. EMBO Rep 22, e52325 (2021). https://doi.org:10.15252/embr.202052325
- van Tilburg, C. M. et al. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. Cancer Discov 11, 2764-2779 (2021). https://doi.org:10.1158/2159-8290.CD-21-0094
- Turk, D. et al. Novel models for the prediction of drug-gene interactions. Expert Opin Drug Metab Toxicol 17, 1293-1310 (2021). https://doi.org:10.1080/17425255.2021.1998455
- Traenkle, B. et al. Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4(+) Cells. Front Immunol 12, 799910 (2021). https://doi.org:10.3389/fimmu.2021.799910
- Thaiss, W. M. et al. Noninvasive, longitudinal imaging-based analysis of body adipose tissue and water composition in a melanoma mouse model and in immune checkpoint inhibitor-treated metastatic melanoma patients. Cancer Immunol Immunother 70, 1263-1275 (2021). https://doi.org:10.1007/s00262-020-02765-8
- Teck, A. T. et al. Correction to: Cancer testis antigen Cyclin A1 harbors several HLA‑A*02:01‑restricted T cell epitopes, which are presented and recognized in vivo. Cancer Immunol Immunother 70, 3055 (2021). https://doi.org:10.1007/s00262-021-02977-6
- Symonds, P. et al. Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses. Front Immunol 12, 764462 (2021). https://doi.org:10.3389/fimmu.2021.764462
- Sugiyama, K. et al. Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms. Cell Rep Med 2, 100261 (2021). https://doi.org:10.1016/j.xcrm.2021.100261
- Stransky, N., Ruth, P., Schwab, M. & Loffler, M. W. Can Any Drug Be Repurposed for Cancer Treatment? A Systematic Assessment of the Scientific Literature. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13246236
- Stotz, S., Bowden, G. D., Cotton, J. M., Pichler, B. J. & Maurer, A. Covalent (18)F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging. Pharmaceuticals (Basel) 14 (2021). https://doi.org:10.3390/ph14090897
- Stanulla, M. et al. Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia. Leukemia 35, 2650-2657 (2021). https://doi.org:10.1038/s41375-021-01203-7
- Sonanini, D. et al. Low-dose total body irradiation facilitates antitumoral Th1 immune responses. Theranostics 11, 7700-7714 (2021). https://doi.org:10.7150/thno.61459
- Smaxwil, C. et al. [(18)F]fluoro-ethylcholine-PET Plus 4D-CT (FEC-PET-CT): A Break-Through Tool to Localize the "Negative" Parathyroid Adenoma. One Year Follow Up Results Involving 170 Patients. J Clin Med 10 (2021). https://doi.org:10.3390/jcm10081648
- Slaats, J. et al. Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery. Cancer Immunol Res 9, 926-938 (2021). https://doi.org:10.1158/2326-6066.CIR-20-0741
- Sirgiovanni, M. et al. Long-term remission of small cell lung cancer after reactivation of tuberculosis following immune-checkpoint blockade: A case report. Thorac Cancer 12, 699-702 (2021). https://doi.org:10.1111/1759-7714.13821
- Simnica, D. et al. Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts. Clin Transl Immunology 10, e1340 (2021). https://doi.org:10.1002/cti2.1340
- Sevgi, F. et al. Imaging of alpha-Synuclein Aggregates in a Rat Model of Parkinson's Disease Using Raman Microspectroscopy. Front Cell Dev Biol 9, 664365 (2021). https://doi.org:10.3389/fcell.2021.664365
- Seitz, C. M. et al. Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting. Oncoimmunology 10, 2003532 (2021). https://doi.org:10.1080/2162402X.2021.2003532
- Seitz, C. M. et al. Immunomonitoring of Stage IV Relapsed Neuroblastoma Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation and Subsequent GD2 (ch14.18/CHO) Antibody Treatment. Front Immunol 12, 690467 (2021). https://doi.org:10.3389/fimmu.2021.690467
- Schollhorn, A. et al. Integrin Activation Enables Sensitive Detection of Functional CD4(+) and CD8(+) T Cells: Application to Characterize SARS-CoV-2 Immunity. Front Immunol 12, 626308 (2021). https://doi.org:10.3389/fimmu.2021.626308
- Schmitt, M. et al. Individualized Proteogenomics Reveals the Mutational Landscape of Melanoma Patients in Response to Immunotherapy. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13215411
- Schmitt, M. et al. Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition. Mol Cell Proteomics 20, 100163 (2021). https://doi.org:10.1016/j.mcpro.2021.100163
- Schmitt, A. et al. Dimethyl fumarate induces ferroptosis and impairs NF-kappaB/STAT3 signaling in DLBCL. Blood 138, 871-884 (2021). https://doi.org:10.1182/blood.2020009404
- Sauter-Meyerhoff, C. et al. Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13246221
- Rudalska, R., Zender, L. & Dauch, D. Exploiting lipotoxicity for the treatment of liver cancer. Br J Cancer 125, 1459-1461 (2021). https://doi.org:10.1038/s41416-021-01479-7
- Rudalska, R. et al. LXRalpha activation and Raf inhibition trigger lethal lipotoxicity in liver cancer. Nat Cancer 2, 201-217 (2021). https://doi.org:10.1038/s43018-020-00168-3
- Romer, S. et al. Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1. Front Pharmacol 12, 661480 (2021). https://doi.org:10.3389/fphar.2021.661480
- Roerden, M. et al. Impact of Mantle Cell Lymphoma Contamination of Autologous Stem Cell Grafts on Outcome after High-Dose Chemotherapy. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13112558
- Roerden, M. et al. Expression levels of HLA-DR in acute myeloid leukemia: implications for antigenicity and clinical outcome. Leuk Lymphoma 62, 1907-1919 (2021). https://doi.org:10.1080/10428194.2021.1885659
- Rocha, C. M. et al. Current jakinibs for the treatment of rheumatoid arthritis: a systematic review. Inflammopharmacology 29, 595-615 (2021). https://doi.org:10.1007/s10787-021-00822-x
- Riegg, F. et al. An Fc-Optimized CD133 Antibody for Induction of NK Cell Reactivity against B Cell Acute Lymphoblastic Leukemia. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13071632
- Richardson, J. R., Schollhorn, A., Gouttefangeas, C. & Schuhmacher, J. CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13040596
- Renner, O. et al. Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review). Int J Oncol 58 (2021). https://doi.org:10.3892/ijo.2021.5215
- Reinert, C. P. et al. Impact of PET/CT on management of patients with esophageal cancer - results from a PET/CT registry study. Eur J Radiol 136, 109524 (2021). https://doi.org:10.1016/j.ejrad.2021.109524
- Reinert, C. P. et al. (18)F-Fluoride PET/CT Imaging of Medication-Related Osteonecrosis of the Jaw in Conservative Treatment-A Case Report. Front Oncol 11, 700397 (2021). https://doi.org:10.3389/fonc.2021.700397
- Reinert, C. P. et al. Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters. Eur Radiol 31, 2357-2367 (2021). https://doi.org:10.1007/s00330-020-07320-8
- Rammensee, H. G. et al. Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups. Vaccines (Basel) 9 (2021). https://doi.org:10.3390/vaccines9050428
- Quante, M. et al. SARS-CoV-2 in Solid Organ Transplant Recipients: A Structured Review of 2020. Transplant Proc 53, 2421-2434 (2021). https://doi.org:10.1016/j.transproceed.2021.08.019
- Przystal, J. M. et al. Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13102400
- Piccirillo, G. et al. Hyaluronic Acid-Functionalized Hybrid Gelatin-Poly-L-Lactide Scaffolds with Tunable Hydrophilicity. Tissue Eng Part C Methods 27, 589-604 (2021). https://doi.org:10.1089/ten.TEC.2021.0178
- Pfister, D. et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature 592, 450-456 (2021). https://doi.org:10.1038/s41586-021-03362-0
- Pfaffenrot, B. et al. Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration. Eur J Med Chem 218, 113371 (2021). https://doi.org:10.1016/j.ejmech.2021.113371
- Petrigliano, F. A. et al. Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. NPJ Regen Med 6, 77 (2021). https://doi.org:10.1038/s41536-021-00187-3
- Park, H. A. et al. Mendelian randomisation study of smoking exposure in relation to breast cancer risk. Br J Cancer 125, 1135-1145 (2021). https://doi.org:10.1038/s41416-021-01432-8
- Nording, H. et al. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun 12, 3352 (2021). https://doi.org:10.1038/s41467-021-23499-w
- Nies, A. T. et al. Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters. Pharmaceutics 13 (2021). https://doi.org:10.3390/pharmaceutics13030369
- Neul, C. et al. Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins. Br J Pharmacol 178, 1459-1474 (2021). https://doi.org:10.1111/bph.15370
- Nelde, A., Rammensee, H. G. & Walz, J. S. The Peptide Vaccine of the Future. Mol Cell Proteomics 20, 100022 (2021). https://doi.org:10.1074/mcp.R120.002309
- Nelde, A. et al. Immunopeptidomics-Guided Warehouse Design for Peptide-Based Immunotherapy in Chronic Lymphocytic Leukemia. Front Immunol 12, 705974 (2021). https://doi.org:10.3389/fimmu.2021.705974
- Nelde, A. et al. SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition. Nat Immunol 22, 74-85 (2021). https://doi.org:10.1038/s41590-020-00808-x
- Morra, A. et al. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment. Breast Cancer Res 23, 86 (2021). https://doi.org:10.1186/s13058-021-01450-7
- Mehling, R. et al. Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics 11, 470-490 (2021). https://doi.org:10.7150/thno.51462
- Maringer, Y. & Walz, J. S. [Tumor vaccination-strategies and time points]. Internist (Berl) 62, 991-997 (2021). https://doi.org:10.1007/s00108-021-01138-2
- Marcu, A. et al. Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors. J Immunother Cancer 9 (2021). https://doi.org:10.1136/jitc-2021-003404
- Marcu, A. et al. HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy. J Immunother Cancer 9 (2021). https://doi.org:10.1136/jitc-2020-002071
- Manoochehri, M. et al. Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients. Clin Epigenetics 13, 207 (2021). https://doi.org:10.1186/s13148-021-01196-1
- Mannheim, J. G. et al. Cross-validation study between the HRRT and the PET component of the SIGNA PET/MRI system with focus on neuroimaging. EJNMMI Phys 8, 20 (2021). https://doi.org:10.1186/s40658-020-00349-0
- Li, X. et al. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer 21, 541-557 (2021). https://doi.org:10.1038/s41568-021-00383-9
- Lauer, A. et al. Ex Vivo Evaluation of the Sepsis Triple Therapy High-Dose Vitamin C in Combination with Vitamin B1 and Hydrocortisone in a Human Peripheral Blood Mononuclear Cells (PBMCs) Model. Nutrients 13 (2021). https://doi.org:10.3390/nu13072366
- Kullmann, S. et al. Central Insulin Modulates Dopamine Signaling in the Human Striatum. J Clin Endocrinol Metab 106, 2949-2961 (2021). https://doi.org:10.1210/clinem/dgab410
- Kolz, C., Schaeffeler, E., Schwab, M. & Nies, A. T. Genetic and Epigenetic Regulation of Organic Cation Transporters. Handb Exp Pharmacol 266, 81-100 (2021). https://doi.org:10.1007/164_2021_450
- Klovekorn, P. et al. From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4). Eur J Med Chem 210, 112963 (2021). https://doi.org:10.1016/j.ejmech.2020.112963
- Keller, A. L. et al. Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49-year old male individual. Stem Cell Res 54, 102427 (2021). https://doi.org:10.1016/j.scr.2021.102427
- Kauer, J. et al. CD18 Antibody Application Blocks Unwanted Off-Target T Cell Activation Caused by Bispecific Antibodies. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13184596
- Kapoor, P. M. et al. Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk. J Natl Cancer Inst 113, 329-337 (2021). https://doi.org:10.1093/jnci/djaa056
- Kaban, K. et al. Therapeutic Silencing of BCL-2 Using NK Cell-Derived Exosomes as a Novel Therapeutic Approach in Breast Cancer. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13102397
- Kaban, K. et al. Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL). Diagnostics (Basel) 11 (2021). https://doi.org:10.3390/diagnostics11112041
- Johnson, N. et al. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. Br J Cancer 124, 842-854 (2021). https://doi.org:10.1038/s41416-020-01185-w
- Jarzebska, N. T. et al. Lipofection with Synthetic mRNA as a Simple Method for T-Cell Immunomonitoring. Viruses 13 (2021). https://doi.org:10.3390/v13071232
- Huergo, L. F. et al. Magnetic Bead-Based Immunoassay Allows Rapid, Inexpensive, and Quantitative Detection of Human SARS-CoV-2 Antibodies. ACS Sens 6, 703-708 (2021). https://doi.org:10.1021/acssensors.0c02544
- Huang, K. M. et al. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proc Natl Acad Sci U S A 118 (2021). https://doi.org:10.1073/pnas.2020168118
- Hottler, A., Marz, L., Lubke, M., Rammensee, H. G. & Stevanovic, S. Broad and Efficient Activation of Memory CD4(+) T Cells by Novel HAdV- and HCMV-Derived Peptide Pools. Front Immunol 12, 700438 (2021). https://doi.org:10.3389/fimmu.2021.700438
