iFIT Publikationen | Universitätsklinikum Tübingen

Publikationen

Hier finden sich alle relevanten Publikationen, die einen direkten Bezug zum iFIT Exzellenzcluster haben, geordnet nach Jahreszahlen.

2019

Zelba, H. et al. PD-1 and LAG-3 Dominate Checkpoint Receptor-Mediated T-cell Inhibition in Renal Cell Carcinoma. Cancer Immunol Res 7, 1891-1899 (2019). https://doi.org:10.1158/2326-6066.CIR-19-0146
Weiss, J. et al. Assessment of Hepatic Perfusion Using GRASP MRI: Bringing Liver MRI on a New Level. Invest Radiol 54, 737-743 (2019). https://doi.org:10.1097/RLI.0000000000000586
Schmied, B. J. et al. An Fc-Optimized CD133 Antibody for Induction of Natural Killer Cell Reactivity against Colorectal Cancer. Cancers (Basel) 11 (2019). https://doi.org:10.3390/cancers11060789
Schmied, B. J. et al. Induction of NK Cell Reactivity against B-Cell Acute Lymphoblastic Leukemia by an Fc-Optimized FLT3 Antibody. Cancers (Basel) 11 (2019). https://doi.org:10.3390/cancers11121966
Roerden, M. et al. The role of autologous stem cell transplantation in peripheral T cell lymphoma: a long-term follow-up single-center experience. J Cancer Res Clin Oncol 145, 2595-2604 (2019). https://doi.org:10.1007/s00432-019-02999-9
Rammensee, H. G. et al. A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer. J Immunother Cancer 7, 307 (2019). https://doi.org:10.1186/s40425-019-0796-5
Paczulla, A. M. et al. Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature 572, 254-259 (2019). https://doi.org:10.1038/s41586-019-1410-1
Paczulla, A. M. et al. Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature 572, E19 (2019). https://doi.org:10.1038/s41586-019-1475-x
Moya, I. M. et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science 366, 1029-1034 (2019). https://doi.org:10.1126/science.aaw9886
Mannheim, J. G. et al. Reproducibility and Comparability of Preclinical PET Imaging Data: A Multicenter Small-Animal PET Study. J Nucl Med 60, 1483-1491 (2019). https://doi.org:10.2967/jnumed.118.221994
Lorscheid, S. et al. Keratinocyte-derived IkappaBzeta drives psoriasis and associated systemic inflammation. JCI Insight 4 (2019). https://doi.org:10.1172/jci.insight.130835
Loffler, M. W. et al. A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer. Front Immunol 10, 2526 (2019). https://doi.org:10.3389/fimmu.2019.02526
Kauer, J. et al. CD105 (Endoglin) as negative prognostic factor in AML. Sci Rep 9, 18337 (2019). https://doi.org:10.1038/s41598-019-54767-x
Kandabarau, S. et al. Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival. Cancers (Basel) 12 (2019). https://doi.org:10.3390/cancers12010006
Jiang, X. et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun 10, 431 (2019). https://doi.org:10.1038/s41467-018-08054-4
Jiang, X. et al. Publisher Correction: Shared heritability and functional enrichment across six solid cancers. Nat Commun 10, 4386 (2019). https://doi.org:10.1038/s41467-019-12095-8
Hoffmann, S. H. L. et al. Visualization and quantification of in vivo homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer. Theranostics 9, 5869-5885 (2019). https://doi.org:10.7150/thno.33275
Hilf, N. et al. Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature 565, 240-245 (2019). https://doi.org:10.1038/s41586-018-0810-y
Hilf, N. et al. Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature 566, E13 (2019). https://doi.org:10.1038/s41586-019-0959-z
Fiz, F. et al. Automated Definition of Skeletal Disease Burden in Metastatic Prostate Carcinoma: A 3D Analysis of SPECT/CT Images. Cancers (Basel) 11 (2019). https://doi.org:10.3390/cancers11060869
Figlioli, G. et al. The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer. NPJ Breast Cancer 5, 38 (2019). https://doi.org:10.1038/s41523-019-0127-5
El Maadidi, S. et al. Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells. Sci Rep 9, 13168 (2019). https://doi.org:10.1038/s41598-019-49017-z
Dork, T. et al. Two truncating variants in FANCC and breast cancer risk. Sci Rep 9, 12524 (2019). https://doi.org:10.1038/s41598-019-48804-y
Dimitrov, S. et al. Galpha(s)-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells. J Exp Med 216, 517-526 (2019). https://doi.org:10.1084/jem.20181169
Brauch, H., Schroth, W., Murdter, T. & Schwab, M. Tamoxifen Pharmacogenetics and Metabolism: The Same Is Not the Same. J Clin Oncol 37, 1981-1982 (2019). https://doi.org:10.1200/JCO.19.00507
Bowden, G. D., Pichler, B. J. & Maurer, A. A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated (18)F-Fluorination Reactions of Arylstannanes. Sci Rep 9, 11370 (2019). https://doi.org:10.1038/s41598-019-47846-6
Bilich, T. et al. The HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy. Blood 133, 550-565 (2019). https://doi.org:10.1182/blood-2018-07-866830
Bichmann, L. et al. MHCquant: Automated and Reproducible Data Analysis for Immunopeptidomics. J Proteome Res 18, 3876-3884 (2019). https://doi.org:10.1021/acs.jproteome.9b00313
Belnoue, E. et al. Targeting self and neo-epitopes with a modular self-adjuvanting cancer vaccine. JCI Insight 5 (2019). https://doi.org:10.1172/jci.insight.127305

