Obesity and metabolic diseases, such as diabetes, pose significant health burdens in both modern and developing societies. The development of obesity is influenced by various factors that disrupt the regulation of energy balance in the human body. While nutrient absorption is a crucial aspect of energy balance, our understanding of how we regulate the absorption of nutrients we consume remains limited. The group led by Prof. Dr. Reiner Jumpertz-von Schwartzenberg investigates the underlying mechanisms that contribute to metabolic diseases, with a specific focus on the interplay between the gut microbiome and host metabolism. Their research is centered around understanding the intricate processes involved in nutrient absorption and how the gut microbiota influences these processes, aiming to shed light on the development of metabolic diseases. By exploring the intersection of nutrient absorption, gut microbiota, and host metabolism, this group strives to uncover new insights into the prevention, treatment and remission of obesity and related metabolic disorders such as prediabetes and overt type 2 diabetes.
Mechanisms that contribute to metabolic diseases
Prof. Dr. Reiner Jumpertz-von Schwartzenberg has been appointed as Full Professor for Clinical Metabolism and Obesity Research at the Medical Faculty of the University of Tübingen in conjunction with the Helmholtz Center Munich since May 2022. He studied medicine in Bochum and Leipzig where he obtained his doctorate in 2012. Between 2011 and 2021 he has completed his clinical training at the Charité in Berlin and became a board-certified internist, endocrinologist and diabetologist. He became member of the first clinician scientist program in Germany focussing on the interaction of diets, metabolism and the gut microbiome. During his stays abroad as a visiting scientist at the National Institute of Health (NIH) in the USA and the University of California/San Francisco, Prof. Dr. Reiner Jumpertz-von Schwartzenberg gained a deep understanding in clinical trial design in human metabolism research and basic translational microbiome science. Since 2021, Prof. Dr. Jumpertz-von Schwartzenberg serves as a senior physician for the Department of Diabetology, Endocrinology, and Nephrology, and is the head of the clinical study center at the Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University Hospital Tübingen. Additionally, he leads a Helmholtz Young Investigator Group and is a Junior Research Group leader in the Cluster of Excellence Controlling Microbes to Fight Infections (CMFI) in Tübingen. His research focuses on understanding the mechanisms underlying the development, treatment and remission of metabolic diseases, with a specific emphasis on exploring the interactions between the gut microbiome and host metabolism.
- Sbierski-Kind J, Grenkowitz S, Schlickeiser S, Sandforth A, Friedrich M, Kunkel D, Glauben R, Brachs S, Mai K , Thürmer A , Radoni A, Drechsel O, Turnbaugh PJ, Bisanz JE, Volk H-D , Spranger J , Jumpertz von Schwartzenberg R. Microbiome 2022 Apr 4;10(1):57.
- Jumpertz von Schwartzenberg R, Bisanz JE , Lyalina S, Spanogiannopoulos P , Ang QY , Cai J , Dickmann S, Friedrich M, Liu S-Y, Collins SL, Ingebrigtsen D, Miller S, Turnbaugh JA, Patterson AD, Pollard KS , Mai K, Spranger J, Turnbaugh PJ. Caloric restriction disrupts the microbiota and colonization resistance. Nature 2021 Jul;595(7866):272-277.
- Basolo A, Hohenadel M, Ang QY, Piaggi P, Heinitz S, Walter M, Walter P, Parrington S, Trinidad D, von Schwartzenberg RJ, Turnbaugh PJ, Krakoff J. Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans. Nat Med 2020 Apr;26(4):589-598.
- Heinitz S, Piaggi P, Vinales K, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R. Specific Skeletal Muscle Sphingolipid Compounds in Energy Expenditure Regulation and Weight Gain in Native Americans of Southwestern Heritage. Int J Obes 2017 Oct;41(10):1585-1593.
- Prehn K, Jumpertz von Schwartzenberg R, Mai K, Zeitz U, Witte AV, Hampel D, Szela AM, Fabian S, Grittner U, Spranger J, Flöel A. Caloric Restriction in Older Adults-Differential Effects of Weight Loss and Reduced Weight on Brain Structure and Function. Cereb Cortex 2016 Mar 1;27(3):1765-1778.
- Jumpertz von Schwartzenberg R, Turnbaugh PJ. Siri, What Should I Eat? Cell 2015 Nov 19;163(5): 1051- 2.
- Jumpertz R, Venti CA, Le DS, Michaels J, Parrington S, Krakoff J, Votruba S. Food label accuracy of common snack foods. Obesity 2013 Jan;21(1):164-9.
- Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr 2011 Jul;94(1):58-65.
- Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG, Krakoff J. Higher energy expenditure in humans predicts natural mortality. J Clin Endocrinol Metab 2011 Jun;96(6):E972-6.
- Jumpertz R, Guijarro A, Pratley RE, Piomelli D, Krakoff J. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. J Clin Endocrinol Metab 2011 Mar;96(3):787-91.