- Horner, S. et al. Mass spectrometry for quality control of bispecific antibodies after SDS-PAGE in-gel digestion. Biotechnol Bioeng 118, 3069-3075 (2021). https://doi.org:10.1002/bit.27817
- Holl, M. et al. Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum. Biomedicines 9 (2021). https://doi.org:10.3390/biomedicines9020176
- Hinterleitner, M. et al. Platelet-Expressed Synaptophysin (pSyn) as Novel Biomarker in Neuroendocrine Malignancies. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13102286
- Hinterleitner, C. et al. Platelet-Expressed TNFRSF13B (TACI) Predicts Breast Cancer Progression. Front Oncol 11, 642170 (2021). https://doi.org:10.3389/fonc.2021.642170
- Hinterleitner, C. et al. Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nat Commun 12, 7005 (2021). https://doi.org:10.1038/s41467-021-27303-7
- Heitmann, J. S., Pfluegler, M., Jung, G. & Salih, H. R. Bispecific Antibodies in Prostate Cancer Therapy: Current Status and Perspectives. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13030549
- Heintze, T. et al. Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis. Front Pharmacol 12, 769703 (2021). https://doi.org:10.3389/fphar.2021.769703
- Heinrich, B. et al. Steatohepatitis Impairs T-cell-Directed Immunotherapies Against Liver Tumors in Mice. Gastroenterology 160, 331-345 e336 (2021). https://doi.org:10.1053/j.gastro.2020.09.031
- Hailfinger, S. & Schulze-Osthoff, K. The paracaspase MALT1 in psoriasis. Biol Chem 402, 1583-1589 (2021). https://doi.org:10.1515/hsz-2021-0250
- Hailfinger, S. & Schulze-Osthoff, K. Impaired Autophagy in Psoriasis and Atopic Dermatitis: A New Therapeutic Target? J Invest Dermatol 141, 2775-2777 (2021). https://doi.org:10.1016/j.jid.2021.06.006
- Hagelstein, I. et al. Bispecific NKG2D-CD3 and NKG2D-CD16 Fusion Proteins as Novel Treatment Option in Advanced Soft Tissue Sarcomas. Front Immunol 12, 653081 (2021). https://doi.org:10.3389/fimmu.2021.653081
- Giampetraglia, M. & Weigelin, B. Recent advances in intravital microscopy for preclinical research. Curr Opin Chem Biol 63, 200-208 (2021). https://doi.org:10.1016/j.cbpa.2021.05.010
- Gerstenecker, S. et al. Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2). Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13205133
- Gassenmaier, S. et al. Accelerated T2-Weighted TSE Imaging of the Prostate Using Deep Learning Image Reconstruction: A Prospective Comparison with Standard T2-Weighted TSE Imaging. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13143593
- Franke, M. et al. The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun 92, 223-233 (2021). https://doi.org:10.1016/j.bbi.2020.12.009
- Forschner, A. et al. Case Report: Combined CDK4/6 and MEK Inhibition in Refractory CDKN2A and NRAS Mutant Melanoma. Front Oncol 11, 643156 (2021). https://doi.org:10.3389/fonc.2021.643156
- Fink, S. et al. Multiplexed Serum Antibody Screening Platform Using Virus Extracts from Endemic Coronaviridae and SARS-CoV-2. ACS Infect Dis 7, 1596-1606 (2021). https://doi.org:10.1021/acsinfecdis.0c00725
- Drakhlis, L. et al. Human heart-forming organoids recapitulate early heart and foregut development. Nat Biotechnol 39, 737-746 (2021). https://doi.org:10.1038/s41587-021-00815-9
- Drakhlis, L. et al. Publisher Correction: Human heart-forming organoids recapitulate early heart and foregut development. Nat Biotechnol 39, 775 (2021). https://doi.org:10.1038/s41587-021-00960-1
- Dittmann, H. et al. The Prognostic Value of Quantitative Bone SPECT/CT Before (223)Ra Treatment in Metastatic Castration-Resistant Prostate Cancer. J Nucl Med 62, 48-54 (2021). https://doi.org:10.2967/jnumed.119.240408
- De Kort, B. J. et al. Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy. Acta Biomater 135, 243-259 (2021). https://doi.org:10.1016/j.actbio.2021.09.005
- Daum, R. et al. Fibronectin adsorption on oxygen plasma-treated polyurethane surfaces modulates endothelial cell response. J Mater Chem B 9, 1647-1660 (2021). https://doi.org:10.1039/d0tb02757j
- Cotton, J. et al. Synthesis and Biological Evaluation of a Radiolabeled PET (Positron Emission Tomography) Probe for Visualization of In Vivo alpha-Fucosidase Expression. Pharmaceuticals (Basel) 14 (2021). https://doi.org:10.3390/ph14080745
- Coignard, J. et al. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. Nat Commun 12, 1078 (2021). https://doi.org:10.1038/s41467-020-20496-3
- Coignard, J. et al. Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. Nat Commun 12, 2986 (2021). https://doi.org:10.1038/s41467-021-23162-4
- Clar, K. L. et al. Receptor Activator of NF-kappaB (RANK) Confers Resistance to Chemotherapy in AML and Associates with Dismal Disease Course. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13236122
- Chirayil, S. et al. Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI. Inorg Chem 60, 2168-2177 (2021). https://doi.org:10.1021/acs.inorgchem.0c02688
- Chashchina, A. et al. DNAM-1/CD226 is functionally expressed on acute myeloid leukemia (AML) cells and is associated with favorable prognosis. Sci Rep 11, 18012 (2021). https://doi.org:10.1038/s41598-021-97400-6
- Castaneda-Vega, S. et al. Machine learning identifies stroke features between species. Theranostics 11, 3017-3034 (2021). https://doi.org:10.7150/thno.51887
- Cardona Gloria, Y. et al. Absence of Non-Canonical, Inhibitory MYD88 Splice Variants in B Cell Lymphomas Correlates With Sustained NF-kappaB Signaling. Front Immunol 12, 616451 (2021). https://doi.org:10.3389/fimmu.2021.616451
- Busche, S. et al. BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment. Cell Death Dis 12, 736 (2021). https://doi.org:10.1038/s41419-021-04020-z
- Bruyere, A. et al. Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters. Xenobiotica 51, 467-478 (2021). https://doi.org:10.1080/00498254.2021.1875516
- Brunk, F. et al. SARS-CoV-2-reactive T-cell receptors isolated from convalescent COVID-19 patients confer potent T-cell effector function. Eur J Immunol 51, 2651-2664 (2021). https://doi.org:10.1002/eji.202149290
- Bruck, J. et al. Non invasive in vivo monitoring of dimethyl fumarate treatment in EAE by assessing the glucose metabolism in secondary lymphoid organs. Eur J Immunol 51, 1006-1009 (2021). https://doi.org:10.1002/eji.202048879
- Brendlin, A. S. et al. A Machine learning model trained on dual-energy CT radiomics significantly improves immunotherapy response prediction for patients with stage IV melanoma. J Immunother Cancer 9 (2021). https://doi.org:10.1136/jitc-2021-003261
- Breast Cancer Association, C. et al. Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women. N Engl J Med 384, 428-439 (2021). https://doi.org:10.1056/NEJMoa1913948
- Bram Ednersson, S. et al. Proteomic analysis in diffuse large B-cell lymphoma identifies dysregulated tumor microenvironment proteins in non-GCB/ABC subtype patients. Leuk Lymphoma 62, 2360-2373 (2021). https://doi.org:10.1080/10428194.2021.1913147
- Brake, L. et al. [SARS-CoV-2 Infections and Clinical Consequences in a Cohort of Solid Organ Transplant Recipients during the first Wave in Germany - a Single Centre Survey and a Case Report]. Zentralbl Chir 146, 597-604 (2021). https://doi.org:10.1055/a-1552-3983
- Bowden, G. D. et al. DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [(18)F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer. J Med Chem 64, 15690-15701 (2021). https://doi.org:10.1021/acs.jmedchem.1c00903
- Bowden, G. D., Chailanggar, N., Pichler, B. J. & Maurer, A. Scalable (18)F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [(18)F]olaparib. Org Biomol Chem 19, 6995-7000 (2021). https://doi.org:10.1039/d1ob00903f
- Bonito, V. et al. Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats. Adv Healthc Mater 10, e2101103 (2021). https://doi.org:10.1002/adhm.202101103
- Bochem, J. et al. Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy. J Immunother Cancer 9 (2021). https://doi.org:10.1136/jitc-2021-003439
- Bilich, T. et al. Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer. Cancer Discov 11, 1982-1995 (2021). https://doi.org:10.1158/2159-8290.CD-21-0191
- Bilich, T. et al. T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals. Sci Transl Med 13 (2021). https://doi.org:10.1126/scitranslmed.abf7517
- Berner, F. et al. Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival. Oncoimmunology 10, 2006893 (2021). https://doi.org:10.1080/2162402X.2021.2006893
- Behling, F. et al. H3K27me3 loss indicates an increased risk of recurrence in the Tubingen meningioma cohort. Neuro Oncol 23, 1273-1281 (2021). https://doi.org:10.1093/neuonc/noaa303
- Becker, M. et al. Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity. Nat Commun 12, 1152 (2021). https://doi.org:10.1038/s41467-021-20973-3
- Becker, M. et al. Immune response to SARS-CoV-2 variants of concern in vaccinated individuals. Nat Commun 12, 3109 (2021). https://doi.org:10.1038/s41467-021-23473-6
- Becker, L. et al. Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13225682
- Beck, R. J., Weigelin, B. & Beltman, J. B. Mathematical Modelling Based on In Vivo Imaging Suggests CD137-Stimulated Cytotoxic T Lymphocytes Exert Superior Tumour Control Due to an Enhanced Antimitotic Effect on Tumour Cells. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13112567
- Beatty, R. et al. The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model. Tissue Eng Part C Methods 27, 515-528 (2021). https://doi.org:10.1089/ten.TEC.2021.0163
- Armento, A. et al. Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model. Biomolecules 11 (2021). https://doi.org:10.3390/biom11111621
- Anbu, S. et al. A Single-Pot Template Reaction Towards a Manganese-Based T(1) Contrast Agent. Angew Chem Weinheim Bergstr Ger 133, 10831-10839 (2021). https://doi.org:10.1002/ange.202100885
- Alim, K. et al. Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors. Fundam Clin Pharmacol 35, 919-929 (2021). https://doi.org:10.1111/fcp.12657
- Affo, S. et al. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell 39, 866-882 e811 (2021). https://doi.org:10.1016/j.ccell.2021.03.012
2022
Publications from 2022
- Zlotos, D. P., Kronenberger, T. & Laufer, S. A. Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands. Pharmaceutics 15 (2022). https://doi.org:10.3390/pharmaceutics15010067
- Zizmare, L. et al. Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model. Commun Biol 5, 1250 (2022). https://doi.org:10.1038/s42003-022-04179-x
- Zhou, Y., Tremmel, R., Schaeffeler, E., Schwab, M. & Lauschke, V. M. Challenges and opportunities associated with rare-variant pharmacogenomics. Trends Pharmacol Sci 43, 852-865 (2022). https://doi.org:10.1016/j.tips.2022.07.002
- Zhang, Y. et al. (131)I-GD2-ch14.18 Scintigraphy to Evaluate Option for Radioimmunotherapy in Patients with Advanced Tumors. J Nucl Med 63, 205-211 (2022). https://doi.org:10.2967/jnumed.120.261854
- Yurttas, C. et al. [Impact of the SARS-CoV-2 Pandemic on Liver Surgery and Liver Transplantations in Germany]. Zentralbl Chir 147, 354-360 (2022). https://doi.org:10.1055/a-1845-1321
- Yurttas, C., Loffler, M. W., Konigsrainer, A. & Horvath, P. [Current status of surgical treatment of peritoneal metastases from colorectal cancer]. Chirurgie (Heidelb) 93, 1126-1132 (2022). https://doi.org:10.1007/s00104-022-01694-9
- Wittlinger, F. et al. Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J Med Chem 65, 1370-1383 (2022). https://doi.org:10.1021/acs.jmedchem.1c00848
- Welz, S. et al. Dose escalation to hypoxic subvolumes in head and neck cancer: A randomized phase II study using dynamic [(18)F]FMISO PET/CT. Radiother Oncol 171, 30-36 (2022). https://doi.org:10.1016/j.radonc.2022.03.021
- Weissinger, M. et al. Multiparametric Dual-Time-Point [(18)F]FDG PET/MRI for Lymph Node Staging in Patients with Untreated FIGO I/II Cervical Carcinoma. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11174943
- Weigelin, B. & Friedl, P. T cell-mediated additive cytotoxicity - death by multiple bullets. Trends Cancer 8, 980-987 (2022). https://doi.org:10.1016/j.trecan.2022.07.007
- Weber, A. N. R. et al. Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3. Rheumatology (Oxford) 61, e299-e313 (2022). https://doi.org:10.1093/rheumatology/keac273
- Weber, A. N. R. Fish TLR5 develops a taste for viral RNA. EMBO Rep 23, e55443 (2022). https://doi.org:10.15252/embr.202255443
- Wagner, T. R. et al. Biparatopic nanobodies protect mice from lethal challenge with SARS-CoV-2 variants of concern. EMBO Rep 23, e53865 (2022). https://doi.org:10.15252/embr.202153865