2020

Zhang, H. et al. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses. Nat Genet 52, 572-581 (2020). https://doi.org:10.1038/s41588-020-0609-2
Zbinden, A. et al. Fluorescence lifetime metabolic mapping of hypoxia-induced damage in pancreatic pseudo-islets. J Biophotonics 13, e202000375 (2020). https://doi.org:10.1002/jbio.202000375
Xiao, Q. et al. Germline variant burden in multidrug resistance transporters is a therapy-specific predictor of survival in breast cancer patients. Int J Cancer 146, 2475-2487 (2020). https://doi.org:10.1002/ijc.32898
Wormann, B. et al. Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper. Oncol Res Treat 43, 628-636 (2020). https://doi.org:10.1159/000510258
Wolter, K. & Zender, L. Therapy-induced senescence - an induced synthetic lethality in liver cancer? Nat Rev Gastroenterol Hepatol 17, 135-136 (2020). https://doi.org:10.1038/s41575-020-0262-3
Wojtyniak, J. G., Britz, H., Selzer, D., Schwab, M. & Lehr, T. Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling. CPT Pharmacometrics Syst Pharmacol 9, 322-331 (2020). https://doi.org:10.1002/psp4.12511
Wistuba-Hamprecht, K., Gouttefangeas, C., Weide, B. & Pawelec, G. Immune Signatures and Survival of Patients With Metastatic Melanoma, Renal Cancer, and Breast Cancer. Front Immunol 11, 1152 (2020). https://doi.org:10.3389/fimmu.2020.01152
Wenzel, T. et al. Trans-Mucosal Efficacy of Non-Thermal Plasma Treatment on Cervical Cancer Tissue and Human Cervix Uteri by a Next Generation Electrosurgical Argon Plasma Device. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12020267
Weissinger, M. et al. Correlation of C-arm CT acquired parenchymal blood volume (PBV) with 99mTc-macroaggregated albumin (MAA) SPECT/CT for radioembolization work-up. PLoS One 15, e0244235 (2020). https://doi.org:10.1371/journal.pone.0244235
Weber, A. N. R. et al. Recent insights into the regulatory networks of NLRP3 inflammasome activation. J Cell Sci 133 (2020). https://doi.org:10.1242/jcs.248344
Wang, J. et al. HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell 183, 1264-1281 e1220 (2020). https://doi.org:10.1016/j.cell.2020.09.054
Walter, A. et al. Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon. Front Phys-Lausanne 8 (2020). https://doi.org:ARTN 47
10.3389/fphy.2020.00047
Volpato, M. et al. Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERalpha-positive breast cancer. Explor Target Antitumor Ther 1, 355-371 (2020). https://doi.org:10.37349/etat.2020.00021
Vogel, M. M. E. et al. Prognostic risk classification for biochemical relapse-free survival in patients with oligorecurrent prostate cancer after [(68)Ga]PSMA-PET-guided metastasis-directed therapy. Eur J Nucl Med Mol Imaging 47, 2328-2338 (2020). https://doi.org:10.1007/s00259-020-04760-8
Urbanczyk, M., Zbinden, A., Layland, S. L., Duffy, G. & Schenke-Layland, K. Controlled Heterotypic Pseudo-Islet Assembly of Human beta-Cells and Human Umbilical Vein Endothelial Cells Using Magnetic Levitation. Tissue Eng Part A 26, 387-399 (2020). https://doi.org:10.1089/ten.TEA.2019.0158
Urbanczyk, M., Layland, S. L. & Schenke-Layland, K. The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues. Matrix Biol 85-86, 1-14 (2020). https://doi.org:10.1016/j.matbio.2019.11.005
Unger, M. S. et al. Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs. Anal Chem 92, 11851-11859 (2020). https://doi.org:10.1021/acs.analchem.0c02186
Tremmel, R. et al. Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression. Hum Genet 139, 137-149 (2020). https://doi.org:10.1007/s00439-019-02093-7
Teck, A. T. et al. Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo. Cancer Immunol Immunother 69, 1217-1227 (2020). https://doi.org:10.1007/s00262-020-02519-6
Tandler, C. et al. Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12102725
Stotz, S., Bleher, D., Kalbacher, H. & Maurer, A. Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D. Biochem Biophys Res Commun 527, 238-241 (2020). https://doi.org:10.1016/j.bbrc.2020.04.070
Spenle, C. et al. Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma. Cancer Immunol Res 8, 1122-1138 (2020). https://doi.org:10.1158/2326-6066.CIR-20-0074
Seitz, C. M. et al. GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cells. Oncoimmunology 9, 1683345 (2020). https://doi.org:10.1080/2162402X.2019.1683345
Seith, F. et al. Is there a link between very early changes of primary and secondary lymphoid organs in (18)F-FDG-PET/MRI and treatment response to checkpoint inhibitor therapy? J Immunother Cancer 8 (2020). https://doi.org:10.1136/jitc-2020-000656
Schwenck, J. et al. Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo(18)F-FDG-PET. Theranostics 10, 925-937 (2020). https://doi.org:10.7150/thno.35989
Schuhmacher, J. et al. Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial. J Immunother Cancer 8 (2020). https://doi.org:10.1136/jitc-2020-001157
Schroth, W. et al. Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor-Positive Breast Cancer Patients. Clin Cancer Res 26, 6523-6534 (2020). https://doi.org:10.1158/1078-0432.CCR-20-1923
Schmidt-Hegemann, N. S. et al. Influence of localization of PSMA-positive oligo-metastases on efficacy of metastasis-directed external-beam radiotherapy-a multicenter retrospective study. Eur J Nucl Med Mol Imaging 47, 1852-1863 (2020). https://doi.org:10.1007/s00259-020-04708-y
Sahbai, S. et al. Influence of 99m-Tc-Nanocolloid Activity Concentration on Sentinel Lymph Node Detection in Endometrial Cancer: A Quantitative SPECT/CT Study. Diagnostics (Basel) 10 (2020). https://doi.org:10.3390/diagnostics10090700
Rudesheim, S. et al. Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and alpha-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions. Pharmaceutics 12 (2020). https://doi.org:10.3390/pharmaceutics12121200
Rohm, S. et al. Selective targeting of the alphaC and DFG-out pocket in p38 MAPK. Eur J Med Chem 208, 112721 (2020). https://doi.org:10.1016/j.ejmech.2020.112721
Roerden, M. et al. Outcome after autologous stem cell transplantation in primary refractory or relapsed Hodgkin lymphoma-a long-term follow-up single center experience. Ann Hematol 99, 265-276 (2020). https://doi.org:10.1007/s00277-019-03900-x
Roerden, M. et al. HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12071835
Reustle, A. et al. Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy. Genome Med 12, 32 (2020). https://doi.org:10.1186/s13073-020-00731-8
Reinert, C. P. et al. Clinical and prognostic value of tumor volumetric parameters in melanoma patients undergoing (18)F-FDG-PET/CT: a comparison with serologic markers of tumor burden and inflammation. Cancer Imaging 20, 44 (2020). https://doi.org:10.1186/s40644-020-00322-1
Rammensee, H. G. et al. [Tumor vaccines-therapeutic vaccination against cancer]. Internist (Berl) 61, 690-698 (2020). https://doi.org:10.1007/s00108-020-00814-z
Rammensee, H. G. & Loffler, M. W. [Individualized immunotherapy for malignant tumors using peptide vaccines-maybe it does work after all?]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63, 1380-1387 (2020). https://doi.org:10.1007/s00103-020-03227-3
Perl, R. M., Haring, A., Horger, M. S., Pfannenberg, C. & Gatidis, S. Paraneoplastic syndrome in undifferentiated embryonic sarcoma of the liver. EJNMMI Res 10, 11 (2020). https://doi.org:10.1186/s13550-020-0602-x
Pedreira, J. G. B. et al. Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38alpha MAP Kinase Inhibitors. J Med Chem 63, 7347-7354 (2020). https://doi.org:10.1021/acs.jmedchem.0c00508
Pedersen, N. W. et al. Optimization in Detection of Antigen-Specific T Cells Through Differentially Labeled MHC Multimers. Cytometry A 97, 955-964 (2020). https://doi.org:10.1002/cyto.a.23942
Okkelman, I. A. et al. Extracellular Ca(2+)-Sensing Fluorescent Protein Biosensor Based on a Collagen-Binding Domain. ACS Appl Bio Mater 3, 5310-5321 (2020). https://doi.org:10.1021/acsabm.0c00649
Oehus, A. K. et al. Efficacy of PSMA ligand PET-based radiotherapy for recurrent prostate cancer after radical prostatectomy and salvage radiotherapy. BMC Cancer 20, 362 (2020). https://doi.org:10.1186/s12885-020-06883-5
Neveu, M. A. et al. Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study. Mol Imaging Biol 22, 1324-1332 (2020). https://doi.org:10.1007/s11307-020-01510-y
Neef, S. K. et al. Optimized protocol for metabolomic and lipidomic profiling in formalin-fixed paraffin-embedded kidney tissue by LC-MS. Anal Chim Acta 1134, 125-135 (2020). https://doi.org:10.1016/j.aca.2020.08.005
Neef, S. K. et al. Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS. Metabolites 10 (2020). https://doi.org:10.3390/metabo10120494
Nardin, J. M. et al. The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer. Clin Transl Sci 13, 284-292 (2020). https://doi.org:10.1111/cts.12707
Muller, A. et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest 130, 5765-5781 (2020). https://doi.org:10.1172/JCI134217
Michelotti, F. C. et al. PET/MRI enables simultaneous in vivo quantification of beta-cell mass and function. Theranostics 10, 398-410 (2020). https://doi.org:10.7150/thno.33410
Meraz-Torres, F., Ploger, S., Garbe, C., Niessner, H. & Sinnberg, T. Disulfiram as a Therapeutic Agent for Metastatic Malignant Melanoma-Old Myth or New Logos? Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12123538
Maurer, S., Kopp, H. G., Salih, H. R. & Kropp, K. N. Modulation of Immune Responses by Platelet-Derived ADAM10. Front Immunol 11, 44 (2020). https://doi.org:10.3389/fimmu.2020.00044
Marzec, J. et al. (68)Ga-PSMA-PET/CT-directed IGRT/SBRT for oligometastases of recurrent prostate cancer after initial surgery. Acta Oncol 59, 149-156 (2020). https://doi.org:10.1080/0284186X.2019.1669816
Marklin, M. et al. CD105 (endoglin) as risk marker in AML patients undergoing stem cell transplantation. Int J Hematol 112, 57-64 (2020). https://doi.org:10.1007/s12185-020-02875-0
Marklin, M. et al. Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis. Exp Biol Med (Maywood) 245, 1254-1259 (2020). https://doi.org:10.1177/1535370220931043
Lubke, M. et al. Identification of HCMV-derived T cell epitopes in seropositive individuals through viral deletion models. J Exp Med 217 (2020). https://doi.org:10.1084/jem.20191164
Liu, J. et al. Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk. Sci Rep 10, 9688 (2020). https://doi.org:10.1038/s41598-020-65665-y
Kramer, I. et al. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk. Am J Hum Genet 107, 837-848 (2020). https://doi.org:10.1016/j.ajhg.2020.09.001
Kosnopfel, C. et al. Tumour Progression Stage-Dependent Secretion of YB-1 Stimulates Melanoma Cell Migration and Invasion. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12082328
Kaufmann, S. et al. Simultaneous whole-body PET/MRI with integrated multiparametric MRI for primary staging of high-risk prostate cancer. World J Urol 38, 2513-2521 (2020). https://doi.org:10.1007/s00345-019-03066-1
Kauer, J. et al. Tocilizumab, but not dexamethasone, prevents CRS without affecting antitumor activity of bispecific antibodies. J Immunother Cancer 8 (2020). https://doi.org:10.1136/jitc-2020-000621
Jodicke, L., Zender, L. & Malek, N. P. [Personalized treatment of cholangiocellular carcinoma (CCA)]. Internist (Berl) 61, 170-174 (2020). https://doi.org:10.1007/s00108-019-00723-w
Jensen, O. et al. Variability and Heritability of Thiamine Pharmacokinetics With Focus on OCT1 Effects on Membrane Transport and Pharmacokinetics in Humans. Clin Pharmacol Ther 107, 628-638 (2020). https://doi.org:10.1002/cpt.1666
Jaeckle, E. et al. Towards automation in biologics production via Raman micro-spectroscopy, laser-induced forward cell transfer and surface-enhanced Raman spectroscopy. J Biotechnol 323, 313-321 (2020). https://doi.org:10.1016/j.jbiotec.2020.09.001
Ilhan, H., la Fougere, C. & Krause, B. J. [PSMA-based theranostics for prostate cancer : From imaging to treatment]. Urologe A 59, 617-625 (2020). https://doi.org:10.1007/s00120-020-01193-x
Hilke, F. J. et al. Distinct Mutation Patterns Reveal Melanoma Subtypes and Influence Immunotherapy Response in Advanced Melanoma Patients. Cancers (Basel) 12 (2020). https://doi.org:10.3390/cancers12092359
Heitmann, J. S. et al. Protocol of a prospective, multicentre phase I study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration-resistant prostate carcinoma. BMJ Open 10, e039639 (2020). https://doi.org:10.1136/bmjopen-2020-039639
Heitmann, J. S. et al. Identification of CD318 (CDCP1) as novel prognostic marker in AML. Ann Hematol 99, 477-486 (2020). https://doi.org:10.1007/s00277-020-03907-9
Heitmann, J. S. et al. Fc gamma receptor expression serves as prognostic and diagnostic factor in AML. Leuk Lymphoma 61, 2466-2474 (2020). https://doi.org:10.1080/10428194.2020.1775208
Haller, V., Nahidino, P., Forster, M. & Laufer, S. A. An updated patent review of p38 MAP kinase inhibitors (2014-2019). Expert Opin Ther Pat 30, 453-466 (2020). https://doi.org:10.1080/13543776.2020.1749263
Haen, S. P., Loffler, M. W., Rammensee, H. G. & Brossart, P. Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire. Nat Rev Clin Oncol 17, 595-610 (2020). https://doi.org:10.1038/s41571-020-0387-x
Guo, S. et al. Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study. Anal Chem 92, 15745-15756 (2020). https://doi.org:10.1021/acs.analchem.0c02696
Grimm, J., Kiessling, F. & Pichler, B. J. Quo Vadis, Molecular Imaging? J Nucl Med 61, 1428-1434 (2020). https://doi.org:10.2967/jnumed.120.241984
Ghosh, M. et al. The Impact of Biomaterial Cell Contact on the Immunopeptidome. Front Bioeng Biotechnol 8, 571294 (2020). https://doi.org:10.3389/fbioe.2020.571294
Gehringer, M. Covalent inhibitors: back on track? Future Med Chem 12, 1363-1368 (2020). https://doi.org:10.4155/fmc-2020-0118
Forster, M. et al. Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK. Int J Mol Sci 21 (2020). https://doi.org:10.3390/ijms21239269
Feng, H. et al. Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. Genet Epidemiol 44, 442-468 (2020). https://doi.org:10.1002/gepi.22288
Fachal, L. et al. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat Genet 52, 56-73 (2020). https://doi.org:10.1038/s41588-019-0537-1
Ewels, P. A. et al. The nf-core framework for community-curated bioinformatics pipelines. Nat Biotechnol 38, 276-278 (2020). https://doi.org:10.1038/s41587-020-0439-x
Escala-Garcia, M. et al. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Nat Commun 11, 312 (2020). https://doi.org:10.1038/s41467-019-14100-6
Daum, R. et al. Fibronectin Adsorption on Electrospun Synthetic Vascular Grafts Attracts Endothelial Progenitor Cells and Promotes Endothelialization in Dynamic In Vitro Culture. Cells 9 (2020). https://doi.org:10.3390/cells9030778
Chenoweth, M. J. et al. Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities. Clin Pharmacol Ther 107, 57-61 (2020). https://doi.org:10.1002/cpt.1664
Chen, M. et al. Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1. Clin Pharmacol Ther 107, 227-237 (2020). https://doi.org:10.1002/cpt.1588
Busche, M. et al. HepaChip-MP - a twenty-four chamber microplate for a continuously perfused liver coculture model. Lab Chip 20, 2911-2926 (2020). https://doi.org:10.1039/d0lc00357c
Bucher, P. et al. Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma. Blood 135, 121-132 (2020). https://doi.org:10.1182/blood.2019001866
Bresnahan, E., Ramadori, P., Heikenwalder, M., Zender, L. & Lujambio, A. Novel patient-derived preclinical models of liver cancer. J Hepatol 72, 239-249 (2020). https://doi.org:10.1016/j.jhep.2019.09.028
Brenner, E. et al. Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun 11, 1335 (2020). https://doi.org:10.1038/s41467-020-14987-6
Brendle, C. et al. Determinants of activity of brown adipose tissue in lymphoma patients. Sci Rep 10, 21802 (2020). https://doi.org:10.1038/s41598-020-78419-7
Bilich, T. et al. Mass spectrometry-based identification of a B-cell maturation antigen-derived T-cell epitope for antigen-specific immunotherapy of multiple myeloma. Blood Cancer J 10, 24 (2020). https://doi.org:10.1038/s41408-020-0288-3
Berchtold, S. et al. Assessing and Overcoming Resistance Phenomena against a Genetically Modified Vaccinia Virus in Selected Cancer Cell Lines. Int J Mol Sci 21 (2020). https://doi.org:10.3390/ijms21207618
Armanious, K. et al. Independent attenuation correction of whole body [(18)F]FDG-PET using a deep learning approach with Generative Adversarial Networks. EJNMMI Res 10, 53 (2020). https://doi.org:10.1186/s13550-020-00644-y

