Das Klinikum

Prof. Dr. Dr. Ayola Akim Adegnika

Prof. Dr. Dr. Ayola Akim Adegnika

Direktor CERMEL and Research group leader

Kontakt

Telefonnummer: Office phone: 07071 29-83449

Telefonnummer: mobile phone: 015226759133

E-Mail-Adresse: ayola-akim.degnika@uni-tuebingen.de

  • Epidemiology
  • Immunology
  • Clinical trials
  • Infectious diseases
  • Currently, I am a Principal Investigator (PI) of some phase I to phase III anti-infectious vaccines (against malaria, Tuberculosis) and drugs trials (malaria, Schistosomiasis, and Soil-transmitted Helminths); and of several studies on clinical, epidemiology, diagnostic and immunology of helminth, tuberculosis, bacteria and malaria with their co-infection in school children and pregnant women. I am leading and supervising the COVID-19 clinical and diagnostic testing and sequencing.
  • 2023Full Professor of Immunology, of of the Concours Africain et Malgache des Enseignements Supérieurs (CAMES)
  • 2016Full Professor of Immuno-Epidemiology clinical of Tropical Medicine University of Tübingen, DE
  • 2014Master of Science (MSc), Epidemiology, at LSHTM in London, UK
  • 2010Post graduate in Epidemiology at LSHTM in London, UK
  • 2008Doctorate degree, PhD in Sciences at the University of Tübingen, DE
  • 2002Doctorate degree, MD in Medicine at the University of Libreville, GA
  • Agnandji ST, Recker M, Mordmüller B, Glöckner S, Adegnika AA, Lell B, Otieno L, Otieno W, Owusu-Agyei S, Asante KP, Agbenyega T, Ansong D, Macete E, Aide P, Sorgho H, Tinto H, Mturi N, Lusingu JPA, Gesase S, Hoffman I, Masoud NS, Newton CR, Bojang K, Krause G, Kremsner PG. Prostration and the prognosis of death in African children with severe malaria. Int J Infect Dis. 2023 Sep;134:240-247. doi: 10.1016/j.ijid.2023.06.022. Epub 2023 Jul 5.PMID: 37414210
  • Inoue J, Weber D, Fernandes JF, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Grobusch MP, Mordmüller B, Held J HHV-6 infections in hospitalized young children of Gabon. Infection. 2023 Jul 27. doi: 10.1007/s15010-023-02077-w. Online ahead of print.PMID: 37501013
  • van Eijk AM, Stepniewska K, Hill J, Taylor SM, Rogerson SJ, Cottrell G, Chico RM, Gutman JR, Tinto H, Unger HW, Yanow SK, Meshnick SR, Ter Kuile FO, Mayor A; Subpatent Malaria in Pregnancy Group. Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis. Lancet Glob Health. 2023 Jul;11(7):e1061-e1074. doi: 10.1016/S2214-109X(23)00194-8. Epub 2023 Jun 2.PMID: 37276878
  • Wiethoff JP, Sandmann S, Theiler T, Nze Nkogue C, Akomo-Okoue EF, Varghese J, Kreidenweiss A, Mellmann A, Lell B, Adegnika AA, Held J, Schaumburg F. Pharyngeal Communities and Antimicrobial Resistance in Pangolins in Gabon. Microbiol Spectr. 2023 Jun 20:e0066423. doi: 10.1128/spectrum.00664-23. Online ahead of print.PMID: 37338382
  • Schnyder JL, Gobbi F, Schunk M, Lindner A, Salvador F, Duvignaud A, Arsuaga Vicente M, Dejon Agobé JC, Cattaneo P, Bertoli G, Rothe C, Wintel M, Pou D, Malvy D, Adegnika AA, De Jong HK, Grobusch MP. Can haematological changes constitute a surrogate diagnostic parameter to detect schistosomiasis in migrants and travellers? - A retrospective analysis. New Microbes New Infect. 2023 Apr 27;53:101136. doi: 10.1016/j.nmni.2023.101136. eCollection 2023 Jun.
  • Adegbite BR, Elegbede-Adegbite NOM, Edoa JR, Honkpehedji YJ, Zinsou JF, Dejon-Agobé JC, Adegnika AA, Grobusch MP. Clinical features, treatment outcomes and mortality risk of tuberculosis sepsis in HIV-negative patients: a systematic review and meta-analysis of case reports. Infection. 2023 Jun;51(3):609-621. doi: 10.1007/s15010-022-01950-4. Epub 2022 Nov 16.PMID: 36385404