- Wabitsch, S. et al. Metformin treatment rescues CD8(+) T-cell response to immune checkpoint inhibitor therapy in mice with NAFLD. J Hepatol 77, 748-760 (2022). https://doi.org:10.1016/j.jhep.2022.03.010
- Visser, D. et al. Green Chemistry for Biomimetic Materials: Synthesis and Electrospinning of High-Molecular-Weight Polycarbonate-Based Nonisocyanate Polyurethanes. ACS Omega 7, 39772-39781 (2022). https://doi.org:10.1021/acsomega.2c03731
- Urena-Bailen, G. et al. Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms232112828
- Urbanczyk, M., Zbinden, A. & Schenke-Layland, K. Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications. Adv Drug Deliv Rev 186, 114323 (2022). https://doi.org:10.1016/j.addr.2022.114323
- Tremmel, R. et al. Hepatic Expression of the Na(+)-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms23137468
- Trautwein, C. et al. Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment. JCI Insight 7 (2022). https://doi.org:10.1172/jci.insight.153526
- Tonduru, A. K., Adla, S. K., Huttunen, K. M., Kronenberger, T. & Poso, A. Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes. Molecules 27 (2022). https://doi.org:10.3390/molecules27238531
- Tegeler, C. M. et al. HLA-DR Presentation of the Tumor Antigen MSLN Associates with Clinical Outcome of Ovarian Cancer Patients. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14092260
- Tegeler, C. M. et al. Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort. Int J Infect Dis 120, 187-195 (2022). https://doi.org:10.1016/j.ijid.2022.04.019
- Stotz, S., Kinzler, J., Nies, A. T., Schwab, M. & Maurer, A. Two experts and a newbie: [(18)F]PARPi vs [(18)F]FTT vs [(18)F]FPyPARP-a comparison of PARP imaging agents. Eur J Nucl Med Mol Imaging 49, 834-846 (2022). https://doi.org:10.1007/s00259-021-05436-7
- Stoll, F. et al. Metabolic Effect of Blocking Sodium-Taurocholate Co-Transporting Polypeptide in Hypercholesterolemic Humans with a Twelve-Week Course of Bulevirtide-An Exploratory Phase I Clinical Trial. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms232415924
- Stadelmann, K. et al. Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model. Acta Biomater 140, 364-378 (2022). https://doi.org:10.1016/j.actbio.2021.11.030
- Slaats, J. et al. Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors. Cancer Immunol Res 10, 1462-1474 (2022). https://doi.org:10.1158/2326-6066.CIR-22-0113
- Seyfried, N. et al. Prolonged Exposure to Oxaliplatin during HIPEC Improves Effectiveness in a Preclinical Micrometastasis Model. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14051158
- Serafim, R. A. M., Elkins, J. M., Zuercher, W. J., Laufer, S. A. & Gehringer, M. Chemical Probes for Understudied Kinases: Challenges and Opportunities. J Med Chem 65, 1132-1170 (2022). https://doi.org:10.1021/acs.jmedchem.1c00980
- Schwenck, J. et al. Antibody-guided Molecular Imaging of Aspergillus Lung Infections in Leukemia Patients. J Nucl Med (2022). https://doi.org:10.2967/jnumed.121.263251
- Schwenck, J. et al. A role for artificial intelligence in molecular imaging of infection and inflammation. Eur J Hybrid Imaging 6, 17 (2022). https://doi.org:10.1186/s41824-022-00138-1
- Schwarz, S. et al. T cells of colorectal cancer patients' stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells. J Immunother Cancer 10 (2022). https://doi.org:10.1136/jitc-2022-005651
- Schussele, L. M. et al. Establishment of a novel method to assess MEK1/2 inhibition in PBMCs for clinical drug development. Front Cell Dev Biol 10, 1063692 (2022). https://doi.org:10.3389/fcell.2022.1063692
- Schuller, S. et al. HELLS Is Negatively Regulated by Wild-Type P53 in Liver Cancer by a Mechanism Involving P21 and FOXM1. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14020459
- Schuhmacher, J. et al. Simultaneous Identification of Functional Antigen-Specific CD8(+) and CD4(+) Cells after In Vitro Expansion Using Elongated Peptides. Cells 11 (2022). https://doi.org:10.3390/cells11213451
- Schollhorn, A. et al. Staining of activated ss(2)-integrins in combination with CD137 and CD154 for sensitive identification of functional antigen-specific CD4(+) and CD8(+) T cells. Front Immunol 13, 1107366 (2022). https://doi.org:10.3389/fimmu.2022.1107366
- Schmitt, J. et al. Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma. Theranostics 12, 5615-5630 (2022). https://doi.org:10.7150/thno.56736
- Schmidt, M. et al. Inflammatory Surrogate Parameters for Predicting Ifosfamide-Induced Neurotoxicity in Sarcoma Patients. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11195798
- Sauter, M. et al. Apolipoprotein E derived from CD11c(+) cells ameliorates atherosclerosis. iScience 25, 103677 (2022). https://doi.org:10.1016/j.isci.2021.103677
- Sanchez-Rivera, F. J. et al. Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol 40, 862-873 (2022). https://doi.org:10.1038/s41587-021-01172-3
- Salmeron-Villalobos, J. et al. A unifying hypothesis for PNMZL and PTFL: morphological variants with a common molecular profile. Blood Adv 6, 4661-4674 (2022). https://doi.org:10.1182/bloodadvances.2022007322
- Ruoff, F. et al. Protein Profiling of Breast Carcinomas Reveals Expression of Immune-Suppressive Factors and Signatures Relevant for Patient Outcome. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14184542
- Rudesheim, S. et al. Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone. Pharmaceutics 14 (2022). https://doi.org:10.3390/pharmaceutics14081734
- Rudesheim, S., Selzer, D., Fuhr, U., Schwab, M. & Lehr, T. Physiologically-based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups. CPT Pharmacometrics Syst Pharmacol 11, 494-511 (2022). https://doi.org:10.1002/psp4.12776
- Rossler, T. et al. Quantitative Serum NMR Spectroscopy Stratifies COVID-19 Patients and Sheds Light on Interfaces of Host Metabolism and the Immune Response with Cytokines and Clinical Parameters. Metabolites 12 (2022). https://doi.org:10.3390/metabo12121277
- Rogal, J. et al. Autologous Human Immunocompetent White Adipose Tissue-on-Chip. Adv Sci (Weinh) 9, e2104451 (2022). https://doi.org:10.1002/advs.202104451
- Rittig, S. M. et al. Controversial Role of the Immune Checkpoint OX40L Expression on Platelets in Breast Cancer Progression. Front Oncol 12, 917834 (2022). https://doi.org:10.3389/fonc.2022.917834
- Reustle, A. et al. Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma. Clin Transl Med 12, e883 (2022). https://doi.org:10.1002/ctm2.883
- Reinert, C. P. et al. [18F]Fluoride Positron-Emission Tomography (PET) and [18F]FDG PET for Assessment of Osteomyelitis of the Jaw in Comparison to Computed Tomography (CT) and Magnetic Resonance Imaging (MRI): A Prospective PET/CT and PET/MRI Pilot Study. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11143998
- Reinert, C. P. et al. Value of CT-Textural Features and Volume-Based PET Parameters in Comparison to Serologic Markers for Response Prediction in Patients with Diffuse Large B-Cell Lymphoma Undergoing CD19-CAR-T Cell Therapy. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11061522
- Reautschnig, P. et al. CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo. Nat Biotechnol 40, 759-768 (2022). https://doi.org:10.1038/s41587-021-01105-0
- Rausch, I., Mannheim, J. G., Kupferschlager, J., la Fougere, C. & Schmidt, F. P. Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for (18)F-FDG. EJNMMI Phys 9, 87 (2022). https://doi.org:10.1186/s40658-022-00516-5
- Rau, A. et al. Triple Targeting of HER Receptors Overcomes Heregulin-mediated Resistance to EGFR Blockade in Colorectal Cancer. Mol Cancer Ther 21, 799-809 (2022). https://doi.org:10.1158/1535-7163.MCT-21-0818
- Rashidian, A. et al. Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist. Comput Struct Biotechnol J 20, 3004-3018 (2022). https://doi.org:10.1016/j.csbj.2022.06.020
- Rappold, P. M. et al. A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma. Cancer Discov 12, 2308-2329 (2022). https://doi.org:10.1158/2159-8290.CD-21-0925
- RA, M. S. et al. Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem 65, 3173-3192 (2022). https://doi.org:10.1021/acs.jmedchem.1c01165
- Pristup, J. et al. Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase. Clin Pharmacol Ther 112, 808-816 (2022). https://doi.org:10.1002/cpt.2637
- Pillaiyar, T. et al. Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination. J Med Chem 65, 9376-9395 (2022). https://doi.org:10.1021/acs.jmedchem.2c00636
- Peisen, F. et al. Combination of Whole-Body Baseline CT Radiomics and Clinical Parameters to Predict Response and Survival in a Stage-IV Melanoma Cohort Undergoing Immunotherapy. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14122992
- Pantsar, T. et al. Decisive role of water and protein dynamics in residence time of p38alpha MAP kinase inhibitors. Nat Commun 13, 569 (2022). https://doi.org:10.1038/s41467-022-28164-4
- Paffenholz, S. V. et al. Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer. Proc Natl Acad Sci U S A 119 (2022). https://doi.org:10.1073/pnas.2117754119
- Ozbay Kurt, F. G. et al. Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2. Front Immunol 13, 1012526 (2022). https://doi.org:10.3389/fimmu.2022.1012526
- Niessner, H. et al. Therapeutic Efficacy of Pharmacological Ascorbate on Braf Inhibitor Resistant Melanoma Cells In Vitro and In Vivo. Cells 11 (2022). https://doi.org:10.3390/cells11071229
- Nies, A. T., Schaeffeler, E. & Schwab, M. Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation. Pharmacol Ther 238, 108268 (2022). https://doi.org:10.1016/j.pharmthera.2022.108268
- Nelde, A. et al. Increased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity. iScience 25, 105643 (2022). https://doi.org:10.1016/j.isci.2022.105643
- Nelde, A. et al. Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens. Cell Mol Life Sci 79, 171 (2022). https://doi.org:10.1007/s00018-022-04145-0
- Mustonen, E. K. et al. Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TuKIC Library. Cells 11 (2022). https://doi.org:10.3390/cells11081299
- Muller, M., Reguzova, A., Loffler, M. W. & Amann, R. Orf Virus-Based Vectors Preferentially Target Professional Antigen-Presenting Cells, Activate the STING Pathway and Induce Strong Antigen-Specific T Cell Responses. Front Immunol 13, 873351 (2022). https://doi.org:10.3389/fimmu.2022.873351
- Montes-Mojarro, I. A. et al. CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL. Leukemia 36, 2050-2063 (2022). https://doi.org:10.1038/s41375-022-01617-x
- Mohr, C. J. et al. Subunits of BK channels promote breast cancer development and modulate responses to endocrine treatment in preclinical models. Br J Pharmacol 179, 2906-2924 (2022). https://doi.org:10.1111/bph.15147
- McDougald, W. A. & Mannheim, J. G. Understanding the importance of quality control and quality assurance in preclinical PET/CT imaging. EJNMMI Phys 9, 77 (2022). https://doi.org:10.1186/s40658-022-00503-w
- Marzi, J. et al. Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14081933
- Marzi, J. et al. Marker-Independent Monitoring of in vitro and in vivo Degradation of Supramolecular Polymers Applied in Cardiovascular in situ Tissue Engineering. Front Cardiovasc Med 9, 885873 (2022). https://doi.org:10.3389/fcvm.2022.885873
- Marzi, J. et al. Non-Invasive Three-Dimensional Cell Analysis in Bioinks by Raman Imaging. ACS Appl Mater Interfaces 14, 30455-30465 (2022). https://doi.org:10.1021/acsami.1c24463
- Maringer, Y. et al. Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination. Sci Immunol 7, eadd3899 (2022). https://doi.org:10.1126/sciimmunol.add3899
- Marconato, M., Maringer, Y., Walz, J. S., Nelde, A. & Heitmann, J. S. Immunopeptidome Diversity in Chronic Lymphocytic Leukemia Identifies Patients with Favorable Disease Outcome. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14194659
- Marconato, M., Kauer, J., Salih, H. R., Marklin, M. & Heitmann, J. S. Expression of the immune checkpoint modulator OX40 indicates poor survival in acute myeloid leukemia. Sci Rep 12, 15856 (2022). https://doi.org:10.1038/s41598-022-19972-1
- Marciano, S. et al. Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks. Proc Natl Acad Sci U S A 119, e2122552119 (2022). https://doi.org:10.1073/pnas.2122552119
- Mansilla-Soto, J. et al. HLA-independent T cell receptors for targeting tumors with low antigen density. Nat Med 28, 345-352 (2022). https://doi.org:10.1038/s41591-021-01621-1
- Lutz, M. S. et al. Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies. J Immunother Cancer 10 (2022). https://doi.org:10.1136/jitc-2021-003655