2021

Zhou, Y. et al. Regulation of Platelet-Derived ADAM17: A Biomarker Approach for Breast Cancer? Diagnostics (Basel) 11 (2021). https://doi.org:10.3390/diagnostics11071188
Zhou, Y. et al. Platelet-expressed immune checkpoint regulator GITRL in breast cancer. Cancer Immunol Immunother 70, 2483-2496 (2021). https://doi.org:10.1007/s00262-021-02866-y
Zhang, Y. et al. A T(2ex) MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach. Dalton Trans 50, 2014-2017 (2021). https://doi.org:10.1039/d0dt03734f
Zekri, L. et al. An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer. EMBO Mol Med 13, e11902 (2021). https://doi.org:10.15252/emmm.201911902
Zbinden, A. et al. Collagen and Endothelial Cell Coculture Improves beta-Cell Functionality and Rescues Pancreatic Extracellular Matrix. Tissue Eng Part A 27, 977-991 (2021). https://doi.org:10.1089/ten.TEA.2020.0250
Zbinden, A. et al. Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration. Adv Sci (Weinh) 8, 2002500 (2021). https://doi.org:10.1002/advs.202002500
Yurttas, C., Konigsrainer, A. & Loffler, M. W. ASO Author Reflections: First Do No Harm-Revisiting Adjuvant Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Trials to Reduce the Risk of Peritoneal Metastasis. Ann Surg Oncol 28, 9096-9097 (2021). https://doi.org:10.1245/s10434-021-10263-z
Yurttas, C. et al. A Prospective, Phase I/II, Open-Label Pilot Trial to Assess the Safety of Hyperthermic Intraperitoneal Chemotherapy After Oncological Resection of Pancreatic Adenocarcinoma. Ann Surg Oncol 28, 9086-9095 (2021). https://doi.org:10.1245/s10434-021-10187-8
Wydra, V. et al. N-(6-Chloro-3-nitropyridin-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine. Molbank 2021 (2021). https://doi.org:10.3390/m1181
Wojtyniak, J. G., Selzer, D., Schwab, M. & Lehr, T. Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis. Clin Pharmacol Ther 109, 201-211 (2021). https://doi.org:10.1002/cpt.2111
Weissinger, M. et al. Lymph Node Staging with a Combined Protocol of (18)F-FDG PET/MRI and Sentinel Node SPECT/CT: A Prospective Study in Patients with FIGO I/II Cervical Carcinoma. J Nucl Med 62, 1062-1067 (2021). https://doi.org:10.2967/jnumed.120.255919
Weigelin, B. et al. Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity. Nat Commun 12, 5217 (2021). https://doi.org:10.1038/s41467-021-25282-3
Weber, A. N. R. Targeting the NLRP3 Inflammasome via BTK. Front Cell Dev Biol 9, 630479 (2021). https://doi.org:10.3389/fcell.2021.630479
Walter, B. et al. Argyrin F Treatment-Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma. Adv Ther-Germany 4 (2021). https://doi.org:ARTN 2100078
10.1002/adtp.202100078
Wagner, T. R. & Rothbauer, U. Nanobodies - Little helpers unravelling intracellular signaling. Free Radic Biol Med 176, 46-61 (2021). https://doi.org:10.1016/j.freeradbiomed.2021.09.005
Wagner, T. R. et al. NeutrobodyPlex-monitoring SARS-CoV-2 neutralizing immune responses using nanobodies. EMBO Rep 22, e52325 (2021). https://doi.org:10.15252/embr.202052325
van Tilburg, C. M. et al. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. Cancer Discov 11, 2764-2779 (2021). https://doi.org:10.1158/2159-8290.CD-21-0094
Turk, D. et al. Novel models for the prediction of drug-gene interactions. Expert Opin Drug Metab Toxicol 17, 1293-1310 (2021). https://doi.org:10.1080/17425255.2021.1998455
Traenkle, B. et al. Single-Domain Antibodies for Targeting, Detection, and In Vivo Imaging of Human CD4(+) Cells. Front Immunol 12, 799910 (2021). https://doi.org:10.3389/fimmu.2021.799910
Thaiss, W. M. et al. Noninvasive, longitudinal imaging-based analysis of body adipose tissue and water composition in a melanoma mouse model and in immune checkpoint inhibitor-treated metastatic melanoma patients. Cancer Immunol Immunother 70, 1263-1275 (2021). https://doi.org:10.1007/s00262-020-02765-8
Teck, A. T. et al. Correction to: Cancer testis antigen Cyclin A1 harbors several HLA‑A*02:01‑restricted T cell epitopes, which are presented and recognized in vivo. Cancer Immunol Immunother 70, 3055 (2021). https://doi.org:10.1007/s00262-021-02977-6
Symonds, P. et al. Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses. Front Immunol 12, 764462 (2021). https://doi.org:10.3389/fimmu.2021.764462
Sugiyama, K. et al. Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms. Cell Rep Med 2, 100261 (2021). https://doi.org:10.1016/j.xcrm.2021.100261
Stransky, N., Ruth, P., Schwab, M. & Loffler, M. W. Can Any Drug Be Repurposed for Cancer Treatment? A Systematic Assessment of the Scientific Literature. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13246236
Stotz, S., Bowden, G. D., Cotton, J. M., Pichler, B. J. & Maurer, A. Covalent (18)F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging. Pharmaceuticals (Basel) 14 (2021). https://doi.org:10.3390/ph14090897
Stanulla, M. et al. Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia. Leukemia 35, 2650-2657 (2021). https://doi.org:10.1038/s41375-021-01203-7
Sonanini, D. et al. Low-dose total body irradiation facilitates antitumoral Th1 immune responses. Theranostics 11, 7700-7714 (2021). https://doi.org:10.7150/thno.61459
Smaxwil, C. et al. [(18)F]fluoro-ethylcholine-PET Plus 4D-CT (FEC-PET-CT): A Break-Through Tool to Localize the "Negative" Parathyroid Adenoma. One Year Follow Up Results Involving 170 Patients. J Clin Med 10 (2021). https://doi.org:10.3390/jcm10081648
Slaats, J. et al. Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery. Cancer Immunol Res 9, 926-938 (2021). https://doi.org:10.1158/2326-6066.CIR-20-0741
Sirgiovanni, M. et al. Long-term remission of small cell lung cancer after reactivation of tuberculosis following immune-checkpoint blockade: A case report. Thorac Cancer 12, 699-702 (2021). https://doi.org:10.1111/1759-7714.13821
Simnica, D. et al. Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts. Clin Transl Immunology 10, e1340 (2021). https://doi.org:10.1002/cti2.1340
Sevgi, F. et al. Imaging of alpha-Synuclein Aggregates in a Rat Model of Parkinson's Disease Using Raman Microspectroscopy. Front Cell Dev Biol 9, 664365 (2021). https://doi.org:10.3389/fcell.2021.664365
Seitz, C. M. et al. Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting. Oncoimmunology 10, 2003532 (2021). https://doi.org:10.1080/2162402X.2021.2003532
Seitz, C. M. et al. Immunomonitoring of Stage IV Relapsed Neuroblastoma Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation and Subsequent GD2 (ch14.18/CHO) Antibody Treatment. Front Immunol 12, 690467 (2021). https://doi.org:10.3389/fimmu.2021.690467
Schollhorn, A. et al. Integrin Activation Enables Sensitive Detection of Functional CD4(+) and CD8(+) T Cells: Application to Characterize SARS-CoV-2 Immunity. Front Immunol 12, 626308 (2021). https://doi.org:10.3389/fimmu.2021.626308
Schmitt, M. et al. Individualized Proteogenomics Reveals the Mutational Landscape of Melanoma Patients in Response to Immunotherapy. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13215411
Schmitt, M. et al. Proteogenomics Reveals Perturbed Signaling Networks in Malignant Melanoma Cells Resistant to BRAF Inhibition. Mol Cell Proteomics 20, 100163 (2021). https://doi.org:10.1016/j.mcpro.2021.100163
Schmitt, A. et al. Dimethyl fumarate induces ferroptosis and impairs NF-kappaB/STAT3 signaling in DLBCL. Blood 138, 871-884 (2021). https://doi.org:10.1182/blood.2020009404
Sauter-Meyerhoff, C. et al. Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13246221
Rudalska, R., Zender, L. & Dauch, D. Exploiting lipotoxicity for the treatment of liver cancer. Br J Cancer 125, 1459-1461 (2021). https://doi.org:10.1038/s41416-021-01479-7
Rudalska, R. et al. LXRalpha activation and Raf inhibition trigger lethal lipotoxicity in liver cancer. Nat Cancer 2, 201-217 (2021). https://doi.org:10.1038/s43018-020-00168-3
Romer, S. et al. Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1. Front Pharmacol 12, 661480 (2021). https://doi.org:10.3389/fphar.2021.661480
Roerden, M. et al. Impact of Mantle Cell Lymphoma Contamination of Autologous Stem Cell Grafts on Outcome after High-Dose Chemotherapy. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13112558
Roerden, M. et al. Expression levels of HLA-DR in acute myeloid leukemia: implications for antigenicity and clinical outcome. Leuk Lymphoma 62, 1907-1919 (2021). https://doi.org:10.1080/10428194.2021.1885659
Rocha, C. M. et al. Current jakinibs for the treatment of rheumatoid arthritis: a systematic review. Inflammopharmacology 29, 595-615 (2021). https://doi.org:10.1007/s10787-021-00822-x
Riegg, F. et al. An Fc-Optimized CD133 Antibody for Induction of NK Cell Reactivity against B Cell Acute Lymphoblastic Leukemia. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13071632
Richardson, J. R., Schollhorn, A., Gouttefangeas, C. & Schuhmacher, J. CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13040596
Renner, O. et al. Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review). Int J Oncol 58 (2021). https://doi.org:10.3892/ijo.2021.5215
Reinert, C. P. et al. Impact of PET/CT on management of patients with esophageal cancer - results from a PET/CT registry study. Eur J Radiol 136, 109524 (2021). https://doi.org:10.1016/j.ejrad.2021.109524
Reinert, C. P. et al. (18)F-Fluoride PET/CT Imaging of Medication-Related Osteonecrosis of the Jaw in Conservative Treatment-A Case Report. Front Oncol 11, 700397 (2021). https://doi.org:10.3389/fonc.2021.700397
Reinert, C. P. et al. Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters. Eur Radiol 31, 2357-2367 (2021). https://doi.org:10.1007/s00330-020-07320-8
Rammensee, H. G. et al. Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups. Vaccines (Basel) 9 (2021). https://doi.org:10.3390/vaccines9050428
Quante, M. et al. SARS-CoV-2 in Solid Organ Transplant Recipients: A Structured Review of 2020. Transplant Proc 53, 2421-2434 (2021). https://doi.org:10.1016/j.transproceed.2021.08.019
Przystal, J. M. et al. Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13102400
Piccirillo, G. et al. Hyaluronic Acid-Functionalized Hybrid Gelatin-Poly-L-Lactide Scaffolds with Tunable Hydrophilicity. Tissue Eng Part C Methods 27, 589-604 (2021). https://doi.org:10.1089/ten.TEC.2021.0178
Pfister, D. et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature 592, 450-456 (2021). https://doi.org:10.1038/s41586-021-03362-0
Pfaffenrot, B. et al. Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration. Eur J Med Chem 218, 113371 (2021). https://doi.org:10.1016/j.ejmech.2021.113371
Petrigliano, F. A. et al. Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. NPJ Regen Med 6, 77 (2021). https://doi.org:10.1038/s41536-021-00187-3
Park, H. A. et al. Mendelian randomisation study of smoking exposure in relation to breast cancer risk. Br J Cancer 125, 1135-1145 (2021). https://doi.org:10.1038/s41416-021-01432-8
Nording, H. et al. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun 12, 3352 (2021). https://doi.org:10.1038/s41467-021-23499-w
Nies, A. T. et al. Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters. Pharmaceutics 13 (2021). https://doi.org:10.3390/pharmaceutics13030369
Neul, C. et al. Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins. Br J Pharmacol 178, 1459-1474 (2021). https://doi.org:10.1111/bph.15370
Nelde, A., Rammensee, H. G. & Walz, J. S. The Peptide Vaccine of the Future. Mol Cell Proteomics 20, 100022 (2021). https://doi.org:10.1074/mcp.R120.002309
Nelde, A. et al. Immunopeptidomics-Guided Warehouse Design for Peptide-Based Immunotherapy in Chronic Lymphocytic Leukemia. Front Immunol 12, 705974 (2021). https://doi.org:10.3389/fimmu.2021.705974
Nelde, A. et al. SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition. Nat Immunol 22, 74-85 (2021). https://doi.org:10.1038/s41590-020-00808-x
Morra, A. et al. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment. Breast Cancer Res 23, 86 (2021). https://doi.org:10.1186/s13058-021-01450-7
Mehling, R. et al. Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics 11, 470-490 (2021). https://doi.org:10.7150/thno.51462
Maringer, Y. & Walz, J. S. [Tumor vaccination-strategies and time points]. Internist (Berl) 62, 991-997 (2021). https://doi.org:10.1007/s00108-021-01138-2
Marcu, A. et al. Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors. J Immunother Cancer 9 (2021). https://doi.org:10.1136/jitc-2021-003404
Marcu, A. et al. HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy. J Immunother Cancer 9 (2021). https://doi.org:10.1136/jitc-2020-002071
Manoochehri, M. et al. Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients. Clin Epigenetics 13, 207 (2021). https://doi.org:10.1186/s13148-021-01196-1
Mannheim, J. G. et al. Cross-validation study between the HRRT and the PET component of the SIGNA PET/MRI system with focus on neuroimaging. EJNMMI Phys 8, 20 (2021). https://doi.org:10.1186/s40658-020-00349-0
Li, X. et al. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer 21, 541-557 (2021). https://doi.org:10.1038/s41568-021-00383-9
Lauer, A. et al. Ex Vivo Evaluation of the Sepsis Triple Therapy High-Dose Vitamin C in Combination with Vitamin B1 and Hydrocortisone in a Human Peripheral Blood Mononuclear Cells (PBMCs) Model. Nutrients 13 (2021). https://doi.org:10.3390/nu13072366
Kullmann, S. et al. Central Insulin Modulates Dopamine Signaling in the Human Striatum. J Clin Endocrinol Metab 106, 2949-2961 (2021). https://doi.org:10.1210/clinem/dgab410
Kolz, C., Schaeffeler, E., Schwab, M. & Nies, A. T. Genetic and Epigenetic Regulation of Organic Cation Transporters. Handb Exp Pharmacol 266, 81-100 (2021). https://doi.org:10.1007/164_2021_450
Klovekorn, P. et al. From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4). Eur J Med Chem 210, 112963 (2021). https://doi.org:10.1016/j.ejmech.2020.112963
Keller, A. L. et al. Generation and characterization of the human induced pluripotent stem cell line NMIi010-A from peripheral blood mononuclear cells of a healthy 49-year old male individual. Stem Cell Res 54, 102427 (2021). https://doi.org:10.1016/j.scr.2021.102427
Kauer, J. et al. CD18 Antibody Application Blocks Unwanted Off-Target T Cell Activation Caused by Bispecific Antibodies. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13184596
Kapoor, P. M. et al. Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk. J Natl Cancer Inst 113, 329-337 (2021). https://doi.org:10.1093/jnci/djaa056
Kaban, K. et al. Therapeutic Silencing of BCL-2 Using NK Cell-Derived Exosomes as a Novel Therapeutic Approach in Breast Cancer. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13102397
Kaban, K. et al. Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL). Diagnostics (Basel) 11 (2021). https://doi.org:10.3390/diagnostics11112041
Johnson, N. et al. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. Br J Cancer 124, 842-854 (2021). https://doi.org:10.1038/s41416-020-01185-w
Jarzebska, N. T. et al. Lipofection with Synthetic mRNA as a Simple Method for T-Cell Immunomonitoring. Viruses 13 (2021). https://doi.org:10.3390/v13071232
Huergo, L. F. et al. Magnetic Bead-Based Immunoassay Allows Rapid, Inexpensive, and Quantitative Detection of Human SARS-CoV-2 Antibodies. ACS Sens 6, 703-708 (2021). https://doi.org:10.1021/acssensors.0c02544
Huang, K. M. et al. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proc Natl Acad Sci U S A 118 (2021). https://doi.org:10.1073/pnas.2020168118
Hottler, A., Marz, L., Lubke, M., Rammensee, H. G. & Stevanovic, S. Broad and Efficient Activation of Memory CD4(+) T Cells by Novel HAdV- and HCMV-Derived Peptide Pools. Front Immunol 12, 700438 (2021). https://doi.org:10.3389/fimmu.2021.700438
Horner, S. et al. Mass spectrometry for quality control of bispecific antibodies after SDS-PAGE in-gel digestion. Biotechnol Bioeng 118, 3069-3075 (2021). https://doi.org:10.1002/bit.27817
Holl, M. et al. Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum. Biomedicines 9 (2021). https://doi.org:10.3390/biomedicines9020176
Hinterleitner, M. et al. Platelet-Expressed Synaptophysin (pSyn) as Novel Biomarker in Neuroendocrine Malignancies. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13102286
Hinterleitner, C. et al. Platelet-Expressed TNFRSF13B (TACI) Predicts Breast Cancer Progression. Front Oncol 11, 642170 (2021). https://doi.org:10.3389/fonc.2021.642170
Hinterleitner, C. et al. Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nat Commun 12, 7005 (2021). https://doi.org:10.1038/s41467-021-27303-7
Heitmann, J. S., Pfluegler, M., Jung, G. & Salih, H. R. Bispecific Antibodies in Prostate Cancer Therapy: Current Status and Perspectives. Cancers (Basel) 13 (2021). https://doi.org:10.3390/cancers13030549
Heintze,