  • Abdul JBPAA, Adegbite BR, Ndanga MED, Edoa JR, Mevyann RC, Mfoumbi GRAI, de Dieu TJ, Mahoumbou J, Biyogho CM, Jeyaraj S, Niemann S, Lell B, Kremsner PG, Alabi AS, Adegnika AA, Grobusch MP. Resistance patterns among drug-resistant tuberculosis patients and trends-over-time analysis of national surveillance data in Gabon, Central Africa. Infection. 2023 Jun; 51(3):697-704. doi: 10.1007/s15010-022-01941-5. Epub 2022 Oct 28.PMID: 36307576
  • Baina MT, Lissom A, Assioro Doulamo NV, Djontu JC, Umuhoza DM, Mbama-Ntabi JD, Diafouka-Kietela S, Mayela J, Missontsa G, Wondji C, Adegnika AA, Nguimbi E, Borrmann S, Ntoumi F. Comparative study of Plasmodium falciparum msp-1 and msp-2 Genetic Diversity in Isolates from Rural and Urban Areas in the South of Brazzaville, Republic of Congo. Pathogens. 2023 May 22;12(5):742. doi: 10.3390/pathogens12050742.PMID: 37242412
  • Ribado Meñe G, Dejon Agobé JC, Momo Besahà JC, Abaga Ondo Ndoho F, Abdulla S, Adegnika AA. Prevalence, intensity and associated risk factors of soil-transmitted helminth infections among individuals living in Bata district, Equatorial Guinea. PLoS Negl Trop Dis. 2023 May 17;17(5):e0011345. doi: 10.1371/journal.pntd.0011345. eCollection 2023 May.PMID: 37196007
  • Penfold S, Adegnika AA, Asogun D, Ayodeji O, Azuogu BN, Fischer WA 2nd, Garry RF, Grant DS, Happi C, N'Faly M, Olayinka A, Samuels R, Sibley J, Wohl DA, Accrombessi M, Adetifa I, Annibaldis G, Camacho A, Dan-Nwafor C, Deha ARE, DeMarco J, Duraffour S, Goba A, Grais R, Günther S, Honvou ÉJJP, Ihekweazu C, Jacobsen C, Kanneh L, Momoh M, Ndiaye A, Nsaibirni R, Okogbenin S, Ochu C, Ogbaini E, Logbo ÉPMA, Sandi JD, Schieffelin JS, Verstraeten T, Vielle NJ, Yadouleton A, Yovo EK; Enable Protocol authorship group. A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)-Study protocol. PLoS One. 2023 Mar 30;18(3):e0283643. doi:10.1371 /journal.pone. 0283643. eCollection 2023.PMID: 36996258
  • Krueger T, Ikegbunam M, Lissom A, Sandri TL, Ntabi JDM, Djontu JC, Baina MT, Lontchi RAL, Maloum M, Ella GZ, Agonhossou R, Akoton R, Djogbenou L, Borrmann S, Held J, Ntoumi F, Adegnika AA, Kremsner PG, Kreidenweiss A. Low Prevalence of Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions-A Multiregional Study in Central and West Africa. Pathogens. 2023 Mar 14;12(3):455. doi: 10.3390/pathogens12030455.
  • Meñe GR, Mpina MG, Lopelo A, Nyakarungu EL, Bijeri JR, Elo AME, Ondo FA, Garcia GA, Phiri WP, Ali AM, Agobé JCD, Adegnika AA, Abdulla SM. Effects of Age, Gender and Soil-Transmitted Helminth Infection on Prevalence of Plasmodium Infection among Population Living in Bata District, Equatorial Guinea. Trop Med Infect Dis. 2023 Feb 27;8(3):149. doi: 10.3390 /tropicalmed 8030149.
  • Manouana GP, Nguema-Moure PA, Tomazatos A, Maloum MN, Bock CT, Kremsner PG, Velavan TP, Adegnika AA, Niendorf S. RT-PCR-based assessment of the SD Bioline Rota/Adeno Antigen-based test in infants with and without diarrhea. Virol J. 2023 Mar 3;20(1):40. doi: 10.1186/s12985-023-01999-z.
  • Babu Rajendran N, Arieti F, Mena-Benítez CA, Galia L, Tebon M, Alvarez J, Gladstone BP, Collineau L, De Angelis G, Duro R, Gaze W, Göpel S, Kanj SS, Käsbohrer A, Limmathurotsakul D, Lopez de Abechuco E, Mazzolini E, Mutters NT, Pezzani MD, Presterl E, Renk H, Rodríguez-Baño J, Săndulescu O, Scali F, Skov R, Velavan TP, Vuong C, Tacconelli E; EPI Net One Health consensus working group -. EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach. Lancet Reg Health Eur. 2022 Dec 22;26:100563. doi: 10.1016/j.lanepe.2022.100563. eCollection 2023 Mar.PMID: 36895445