- Loffler, M. W. et al. Phase I/II Multicenter Trial of a Novel Therapeutic Cancer Vaccine, HepaVac-101, for Hepatocellular Carcinoma. Clin Cancer Res 28, 2555-2566 (2022). https://doi.org:10.1158/1078-0432.CCR-21-4424
- Laux, J. et al. Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells. ACS Pharmacol Transl Sci 5, 573-602 (2022). https://doi.org:10.1021/acsptsci.2c00054
- Laufer, S. et al. Publication Criteria and Requirements for Studies on Protein Kinase Inhibitors horizontal line What Is Expected? J Med Chem 65, 6973-6974 (2022). https://doi.org:10.1021/acs.jmedchem.2c00623
- Lauer, U. M., Hinterleitner, M., Horger, M., Ohnesorge, P. V. & Zender, L. NUT Carcinoma-An Underdiagnosed Malignancy. Front Oncol 12, 914031 (2022). https://doi.org:10.3389/fonc.2022.914031
- Lacom, C. et al. Assay validity of point-of-care platelet function tests in thrombocytopenic blood samples. Biochem Med (Zagreb) 32, 020713 (2022). https://doi.org:10.11613/BM.2022.020713
- Lackner, M. et al. Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kbeta inhibition on metabolic pathway activities in a PTEN null breast cancer cell line. Front Mol Biosci 9, 1004602 (2022). https://doi.org:10.3389/fmolb.2022.1004602
- Kustner, T. et al. Development of a Hybrid-Imaging-Based Prognostic Index for Metastasized-Melanoma Patients in Whole-Body 18F-FDG PET/CT and PET/MRI Data. Diagnostics (Basel) 12 (2022). https://doi.org:10.3390/diagnostics12092102
- Kubiniok, P. et al. Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues. iScience 25, 103768 (2022). https://doi.org:10.1016/j.isci.2022.103768
- Korde, A. et al. Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals. EJNMMI Radiopharm Chem 7, 18 (2022). https://doi.org:10.1186/s41181-022-00168-x
- Keller, A. L., Binner, A., Schenke-Layland, K. & Schmees, C. Establishment of Four Induced Pluripotent Stem Cell Lines from CD34+ Hematopoietic Stem and Progenitor Cells from a Patient Diagnosed with an Invasive Lobular Mammary Carcinoma. Stem Cell Res 64, 102902 (2022). https://doi.org:10.1016/j.scr.2022.102902
- Kazmierski, J. et al. A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. J Immunol 209, 535-547 (2022). https://doi.org:10.4049/jimmunol.2100685
- Kauer, J. et al. BCR::ABL1 tyrosine kinase inhibitors hamper the therapeutic efficacy of blinatumomab in vitro. J Cancer Res Clin Oncol 148, 2759-2771 (2022). https://doi.org:10.1007/s00432-022-04039-5
- Junker, D. et al. COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants. Sci Rep 12, 7168 (2022). https://doi.org:10.1038/s41598-022-10987-2
- Juchum, M. et al. Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors. Eur J Med Chem 240, 114584 (2022). https://doi.org:10.1016/j.ejmech.2022.114584
- Jimenez-Altayo, F. et al. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone. J Cereb Blood Flow Metab 42, 162-174 (2022). https://doi.org:10.1177/0271678X211033362
- Horner, S. et al. IgG-Based Bispecific Anti-CD95 Antibodies for the Treatment of B Cell-Derived Malignancies and Autoimmune Diseases. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14163941
- Holl, M. et al. Cell Type-Specific Anti-Adhesion Properties of Peritoneal Cell Treatment with Plasma-Activated Media (PAM). Biomedicines 10 (2022). https://doi.org:10.3390/biomedicines10040927
- Hoffmann, E. et al. Radiotherapy planning parameters correlate with changes in the peripheral immune status of patients undergoing curative radiotherapy for localized prostate cancer. Cancer Immunol Immunother 71, 541-552 (2022). https://doi.org:10.1007/s00262-021-03002-6
- Hirte, S. et al. Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR. Cells 11 (2022). https://doi.org:10.3390/cells11081253
- Hinterleitner, M. et al. Early Reconstitution of Antibody Secreting Cells after Allogeneic Stem Cell Transplantation. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11010270
- Hillebrand, L. & Gehringer, M. Never Gonna Give You Up - Current Developments in Covalent Protein Kinase Inhibitors. Chimia (Aarau) 76, 435-447 (2022). https://doi.org:10.2533/chimia.2022.435
- Heumos, S. et al. Multiomics surface receptor profiling of the NCI-60 tumor cell panel uncovers novel theranostics for cancer immunotherapy. Cancer Cell Int 22, 311 (2022). https://doi.org:10.1186/s12935-022-02710-y
- Herold, N. et al. Integrin activation enables rapid detection of functional Vdelta1(+) and Vdelta2(+) gammadelta T cells. Eur J Immunol 52, 730-736 (2022). https://doi.org:10.1002/eji.202149682
- Heppner, D. E. et al. Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). ACS Med Chem Lett 13, 1856-1863 (2022). https://doi.org:10.1021/acsmedchemlett.2c00213
- Heitmann, J. S. et al. A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity. Nature 601, 617-622 (2022). https://doi.org:10.1038/s41586-021-04232-5
- Hagelstein, I. et al. B7-H3-targeting Fc-optimized antibody for induction of NK cell reactivity against sarcoma. Front Immunol 13, 1002898 (2022). https://doi.org:10.3389/fimmu.2022.1002898
- Gurgen, D. et al. A Molecularly Characterized Preclinical Platform of Subcutaneous Renal Cell Carcinoma (RCC) Patient-Derived Xenograft Models to Evaluate Novel Treatment Strategies. Front Oncol 12, 889789 (2022). https://doi.org:10.3389/fonc.2022.889789
- Grishina, A. et al. A survey among physicians in surgery and anesthesiology departments after the first surge of SARS-CoV-2 infections in Germany : Preparing for further challenges ahead. Wien Klin Wochenschr 134, 361-370 (2022). https://doi.org:10.1007/s00508-021-02000-z
- Griessinger, J. et al. Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis. NPJ Breast Cancer 8, 41 (2022). https://doi.org:10.1038/s41523-022-00398-x
- Greiner, S. M. et al. Identification of CD105 (endoglin) as novel risk marker in CLL. Ann Hematol 101, 773-780 (2022). https://doi.org:10.1007/s00277-022-04756-4
- Gomez Solsona, B., Schmitt, A., Schulze-Osthoff, K. & Hailfinger, S. The Paracaspase MALT1 in Cancer. Biomedicines 10 (2022). https://doi.org:10.3390/biomedicines10020344
- Giuseppe, M. et al. Ceramic-on-ceramic versus ceramic-on-polyethylene in total hip arthroplasty: a comparative study at a minimum of 13 years follow-up. BMC Musculoskelet Disord 22, 1062 (2022). https://doi.org:10.1186/s12891-021-04950-x
- Gatidis, S. et al. A whole-body FDG-PET/CT Dataset with manually annotated Tumor Lesions. Sci Data 9, 601 (2022). https://doi.org:10.1038/s41597-022-01718-3
- Garces de Los Fayos Alonso, I. et al. PDGFRbeta promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma. Mol Cancer 21, 172 (2022). https://doi.org:10.1186/s12943-022-01640-7
- Gallage, S. et al. A researcher's guide to preclinical mouse NASH models. Nat Metab 4, 1632-1649 (2022). https://doi.org:10.1038/s42255-022-00700-y
- Gaissler, A. et al. Dynamics of Melanoma-Associated Epitope-Specific CD8+ T Cells in the Blood Correlate With Clinical Outcome Under PD-1 Blockade. Front Immunol 13, 906352 (2022). https://doi.org:10.3389/fimmu.2022.906352
- Fu, J. F. et al. Spatiotemporal patterns of putaminal dopamine processing in Parkinson's disease: A multi-tracer positron emission tomography study. Neuroimage Clin 36, 103246 (2022). https://doi.org:10.1016/j.nicl.2022.103246
- Fruhwirth, G. O., Weigelin, B., Daldrup-Link, H. E. & Ponomarev, V. Editorial to the Special Issue Entitled "Imaging in Immunooncology". Mol Imaging Biol 24, 177-180 (2022). https://doi.org:10.1007/s11307-022-01719-z
- Frauenfeld, L. et al. Diffuse large B-cell lymphomas in adults with aberrant coexpression of CD10, BCL6, and MUM1 are enriched in IRF4 rearrangements. Blood Adv 6, 2361-2372 (2022). https://doi.org:10.1182/bloodadvances.2021006034
- Forschner, A. et al. Circulating tumor DNA (ctDNA) in the detection of relapse in melanoma patients with adjuvant anti-PD-1 therapy. J Dtsch Dermatol Ges 20, 867-871 (2022). https://doi.org:10.1111/ddg.14766
- Forschner, A. et al. Zirkulierende Tumor-DNA (ctDNA) bei der Entdeckung von Rezidiven bei Melanompatienten mit adjuvanter Anti-PD-1-Therapie. J Dtsch Dermatol Ges 20, 867-871 (2022). https://doi.org:10.1111/ddg.14766_g
- Filali-Mouncef, Y. et al. The menage a trois of autophagy, lipid droplets and liver disease. Autophagy 18, 50-72 (2022). https://doi.org:10.1080/15548627.2021.1895658
- Feuerer, N. et al. Raman Microspectroscopy Identifies Biochemical Activation Fingerprints in THP-1- and PBMC-Derived Macrophages. Biomedicines 10 (2022). https://doi.org:10.3390/biomedicines10050989
- Epah, J. et al. From Unit to Dose: A Machine Learning Approach for Precise Prediction of Hemoglobin and Iron Content in Individual Packed Red Blood Cell Units. Adv Sci (Weinh) 9, e2204077 (2022). https://doi.org:10.1002/advs.202204077
- Dorr, J. A. et al. Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms232415634
- Disselhorst, J. A. et al. NEMA NU 4-2008 performance evaluation and MR compatibility tests of an APD-based small animal PET-insert for simultaneous PET/MR imaging. Phys Med Biol 67 (2022). https://doi.org:10.1088/1361-6560/ac499d
- Dimitrov, T. et al. Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem 235, 114234 (2022). https://doi.org:10.1016/j.ejmech.2022.114234
- Dao, E. et al. Using micro-synchrotron radiation x-ray fluorescence (micro-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging. J Trace Elem Med Biol 74, 127054 (2022). https://doi.org:10.1016/j.jtemb.2022.127054
- Coutinho, J. V. P. et al. Glycoprotein molecular dynamics analysis: SARS-CoV-2 spike glycoprotein case study. Adv Protein Chem Struct Biol 131, 277-309 (2022). https://doi.org:10.1016/bs.apcsb.2022.05.004
- Carrillo Garcia, C. et al. High-Throughput Screening Platform in Postnatal Heart Cells and Chemical Probe Toolbox to Assess Cardiomyocyte Proliferation. J Med Chem 65, 1505-1524 (2022). https://doi.org:10.1021/acs.jmedchem.1c01173
- Calvanese, V. et al. Mapping human haematopoietic stem cells from haemogenic endothelium to birth. Nature 604, 534-540 (2022). https://doi.org:10.1038/s41586-022-04571-x
- Buttner, F. A. et al. A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy. Genome Med 14, 105 (2022). https://doi.org:10.1186/s13073-022-01105-y
- Brendle, C. et al. Impact of (18)F-FET PET/MRI on Clinical Management of Brain Tumor Patients. J Nucl Med 63, 522-527 (2022). https://doi.org:10.2967/jnumed.121.262051
- Brandhorst, D. et al. Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation. Acta Biomater 137, 92-102 (2022). https://doi.org:10.1016/j.actbio.2021.10.013
- Bonzheim, I. et al. The molecular hallmarks of primary and secondary vitreoretinal lymphoma. Blood Adv 6, 1598-1607 (2022). https://doi.org:10.1182/bloodadvances.2021004212
- Berner, F. et al. Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade. Sci Immunol 7, eabn9644 (2022). https://doi.org:10.1126/sciimmunol.abn9644
- Bender, B. et al. GLINT: GlucoCEST in neoplastic tumors at 3 T-clinical results of GlucoCEST in gliomas. MAGMA 35, 77-85 (2022). https://doi.org:10.1007/s10334-021-00982-5
- Becker, L. et al. Data-Driven Identification of Biomarkers for In Situ Monitoring of Drug Treatment in Bladder Cancer Organoids. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms23136956
- Becker, H. et al. Multiparametric Longitudinal Profiling of RCAS-tva-Induced PDGFB-Driven Experimental Glioma. Brain Sci 12 (2022). https://doi.org:10.3390/brainsci12111426
- Bauer, J. et al. The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma. Nat Commun 13, 6401 (2022). https://doi.org:10.1038/s41467-022-33746-3
- Bartuzi, D. et al. Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes. Sci Rep 12, 21192 (2022). https://doi.org:10.1038/s41598-022-25478-7
- Bareiss, A. et al. Vaccine Side Effects in Health Care Workers after Vaccination against SARS-CoV-2: Data from TuSeRe:exact Study. Viruses 15 (2022). https://doi.org:10.3390/v15010065
- Baranasic, J. et al. TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line. Biomedicines 10 (2022). https://doi.org:10.3390/biomedicines10092240
- Aung, T. N. et al. Objective assessment of tumor infiltrating lymphocytes as a prognostic marker in melanoma using machine learning algorithms. EBioMedicine 82, 104143 (2022). https://doi.org:10.1016/j.ebiom.2022.104143
- Atar, D. et al. Adapter CAR T Cell Therapy for the Treatment of B-Lineage Lymphomas. Biomedicines 10 (2022). https://doi.org:10.3390/biomedicines10102420
- Anderle, N. et al. A Platform of Patient-Derived Microtumors Identifies Individual Treatment Responses and Therapeutic Vulnerabilities in Ovarian Cancer. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14122895
- Almeida, T. et al. (Z)-Endoxifen and Early Recurrence of Breast Cancer: An Explorative Analysis in a Prospective Brazilian Study. J Pers Med 12 (2022). https://doi.org:10.3390/jpm12040511