2022

Zlotos, D. P., Kronenberger, T. & Laufer, S. A. Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands. Pharmaceutics 15 (2022). https://doi.org:10.3390/pharmaceutics15010067
Zizmare, L. et al. Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model. Commun Biol 5, 1250 (2022). https://doi.org:10.1038/s42003-022-04179-x
Zhou, Y., Tremmel, R., Schaeffeler, E., Schwab, M. & Lauschke, V. M. Challenges and opportunities associated with rare-variant pharmacogenomics. Trends Pharmacol Sci 43, 852-865 (2022). https://doi.org:10.1016/j.tips.2022.07.002
Zhang, Y. et al. (131)I-GD2-ch14.18 Scintigraphy to Evaluate Option for Radioimmunotherapy in Patients with Advanced Tumors. J Nucl Med 63, 205-211 (2022). https://doi.org:10.2967/jnumed.120.261854
Yurttas, C. et al. [Impact of the SARS-CoV-2 Pandemic on Liver Surgery and Liver Transplantations in Germany]. Zentralbl Chir 147, 354-360 (2022). https://doi.org:10.1055/a-1845-1321
Yurttas, C., Loffler, M. W., Konigsrainer, A. & Horvath, P. [Current status of surgical treatment of peritoneal metastases from colorectal cancer]. Chirurgie (Heidelb) 93, 1126-1132 (2022). https://doi.org:10.1007/s00104-022-01694-9
Wittlinger, F. et al. Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J Med Chem 65, 1370-1383 (2022). https://doi.org:10.1021/acs.jmedchem.1c00848
Welz, S. et al. Dose escalation to hypoxic subvolumes in head and neck cancer: A randomized phase II study using dynamic [(18)F]FMISO PET/CT. Radiother Oncol 171, 30-36 (2022). https://doi.org:10.1016/j.radonc.2022.03.021
Weissinger, M. et al. Multiparametric Dual-Time-Point [(18)F]FDG PET/MRI for Lymph Node Staging in Patients with Untreated FIGO I/II Cervical Carcinoma. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11174943
Weigelin, B. & Friedl, P. T cell-mediated additive cytotoxicity - death by multiple bullets. Trends Cancer 8, 980-987 (2022). https://doi.org:10.1016/j.trecan.2022.07.007
Weber, A. N. R. et al. Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3. Rheumatology (Oxford) 61, e299-e313 (2022). https://doi.org:10.1093/rheumatology/keac273
Weber, A. N. R. Fish TLR5 develops a taste for viral RNA. EMBO Rep 23, e55443 (2022). https://doi.org:10.15252/embr.202255443
Wagner, T. R. et al. Biparatopic nanobodies protect mice from lethal challenge with SARS-CoV-2 variants of concern. EMBO Rep 23, e53865 (2022). https://doi.org:10.15252/embr.202153865
Wabitsch, S. et al. Metformin treatment rescues CD8(+) T-cell response to immune checkpoint inhibitor therapy in mice with NAFLD. J Hepatol 77, 748-760 (2022). https://doi.org:10.1016/j.jhep.2022.03.010
Visser, D. et al. Green Chemistry for Biomimetic Materials: Synthesis and Electrospinning of High-Molecular-Weight Polycarbonate-Based Nonisocyanate Polyurethanes. ACS Omega 7, 39772-39781 (2022). https://doi.org:10.1021/acsomega.2c03731
Urena-Bailen, G. et al. Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms232112828
Urbanczyk, M., Zbinden, A. & Schenke-Layland, K. Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications. Adv Drug Deliv Rev 186, 114323 (2022). https://doi.org:10.1016/j.addr.2022.114323
Tremmel, R. et al. Hepatic Expression of the Na(+)-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms23137468
Trautwein, C. et al. Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment. JCI Insight 7 (2022). https://doi.org:10.1172/jci.insight.153526
Tonduru, A. K., Adla, S. K., Huttunen, K. M., Kronenberger, T. & Poso, A. Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes. Molecules 27 (2022). https://doi.org:10.3390/molecules27238531
Tegeler, C. M. et al. HLA-DR Presentation of the Tumor Antigen MSLN Associates with Clinical Outcome of Ovarian Cancer Patients. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14092260
Tegeler, C. M. et al. Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort. Int J Infect Dis 120, 187-195 (2022). https://doi.org:10.1016/j.ijid.2022.04.019
Stotz, S., Kinzler, J., Nies, A. T., Schwab, M. & Maurer, A. Two experts and a newbie: [(18)F]PARPi vs [(18)F]FTT vs [(18)F]FPyPARP-a comparison of PARP imaging agents. Eur J Nucl Med Mol Imaging 49, 834-846 (2022). https://doi.org:10.1007/s00259-021-05436-7
Stoll, F. et al. Metabolic Effect of Blocking Sodium-Taurocholate Co-Transporting Polypeptide in Hypercholesterolemic Humans with a Twelve-Week Course of Bulevirtide-An Exploratory Phase I Clinical Trial. Int J Mol Sci 23 (2022). https://doi.org:10.3390/ijms232415924
Stadelmann, K. et al. Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model. Acta Biomater 140, 364-378 (2022). https://doi.org:10.1016/j.actbio.2021.11.030
Slaats, J. et al. Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors. Cancer Immunol Res 10, 1462-1474 (2022). https://doi.org:10.1158/2326-6066.CIR-22-0113
Seyfried, N. et al. Prolonged Exposure to Oxaliplatin during HIPEC Improves Effectiveness in a Preclinical Micrometastasis Model. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14051158
Serafim, R. A. M., Elkins, J. M., Zuercher, W. J., Laufer, S. A. & Gehringer, M. Chemical Probes for Understudied Kinases: Challenges and Opportunities. J Med Chem 65, 1132-1170 (2022). https://doi.org:10.1021/acs.jmedchem.1c00980
Schwenck, J. et al. Antibody-guided Molecular Imaging of Aspergillus Lung Infections in Leukemia Patients. J Nucl Med (2022). https://doi.org:10.2967/jnumed.121.263251
Schwenck, J. et al. A role for artificial intelligence in molecular imaging of infection and inflammation. Eur J Hybrid Imaging 6, 17 (2022). https://doi.org:10.1186/s41824-022-00138-1
Schwarz, S. et al. T cells of colorectal cancer patients' stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells. J Immunother Cancer 10 (2022). https://doi.org:10.1136/jitc-2022-005651
Schussele, L. M. et al. Establishment of a novel method to assess MEK1/2 inhibition in PBMCs for clinical drug development. Front Cell Dev Biol 10, 1063692 (2022). https://doi.org:10.3389/fcell.2022.1063692
Schuller, S. et al. HELLS Is Negatively Regulated by Wild-Type P53 in Liver Cancer by a Mechanism Involving P21 and FOXM1. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14020459
Schuhmacher, J. et al. Simultaneous Identification of Functional Antigen-Specific CD8(+) and CD4(+) Cells after In Vitro Expansion Using Elongated Peptides. Cells 11 (2022). https://doi.org:10.3390/cells11213451
Schollhorn, A. et al. Staining of activated ss(2)-integrins in combination with CD137 and CD154 for sensitive identification of functional antigen-specific CD4(+) and CD8(+) T cells. Front Immunol 13, 1107366 (2022). https://doi.org:10.3389/fimmu.2022.1107366
Schmitt, J. et al. Translational immunoPET imaging using a radiolabeled GD2-specific antibody in neuroblastoma. Theranostics 12, 5615-5630 (2022). https://doi.org:10.7150/thno.56736
Schmidt, M. et al. Inflammatory Surrogate Parameters for Predicting Ifosfamide-Induced Neurotoxicity in Sarcoma Patients. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11195798
Sauter, M. et al. Apolipoprotein E derived from CD11c(+) cells ameliorates atherosclerosis. iScience 25, 103677 (2022). https://doi.org:10.1016/j.isci.2021.103677
Sanchez-Rivera, F. J. et al. Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol 40, 862-873 (2022). https://doi.org:10.1038/s41587-021-01172-3
Salmeron-Villalobos, J. et al. A unifying hypothesis for PNMZL and PTFL: morphological variants with a common molecular profile. Blood Adv 6, 4661-4674 (2022). https://doi.org:10.1182/bloodadvances.2022007322
Ruoff, F. et al. Protein Profiling of Breast Carcinomas Reveals Expression of Immune-Suppressive Factors and Signatures Relevant for Patient Outcome. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14184542
Rudesheim, S. et al. Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone. Pharmaceutics 14 (2022). https://doi.org:10.3390/pharmaceutics14081734
Rudesheim, S., Selzer, D., Fuhr, U., Schwab, M. & Lehr, T. Physiologically-based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups. CPT Pharmacometrics Syst Pharmacol 11, 494-511 (2022). https://doi.org:10.1002/psp4.12776
Rossler, T. et al. Quantitative Serum NMR Spectroscopy Stratifies COVID-19 Patients and Sheds Light on Interfaces of Host Metabolism and the Immune Response with Cytokines and Clinical Parameters. Metabolites 12 (2022). https://doi.org:10.3390/metabo12121277
Rogal, J. et al. Autologous Human Immunocompetent White Adipose Tissue-on-Chip. Adv Sci (Weinh) 9, e2104451 (2022). https://doi.org:10.1002/advs.202104451
Rittig, S. M. et al. Controversial Role of the Immune Checkpoint OX40L Expression on Platelets in Breast Cancer Progression. Front Oncol 12, 917834 (2022). https://doi.org:10.3389/fonc.2022.917834
Reustle, A. et al. Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma. Clin Transl Med 12, e883 (2022). https://doi.org:10.1002/ctm2.883
Reinert, C. P. et al. [18F]Fluoride Positron-Emission Tomography (PET) and [18F]FDG PET for Assessment of Osteomyelitis of the Jaw in Comparison to Computed Tomography (CT) and Magnetic Resonance Imaging (MRI): A Prospective PET/CT and PET/MRI Pilot Study. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11143998
Reinert, C. P. et al. Value of CT-Textural Features and Volume-Based PET Parameters in Comparison to Serologic Markers for Response Prediction in Patients with Diffuse Large B-Cell Lymphoma Undergoing CD19-CAR-T Cell Therapy. J Clin Med 11 (2022). https://doi.org:10.3390/jcm11061522
Reautschnig, P. et al. CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo. Nat Biotechnol 40, 759-768 (2022). https://doi.org:10.1038/s41587-021-01105-0
Rausch, I., Mannheim, J. G., Kupferschlager, J., la Fougere, C. & Schmidt, F. P. Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for (18)F-FDG. EJNMMI Phys 9, 87 (2022). https://doi.org:10.1186/s40658-022-00516-5
Rau, A. et al. Triple Targeting of HER Receptors Overcomes Heregulin-mediated Resistance to EGFR Blockade in Colorectal Cancer. Mol Cancer Ther 21, 799-809 (2022). https://doi.org:10.1158/1535-7163.MCT-21-0818
Rashidian, A. et al. Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist. Comput Struct Biotechnol J 20, 3004-3018 (2022). https://doi.org:10.1016/j.csbj.2022.06.020
Rappold, P. M. et al. A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma. Cancer Discov 12, 2308-2329 (2022). https://doi.org:10.1158/2159-8290.CD-21-0925
RA, M. S. et al. Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem 65, 3173-3192 (2022). https://doi.org:10.1021/acs.jmedchem.1c01165
Pristup, J. et al. Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase. Clin Pharmacol Ther 112, 808-816 (2022). https://doi.org:10.1002/cpt.2637
Pillaiyar, T. et al. Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination. J Med Chem 65, 9376-9395 (2022). https://doi.org:10.1021/acs.jmedchem.2c00636
Peisen, F. et al. Combination of Whole-Body Baseline CT Radiomics and Clinical Parameters to Predict Response and Survival in a Stage-IV Melanoma Cohort Undergoing Immunotherapy. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14122992
Pantsar, T. et al. Decisive role of water and protein dynamics in residence time of p38alpha MAP kinase inhibitors. Nat Commun 13, 569 (2022). https://doi.org:10.1038/s41467-022-28164-4
Paffenholz, S. V. et al. Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer. Proc Natl Acad Sci U S A 119 (2022). https://doi.org:10.1073/pnas.2117754119
Ozbay Kurt, F. G. et al. Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2. Front Immunol 13, 1012526 (2022). https://doi.org:10.3389/fimmu.2022.1012526
Niessner, H. et al. Therapeutic Efficacy of Pharmacological Ascorbate on Braf Inhibitor Resistant Melanoma Cells In Vitro and In Vivo. Cells 11 (2022). https://doi.org:10.3390/cells11071229
Nies, A. T., Schaeffeler, E. & Schwab, M. Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation. Pharmacol Ther 238, 108268 (2022). https://doi.org:10.1016/j.pharmthera.2022.108268
Nelde, A. et al. Increased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity. iScience 25, 105643 (2022). https://doi.org:10.1016/j.isci.2022.105643
Nelde, A. et al. Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens. Cell Mol Life Sci 79, 171 (2022). https://doi.org:10.1007/s00018-022-04145-0
Mustonen, E. K. et al. Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TuKIC Library. Cells 11 (2022). https://doi.org:10.3390/cells11081299
Muller, M., Reguzova, A., Loffler, M. W. & Amann, R. Orf Virus-Based Vectors Preferentially Target Professional Antigen-Presenting Cells, Activate the STING Pathway and Induce Strong Antigen-Specific T Cell Responses. Front Immunol 13, 873351 (2022). https://doi.org:10.3389/fimmu.2022.873351
Montes-Mojarro, I. A. et al. CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL. Leukemia 36, 2050-2063 (2022). https://doi.org:10.1038/s41375-022-01617-x
Mohr, C. J. et al. Subunits of BK channels promote breast cancer development and modulate responses to endocrine treatment in preclinical models. Br J Pharmacol 179, 2906-2924 (2022). https://doi.org:10.1111/bph.15147
McDougald, W. A. & Mannheim, J. G. Understanding the importance of quality control and quality assurance in preclinical PET/CT imaging. EJNMMI Phys 9, 77 (2022). https://doi.org:10.1186/s40658-022-00503-w
Marzi, J. et al. Noninvasive Physical Plasma as Innovative and Tissue-Preserving Therapy for Women Positive for Cervical Intraepithelial Neoplasia. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14081933
Marzi, J. et al. Marker-Independent Monitoring of in vitro and in vivo Degradation of Supramolecular Polymers Applied in Cardiovascular in situ Tissue Engineering. Front Cardiovasc Med 9, 885873 (2022). https://doi.org:10.3389/fcvm.2022.885873
Marzi, J. et al. Non-Invasive Three-Dimensional Cell Analysis in Bioinks by Raman Imaging. ACS Appl Mater Interfaces 14, 30455-30465 (2022). https://doi.org:10.1021/acsami.1c24463
Maringer, Y. et al. Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination. Sci Immunol 7, eadd3899 (2022). https://doi.org:10.1126/sciimmunol.add3899
Marconato, M., Maringer, Y., Walz, J. S., Nelde, A. & Heitmann, J. S. Immunopeptidome Diversity in Chronic Lymphocytic Leukemia Identifies Patients with Favorable Disease Outcome. Cancers (Basel) 14 (2022). https://doi.org:10.3390/cancers14194659
Marconato, M., Kauer, J., Salih, H. R., Marklin, M. & Heitmann, J. S. Expression of the immune checkpoint modulator OX40 indicates poor survival in acute myeloid leukemia. Sci Rep 12, 15856 (2022). https://doi.org:10.1038/s41598-022-19972-1
Marciano, S. et al. Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks. Proc Natl Acad Sci U S A 119, e2122552119 (2022). https://doi.org:10.1073/pnas.2122552119
Mansilla-Soto, J. et al. HLA-independent T cell receptors for targeting tumors with low antigen density. Nat Med 28, 345-352 (2022). https://doi.org:10.1038/s41591-021-01621-1
Lutz, M. S. et al. Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies. J Immunother Cancer 10 (2022). https://doi.org:10.1136/jitc-2021-003655
Loffler, M. W. et al. Phase I/II Multicenter Trial of a Novel Therapeutic Cancer Vaccine, HepaVac-101, for Hepatocellular Carcinoma. Clin Cancer Res 28, 2555-2566 (2022). https://doi.org:10.1158/1078-0432.CCR-21-4424
Laux, J. et al. Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells. ACS Pharmacol Transl Sci 5, 573-602 (2022). https://doi.org:10.1021/acsptsci.2c00054
Laufer, S. et al. Publication Criteria and Requirements for Studies on Protein Kinase Inhibitors horizontal line What Is Expected? J Med Chem 65, 6973-6974 (2022). https://doi.org:10.1021/acs.jmedchem.2c00623
Lauer, U. M., Hinterleitner, M., Horger, M., Ohnesorge, P. V. & Zender, L. NUT Carcinoma-An Underdiagnosed Malignancy. Front Oncol 12, 914031 (2022). https://doi.org:10.3389/fonc.2022.914031
Lacom, C. et al. Assay validity of point-of-care platelet function tests in thrombocytopenic blood samples. Biochem Med (Zagreb) 32, 020713 (2022). https://doi.org:10.11613/BM.2022.020713
Lackner, M. et al. Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kbeta inhibition on metabolic pathway activities in a PTEN null breast cancer cell line. Front Mol Biosci 9, 1004602 (2022). https://doi.org:10.3389/fmolb.2022.1004602
Kustner, T. et al. Development of a Hybrid-Imaging-Based Prognostic Index for Metastasized-Melanoma Patients in Whole-Body 18F-FDG PET/CT and PET/MRI Data. Diagnostics (Basel) 12 (2022). https://doi.org:10.3390/diagnostics12092102
Kubiniok, P. et al. Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues. iScience 25, 103768 (2022). https://doi.org:10.1016/j.isci.2022.103768
Korde, A. et al. Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals. EJNMMI Radiopharm Chem 7, 18 (2022). https://doi.org:10.1186/s41181-022-00168-x
Keller, A. L., Binn

