Der Vorstand des Clusters besteht aus drei Sprechern, der Geschäftsführerin und der Beauftragtin für Chancengleichheit und Nachwuchsförderung.
Vorstand


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Prof. Dr. Lars Zender
Ärztlicher Direktor der Klinik für Medizinische Onkologie & Pneumologie
Sprecher des iFIT Exzellenzclusters
Lebenslauf
Publikationen
Auswahl von iFIT-bezogenen Publikationen mit dem höchsten Impact Factor.
- Wolter, K., Zender, L. Therapy-induced senescence — an induced synthetic lethality in liver cancer?. Nat Rev Gastroenterol Hepatol 17, 135–136 (2020). https://doi.org/10.1038/s41575-020-0262-3
- Li, X., Ramadori, P., Pfister, D. et al. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer 21, 541–557 (2021). https://doi.org/10.1038/s41568-021-00383-9
- Pfister, D., Núñez, N.G., Pinyol, R. et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature 592, 450–456 (2021). https://doi.org/10.1038/s41586-021-03362-0
- Reautschnig, P., Wahn, N., Wettengel, J. et al. CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo. Nat Biotechnol 40, 759–768 (2022). https://doi.org/10.1038/s41587-021-01105-0
- Schwabe, R., Affo, S., Nair, A. et al. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell 39, 866-882 (2021). https://doi.org/10.1016/j.ccell.2021.03.012
- Bresnahan E, Ramadori P, Heikenwalder M, Zender L, Lujambio A. Novel patient-derived preclinical models of liver cancer. J Hepatol. 2020 Feb;72(2):239-249. 10.1016/j.jhep.2019.09.028.
- Zender, L., Artista, L., Moschopoulou, A. et al. MYC determines lineage commitment in kras driven primary liver cancer development. J Hepatol. 2023 Mar 9;S0168-8278(23). 10.1016/j.jhep.2023.02.039
- Rudalska, R., Harbig, J., Snaebjornsson, M.T. et al. LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer. Nat Cancer 2, 201–217 (2021). https://doi.org/10.1038/s43018-020-00168-3
- Brenner, E., Schörg, B.F., Ahmetlić, F. et al. Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun 11, 1335 (2020). https://doi.org/10.1038/s41467-020-14987-6
- Hinterleitner, C., Strähle, J., Malenke, E. et al. Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nat Commun 12, 7005 (2021). https://doi.org/10.1038/s41467-021-27303-7
Preise & Auszeichnungen
- 2011Johann-Georg-Zimmermann-Preis
- 2013Württembergischer Krebspreis
- 2013Deutscher Krebspreis
- 2014Gottfried Wilhelm Leibniz-Preis
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Prof. Dr. Bernd Pichler
Direktor der Abteilung für Präklinische Bildgebung und Radiopharmazie
Sprecher des iFIT Exzellenzclusters
Lebenslauf
Publikationen
Auswahl von iFIT-bezogenen Publikationen mit dem höchsten Impact Factor.
- Feil S, Stowbur D, Schörg BF, Ehrlichmann W, Reischl G, Kneilling M, Pichler BJ, Feil R. Noninvasive Detection of Smooth Muscle Cell-Derived Hot Spots to Study Atherosclerosis by PET/MRI in Mice. Circ Res. 2023 Mar 17;132(6):747-750. 10.1161/CIRCRESAHA.122.322296.
- Rudalska, R., Harbig, J., Snaebjornsson, M.T. et al. LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer. Nat Cancer 2, 201–217 (2021). https://doi.org/10.1038/s43018-020-00168-3.
- Brenner, E., Schörg, B.F., Ahmetlić, F. et al. Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun 11, 1335 (2020). https://doi.org/10.1038/s41467-020-14987-6
- Nording, H., Baron, L., Haberthür, D. et al. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun 12, 3352 (2021). https://doi.org/10.1038/s41467-021-23499-w
- Zekri, L., Vogt, F., Jung, G. et al. An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer. EMBO Mol Med. 2021, Feb 5;13(2):e11902. 10.15252/emmm.201911902.
- Montes-Mojarro, IA., Steinhilber, J., Griessinger, C.M. et al. CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL. Leukemia 36, 2050–2063 (2022). https://doi.org/10.1038/s41375-022-01617-x
- Marciano S, Ionescu TM, Saw RS, Cheong RY, Kirik D, Maurer A, Pichler BJ, Herfert K. Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2122552119. 10.1073/pnas.2122552119.
- Rammensee, HG., Wiesmüller, KH., Chandran, P.A. et al. A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer. j. immunotherapy cancer 7, 307 (2019). https://doi.org/10.1186/s40425-019-0796-5.
- Hoffmann, S., Reck, D., Griessinger, C. et al. Visualization and quantification of in vivo homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer. Theranostics. 2019 Aug 12;9(20): 5869-5885. 10.7150/thno.33275.
- Schwenk, J., Schörg, B., Kneilling, M. et al. Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo (18)F-FDG-PET. Theranostics. 2020 Jan 1;10(2):925-937. 10.7150/thno.35989
Preise & Auszeichnungen
- 2017Aufnahme in die Akademie der Wissenschaft Leopoldina
- 2021Georg von Hevesy Medaille der Deutschen Gesellschaft für Nuklearmedizin
- 2023WMIS Medaille in Gold
- 2023Ehrenmitglied der Europäischen Gesellschaft für Molekulare Bildgebung 2023