- Ahearn, T. U. et al. Common variants in breast cancer risk loci predispose to distinct tumor subtypes. Breast Cancer Res 24, 2 (2022). https://doi.org:10.1186/s13058-021-01484-x
- Abdelmalek, C. M. et al. Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer. J Med Chem 65, 4616-4632 (2022). https://doi.org:10.1021/acs.jmedchem.1c01646
2023
Publications from 2023
- Zhu, V. et al. Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers. Front Pharmacol 14, 1128547 (2023). https://doi.org:10.3389/fphar.2023.1128547
- Zekri, L. et al. Novel ACE2 fusion protein with adapting activity against SARS-CoV-2 variants in vitro. Front Immunol 14, 1112505 (2023). https://doi.org:10.3389/fimmu.2023.1112505
- Zekri, L. et al. An optimized IgG-based B7-H3xCD3 bispecific antibody for treatment of gastrointestinal cancers. Mol Ther 31, 1033-1045 (2023). https://doi.org:10.1016/j.ymthe.2023.02.010
- Wydra, V. R., Ditzinger, R. B., Seidler, N. J., Hacker, F. W. & Laufer, S. A. A patent review of MAPK inhibitors (2018 - present). Expert Opin Ther Pat 33, 421-444 (2023). https://doi.org:10.1080/13543776.2023.2242584
- Wuestefeld, A. et al. A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes. Cancer Res 83, 428-440 (2023). https://doi.org:10.1158/0008-5472.CAN-22-1477
- Wimmers, F. et al. Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth. Cell 186, 4632-4651 e4623 (2023). https://doi.org:10.1016/j.cell.2023.08.044
- Wimmers, F. et al. Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life. medRxiv (2023). https://doi.org:10.1101/2023.01.28.23285133
- Wichert, K. et al. Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer. Eur J Epidemiol 38, 1053-1068 (2023). https://doi.org:10.1007/s10654-023-01048-7
- Werner, S. et al. Influence of [(18)F]FDG-PET/CT on Clinical Management Decisions in Breast Cancer Patients-A PET/CT Registry Study. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13142420
- Weissinger, M. et al. Non-invasive estimation of split renal function from routine (68)Ga-SSR-PET/CT scans. Front Med (Lausanne) 10, 1169451 (2023). https://doi.org:10.3389/fmed.2023.1169451
- Weissinger, M. et al. Diagnostic Performance of Dynamic Whole-Body Patlak [(18)F]FDG-PET/CT in Patients with Indeterminate Lung Lesions and Lymph Nodes. J Clin Med 12 (2023). https://doi.org:10.3390/jcm12123942
- Weber, A. N. R. et al. Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3: Reply. Rheumatology (Oxford) 62, e168-e169 (2023). https://doi.org:10.1093/rheumatology/keac718
- Wang, J. Z. et al. Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Acta Neuropathol 146, 145-162 (2023). https://doi.org:10.1007/s00401-023-02571-3
- Wang, J. Z. et al. Correction: Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Acta Neuropathol 146, 171-172 (2023). https://doi.org:10.1007/s00401-023-02584-y
- Wallisch, S. et al. Protocol for establishing a coculture with fibroblasts and colorectal cancer organoids. STAR Protoc 4, 102481 (2023). https://doi.org:10.1016/j.xpro.2023.102481
- Wagner, T. R. et al. Two birds with one stone: human SIRPalpha nanobodies for functional modulation and in vivo imaging of myeloid cells. Front Immunol 14, 1264179 (2023). https://doi.org:10.3389/fimmu.2023.1264179
- Wacker, M. et al. Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics. Front Immunol 14, 1219720 (2023). https://doi.org:10.3389/fimmu.2023.1219720
- Vogel, J. et al. Impact of Tracer Dose Reduction in [18 F]-Labelled Fluorodeoxyglucose-Positron Emission Tomography ([18 F]-FDG)-PET) on Texture Features and Histogram Indices: A Study in Homogeneous Tissues of Phantom and Patient. Tomography 9, 1799-1810 (2023). https://doi.org:10.3390/tomography9050143
- Visser, D. et al. Electrospinning of collagen: enzymatic and spectroscopic analyses reveal solvent-independent disruption of the triple-helical structure. J Mater Chem B 11, 2207-2218 (2023). https://doi.org:10.1039/d2tb02602c
- Urbanczyk, M. et al. Decorin improves human pancreatic beta-cell function and regulates ECM expression in vitro. Matrix Biol 115, 160-183 (2023). https://doi.org:10.1016/j.matbio.2022.12.005
- Turk, D. et al. Significant impact of time-of-day variation on metformin pharmacokinetics. Diabetologia 66, 1024-1034 (2023). https://doi.org:10.1007/s00125-023-05898-4
- Trautwein, N. F. et al. Long-term prognostic factors for PRRT in neuroendocrine tumors. Front Med (Lausanne) 10, 1169970 (2023). https://doi.org:10.3389/fmed.2023.1169970
- Trautwein, N. F. et al. First-in-Humans PET/MRI of In Vivo GD2 Expression in Osteosarcoma. J Nucl Med 64, 337-338 (2023). https://doi.org:10.2967/jnumed.122.264626
- Tonduru, A. K. et al. Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs. J Med Chem 66, 15094-15114 (2023). https://doi.org:10.1021/acs.jmedchem.3c01026
- Swen, J. J. et al. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet 401, 347-356 (2023). https://doi.org:10.1016/S0140-6736(22)01841-4
- Stransky, N. et al. Efficacy of combined tumor irradiation and K(Ca)3.1-targeting with TRAM-34 in a syngeneic glioma mouse model. Sci Rep 13, 20604 (2023). https://doi.org:10.1038/s41598-023-47552-4
- Steigerwald, H. et al. Peach extract induces systemic and local immune responses in an experimental food allergy model. Sci Rep 13, 1892 (2023). https://doi.org:10.1038/s41598-023-28933-1
- Sporbeck, K. et al. The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension. Commun Biol 6, 872 (2023). https://doi.org:10.1038/s42003-023-05236-9
- Song, J. Y. et al. Diffuse large B-cell lymphomas, not otherwise specified, and emerging entities. Virchows Arch 482, 179-192 (2023). https://doi.org:10.1007/s00428-022-03466-6
- Sivula, T. et al. Machine Learning-Boosted Docking Enables the Efficient Structure-Based Virtual Screening of Giga-Scale Enumerated Chemical Libraries. J Chem Inf Model 63, 5773-5783 (2023). https://doi.org:10.1021/acs.jcim.3c01239
- Sinnberg, T. et al. Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. Am J Respir Crit Care Med 207, 38-49 (2023). https://doi.org:10.1164/rccm.202201-0011OC
- Sigle, M. et al. Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution. Nat Commun 14, 5799 (2023). https://doi.org:10.1038/s41467-023-41417-0
- Serafim, R. A. M., Haarer, L., Pedreira, J. G. B. & Gehringer, M. Covalent chemical probes for protein kinases. Current Research in Chemical Biology 3 (2023). https://doi.org:10.1016/j.crchbi.2022.100040
- Seller, A., Hackenbruch, C., Walz, J. S., Nelde, A. & Heitmann, J. S. Long-Term Follow-Up of COVID-19 Convalescents-Immune Response Associated with Reinfection Rate and Symptoms. Viruses 15 (2023). https://doi.org:10.3390/v15102100
- Schwenck, J. et al. In vivo imaging of CD8(+) T cells in metastatic cancer patients: first clinical experience with simultaneous [(89)Zr]Zr-Df-IAB22M2C PET/MRI. Theranostics 13, 2408-2423 (2023). https://doi.org:10.7150/thno.79976
- Schwenck, J. et al. Advances in PET imaging of cancer. Nat Rev Cancer 23, 474-490 (2023). https://doi.org:10.1038/s41568-023-00576-4
- Schroeder, S. M., Nelde, A. & Walz, J. S. Viral T-cell epitopes - Identification, characterization and clinical application. Semin Immunol 66, 101725 (2023). https://doi.org:10.1016/j.smim.2023.101725
- Schmitt, A. et al. BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis. Blood 142, 1143-1155 (2023). https://doi.org:10.1182/blood.2022019274
- Schmidt, M. et al. NOTCH3 missense mutations as predictor of long-term response to gemcitabine in a patient with epithelioid hemangioendothelioma. J Cancer Res Clin Oncol 149, 6753-6757 (2023). https://doi.org:10.1007/s00432-023-04598-1
- Schmidt, M. et al. Diagnostic Approaches for Neuroendocrine Neoplasms of Unknown Primary (NEN-UPs) and Their Prognostic Relevance-A Retrospective, Long-Term Single-Center Experience. Cancers (Basel) 15 (2023). https://doi.org:10.3390/cancers15174316
- Schmidt, F. P. et al. Impact of the maximum ring difference on image quality and noise characteristics of a total-body PET/CT scanner. Z Med Phys (2023). https://doi.org:10.1016/j.zemedi.2023.09.001
- Schmidt, F. P., Kramer, J. C., Parl, C., Schmand, M. & Pichler, B. J. Evaluation of a modular all-in-one high-resolution PET detector and readout electronics setup. Phys Med Biol 68 (2023). https://doi.org:10.1088/1361-6560/acd432
- Salimi, A. et al. XBP1 promotes NRAS(G12D) pre-B acute lymphoblastic leukaemia through IL-7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS. J Cell Mol Med 27, 3363-3377 (2023). https://doi.org:10.1111/jcmm.17904
- Salaverria, I., Weigert, O. & Quintanilla-Martinez, L. The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas. Blood Adv 7, 5258-5271 (2023). https://doi.org:10.1182/bloodadvances.2022009456
- Rousseau, V. et al. Trim33 masks a non-transcriptional function of E2f4 in replication fork progression. Nat Commun 14, 5143 (2023). https://doi.org:10.1038/s41467-023-40847-0
- Roitberg, F. et al. Essential cancer medicines: adding feasibility to the magnitude of clinical benefit value chain. ESMO Open 8, 101617 (2023). https://doi.org:10.1016/j.esmoop.2023.101617
- Renovanz, M. et al. Clinical outcome of biomarker-guided therapies in adult patients with tumors of the nervous system. Neurooncol Adv 5, vdad012 (2023). https://doi.org:10.1093/noajnl/vdad012
- Reinert, C. P. et al. Whole-Body Magnetic Resonance Imaging (MRI) for Staging Melanoma Patients in Direct Comparison to Computed Tomography (CT): Results from a Prospective Positron Emission Tomography (PET)/CT and PET/MRI Study. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13111963
- Quintanilla-Martinez, L. et al. Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop. Virchows Arch 483, 281-298 (2023). https://doi.org:10.1007/s00428-023-03590-x
- Pommranz, C. M. et al. Design and performance simulation studies of a breast PET insert integrable into a clinical whole-body PET/MRI scanner. Phys Med Biol 68 (2023). https://doi.org:10.1088/1361-6560/acba77
- Pillaiyar, T. et al. Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and Potency. J Med Chem 66, 17118-17137 (2023). https://doi.org:10.1021/acs.jmedchem.3c02030
- Perez-Gracia, J. L. et al. Streamlining clinical research: an ESMO awareness call to improve sponsoring and monitoring of clinical trials. Ann Oncol 34, 70-77 (2023). https://doi.org:10.1016/j.annonc.2022.09.162
- Perez-Gracia, J. L. et al. Reply to letter to the editor "Bureaucracy or Streamlining the Rules in "Good Clinical Practice (GCP)" - Has Equipoise Occurred?" by H. K. Kotikonda, V. G. Jonnalagadda and S. R. Venna. Ann Oncol 34, 498-499 (2023). https://doi.org:10.1016/j.annonc.2023.02.003
- Peisen, F. et al. Can Whole-Body Baseline CT Radiomics Add Information to the Prediction of Best Response, Progression-Free Survival, and Overall Survival of Stage IV Melanoma Patients Receiving First-Line Targeted Therapy: A Retrospective Register Study. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13203210
- Patzwaldt, K. et al. Repurposing the mucolytic agent ambroxol for treatment of sub-acute and chronic ischaemic stroke. Brain Commun 5, fcad099 (2023). https://doi.org:10.1093/braincomms/fcad099
- Onder, C. E. et al. Precision Immunotherapy Utilizing Adapter CAR-T Cells (AdCAR-T) in Metastatic Breast Cancer Leads to Target Specific Lysis. Cancers (Basel) 16 (2023). https://doi.org:10.3390/cancers16010168
- Odak, A. et al. Novel extragenic genomic safe harbors for precise therapeutic T-cell engineering. Blood 141, 2698-2712 (2023). https://doi.org:10.1182/blood.2022018924
- Nunez, N. G. et al. Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors. Med 4, 113-129 e117 (2023). https://doi.org:10.1016/j.medj.2022.12.007
- Nubel, C., Amaral, T., Leiter, U., Flatz, L. & Forschner, A. Outcome and treatment-related adverse events of combined immune checkpoint inhibition with flipped dosing in a real-world cohort of 79 patients with metastasized melanoma. Front Oncol 13, 1256800 (2023). https://doi.org:10.3389/fonc.2023.1256800
- Nixdorf, D. et al. Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML. Leukemia 37, 1298-1310 (2023). https://doi.org:10.1038/s41375-023-01905-0
- Niessner, H. et al. Exploring the In Vitro and In Vivo Therapeutic Potential of BRAF and MEK Inhibitor Combination in NRAS-Mutated Melanoma. Cancers (Basel) 15 (2023). https://doi.org:10.3390/cancers15235521
- Nies, A. T. et al. Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation. Pharmacol Res 196, 106941 (2023). https://doi.org:10.1016/j.phrs.2023.106941