2023

Zhu, V. et al. Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers. Front Pharmacol 14, 1128547 (2023). https://doi.org:10.3389/fphar.2023.1128547
Zekri, L. et al. Novel ACE2 fusion protein with adapting activity against SARS-CoV-2 variants in vitro. Front Immunol 14, 1112505 (2023). https://doi.org:10.3389/fimmu.2023.1112505
Zekri, L. et al. An optimized IgG-based B7-H3xCD3 bispecific antibody for treatment of gastrointestinal cancers. Mol Ther 31, 1033-1045 (2023). https://doi.org:10.1016/j.ymthe.2023.02.010
Wydra, V. R., Ditzinger, R. B., Seidler, N. J., Hacker, F. W. & Laufer, S. A. A patent review of MAPK inhibitors (2018 - present). Expert Opin Ther Pat 33, 421-444 (2023). https://doi.org:10.1080/13543776.2023.2242584
Wuestefeld, A. et al. A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes. Cancer Res 83, 428-440 (2023). https://doi.org:10.1158/0008-5472.CAN-22-1477
Wimmers, F. et al. Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth. Cell 186, 4632-4651 e4623 (2023). https://doi.org:10.1016/j.cell.2023.08.044
Wimmers, F. et al. Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life. medRxiv (2023). https://doi.org:10.1101/2023.01.28.23285133
Wichert, K. et al. Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer. Eur J Epidemiol 38, 1053-1068 (2023). https://doi.org:10.1007/s10654-023-01048-7
Werner, S. et al. Influence of [(18)F]FDG-PET/CT on Clinical Management Decisions in Breast Cancer Patients-A PET/CT Registry Study. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13142420
Weissinger, M. et al. Non-invasive estimation of split renal function from routine (68)Ga-SSR-PET/CT scans. Front Med (Lausanne) 10, 1169451 (2023). https://doi.org:10.3389/fmed.2023.1169451
Weissinger, M. et al. Diagnostic Performance of Dynamic Whole-Body Patlak [(18)F]FDG-PET/CT in Patients with Indeterminate Lung Lesions and Lymph Nodes. J Clin Med 12 (2023). https://doi.org:10.3390/jcm12123942
Weber, A. N. R. et al. Comment on: Effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3: Reply. Rheumatology (Oxford) 62, e168-e169 (2023). https://doi.org:10.1093/rheumatology/keac718
Wang, J. Z. et al. Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Acta Neuropathol 146, 145-162 (2023). https://doi.org:10.1007/s00401-023-02571-3
Wang, J. Z. et al. Correction: Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Acta Neuropathol 146, 171-172 (2023). https://doi.org:10.1007/s00401-023-02584-y
Wallisch, S. et al. Protocol for establishing a coculture with fibroblasts and colorectal cancer organoids. STAR Protoc 4, 102481 (2023). https://doi.org:10.1016/j.xpro.2023.102481
Wagner, T. R. et al. Two birds with one stone: human SIRPalpha nanobodies for functional modulation and in vivo imaging of myeloid cells. Front Immunol 14, 1264179 (2023). https://doi.org:10.3389/fimmu.2023.1264179
Wacker, M. et al. Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics. Front Immunol 14, 1219720 (2023). https://doi.org:10.3389/fimmu.2023.1219720
Vogel, J. et al. Impact of Tracer Dose Reduction in [18 F]-Labelled Fluorodeoxyglucose-Positron Emission Tomography ([18 F]-FDG)-PET) on Texture Features and Histogram Indices: A Study in Homogeneous Tissues of Phantom and Patient. Tomography 9, 1799-1810 (2023). https://doi.org:10.3390/tomography9050143
Visser, D. et al. Electrospinning of collagen: enzymatic and spectroscopic analyses reveal solvent-independent disruption of the triple-helical structure. J Mater Chem B 11, 2207-2218 (2023). https://doi.org:10.1039/d2tb02602c
Urbanczyk, M. et al. Decorin improves human pancreatic beta-cell function and regulates ECM expression in vitro. Matrix Biol 115, 160-183 (2023). https://doi.org:10.1016/j.matbio.2022.12.005
Turk, D. et al. Significant impact of time-of-day variation on metformin pharmacokinetics. Diabetologia 66, 1024-1034 (2023). https://doi.org:10.1007/s00125-023-05898-4
Trautwein, N. F. et al. Long-term prognostic factors for PRRT in neuroendocrine tumors. Front Med (Lausanne) 10, 1169970 (2023). https://doi.org:10.3389/fmed.2023.1169970
Trautwein, N. F. et al. First-in-Humans PET/MRI of In Vivo GD2 Expression in Osteosarcoma. J Nucl Med 64, 337-338 (2023). https://doi.org:10.2967/jnumed.122.264626
Tonduru, A. K. et al. Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs. J Med Chem 66, 15094-15114 (2023). https://doi.org:10.1021/acs.jmedchem.3c01026
Swen, J. J. et al. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet 401, 347-356 (2023). https://doi.org:10.1016/S0140-6736(22)01841-4
Stransky, N. et al. Efficacy of combined tumor irradiation and K(Ca)3.1-targeting with TRAM-34 in a syngeneic glioma mouse model. Sci Rep 13, 20604 (2023). https://doi.org:10.1038/s41598-023-47552-4
Steigerwald, H. et al. Peach extract induces systemic and local immune responses in an experimental food allergy model. Sci Rep 13, 1892 (2023). https://doi.org:10.1038/s41598-023-28933-1
Sporbeck, K. et al. The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension. Commun Biol 6, 872 (2023). https://doi.org:10.1038/s42003-023-05236-9
Song, J. Y. et al. Diffuse large B-cell lymphomas, not otherwise specified, and emerging entities. Virchows Arch 482, 179-192 (2023). https://doi.org:10.1007/s00428-022-03466-6
Sivula, T. et al. Machine Learning-Boosted Docking Enables the Efficient Structure-Based Virtual Screening of Giga-Scale Enumerated Chemical Libraries. J Chem Inf Model 63, 5773-5783 (2023). https://doi.org:10.1021/acs.jcim.3c01239
Sinnberg, T. et al. Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. Am J Respir Crit Care Med 207, 38-49 (2023). https://doi.org:10.1164/rccm.202201-0011OC
Sigle, M. et al. Translating genomic tools to Raman spectroscopy analysis enables high-dimensional tissue characterization on molecular resolution. Nat Commun 14, 5799 (2023). https://doi.org:10.1038/s41467-023-41417-0
Serafim, R. A. M., Haarer, L., Pedreira, J. G. B. & Gehringer, M. Covalent chemical probes for protein kinases. Current Research in Chemical Biology 3 (2023). https://doi.org:10.1016/j.crchbi.2022.100040
Seller, A., Hackenbruch, C., Walz, J. S., Nelde, A. & Heitmann, J. S. Long-Term Follow-Up of COVID-19 Convalescents-Immune Response Associated with Reinfection Rate and Symptoms. Viruses 15 (2023). https://doi.org:10.3390/v15102100
Schwenck, J. et al. In vivo imaging of CD8(+) T cells in metastatic cancer patients: first clinical experience with simultaneous [(89)Zr]Zr-Df-IAB22M2C PET/MRI. Theranostics 13, 2408-2423 (2023). https://doi.org:10.7150/thno.79976
Schwenck, J. et al. Advances in PET imaging of cancer. Nat Rev Cancer 23, 474-490 (2023). https://doi.org:10.1038/s41568-023-00576-4
Schroeder, S. M., Nelde, A. & Walz, J. S. Viral T-cell epitopes - Identification, characterization and clinical application. Semin Immunol 66, 101725 (2023). https://doi.org:10.1016/j.smim.2023.101725
Schmitt, A. et al. BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis. Blood 142, 1143-1155 (2023). https://doi.org:10.1182/blood.2022019274
Schmidt, M. et al. NOTCH3 missense mutations as predictor of long-term response to gemcitabine in a patient with epithelioid hemangioendothelioma. J Cancer Res Clin Oncol 149, 6753-6757 (2023). https://doi.org:10.1007/s00432-023-04598-1
Schmidt, M. et al. Diagnostic Approaches for Neuroendocrine Neoplasms of Unknown Primary (NEN-UPs) and Their Prognostic Relevance-A Retrospective, Long-Term Single-Center Experience. Cancers (Basel) 15 (2023). https://doi.org:10.3390/cancers15174316
Schmidt, F. P. et al. Impact of the maximum ring difference on image quality and noise characteristics of a total-body PET/CT scanner. Z Med Phys (2023). https://doi.org:10.1016/j.zemedi.2023.09.001
Schmidt, F. P., Kramer, J. C., Parl, C., Schmand, M. & Pichler, B. J. Evaluation of a modular all-in-one high-resolution PET detector and readout electronics setup. Phys Med Biol 68 (2023). https://doi.org:10.1088/1361-6560/acd432
Salimi, A. et al. XBP1 promotes NRAS(G12D) pre-B acute lymphoblastic leukaemia through IL-7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS. J Cell Mol Med 27, 3363-3377 (2023). https://doi.org:10.1111/jcmm.17904
Salaverria, I., Weigert, O. & Quintanilla-Martinez, L. The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas. Blood Adv 7, 5258-5271 (2023). https://doi.org:10.1182/bloodadvances.2022009456
Rousseau, V. et al. Trim33 masks a non-transcriptional function of E2f4 in replication fork progression. Nat Commun 14, 5143 (2023). https://doi.org:10.1038/s41467-023-40847-0
Roitberg, F. et al. Essential cancer medicines: adding feasibility to the magnitude of clinical benefit value chain. ESMO Open 8, 101617 (2023). https://doi.org:10.1016/j.esmoop.2023.101617