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Prof. Dr. Juliane Walz
iFIT Sprecherin
Beauftragte für Chancengleichheit und Nachwuchsarbeit
Lebenslauf
Publikationen
Auswahl von iFIT-bezogenen Publikationen mit dem höchsten Impact Factor.
- Nelde, A., Bilich, T., Heitmann, J.S. et al. SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition. Nat Immunol 22, 74–85 (2021). https://doi.org/10.1038/s41590-020-00808-x
- Bilich T, Roerden M, Maringer Y et al. Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer. Cancer Discov. 2021 Aug;11(8):1982-1995. (2021). 10.1158/2159-8290.CD-21-0191
- Heitmann, J.S., Bilich, T., Tandler, C. et al. A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity. Nature 601, 617–622 (2022). https://doi.org/10.1038/s41586-021-04232-5
- Bauer, J., Köhler, N., Maringer, Y. et al. The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma. Nat Commun 13, 6401 (2022). https://doi.org/10.1038/s41467-022-33746-3
- Maringer Y, Nelde A, Schroeder SM. et al. Durable spike-specific T-cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination. Science Immunol. 2022 Nov 1:eadd3899 (2022). 10.1126/sciimmunol.add3899
- Naghavian R, Faigle W, Oldrati P. et al. Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma. Nature. 2023 May 17 (2023). doi: 10.1038/s41586-023-06081-w
- Heitmann JS, Tandler C, Marconato M et al. Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency. Nat Commun. 2023 Aug 18;14(1):5032 (2023). doi: 10.1038/s41467-023-40758-0
- Goyal A, Bauer J, Hey J, Papageorgiou DN et al. DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts. Nat Commun. 2023 Oct 23;14(1):6731 (2023). doi: 10.1038/s41467-023-42417-w.
- Nelde A, Schuster H, Heitmann JS et al. Immune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells. . Blood Cancer Dis. 2023 Nov 1;4(6):468-489. doi: 10.1158/2643-3230.BCD-23-0020.
- Hoenisch Gravel N, Nelde A, Bauer J et al. TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification. Nat Commun. 2023 Nov 17;14(1):7472. doi: 10.1038/s41467-023-42692-7.
Preise & Auszeichnungen
- 2015Württembergischer Krebspreis
- 2021Best Abstract Award der Deutschen Gesellschaft für Hämatologie und Onkologie
- 2022International Immunocompromised Host Society Takeda Virology Award
- 2022Best Abstract Award der Deutschen Gesellschaft für Hämatologie und Onkologie
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Dr. Ellen Brenner
Geschäftsführerin
iFIT Exzellenzcluster
07071 29-86219

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Prof. Dr. Bettina Weigelin
Professorin für Preclinical Imaging of the Immune System
iFIT Beauftragte für Chancengleichheit und Nachwuchsarbeit
Lebenslauf
Publikationen
Auswahl von iFIT-bezogenen Publikationen mit dem höchsten Impact Factor.
- Weigelin, B., den Boer, A., Wagena, E. et al. Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity. Nat Comm. Sep 1;12(1):5217 (2021). https://doi.org/10.1038/s41467-021-25282-3
- Hinterleitner, C., Strähle, J., Malenke, E. et al. Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nat Commun 12, 7005 (2021). https://doi.org/10.1038/s41467-021-27303-7
- Slaats, J., Dieterin, C., Wagena, E. et al. Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery. Cancer Immunol Res. Aug;9(8):926-938. (2021). 10.1158/2326-6066.CIR-20-0741
- Slaats, J., Wagena, E., Smits, D. et al. Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors. Cancer Immunol Res. Dec 2;10(12):1462-1474. (2022). 10.1158/2326-6066.CIR-22-0113
- Köhler, D., Leiss, V., Beichert, L. et al. Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury. Basic Res Cardiol. May 30. (2024). 10.1007/s00395-024-01057-x
- Bowden, G., Stotz, S., Dunkel, G. et al. [18F] p FBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain. Bioconjug Chem. Feb 21;35(2):254-264. (2024). 10.1021/acs.bioconjchem.3c00551
- Scheurer, J., Sauer, B., Focken, J. et al. Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis (2024). 10.1242/dmm.050541
Preise & Auszeichnungen
- 2017NITA, Young Investigator Award, Society for Thermal Medicine
- 2017Best Talk Young Investigator Workshop, MD Anderson Cancer Center
- 2017Nomination ‘VIVA 400’, Women in Science
- 2020Best Talk, Imaging the Tumor Microenvironment, EMIM