- Nelde, A. et al. Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells. Blood Cancer Discov 4, 468-489 (2023). https://doi.org:10.1158/2643-3230.BCD-23-0020
- Neef, S. K., Hofmann, U., Murdter, T. E., Schwab, M. & Haag, M. Performance comparison of narrow-bore and capillary liquid-chromatography for non-targeted metabolomics profiling by HILIC-QTOF-MS. Talanta 260, 124578 (2023). https://doi.org:10.1016/j.talanta.2023.124578
- Nann, D. et al. Targeted NGS on sequential bone marrow biopsies aids in the evaluation of cytopenias and monocytosis and documents clonal evolution-a proof of principle study. Virchows Arch 483, 835-845 (2023). https://doi.org:10.1007/s00428-023-03627-1
- Naghavian, R. et al. Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma. Nature 617, 807-817 (2023). https://doi.org:10.1038/s41586-023-06081-w
- Muranyi, A. et al. Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice. Blood Adv 7, 351-364 (2023). https://doi.org:10.1182/bloodadvances.2022007015
- Muhlenbruch, L. et al. The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination. Br J Cancer 128, 1777-1787 (2023). https://doi.org:10.1038/s41416-023-02197-y
- Morra, A. et al. Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Cancer Med 12, 16142-16162 (2023). https://doi.org:10.1002/cam4.6272
- Morra, A. et al. The impact of coding germline variants on contralateral breast cancer risk and survival. Am J Hum Genet 110, 475-486 (2023). https://doi.org:10.1016/j.ajhg.2023.02.003
- Middha, P. et al. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. Breast Cancer Res 25, 93 (2023). https://doi.org:10.1186/s13058-023-01691-8
- Menzel, F. et al. FOMSy: 3D-printed flexible open-source microfluidic system and flow synthesis of PET-tracer. J Flow Chem 13, 247-256 (2023). https://doi.org:10.1007/s41981-023-00267-z
- Medici, G. et al. A T-cell antigen atlas for meningioma: novel options for immunotherapy. Acta Neuropathol 146, 173-190 (2023). https://doi.org:10.1007/s00401-023-02605-w
- Marok, F. Z. et al. A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators. Pharmaceutics 15 (2023). https://doi.org:10.3390/pharmaceutics15020679
- Manoochehri, M. et al. DNA methylation biomarkers for noninvasive detection of triple-negative breast cancer using liquid biopsy. Int J Cancer 152, 1025-1035 (2023). https://doi.org:10.1002/ijc.34337
- Mannheim, J. G., Rausch, I., Conti, M., la Fougere, C. & Schmidt, F. P. Characterization of the partial volume effect along the axial field-of-view of the Biograph Vision Quadra total-body PET/CT system for multiple isotopes. EJNMMI Phys 10, 33 (2023). https://doi.org:10.1186/s40658-023-00554-7
- Maltarollo, V. G. et al. Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors. Future Med Chem 15, 959-985 (2023). https://doi.org:10.4155/fmc-2023-0034
- Maksymenko, K. et al. The design of functional proteins using tensorized energy calculations. Cell Rep Methods 3, 100560 (2023). https://doi.org:10.1016/j.crmeth.2023.100560
- Maia, A., Schollhorn, A., Schuhmacher, J. & Gouttefangeas, C. CAF-immune cell crosstalk and its impact in immunotherapy. Semin Immunopathol 45, 203-214 (2023). https://doi.org:10.1007/s00281-022-00977-x
- Maia, A. et al. Chitin oligomers promote lymphoid innate and adaptive immune cell activation. J Leukoc Biol 114, 180-186 (2023). https://doi.org:10.1093/jleuko/qiad044
- Lutz, M. S. et al. IgG-based B7-H3xCD3 bispecific antibody for treatment of pancreatic, hepatic and gastric cancer. Front Immunol 14, 1163136 (2023). https://doi.org:10.3389/fimmu.2023.1163136
- Lumish, M. et al. Precision Management of a Patient With Dihydropyrimidine Dehydrogenase Deficiency and Liver-Predominant Metastatic Rectal Cancer Using Hepatic Arterial Floxuridine. JCO Precis Oncol 7, e2200442 (2023). https://doi.org:10.1200/PO.22.00442
- Lu, C. E. et al. Monitoring the macrophage response towards biomaterial implants using label-free imaging. Mater Today Bio 21, 100696 (2023). https://doi.org:10.1016/j.mtbio.2023.100696
- Loer, H. L. H. et al. Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT Pharmacometrics Syst Pharmacol 12, 724-738 (2023). https://doi.org:10.1002/psp4.12946
- Linder, P. M. et al. Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13223418
- Lim, K. H. J., Westphalen, C. B., Mateo, J., Lambertini, M. & Amaral, T. Response to the letter entitled 'On finding acceptance'. ESMO Open 8, 102059 (2023). https://doi.org:10.1016/j.esmoop.2023.102059
- Lim, K. H. J. et al. Young oncologists' perspective on the role and future of the clinician-scientist in oncology. ESMO Open 8, 101625 (2023). https://doi.org:10.1016/j.esmoop.2023.101625
- Lichtensteiger, C. et al. Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients. J Autoimmun 140, 103118 (2023). https://doi.org:10.1016/j.jaut.2023.103118
- Liang, C. et al. How [18F]-FDG-PET/CT Affects Clinical Management of Patients with Germ Cell Tumors in the Real World. Cancers (Basel) 15 (2023). https://doi.org:10.3390/cancers15143652
- Li, C., Dubbelaar, M. L., Zhang, X. & Zheng, J. C. Editorial: Understanding the heterogeneity and spatial brain environment of neurodegenerative diseases through conventional and future methods. Front Cell Neurosci 17, 1211273 (2023). https://doi.org:10.3389/fncel.2023.1211273
- Leiss, V. et al. Data on common carotid artery occlusion inducing focalized stroke lesions after Pertussis toxin injection. Data Brief 46, 108851 (2023). https://doi.org:10.1016/j.dib.2022.108851
- Leischner, C. et al. Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer. Antioxidants (Basel) 12 (2023). https://doi.org:10.3390/antiox12040916
- Laux, J. et al. Inherent Fluorescence Demonstrates Immunotropic Properties for Novel Janus Kinase 3 Inhibitors. ACS Pharmacol Transl Sci 6, 1433-1452 (2023). https://doi.org:10.1021/acsptsci.3c00119
- Laux, J. et al. Selective Inhibitors of Janus Kinase 3 Modify Responses to Lipopolysaccharides by Increasing the Interleukin-10-to-Tumor Necrosis Factor alpha Ratio. ACS Pharmacol Transl Sci 6, 892-906 (2023). https://doi.org:10.1021/acsptsci.3c00043
- Kruger, N. et al. Discovery of Polyphenolic Natural Products as SARS-CoV-2 M(pro) Inhibitors for COVID-19. Pharmaceuticals (Basel) 16 (2023). https://doi.org:10.3390/ph16020190
- Kronenberger, T., Laufer, S. A. & Pillaiyar, T. COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease. Drug Discov Today 28, 103579 (2023). https://doi.org:10.1016/j.drudis.2023.103579
- Kosnopfel, C. et al. Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion. J Exp Clin Cancer Res 42, 175 (2023). https://doi.org:10.1186/s13046-023-02755-5
- Knopf, P. et al. Acidosis-mediated increase in IFN-gamma-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors. Mol Cancer 22, 207 (2023). https://doi.org:10.1186/s12943-023-01900-0
- Knopf, P. et al. Preclinical Identification Of Tumor-Draining Lymph Nodes Using a Multimodal Non-invasive In vivo Imaging Approach. Mol Imaging Biol 25, 606-618 (2023). https://doi.org:10.1007/s11307-022-01797-z
- Khor, C. C. et al. Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations. Clin Pharmacol Ther 113, 712-723 (2023). https://doi.org:10.1002/cpt.2846
- Keller, A. L. et al. Generation and characterization of three induced pluripotent stem cells lines from an 86-year old female individual diagnosed with an invasive lobular mammary carcinoma. Stem Cell Res 66, 102988 (2023). https://doi.org:10.1016/j.scr.2022.102988
- Katzengruber, L., Sander, P. & Laufer, S. MKK4 Inhibitors-Recent Development Status and Therapeutic Potential. Int J Mol Sci 24 (2023). https://doi.org:10.3390/ijms24087495
- Katiyar, P. et al. Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data. Nat Biomed Eng 7, 1014-1027 (2023). https://doi.org:10.1038/s41551-023-01047-9
- Kaidun, P. et al. Targeting NKG2DL with Bispecific NKG2D-CD16 and NKG2D-CD3 Fusion Proteins on Triple-Negative Breast Cancer. Int J Mol Sci 24 (2023). https://doi.org:10.3390/ijms241713156
- Junker, D. et al. Antibody Binding and Angiotensin-Converting Enzyme 2 Binding Inhibition Is Significantly Reduced for Both the BA.1 and BA.2 Omicron Variants. Clin Infect Dis 76, e240-e249 (2023). https://doi.org:10.1093/cid/ciac498
- Junk, S. V. et al. Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group. J Exp Clin Cancer Res 42, 21 (2023). https://doi.org:10.1186/s13046-022-02585-x
- Isser, S. et al. Radiolabeled GPVI-Fc for PET Imaging of Multiple Extracellular Matrix Fibers: A New Look into Pulmonary Fibrosis Progression. J Nucl Med 64, 940-945 (2023). https://doi.org:10.2967/jnumed.122.264552
- Ionescu, T. M. et al. Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of 3,4-Methylenedioxymethamphetamine. J Nucl Med 64, 466-471 (2023). https://doi.org:10.2967/jnumed.122.264391
- Huttunen, J. et al. Sodium-Dependent Neutral Amino Acid Transporter 2 Can Serve as a Tertiary Carrier for l-Type Amino Acid Transporter 1-Utilizing Prodrugs. Mol Pharm 20, 1331-1346 (2023). https://doi.org:10.1021/acs.molpharmaceut.2c00948
- Huth, T. et al. Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer. Sci Adv 9, eadh1442 (2023). https://doi.org:10.1126/sciadv.adh1442
- Hoenisch Gravel, N. et al. TOF(IMS) mass spectrometry-based immunopeptidomics refines tumor antigen identification. Nat Commun 14, 7472 (2023). https://doi.org:10.1038/s41467-023-42692-7
- Hinterleitner, M. et al. Treatment modalities favoring outcome in well-differentiated neuroendocrine tumors G3. Front Endocrinol (Lausanne) 14, 1285529 (2023). https://doi.org:10.3389/fendo.2023.1285529
- Heitmann, J. S. et al. Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency. Nat Commun 14, 5032 (2023). https://doi.org:10.1038/s41467-023-40758-0
- Heitmann, J. S. et al. Phase I study evaluating the Fc-optimized FLT3 antibody FLYSYN in AML patients with measurable residual disease. J Hematol Oncol 16, 96 (2023). https://doi.org:10.1186/s13045-023-01490-w
- Hartleif, S. et al. Long-term Outcome of Asymptomatic Patients With Graft Fibrosis in Protocol Biopsies After Pediatric Liver Transplantation. Transplantation 107, 2394-2405 (2023). https://doi.org:10.1097/TP.0000000000004603
- Hackenbruch, C. et al. Elevated SARS-CoV-2-Specific Antibody Levels in Patients with Post-COVID Syndrome. Viruses 15 (2023). https://doi.org:10.3390/v15030701
- Goyal, A. et al. DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts. Nat Commun 14, 6731 (2023). https://doi.org:10.1038/s41467-023-42417-w
- Gouttefangeas, C., Klein, R. & Maia, A. The good and the bad of T cell cross-reactivity: challenges and opportunities for novel therapeutics in autoimmunity and cancer. Front Immunol 14, 1212546 (2023). https://doi.org:10.3389/fimmu.2023.1212546
- Gomez Solsona, B. et al. Inhibition of glutaminase-1 in DLBCL potentiates venetoclax-induced antitumor activity by promoting oxidative stress. Blood Adv 7, 7433-7444 (2023). https://doi.org:10.1182/bloodadvances.2023010964
- Gaissler, A. et al. Early decrease of blood myeloid-derived suppressor cells during checkpoint inhibition is a favorable biomarker in metastatic melanoma. J Immunother Cancer 11 (2023). https://doi.org:10.1136/jitc-2023-006802
- Frohlich, L. M. et al. PARP Inhibitors Effectively Reduce MAPK Inhibitor Resistant Melanoma Cell Growth and Synergize with MAPK Inhibitors through a Synthetic Lethal Interaction In Vitro and In Vivo. Cancer Res Commun 3, 1743-1755 (2023). https://doi.org:10.1158/2767-9764.CRC-23-0101
- Fritz, V., Martirosian, P., Machann, J., Thorwarth, D. & Schick, F. Soy lecithin: A beneficial substance for adjusting the ADC in aqueous solutions to the values of biological tissues. Magn Reson Med 89, 1674-1683 (2023). https://doi.org:10.1002/mrm.29543
- Freidel, L., Li, S., Choffart, A., Kuebler, L. & Martins, A. F. Imaging Techniques in Pharmacological Precision Medicine. Handb Exp Pharmacol 280, 213-235 (2023). https://doi.org:10.1007/164_2023_641
- Flaadt, T. et al. Anti-GD2 Antibody Dinutuximab Beta and Low-Dose Interleukin 2 After Haploidentical Stem-Cell Transplantation in Patients With Relapsed Neuroblastoma: A Multicenter, Phase I/II Trial. J Clin Oncol 41, 3135-3148 (2023). https://doi.org:10.1200/JCO.22.01630
- Feil, S. et al. Noninvasive Detection of Smooth Muscle Cell-Derived Hot Spots to Study Atherosclerosis by PET/MRI in Mice. Circ Res 132, 747-750 (2023). https://doi.org:10.1161/CIRCRESAHA.122.322296
- Feick, D. et al. Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug-drug-gene interaction network. CPT Pharmacometrics Syst Pharmacol 12, 1143-1156 (2023). https://doi.org:10.1002/psp4.12981
- Einhaus, J. et al. Spatial subsetting enables integrative modeling of oral squamous cell carcinoma multiplex imaging data. iScience 26, 108486 (2023). https://doi.org:10.1016/j.isci.2023.108486