Renovanz, M. et al. Clinical outcome of biomarker-guided therapies in adult patients with tumors of the nervous system. Neurooncol Adv 5, vdad012 (2023). https://doi.org:10.1093/noajnl/vdad012
Reinert, C. P. et al. Whole-Body Magnetic Resonance Imaging (MRI) for Staging Melanoma Patients in Direct Comparison to Computed Tomography (CT): Results from a Prospective Positron Emission Tomography (PET)/CT and PET/MRI Study. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13111963
Quintanilla-Martinez, L. et al. Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop. Virchows Arch 483, 281-298 (2023). https://doi.org:10.1007/s00428-023-03590-x
Pommranz, C. M. et al. Design and performance simulation studies of a breast PET insert integrable into a clinical whole-body PET/MRI scanner. Phys Med Biol 68 (2023). https://doi.org:10.1088/1361-6560/acba77
Pillaiyar, T. et al. Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and Potency. J Med Chem 66, 17118-17137 (2023). https://doi.org:10.1021/acs.jmedchem.3c02030
Perez-Gracia, J. L. et al. Streamlining clinical research: an ESMO awareness call to improve sponsoring and monitoring of clinical trials. Ann Oncol 34, 70-77 (2023). https://doi.org:10.1016/j.annonc.2022.09.162
Perez-Gracia, J. L. et al. Reply to letter to the editor "Bureaucracy or Streamlining the Rules in "Good Clinical Practice (GCP)" - Has Equipoise Occurred?" by H. K. Kotikonda, V. G. Jonnalagadda and S. R. Venna. Ann Oncol 34, 498-499 (2023). https://doi.org:10.1016/j.annonc.2023.02.003
Peisen, F. et al. Can Whole-Body Baseline CT Radiomics Add Information to the Prediction of Best Response, Progression-Free Survival, and Overall Survival of Stage IV Melanoma Patients Receiving First-Line Targeted Therapy: A Retrospective Register Study. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13203210
Patzwaldt, K. et al. Repurposing the mucolytic agent ambroxol for treatment of sub-acute and chronic ischaemic stroke. Brain Commun 5, fcad099 (2023). https://doi.org:10.1093/braincomms/fcad099
Onder, C. E. et al. Precision Immunotherapy Utilizing Adapter CAR-T Cells (AdCAR-T) in Metastatic Breast Cancer Leads to Target Specific Lysis. Cancers (Basel) 16 (2023). https://doi.org:10.3390/cancers16010168
Odak, A. et al. Novel extragenic genomic safe harbors for precise therapeutic T-cell engineering. Blood 141, 2698-2712 (2023). https://doi.org:10.1182/blood.2022018924
Nunez, N. G. et al. Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors. Med 4, 113-129 e117 (2023). https://doi.org:10.1016/j.medj.2022.12.007
Nubel, C., Amaral, T., Leiter, U., Flatz, L. & Forschner, A. Outcome and treatment-related adverse events of combined immune checkpoint inhibition with flipped dosing in a real-world cohort of 79 patients with metastasized melanoma. Front Oncol 13, 1256800 (2023). https://doi.org:10.3389/fonc.2023.1256800
Nixdorf, D. et al. Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML. Leukemia 37, 1298-1310 (2023). https://doi.org:10.1038/s41375-023-01905-0
Niessner, H. et al. Exploring the In Vitro and In Vivo Therapeutic Potential of BRAF and MEK Inhibitor Combination in NRAS-Mutated Melanoma. Cancers (Basel) 15 (2023). https://doi.org:10.3390/cancers15235521
Nies, A. T. et al. Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation. Pharmacol Res 196, 106941 (2023). https://doi.org:10.1016/j.phrs.2023.106941
Nelde, A. et al. Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells. Blood Cancer Discov 4, 468-489 (2023). https://doi.org:10.1158/2643-3230.BCD-23-0020
Neef, S. K., Hofmann, U., Murdter, T. E., Schwab, M. & Haag, M. Performance comparison of narrow-bore and capillary liquid-chromatography for non-targeted metabolomics profiling by HILIC-QTOF-MS. Talanta 260, 124578 (2023). https://doi.org:10.1016/j.talanta.2023.124578
Nann, D. et al. Targeted NGS on sequential bone marrow biopsies aids in the evaluation of cytopenias and monocytosis and documents clonal evolution-a proof of principle study. Virchows Arch 483, 835-845 (2023). https://doi.org:10.1007/s00428-023-03627-1
Naghavian, R. et al. Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma. Nature 617, 807-817 (2023). https://doi.org:10.1038/s41586-023-06081-w
Muranyi, A. et al. Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice. Blood Adv 7, 351-364 (2023). https://doi.org:10.1182/bloodadvances.2022007015
Muhlenbruch, L. et al. The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination. Br J Cancer 128, 1777-1787 (2023). https://doi.org:10.1038/s41416-023-02197-y
Morra, A. et al. Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Cancer Med 12, 16142-16162 (2023). https://doi.org:10.1002/cam4.6272
Morra, A. et al. The impact of coding germline variants on contralateral breast cancer risk and survival. Am J Hum Genet 110, 475-486 (2023). https://doi.org:10.1016/j.ajhg.2023.02.003
Middha, P. et al. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. Breast Cancer Res 25, 93 (2023). https://doi.org:10.1186/s13058-023-01691-8
Menzel, F. et al. FOMSy: 3D-printed flexible open-source microfluidic system and flow synthesis of PET-tracer. J Flow Chem 13, 247-256 (2023). https://doi.org:10.1007/s41981-023-00267-z
Medici, G. et al. A T-cell antigen atlas for meningioma: novel options for immunotherapy. Acta Neuropathol 146, 173-190 (2023). https://doi.org:10.1007/s00401-023-02605-w
Marok, F. Z. et al. A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators. Pharmaceutics 15 (2023). https://doi.org:10.3390/pharmaceutics15020679
Manoochehri, M. et al. DNA methylation biomarkers for noninvasive detection of triple-negative breast cancer using liquid biopsy. Int J Cancer 152, 1025-1035 (2023). https://doi.org:10.1002/ijc.34337
Mannheim, J. G., Rausch, I., Conti, M., la Fougere, C. & Schmidt, F. P. Characterization of the partial volume effect along the axial field-of-view of the Biograph Vision Quadra total-body PET/CT system for multiple isotopes. EJNMMI Phys 10, 33 (2023). https://doi.org:10.1186/s40658-023-00554-7
Maltarollo, V. G. et al. Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors. Future Med Chem 15, 959-985 (2023). https://doi.org:10.4155/fmc-2023-0034
Maksymenko, K. et al. The design of functional proteins using tensorized energy calculations. Cell Rep Methods 3, 100560 (2023). https://doi.org:10.1016/j.crmeth.2023.100560
Maia, A., Schollhorn, A., Schuhmacher, J. & Gouttefangeas, C. CAF-immune cell crosstalk and its impact in immunotherapy. Semin Immunopathol 45, 203-214 (2023). https://doi.org:10.1007/s00281-022-00977-x
Maia, A. et al. Chitin oligomers promote lymphoid innate and adaptive immune cell activation. J Leukoc Biol 114, 180-186 (2023). https://doi.org:10.1093/jleuko/qiad044
Lutz, M. S. et al. IgG-based B7-H3xCD3 bispecific antibody for treatment of pancreatic, hepatic and gastric cancer. Front Immunol 14, 1163136 (2023). https://doi.org:10.3389/fimmu.2023.1163136
Lumish, M. et al. Precision Management of a Patient With Dihydropyrimidine Dehydrogenase Deficiency and Liver-Predominant Metastatic Rectal Cancer Using Hepatic Arterial Floxuridine. JCO Precis Oncol 7, e2200442 (2023). https://doi.org:10.1200/PO.22.00442
Lu, C. E. et al. Monitoring the macrophage response towards biomaterial implants using label-free imaging. Mater Today Bio 21, 100696 (2023). https://doi.org:10.1016/j.mtbio.2023.100696
Loer, H. L. H. et al. Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT Pharmacometrics Syst Pharmacol 12, 724-738 (2023). https://doi.org:10.1002/psp4.12946
Linder, P. M. et al. Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner. Diagnostics (Basel) 13 (2023). https://doi.org:10.3390/diagnostics13223418
Lim, K. H. J., Westphalen, C. B., Mateo, J., Lambertini, M. & Amaral, T. Response to the letter entitled 'On finding acceptance'. ESMO Open 8, 102059 (2023). https://doi.org:10.1016/j.esmoop.2023.102059
Lim, K. H. J. et al. Young oncologists' perspective on the role and future of the clinician-scientist in oncology. ESMO Open 8, 101625 (2023). https://doi.org:10.1016/j.esmoop.2023.101625
Lichtensteiger, C. et al. Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients. J Autoimmun 140, 103118 (2023). https://doi.org:10.1016/j.jaut.2023.103118
Liang, C. et al. How [18F]-FDG-PET/CT Affects Clinical Management of Patients with Germ Cell Tumors in the Real World. Cancers (Basel) 15 (2023). https://doi.org:10.3390/cancers15143652
Li, C., Dubbelaar, M. L., Zhang, X. & Zheng, J. C. Editorial: Understanding the heterogeneity and spatial brain environment of neurodegenerative diseases through conventional and future methods. Front Cell Neurosci 17, 1211273 (2023). https://doi.o

2024

Zwirner, S. et al. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure. Cell 187, 1666-1684 e1626 (2024). https://doi.org:10.1016/j.cell.2024.02.023
Zimmermann, V., Frauenfeld, L., Loffler, M. W., Mihaljevic, A. L. & Yurttas, C. Long-term recurrence-free survival following pancreatic surgery with HIPEC treatment for locally advanced pancreatic adenocarcinoma. BMJ Case Rep 17 (2024). https://doi.org:10.1136/bcr-2023-258626
Zekri, L. et al. Immunocytokines with target cell-restricted IL-15 activity for treatment of B cell malignancies. Sci Transl Med 16, eadh1988 (2024). https://doi.org:10.1126/scitranslmed.adh1988
Yurttas, C. et al. Efficacy of Different Oncolytic Vaccinia Virus Strains for the Treatment of Murine Peritoneal Mesothelioma. Cancers (Basel) 16 (2024). https://doi.org:10.3390/cancers16020368
Yiangou, K. et al. Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction. medRxiv (2024). https://doi.org:10.1101/2024.02.12.24302043
Yi, F. et al. CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit. bioRxiv (2024). https://doi.org:10.1101/2024.02.26.582108
Yang, Q. et al. Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake. Clin Transl Med 14, e1550 (2024). https://doi.org:10.1002/ctm2.1550
Yang, A. Y., Wistuba-Hamprecht, K., Greten, T. F. & Ruf, B. Innate-like T cells in liver disease. Trends Immunol (2024). https://doi.org:10.1016/j.it.2024.05.008
Wyss, N. et al. Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade. Am J Respir Crit Care Med (2024). https://doi.org:10.1164/rccm.202311-2136OC
Wittlinger, F. et al. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem 7, 38 (2024). https://doi.org:10.1038/s42004-024-01108-3
Weissinger, M. et al. Additional Value of FDG-PET/MRI Complementary to Sentinel Lymphonodectomy for Minimal Invasive Lymph Node Staging in Patients with Endometrial Cancer: A Prospective Study. Diagnostics (Basel) 14 (2024). https://doi.org:10.3390/diagnostics14040376
Weber, A. N. R., Tortola, M. M. & Kuemmerle-Deschner, J. B. Cracking the NLRP3 code: Pioneering precision medicine for inflammation. J Exp Med 221 (2024). https://doi.org:10.1084/jem.20240221
Webb, E. W. et al. Development of High-Throughput Experimentation Approaches for Rapid Radiochemical Exploration. J Am Chem Soc 146, 10581-10590 (2024). https://doi.org:10.1021/jacs.3c14822
Wang, J. Z. et al. Meningioma: International Consortium on Meningiomas (ICOM) consensus review on scientific advances & treatment paradigms for clinicians, researchers, and patients. Neuro Oncol (2024). https://doi.org:10.1093/neuonc/noae082
Walter, B. et al. Functionally-instructed modifiers of response to ATR inhibition in experimental glioma. J Exp Clin Cancer Res 43, 77 (2024). https://doi.org:10.1186/s13046-024-02995-z
Vogel, J. et al. How [(18)F]FDG-PET/CT Affects the Management of Patients with Differentiated Thyroid Carcinoma in Clinical Routines. Cancers (Basel) 16 (2024). https://doi.org:10.3390/cancers16030588
Tremmel, R., Hofmann, U., Haag, M., Schaeffeler, E. & Schwab, M. Circulating Biomarkers Instead of Genotyping to Establish Metabolizer Phenotypes. Annu Rev Pharmacol Toxicol 64, 65-87 (2024). https://doi.org:10.1146/annurev-pharmtox-032023-121106
Trautwein, N. F. et al. A novel approach to guide GD2-targeted therapy in pediatric tumors by PET and [(64)Cu]Cu-NOTA-ch14.18/CHO. Theranostics 14, 1212-1223 (2024). https://doi.org:10.7150/thno.92481
Trautwein, N. F. et al. Radiosensitizing Favors Response to Peptide Receptor Radionuclide Therapy in Patients With Highly Proliferative Neuroendocrine Malignancies: Preliminary Evidence From a Clinical Pilot Study. Clin Nucl Med 49, 207-214 (2024). https://doi.org:10.1097/RLU.0000000000005006
Tandler, C. et al. Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults. Int J Infect Dis 139, 69-77 (2024). https://doi.org:10.1016/j.ijid.2023.11.009
Stuhler, V. et al. Analysis of the immunological markers BTLA, TIM-3, and PD-L1 at the invasion front and tumor center in clear cell renal cell carcinoma. World J Urol 42, 53 (2024). https://doi.org:10.1007/s00345-023-04721-4
Steigerwald, H. et al. Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice. Carbohydr Polym 334, 122007 (2024). https://doi.org:10.1016/j.carbpol.2024.122007
Stefanczyk, S. A. et al. Induction of NK cell reactivity against acute myeloid leukemia by Fc-optimized CD276 (B7-H3) antibody. Blood Cancer J 14, 67 (2024). https://doi.org:10.1038/s41408-024-01050-6
Sonanini, D. et al. CD19-immunoPET for noninvasive visualization of CD19 expression in B-cell lymphoma patients. Biomark Res 12, 50 (2024). https://doi.org:10.1186/s40364-024-00595-9
Sleeboom, J. J. F. et al. The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets. Sci Transl Med 16, eadg3840 (2024). https://doi.org:10.1126/scitranslmed.adg3840
Singvogel, K. & Schittek, B. Dormancy of cutaneous melanoma. Cancer Cell Int 24, 88 (2024). https://doi.org:10.1186/s12935-024-03278-5
Serafim, R. A. M., Gehringer, M. & Borsari, C. Targeted Covalent Inhibitors in Drug Discovery, Chemical Biology and Beyond. Pharmaceuticals (Basel) 17 (2024). https://doi.org:10.3390/ph17020206
Seller, A. et al. Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome. Int J Mol Sci 25 (2024). https://doi.org:10.3390/ijms25074126
Schwarz, M. et al. Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S(N)Ar Electrophiles. J Med Chem 67, 6549-6569 (2024). https://doi.org:10.1021/acs.jmedchem.3c02483
Schmidt, F. P. et al. Evaluation of the MRI compatibility of PET detectors modules for organ-specific inserts in a 3T and 7T MRI scanner. Med Phys 51, 991-1006 (2024). https://doi.org:10.1002/mp.16923
Scheurer, J. et al. Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis. Dis Model Mech 17 (2024). https://doi.org:10.1242/dmm.050541
Scheuermann, S. et al. Unveiling spatial complexity in solid tumor immune microenvironments through multiplexed imaging. Front Immunol 15, 1383932 (2024). https://doi.org:10.3389/fimmu.2024.1383932
Ruf, T. et al. Second-line therapies for steroid-refractory immune-related adverse events in patients treated with immune checkpoint inhibitors. Eur J Cancer 203, 114028 (2024). https://doi.org:10.1016/j.ejca.2024.114028
Riester, O., Kaiser, L., Laufer, S. & Deigner, H. P. Rapid Phenotypic Antibiotics Susceptibility Analysis by a 3D Printed Prototype. Adv Sci (Weinh), e2308806 (2024). https://doi.org:10.1002/advs.202308806
Reinert, C. P. et al. Preoperative Assessment of Medication-Related Osteonecrosis of the Jaw Using [18F]fluoride Positron Emission Tomography (PET)/CT and [18F]fluorodeoxyglucose PET/MRI in Correlation with Histomorphometry and Micro-CT-A Prospective Comparative Study. Diagnostics (Basel) 14 (2024). https://doi.org:10.3390/diagnostics14040428
Rein, A. F. et al. Identification of novel canonical and cryptic HCMV-specific T-cell epitopes for HLA-A *03 and HLA-B *15 via peptide-PRISM. Blood Adv 8, 712-724 (2024). https://doi.org:10.1182/bloodadvances.2023011120
Poxleitner, M. et al. Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis. J Neuroinflammation 21, 129 (2024). https://doi.org:10.1186/s12974-024-03080-0
Perelo, L. W., Gabernet, G., Straub, D. & Nahnsen, S. How tool combinations in different pipeline versions affect the outcome in RNA-seq analysis. NAR Genom Bioinform 6, lqae020 (2024). https://doi.org:10.1093/nargab/lqae020
Peisen, F. et al. Pre-treatment 18F-FDG-PET/CT parameters as biomarkers for progression free survival, best overall response and overall survival in metastatic melanoma patients undergoing first-line immunotherapy. PLoS One 19, e0296253 (2024). https://doi.org:10.1371/journal.pone.0296253
Paranawithana, N. N. et al. Enhancing r(1) Relaxivity in GdDOTA-Monoamide Complexes through Polar Group-Mediated Ordering of Second-Sphere Water Molecules. Inorg Chem 63, 4072-4077 (2024). https://doi.org:10.1021/acs.inorgchem.3c03639
Moraes Ribeiro, E. et al. PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity. J Immunother Cancer 12 (2024). https://doi.org:10.1136/jitc-2023-007829
Merk, D. J. et al. CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines. Genome Med 16, 82 (2024). https://doi.org:10.1186/s13073-024-01341-4
Meraz-Torres, F. et al. Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy. J Exp Clin Cancer Res 43, 30 (2024). https://doi.org:10.1186/s13046-023-02941-5
Menzel, F., Cotton, J., Ziegler, T., Maurer, A. & Neumaier, J. M. Open-source flow setup for rapid and efficient [(18) F]fluoride drying for automation of PET tracer syntheses. J Labelled Comp Radiopharm 67, 40-58 (2024). https://doi.org:10.1002/jlcr.4080
Meng, J. H. et al. Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS. iScience 27, 109469 (2024). https://doi.org:10.1016/j.isci.2024.109469
Mc Laughlin, A. M. et al. Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort. Clin Pharmacol Ther (2024). https://doi.org:10.1002/cpt.3238