- Dutra, J. P. et al. Structural and molecular characterization of lopinavir and ivermectin as breast cancer resistance protein (BCRP/ABCG2) inhibitors. EXCLI J 22, 1155-1172 (2023). https://doi.org:10.17179/excli2023-6427
- Dong, M. et al. Perfusion Air Culture of Precision-Cut Tumor Slices: An Ex Vivo System to Evaluate Individual Drug Response under Controlled Culture Conditions. Cells 12 (2023). https://doi.org:10.3390/cells12050807
- Dimitrov, T. et al. Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities. J Med Chem 66, 7304-7330 (2023). https://doi.org:10.1021/acs.jmedchem.2c02104
- Di Nanni, A. et al. The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to alpha-Synuclein but Reveals Promising Affinity to Amyloid beta. Molecules 28 (2023). https://doi.org:10.3390/molecules28104001
- Di Nanni, A. et al. A Fluorescent Probe as a Lead Compound for a Selective alpha-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [(18)F]PFSB and [(18)F]MFSB. ACS Omega 8, 31450-31467 (2023). https://doi.org:10.1021/acsomega.3c04292
- Damghani, T. et al. Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors. Methods Enzymol 685, 171-198 (2023). https://doi.org:10.1016/bs.mie.2023.03.013
- D'Artista, L. et al. MYC determines lineage commitment in KRAS-driven primary liver cancer development. J Hepatol 79, 141-149 (2023). https://doi.org:10.1016/j.jhep.2023.02.039
- Chatziioannou, E. et al. Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases. EBioMedicine 93, 104644 (2023). https://doi.org:10.1016/j.ebiom.2023.104644
- Chatziioannou, E. et al. Features and Long-Term Outcomes of Stage IV Melanoma Patients Achieving Complete Response Under Anti-PD-1-Based Immunotherapy. Am J Clin Dermatol 24, 453-467 (2023). https://doi.org:10.1007/s40257-023-00775-7
- Castaneda-Vega, S. et al. Cerebrovascular G(i) Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia. Mol Imaging Biol 25, 363-374 (2023). https://doi.org:10.1007/s11307-022-01764-8
- Cardona Gloria, Y. & Weber, A. N. R. Inflammasome Activation in Human Macrophages: IL-1beta Cleavage Detection by Fully Automated Capillary-Based Immunoassay. Methods Mol Biol 2696, 239-256 (2023). https://doi.org:10.1007/978-1-0716-3350-2_16
- Calderon, E. et al. Image Quality and Quantitative PET Parameters of Low-Dose [(18)F]FDG PET in a Long Axial Field-of-View PET/CT Scanner. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13203240
- Burkard, M. et al. High-Dose Ascorbate in Combination with Anti-PD1 Checkpoint Inhibition as Treatment Option for Malignant Melanoma. Cells 12 (2023). https://doi.org:10.3390/cells12020254
- Bucher, P. & Feucht, J. LINKing signaling domains to enhance CAR T cells. Nat Cancer 4, 447-449 (2023). https://doi.org:10.1038/s43018-023-00538-7
- Bowden, G. D., Scott, P. J. H. & Boros, E. Radiochemistry: A Hot Field with Opportunities for Cool Chemistry. ACS Cent Sci 9, 2183-2195 (2023). https://doi.org:10.1021/acscentsci.3c01050
- Boeke, S. et al. Machine learning identifies multi-parametric functional PET/MR imaging cluster to predict radiation resistance in preclinical head and neck cancer models. Eur J Nucl Med Mol Imaging 50, 3084-3096 (2023). https://doi.org:10.1007/s00259-023-06254-9
- Bhattacharya, S. et al. The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. PLoS One 18, e0282347 (2023). https://doi.org:10.1371/journal.pone.0282347
- Bellut, M. et al. Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice. J Neuroinflammation 20, 4 (2023). https://doi.org:10.1186/s12974-022-02674-w
- Behling, F. et al. Loss of H3K27me3 in meningiomas: an independent marker for CNS WHO grade 2? Neurooncol Adv 5, vdad112 (2023). https://doi.org:10.1093/noajnl/vdad112
- Behling, F. et al. The prognostic role of the immunohistochemical expression of S100 in meningiomas. J Cancer Res Clin Oncol 149, 2975-2985 (2023). https://doi.org:10.1007/s00432-022-04186-9
- Becker, L. et al. Exploring the relationship between epigenetic DNA methylation and cardiac fibrosis through Raman microspectroscopy. Am J Physiol Cell Physiol 325, C332-C343 (2023). https://doi.org:10.1152/ajpcell.00209.2023
- Becker, L. et al. Raman microspectroscopy identifies fibrotic tissues in collagen-related disorders via deconvoluted collagen type I spectra. Acta Biomater 162, 278-291 (2023). https://doi.org:10.1016/j.actbio.2023.03.016
- Bamezai, S. et al. A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. Blood 142, 90-105 (2023). https://doi.org:10.1182/blood.2022018651
- Anderle, N. et al. Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment. J Exp Clin Cancer Res 42, 210 (2023). https://doi.org:10.1186/s13046-023-02782-2
- Amor, C. et al. Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Res Sq (2023). https://doi.org:10.21203/rs.3.rs-3385749/v1
- Amaral, T. et al. Identification of stage I/II melanoma patients at high risk for recurrence using a model combining clinicopathologic factors with gene expression profiling (CP-GEP). Eur J Cancer 182, 155-162 (2023). https://doi.org:10.1016/j.ejca.2022.12.021
- Amaral, T. et al. EGFR expression is associated with relapse in a melanoma cohort receiving adjuvant PD-1-based immunotherapy. J Am Acad Dermatol 89, 1072-1074 (2023). https://doi.org:10.1016/j.jaad.2023.06.057
- Almansour, H. et al. Longitudinal monitoring of Apparent Diffusion Coefficient (ADC) in patients with prostate cancer undergoing MR-guided radiotherapy on an MR-Linac at 1.5 T: a prospective feasibility study. Radiol Oncol 57, 184-190 (2023). https://doi.org:10.2478/raon-2023-0020
- Agema, B. C. et al. Toward model-informed precision dosing for tamoxifen: A population-pharmacokinetic model with a continuous CYP2D6 activity scale. Biomed Pharmacother 160, 114369 (2023). https://doi.org:10.1016/j.biopha.2023.114369
- Afat, S. et al. Acquisition time reduction of diffusion-weighted liver imaging using deep learning image reconstruction. Diagn Interv Imaging 104, 178-184 (2023). https://doi.org:10.1016/j.diii.2022.11.002
2024
Publications from 2024
- Zwirner, S. et al. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure. Cell 187, 1666-1684 e1626 (2024). https://doi.org:10.1016/j.cell.2024.02.023
- Zimmermann, V., Frauenfeld, L., Loffler, M. W., Mihaljevic, A. L. & Yurttas, C. Long-term recurrence-free survival following pancreatic surgery with HIPEC treatment for locally advanced pancreatic adenocarcinoma. BMJ Case Rep 17 (2024). https://doi.org:10.1136/bcr-2023-258626
- Zekri, L. et al. Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies. Sci Transl Med 16, eadh1988 (2024). https://doi.org:10.1126/scitranslmed.adh1988
- Yurttas, C. et al. Efficacy of Different Oncolytic Vaccinia Virus Strains for the Treatment of Murine Peritoneal Mesothelioma. Cancers (Basel) 16 (2024). https://doi.org:10.3390/cancers16020368
- Yiangou, K. et al. Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction. medRxiv (2024). https://doi.org:10.1101/2024.02.12.24302043
- Yi, F. et al. CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit. bioRxiv (2024). https://doi.org:10.1101/2024.02.26.582108
- Yang, Q. et al. Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake. Clin Transl Med 14, e1550 (2024). https://doi.org:10.1002/ctm2.1550
- Yang, A. Y., Wistuba-Hamprecht, K., Greten, T. F. & Ruf, B. Innate-like T cells in liver disease. Trends Immunol (2024). https://doi.org:10.1016/j.it.2024.05.008
- Wyss, N. et al. Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade. Am J Respir Crit Care Med (2024). https://doi.org:10.1164/rccm.202311-2136OC
- Wittlinger, F. et al. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem 7, 38 (2024). https://doi.org:10.1038/s42004-024-01108-3
- Weissinger, M. et al. Additional Value of FDG-PET/MRI Complementary to Sentinel Lymphonodectomy for Minimal Invasive Lymph Node Staging in Patients with Endometrial Cancer: A Prospective Study. Diagnostics (Basel) 14 (2024). https://doi.org:10.3390/diagnostics14040376
- Weber, A. N. R., Tortola, M. M. & Kuemmerle-Deschner, J. B. Cracking the NLRP3 code: Pioneering precision medicine for inflammation. J Exp Med 221 (2024). https://doi.org:10.1084/jem.20240221
- Webb, E. W. et al. Development of High-Throughput Experimentation Approaches for Rapid Radiochemical Exploration. J Am Chem Soc 146, 10581-10590 (2024). https://doi.org:10.1021/jacs.3c14822
- Wang, J. Z. et al. Meningioma: International Consortium on Meningiomas (ICOM) consensus review on scientific advances & treatment paradigms for clinicians, researchers, and patients. Neuro Oncol (2024). https://doi.org:10.1093/neuonc/noae082
- Walter, B. et al. Functionally-instructed modifiers of response to ATR inhibition in experimental glioma. J Exp Clin Cancer Res 43, 77 (2024). https://doi.org:10.1186/s13046-024-02995-z
- Vogel, J. et al. How [(18)F]FDG-PET/CT Affects the Management of Patients with Differentiated Thyroid Carcinoma in Clinical Routines. Cancers (Basel) 16 (2024). https://doi.org:10.3390/cancers16030588
- Tremmel, R., Hofmann, U., Haag, M., Schaeffeler, E. & Schwab, M. Circulating Biomarkers Instead of Genotyping to Establish Metabolizer Phenotypes. Annu Rev Pharmacol Toxicol 64, 65-87 (2024). https://doi.org:10.1146/annurev-pharmtox-032023-121106
- Trautwein, N. F. et al. A novel approach to guide GD2-targeted therapy in pediatric tumors by PET and [(64)Cu]Cu-NOTA-ch14.18/CHO. Theranostics 14, 1212-1223 (2024). https://doi.org:10.7150/thno.92481
- Trautwein, N. F. et al. Radiosensitizing Favors Response to Peptide Receptor Radionuclide Therapy in Patients With Highly Proliferative Neuroendocrine Malignancies: Preliminary Evidence From a Clinical Pilot Study. Clin Nucl Med 49, 207-214 (2024). https://doi.org:10.1097/RLU.0000000000005006
- Tandler, C. et al. Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults. Int J Infect Dis 139, 69-77 (2024). https://doi.org:10.1016/j.ijid.2023.11.009
- Stuhler, V. et al. Analysis of the immunological markers BTLA, TIM-3, and PD-L1 at the invasion front and tumor center in clear cell renal cell carcinoma. World J Urol 42, 53 (2024). https://doi.org:10.1007/s00345-023-04721-4
- Steigerwald, H. et al. Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice. Carbohydr Polym 334, 122007 (2024). https://doi.org:10.1016/j.carbpol.2024.122007
- Stefanczyk, S. A. et al. Induction of NK cell reactivity against acute myeloid leukemia by Fc-optimized CD276 (B7-H3) antibody. Blood Cancer J 14, 67 (2024). https://doi.org:10.1038/s41408-024-01050-6
- Sonanini, D. et al. CD19-immunoPET for noninvasive visualization of CD19 expression in B-cell lymphoma patients. Biomark Res 12, 50 (2024). https://doi.org:10.1186/s40364-024-00595-9
- Sleeboom, J. J. F. et al. The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets. Sci Transl Med 16, eadg3840 (2024). https://doi.org:10.1126/scitranslmed.adg3840
- Singvogel, K. & Schittek, B. Dormancy of cutaneous melanoma. Cancer Cell Int 24, 88 (2024). https://doi.org:10.1186/s12935-024-03278-5
- Serafim, R. A. M., Gehringer, M. & Borsari, C. Targeted Covalent Inhibitors in Drug Discovery, Chemical Biology and Beyond. Pharmaceuticals (Basel) 17 (2024). https://doi.org:10.3390/ph17020206
- Seller, A. et al. Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome. Int J Mol Sci 25 (2024). https://doi.org:10.3390/ijms25074126
- Schwarz, M. et al. Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S(N)Ar Electrophiles. J Med Chem 67, 6549-6569 (2024). https://doi.org:10.1021/acs.jmedchem.3c02483
- Schmidt, F. P. et al. Evaluation of the MRI compatibility of PET detectors modules for organ-specific inserts in a 3T and 7T MRI scanner. Med Phys 51, 991-1006 (2024). https://doi.org:10.1002/mp.16923
- Scheurer, J. et al. Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis. Dis Model Mech 17 (2024). https://doi.org:10.1242/dmm.050541
- Scheuermann, S. et al. Unveiling spatial complexity in solid tumor immune microenvironments through multiplexed imaging. Front Immunol 15, 1383932 (2024). https://doi.org:10.3389/fimmu.2024.1383932
- Ruf, T. et al. Second-line therapies for steroid-refractory immune-related adverse events in patients treated with immune checkpoint inhibitors. Eur J Cancer 203, 114028 (2024). https://doi.org:10.1016/j.ejca.2024.114028
- Riester, O., Kaiser, L., Laufer, S. & Deigner, H. P. Rapid Phenotypic Antibiotics Susceptibility Analysis by a 3D Printed Prototype. Adv Sci (Weinh), e2308806 (2024). https://doi.org:10.1002/advs.202308806