Marok, F. Z. et al. Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically-Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy. Clin Pharmacol Ther 115, 1282-1292 (2024). https://doi.org:10.1002/cpt.3181
Mannheim, J. G. et al. Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls. Neuroimage Clin 42, 103600 (2024). https://doi.org:10.1016/j.nicl.2024.103600
Mannheim, J. G. et al. Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls. Neuroimage Clin 42, 103600 (2024). https://doi.org:10.1016/j.nicl.2024.103600
Maier, C. P. et al. Influence of ATLG serum levels on CD3/CD19-depleted hematopoietic grafts and on immune recovery in pediatric haplo-HSCT. Blood Adv 8, 2160-2171 (2024). https://doi.org:10.1182/bloodadvances.2023011016
Lutz, M. S., Wang, K., Jung, G., Salih, H. R. & Hagelstein, I. An Fc-modified monoclonal antibody as novel treatment option for pancreatic cancer. Front Immunol 15, 1343929 (2024). https://doi.org:10.3389/fimmu.2024.1343929
Loer, H. L. H. et al. Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT Pharmacometrics Syst Pharmacol (2024). https://doi.org:10.1002/psp4.13127
Locatelli, F. et al. Exagamglogene Autotemcel for Transfusion-Dependent beta-Thalassemia. N Engl J Med 390, 1663-1676 (2024). https://doi.org:10.1056/NEJMoa2309673
Leibold, J. et al. Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease. Nat Cancer 5, 315-329 (2024). https://doi.org:10.1038/s43018-023-00686-w
Le Teuff, G. et al. Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis. Br J Cancer 130, 808-818 (2024). https://doi.org:10.1038/s41416-023-02517-2
Lan, W., Sari, H., Rominger, A., Fougere, C. & Schmidt, F. P. Optimization and impact of sensitivity mode on abbreviated scan protocols with population-based input function for parametric imaging of [(18)F]-FDG for a long axial FOV PET scanner. Eur J Nucl Med Mol Imaging (2024). https://doi.org:10.1007/s00259-024-06745-3
Kuntner, C. et al. Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization. Mol Imaging Biol (2024). https://doi.org:10.1007/s11307-024-01927-9
Kovar, C. et al. A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT Pharmacometrics Syst Pharmacol (2024). https://doi.org:10.1002/psp4.13146
Kohler, D. et al. Targeting Galpha(i2) in neutrophils protects from myocardial ischemia reperfusion injury. Basic Res Cardiol (2024). https://doi.org:10.1007/s00395-024-01057-x
Knopf, P. et al. Metabolic fingerprinting by nuclear magnetic resonance of hepatocellular carcinoma cells during p53 reactivation-induced senescence. NMR Biomed, e5157 (2024). https://doi.org:10.1002/nbm.5157
Jung, S. et al. Protocol of a first-in-human clinical trial to evaluate the safety, tolerability, and preliminary efficacy of the bispecific CD276xCD3 antibody CC-3 in patients with colorectal cancer (CoRe_CC-3). Front Oncol 14, 1351901 (2024). https://doi.org:10.3389/fonc.2024.1351901
Jin, C. et al. The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage. Nucleic Acids Res 52, 3011-3030 (2024). https://doi.org:10.1093/nar/gkae004
Jansen, R. A. et al. Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers. Proc Natl Acad Sci U S A 121, e2319492121 (2024). https://doi.org:10.1073/pnas.2319492121
Hoyt, K. W. et al. Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors. J Med Chem 67, 2-16 (2024). https://doi.org:10.1021/acs.jmedchem.3c01502
Holzmayer, S. J., Liebel, K., Hagelstein, I., Salih, H. R. & Marklin, M. The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas. Front Immunol 15, 1391954 (2024). https://doi.org:10.3389/fimmu.2024.1391954
Holzmayer, S. J., Kauer, J., Mauermann, J., Roider, T. & Marklin, M. Asciminib Maintains Antibody-Dependent Cellular Cytotoxicity against Leukemic Blasts. Cancers (Basel) 16 (2024). https://doi.org:10.3390/cancers16071288
Hillebrand, L., Liang, X. J., Serafim, R. A. M. & Gehringer, M. Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update. J Med Chem 67, 7668-7758 (2024). https://doi.org:10.1021/acs.jmedchem.3c01825
Herold, N. et al. High-dimensional in situ proteomics imaging to assess gammadelta T cells in spatial biology. J Leukoc Biol 115, 750-759 (2024). https://doi.org:10.1093/jleuko/qiad167
Hering, A. et al. Improving assessment of lesions in longitudinal CT scans: a bi-institutional reader study on an AI-assisted registration and volumetric segmentation workflow. Int J Comput Assist Radiol Surg (2024). https://doi.org:10.1007/s11548-024-03181-4
Hartmann, T. et al. Basic principles of artificial intelligence in dermatology explained using melanoma. J Dtsch Dermatol Ges 22, 339-347 (2024). https://doi.org:10.1111/ddg.15322
Hartmann, T. et al. [Not Available]. J Dtsch Dermatol Ges 22, 339-349 (2024). https://doi.org:10.1111/ddg.15322_g
Hanssen, F. et al. Scalable and efficient DNA sequencing analysis on different compute infrastructures aiding variant discovery. NAR Genom Bioinform 6, lqae031 (2024). https://doi.org:10.1093/nargab/lqae031
Hamza, H., Ghosh, M., Loffler, M. W., Rammensee, H. G. & Planz, O. Identification and relative abundance of naturally presented and cross-reactive influenza A virus MHC class I-restricted T cell epitopes. Emerg Microbes Infect 13, 2306959 (2024). https://doi.org:10.1080/22221751.2024.2306959
Hackenbruch, C. et al. FusionVAC22_01: a phase I clinical trial evaluating a DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocellular carcinoma and other tumor entities carrying the oncogenic driver fusion. Front Oncol 14, 1367450 (2024). https://doi.org:10.3389/fonc.2024.1367450
Ghasemi, A. et al. Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy. Nat Cancer 5, 240-261 (2024). https://doi.org:10.1038/s43018-023-00668-y
Ghallab, A. et al. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. J Hepatol 80, 268-281 (2024). https://doi.org:10.1016/j.jhep.2023.10.035
Gauvrit, S., Zhao, S., Rothbauer, U. & Stainier, D. Y. R. A beta-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo. Development 151 (2024). https://doi.org:10.1242/dev.202122
Gallage, S. et al. A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARalpha and PCK1. Cell Metab (2024). https://doi.org:10.1016/j.cmet.2024.04.015
Frohlich, L. M., Villar-Miyar, A., Heintze, T., Sauer, B. & Schittek, B. PARP1 expression predicts PARP inhibitor sensitivity and correlates with metastatic potential and overall survival in melanoma. Int J Cancer 155, 203-210 (2024). https://doi.org:10.1002/ijc.34947
Froehlich, T. et al. Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1. Life Sci Alliance 7 (2024). https://doi.org:10.26508/lsa.202402608
Fortuna, A. & Amaral, T. Multidisciplinary approach and treatment of acral and mucosal melanoma. Front Oncol 14, 1340408 (2024). https://doi.org:10.3389/fonc.2024.1340408
Fend, F., van den Brand, M., Groenen, P. J., Quintanilla-Martinez, L. & Bagg, A. Diagnostic and prognostic molecular pathology of lymphoid malignancies. Virchows Arch 484, 195-214 (2024). https://doi.org:10.1007/s00428-023-03644-0
El-Ayoubi, A. et al. Development of an optimized, non-stem cell line for intranasal delivery of therapeutic cargo to the central nervous system. Mol Oncol 18, 528-546 (2024). https://doi.org:10.1002/1878-0261.13569
Eichholz, T. et al. Targeted therapies in retinoblastoma: GD2-directed immunotherapy following autologous stem cell transplantation and evaluation of alternative target B7-H3. Cancer Immunol Immunother 73, 19 (2024). https://doi.org:10.1007/s00262-023-03587-0
Duran, I. et al. Detection of senescence using machine learning algorithms based on nuclear features. Nat Commun 15, 1041 (2024). https://doi.org:10.1038/s41467-024-45421-w
Dorner, L. et al. App-based assessment of patient-reported outcomes in the Molecular Tumor Board in the Center for Personalized Medicine-(TRACE). Neurooncol Pract 11, 336-346 (2024). https://doi.org:10.1093/nop/npae002
Cheng, K. et al. Photo- and Cu-Mediated (11)C Cyanation of (Hetero)Aryl Thianthrenium Salts. Org Lett 26, 3419-3423 (2024). https://doi.org:10.1021/acs.orglett.4c00929
Chen, X. et al. Cytokines-activated nuclear IKKalpha-FAT10 pathway induces breast cancer tamoxifen-resistance. Sci China Life Sci (2024). https://doi.org:10.1007/s11427-023-2460-0
Buniatian, G. H. et al. Consequences of Amyloid-beta Deficiency for the Liver. Adv Sci (Weinh) 11, e2307734 (2024). https://doi.org:10.1002/advs.202

Krebsforschung made in Tübingen
Exzellenzcluster iFIT

Publikationen

2019

Publikationen aus dem Jahr 2019

2020

Publikationen aus dem Jahr 2020

2021

Publikationen aus dem Jahr 2021

2022

Publikationen aus dem Jahr 2022

2023

Publikationen aus dem Jahr 2023

2024

Publikationen aus dem Jahr 2024

Krebsforschung made in Tübingen Exzellenzcluster iFIT

Publikationen

2019

Publikationen aus dem Jahr 2019

2020

Publikationen aus dem Jahr 2020

2021

Publikationen aus dem Jahr 2021

2022

Publikationen aus dem Jahr 2022

2023

Publikationen aus dem Jahr 2023

2024

Publikationen aus dem Jahr 2024

Krebsforschung made in Tübingen
Exzellenzcluster iFIT