- Reinert, C. P. et al. Preoperative Assessment of Medication-Related Osteonecrosis of the Jaw Using [18F]fluoride Positron Emission Tomography (PET)/CT and [18F]fluorodeoxyglucose PET/MRI in Correlation with Histomorphometry and Micro-CT-A Prospective Comparative Study. Diagnostics (Basel) 14 (2024). https://doi.org:10.3390/diagnostics14040428
- Rein, A. F. et al. Identification of novel canonical and cryptic HCMV-specific T-cell epitopes for HLA-A *03 and HLA-B *15 via peptide-PRISM. Blood Adv 8, 712-724 (2024). https://doi.org:10.1182/bloodadvances.2023011120
- Poxleitner, M. et al. Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis. J Neuroinflammation 21, 129 (2024). https://doi.org:10.1186/s12974-024-03080-0
- Perelo, L. W., Gabernet, G., Straub, D. & Nahnsen, S. How tool combinations in different pipeline versions affect the outcome in RNA-seq analysis. NAR Genom Bioinform 6, lqae020 (2024). https://doi.org:10.1093/nargab/lqae020
- Peisen, F. et al. Pre-treatment 18F-FDG-PET/CT parameters as biomarkers for progression free survival, best overall response and overall survival in metastatic melanoma patients undergoing first-line immunotherapy. PLoS One 19, e0296253 (2024). https://doi.org:10.1371/journal.pone.0296253
- Paranawithana, N. N. et al. Enhancing r(1) Relaxivity in GdDOTA-Monoamide Complexes through Polar Group-Mediated Ordering of Second-Sphere Water Molecules. Inorg Chem 63, 4072-4077 (2024). https://doi.org:10.1021/acs.inorgchem.3c03639
- Moraes Ribeiro, E. et al. PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity. J Immunother Cancer 12 (2024). https://doi.org:10.1136/jitc-2023-007829
- Merk, D. J. et al. CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines. Genome Med 16, 82 (2024). https://doi.org:10.1186/s13073-024-01341-4
- Meraz-Torres, F. et al. Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy. J Exp Clin Cancer Res 43, 30 (2024). https://doi.org:10.1186/s13046-023-02941-5
- Menzel, F., Cotton, J., Ziegler, T., Maurer, A. & Neumaier, J. M. Open-source flow setup for rapid and efficient [(18) F]fluoride drying for automation of PET tracer syntheses. J Labelled Comp Radiopharm 67, 40-58 (2024). https://doi.org:10.1002/jlcr.4080
- Meng, J. H. et al. Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS. iScience 27, 109469 (2024). https://doi.org:10.1016/j.isci.2024.109469
- Mc Laughlin, A. M. et al. Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort. Clin Pharmacol Ther (2024). https://doi.org:10.1002/cpt.3238
- Marok, F. Z. et al. Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically-Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy. Clin Pharmacol Ther 115, 1282-1292 (2024). https://doi.org:10.1002/cpt.3181
- Mannheim, J. G. et al. Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls. Neuroimage Clin 42, 103600 (2024). https://doi.org:10.1016/j.nicl.2024.103600
- Mannheim, J. G. et al. Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls. Neuroimage Clin 42, 103600 (2024). https://doi.org:10.1016/j.nicl.2024.103600
- Maier, C. P. et al. Influence of ATLG serum levels on CD3/CD19-depleted hematopoietic grafts and on immune recovery in pediatric haplo-HSCT. Blood Adv 8, 2160-2171 (2024). https://doi.org:10.1182/bloodadvances.2023011016
- Lutz, M. S., Wang, K., Jung, G., Salih, H. R. & Hagelstein, I. An Fc-modified monoclonal antibody as novel treatment option for pancreatic cancer. Front Immunol 15, 1343929 (2024). https://doi.org:10.3389/fimmu.2024.1343929
- Loer, H. L. H. et al. Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT Pharmacometrics Syst Pharmacol (2024). https://doi.org:10.1002/psp4.13127
- Locatelli, F. et al. Exagamglogene Autotemcel for Transfusion-Dependent beta-Thalassemia. N Engl J Med 390, 1663-1676 (2024). https://doi.org:10.1056/NEJMoa2309673
- Leibold, J. et al. Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease. Nat Cancer 5, 315-329 (2024). https://doi.org:10.1038/s43018-023-00686-w
- Le Teuff, G. et al. Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis. Br J Cancer 130, 808-818 (2024). https://doi.org:10.1038/s41416-023-02517-2
- Lan, W., Sari, H., Rominger, A., Fougere, C. & Schmidt, F. P. Optimization and impact of sensitivity mode on abbreviated scan protocols with population-based input function for parametric imaging of [(18)F]-FDG for a long axial FOV PET scanner. Eur J Nucl Med Mol Imaging (2024). https://doi.org:10.1007/s00259-024-06745-3
- Kuntner, C. et al. Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization. Mol Imaging Biol (2024). https://doi.org:10.1007/s11307-024-01927-9
- Kovar, C. et al. A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT Pharmacometrics Syst Pharmacol (2024). https://doi.org:10.1002/psp4.13146
- Kohler, D. et al. Targeting Galpha(i2) in neutrophils protects from myocardial ischemia reperfusion injury. Basic Res Cardiol (2024). https://doi.org:10.1007/s00395-024-01057-x
- Knopf, P. et al. Metabolic fingerprinting by nuclear magnetic resonance of hepatocellular carcinoma cells during p53 reactivation-induced senescence. NMR Biomed, e5157 (2024). https://doi.org:10.1002/nbm.5157
- Jung, S. et al. Protocol of a first-in-human clinical trial to evaluate the safety, tolerability, and preliminary efficacy of the bispecific CD276xCD3 antibody CC-3 in patients with colorectal cancer (CoRe_CC-3). Front Oncol 14, 1351901 (2024). https://doi.org:10.3389/fonc.2024.1351901
- Jin, C. et al. The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage. Nucleic Acids Res 52, 3011-3030 (2024). https://doi.org:10.1093/nar/gkae004
- Jansen, R. A. et al. Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers. Proc Natl Acad Sci U S A 121, e2319492121 (2024). https://doi.org:10.1073/pnas.2319492121
- Hoyt, K. W. et al. Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors. J Med Chem 67, 2-16 (2024). https://doi.org:10.1021/acs.jmedchem.3c01502
- Holzmayer, S. J., Liebel, K., Hagelstein, I., Salih, H. R. & Marklin, M. The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas. Front Immunol 15, 1391954 (2024). https://doi.org:10.3389/fimmu.2024.1391954
- Holzmayer, S. J., Kauer, J., Mauermann, J., Roider, T. & Marklin, M. Asciminib Maintains Antibody-Dependent Cellular Cytotoxicity against Leukemic Blasts. Cancers (Basel) 16 (2024). https://doi.org:10.3390/cancers16071288
- Hillebrand, L., Liang, X. J., Serafim, R. A. M. & Gehringer, M. Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update. J Med Chem 67, 7668-7758 (2024). https://doi.org:10.1021/acs.jmedchem.3c01825
- Herold, N. et al. High-dimensional in situ proteomics imaging to assess gammadelta T cells in spatial biology. J Leukoc Biol 115, 750-759 (2024). https://doi.org:10.1093/jleuko/qiad167
- Hering, A. et al. Improving assessment of lesions in longitudinal CT scans: a bi-institutional reader study on an AI-assisted registration and volumetric segmentation workflow. Int J Comput Assist Radiol Surg (2024). https://doi.org:10.1007/s11548-024-03181-4
- Hartmann, T. et al. Basic principles of artificial intelligence in dermatology explained using melanoma. J Dtsch Dermatol Ges 22, 339-347 (2024). https://doi.org:10.1111/ddg.15322
- Hartmann, T. et al. [Not Available]. J Dtsch Dermatol Ges 22, 339-349 (2024). https://doi.org:10.1111/ddg.15322_g
- Hanssen, F. et al. Scalable and efficient DNA sequencing analysis on different compute infrastructures aiding variant discovery. NAR Genom Bioinform 6, lqae031 (2024). https://doi.org:10.1093/nargab/lqae031
- Hamza, H., Ghosh, M., Loffler, M. W., Rammensee, H. G. & Planz, O. Identification and relative abundance of naturally presented and cross-reactive influenza A virus MHC class I-restricted T cell epitopes. Emerg Microbes Infect 13, 2306959 (2024). https://doi.org:10.1080/22221751.2024.2306959
- Hackenbruch, C. et al. FusionVAC22_01: a phase I clinical trial evaluating a DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocellular carcinoma and other tumor entities carrying the oncogenic driver fusion. Front Oncol 14, 1367450 (2024). https://doi.org:10.3389/fonc.2024.1367450
- Ghasemi, A. et al. Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy. Nat Cancer 5, 240-261 (2024). https://doi.org:10.1038/s43018-023-00668-y
- Ghallab, A. et al. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80, 268-281 (2024). https://doi.org:10.1016/j.jhep.2023.10.035
- Gauvrit, S., Zhao, S., Rothbauer, U. & Stainier, D. Y. R. A beta-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo. Development 151 (2024). https://doi.org:10.1242/dev.202122
- Gallage, S. et al. A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARalpha and PCK1. Cell Metab (2024). https://doi.org:10.1016/j.cmet.2024.04.015
- Frohlich, L. M., Villar-Miyar, A., Heintze, T., Sauer, B. & Schittek, B. PARP1 expression predicts PARP inhibitor sensitivity and correlates with metastatic potential and overall survival in melanoma. Int J Cancer 155, 203-210 (2024). https://doi.org:10.1002/ijc.34947
- Froehlich, T. et al. Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. Life Sci Alliance 7 (2024). https://doi.org:10.26508/lsa.202402608
- Fortuna, A. & Amaral, T. Multidisciplinary approach and treatment of acral and mucosal melanoma. Front Oncol 14, 1340408 (2024). https://doi.org:10.3389/fonc.2024.1340408
- Fend, F., van den Brand, M., Groenen, P. J., Quintanilla-Martinez, L. & Bagg, A. Diagnostic and prognostic molecular pathology of lymphoid malignancies. Virchows Arch 484, 195-214 (2024). https://doi.org:10.1007/s00428-023-03644-0
- El-Ayoubi, A. et al. Development of an optimized, non-stem cell line for intranasal delivery of therapeutic cargo to the central nervous system. Mol Oncol 18, 528-546 (2024). https://doi.org:10.1002/1878-0261.13569
- Eichholz, T. et al. Targeted therapies in retinoblastoma: GD2-directed immunotherapy following autologous stem cell transplantation and evaluation of alternative target B7-H3. Cancer Immunol Immunother 73, 19 (2024). https://doi.org:10.1007/s00262-023-03587-0
- Duran, I. et al. Detection of senescence using machine learning algorithms based on nuclear features. Nat Commun 15, 1041 (2024). https://doi.org:10.1038/s41467-024-45421-w
- Dorner, L. et al. App-based assessment of patient-reported outcomes in the Molecular Tumor Board in the Center for Personalized Medicine-(TRACE). Neurooncol Pract 11, 336-346 (2024). https://doi.org:10.1093/nop/npae002
- Cheng, K. et al. Photo- and Cu-Mediated (11)C Cyanation of (Hetero)Aryl Thianthrenium Salts. Org Lett 26, 3419-3423 (2024). https://doi.org:10.1021/acs.orglett.4c00929
- Chen, X. et al. Cytokines-activated nuclear IKKalpha-FAT10 pathway induces breast cancer tamoxifen-resistance. Sci China Life Sci (2024). https://doi.org:10.1007/s11427-023-2460-0
- Buniatian, G. H. et al. Consequences of Amyloid-beta Deficiency for the Liver. Adv Sci (Weinh) 11, e2307734 (2024). https://doi.org:10.1002/advs.202307734
- Bowden, G. D. et al. [(18)F]pFBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain. Bioconjug Chem 35, 254-264 (2024). https://doi.org:10.1021/acs.bioconjchem.3c00551
- Bork, F. et al. naRNA-LL37 composite DAMPs define sterile NETs as self-propagating drivers of inflammation. EMBO Rep (2024). https://doi.org:10.1038/s44319-024-00150-5
- Bonanno, F. et al. Advancing Parkinson's Disease Diagnostics: The Potential of Arylpyrazolethiazole Derivatives for Imaging alpha-Synuclein Aggregates. ACS Omega 9, 24774-24788 (2024). https://doi.org:10.1021/acsomega.4c01301
- Bischof, H. et al. mitoBK(Ca) is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming. Elife 12 (2024). https://doi.org:10.7554/eLife.92511
- Baumgartner, F. et al. Activation of gp130 signaling in T cells drives T(H)17-mediated multi-organ autoimmunity. Sci Signal 17, eadc9662 (2024). https://doi.org:10.1126/scisignal.adc9662
- Bae, G. et al. Quantitative Metabolomics and Lipoprotein Analysis of PDAC Patients Suggests Serum Marker Categories for Pancreatic Function, Pancreatectomy, Cancer Metabolism, and Systemic Disturbances. J Proteome Res 23, 1249-1262 (2024). https://doi.org:10.1021/acs.jproteome.3c00611
- Amor, C. et al. Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nat Aging 4, 336-349 (2024). https://doi.org:10.1038/s43587-023-00560-5
- Amaral, T. et al. Isolated melanoma cells in sentinel lymph node in stage IIIA melanoma correlate with a favorable prognosis similar to stage IB. Eur J Cancer 201, 113912 (2024). https://doi.org:10.1016/j.ejca.2024.113912
- Altenburg, A. F., Morley, J. L., Bauer, J., Walz, J. S. & Boyle, L. H. Reanalysis of Immunopeptidomics Datasets Provides Mechanistic Insight into TAPBPR-Mediated Peptide Editing on HLA-A, -B and -C Molecules. Wellcome Open Res 9, 113 (2024). https://doi.org:10.12688/wellcomeopenres.20738.1