  • Badr HS, Colston JM, Nguyen NH, Chen YT, Burnett E, Ali SA, Rayamajhi A, Satter SM, Van Trang N, Eibach D, Krumkamp R, May J, Adegnika AA, Manouana GP, Kremsner PG, Chilengi R, Hatyoka L, Debes AK, Ateudjieu J, Faruque ASG, Hossain MJ, Kanungo S, Kotloff KL, Mandomando I, Nisar MI, Omore R, Sow SO, Zaidi AKM, Lambrecht N, Adu B, Page N, Platts-Mills JA, Mavacala Freitas C, Pelkonen T, Ashorn P, Maleta K, Ahmed T, Bessong P, Bhutta ZA, Mason C, Mduma E, Olortegui MP, Peñataro Yori P, Lima AAM, Kang G, Humphrey J, Ntozini R, Prendergast AJ, Okada K, Wongboot W, Langeland N, Moyo SJ, Gaensbauer J, Melgar M, Freeman M, Chard AN, Thongpaseuth V, Houpt E, Zaitchik BF, Kosek MN. Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data. Lancet Glob Health. 2023 Mar;11(3):e373-e384. doi: 10.1016/S2214-109X(22)00549-6.
  • Nguiffo-Nguete D, Nongley Nkemngo F, Ndo C, Agbor JP, Boussougou-Sambe ST, Salako Djogbénou L, Ntoumi F, Adegnika AA, Borrmann S, Wondji CS. Plasmodium malariae contributes to high levels of malaria transmission in a forest-savannah transition area in Cameroon. Parasit Vectors. 2023 Jan 25;16(1):31. doi: 10.1186/s13071-022-05635-7.
  • Meulah B, Bengtson M, Lieshout LV, Hokke CH, Kreidenweiss A, Diehl JC, Adegnika AA, Agbana TE. A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis: from research and development to commercialization. Parasitology. 2023 Feb;150(2):137-149. doi: 10.1017/S0031182022001664. Epub 2022 Dec 9.
  • Nguyen TT, Nzigou Mombo B, Lalremruata A, Koehne E, Zoleko Manego R, Dimessa Mbadinga LB, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Velavan TP, Ramharter M, Mordmüller B, Mombo-Ngoma G. DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon. Malar J. 2019 Oct 2;18(1):336. doi: 10.1186/s12936-019-2972-y
  • Mebius MM, Adegnika AA, Zinsou JF, Agobe JCD, Honkpehedji YJ, Yazdanbakhsh M, van Dam GJ, Corstjens PLAM, Tielens AGM, de Groot PG, Urbanus RT, van Hellemond JJ. Haemostatic changes in urogenital schistosomiasis haematobium: a case-control study in Gabonese schoolchildren J Helminthol. 2019 Sep 10:1-6. doi: 10.1017/S0022149X19000798. [Epub ahead of print] PMID: 31500673
  • Dejon-Agobe JC, Ateba-Ngoa U, Lalremruata A, Homoet A, Engelhorn J, Paterne Nouatin O, Edoa JR, Fernandes JF, Esen M, Mouwenda YD, Betouke Ongwe EM, Massinga-Loembe M, Hoffman SL, Sim BKL, Theisen M, Kremsner PG, Adegnika AA, Lell B, Mordmüller B.Controlled human malaria infection of healthy lifelong malaria-exposed adults to assess safety, immunogenicity and efficacy of the asexual blood stage malaria vaccine candidate GMZ2. Clin Infect Dis. 2018 Dec 18. doi: 10.1093/cid/ciy1087.
  • Dejon-Agobé JC, Zinsou JF, Honkpehedji YJ, Ateba-Ngoa U, Edoa JR, Adegbite BR, Mombo-Ngoma G, Agnandji ST, Ramharter M, Kremsner PG, Lell B, Grobusch MP, Adegnika AA. Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon. PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006663.
  • Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F, Mischlinger J, Flohr L, Kim J, Cattaneo C, Hutchinson D, Duparc S, Joerg M, Velavan TP, Lell B, Ramharter M, Adegnika AA, Mordmüller B, Kremsner PG. Efficacy and safety of fosmidomycin-piperaquine as non-artemisinin-based combination therapy for uncomplicated falciparum malaria - A single-arm, age-de-escalation proof of concept study in Gabon. Clin Infect Dis. Clin Infect Dis. 2018 Jun 1;66(12):1823-1830.
  • Lell B, Mordmüller B, Dejon Agobe JC, Honkpehedji J, Zinsou J, Mengue JB, Loembe MM, AdegnikaAA, Held J, Lalremruata A, Nguyen TT, Esen M, Kc N, Ruben AJ, Chakravarty S, Lee Sim BK, Billingsley P, James E, Richie TL, Hoffman SL, Kremsner PG. Impact of Sickle Cell Trait and Naturally Acquired Immunity on Uncomplicated Malaria after Controlled Human Malaria Infection in Adults in Gabon. Am J Trop Med Hyg. 2018 Feb;98(2):508-515. doi: 10.4269/ajtmh.17-0343.
  • Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H. Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity. 2017 Dec 19;47(6):1197-1209.e10. doi: 10.1016/j.immuni.2017.11.00.
  • Agnandji ST, Fernandes JF, Bache EB, Obiang Mba RM, Brosnahan JS, Kabwende L, Pitzinger P, Staarink P, Massinga-Loembe M, Krähling V, Biedenkopf N, Fehling SK, Strecker T, Clark DJ, Staines HM, Hooper JW, Silvera P, Moorthy V, Kieny MP, Adegnika AA, Grobusch MP, Becker S, Ramharter M, Mordmüller B, Lell B; VEBCON Consortium, Krishna S, Kremsner PG. Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial. PLoS Med. 2017 Oct 6;14(10):e1002402. doi: 10.1371/journal.pmed.1002402. eCollection 2017 Oct.
  • Nguetse CN, Adegnika AA, Agbenyega T, Ogutu BR, Krishna S, Kremsner PG, Velavan TP. Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. Malar J. 2017 May 23;16(1):217. doi: 10.1186/s12936-017-1868-y.
  • Mombo-Ngoma G, Honkpehedji J, Basra A, Mackanga JR, Zoleko RM, Zinsou J, Agobe JC, Lell B, Matsiegui PB, Gonzales R, Agnandji ST, Yazdanbakhsh M, Menendez C, Kremsner PG, Adegnika AA, Ramharter M. Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon., Int J Parasitol. 2016 Dec 18. pii: S0020-7519(16)30270-3. doi: 10.1016/j.ijpara.2016.11.001.
  • Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FJ, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-Wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium. A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms N Engl J Med. 2016 Jun 23;374(25):2453-2464.
  • de Jong SE, Selman MH, Adegnika AA, Amoah AS, van Riet E, Kruize YC, Raynes JG, Rodriguez A, Boakye D, von Mutius E, Knulst AC, Genuneit J, Cooper PJ, Hokke CH, Wuhrer M, Yazdanbakhsh M. IgG1 Fc N-glycan galactosylation as a biomarker for immune activation. Sci Rep. 2016 Jun 16;6:28207. doi: 10.1038/srep28207.
  • Kremsner PG, Adegnika AA, Hounkpatin AB, Zinsou JF, Taylor TE, Chimalizeni Y, Liomba A, Kombila M, Bouyou-Akotet MK, Mawili Mboumba DP, Agbenyega T, Ansong D, Sylverken J, Ogutu BR, Otieno GA, Wangwe A, Bojang KA, Okomo U, Sanya-Isijola F, Newton CR, Njuguna P, Kazungu M, Kerb R, Geditz M, Schwab M, Velavan TP, Nguetse C, Köhler C, Issifou S, Bolte S, Engleitner T, Mordmüller B, Krishna S. Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial. PLoS Med. 2016 Jan 12;13(1):e1001938. doi: 10.1371/journal.pmed.1001938.
  • Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe - Preliminary Report. N Engl J Med. 2015 Apr 1.
  • Ateba-Ngoa U, Adegnika AA, Zinsou JF, Kassa Kassa RF, Smits H, Massinga-Loembe M, Mordmüller B, Kremsner PG, Yazdanbakhsh M. Cytokine and chemokine profile of the innate and adaptive imm AAune response of schistosoma haematobium and plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon. Malar J. 2015 Feb 25;14:94. doi: 10.1186/s12936-015-0608-4.
  • Ateba-Ngoa U, Mombo-Ngoma G, Zettlmeissl E, van der Vlugt LE, de Jong S, Matsiegui PB, Ramharter M, Kremsner PG, Yazdanbakhsh M, Adegnika AA. CD4+CD25hiFOXP3+ Cells in Cord Blood of Neonates Born from Filaria Infected Mother Are Negatively Associated with CD4+Tbet+ and CD4+RORγt+ T Cells. PLoS One. 2014 Dec 22;9(12):e114630.
  • Adegnika AA, Zinsou JF, Issifou S, Ateba-Ngoa U, Kassa RF, Feugap EN, Honkpehedji YJ, Dejon Agobe JC, Kenguele HM, Massinga-Loembe M, Agnandji ST, Mordmüller B, Ramharter M, Yazdanbakhsh M, Kremsner PG, Lell B. Randomized, Controlled, Assessor-Blind Clinical Trial To Assess the Efficacy of Single- versus Repeated-Dose Albendazole To Treat Ascaris lumbricoides, Trichuris trichiura, and Hookworm Infection. Antimicrob Agents Chemother. 2014 May;58(5):2535-40.
  • AA Adegnika, C Köhler, ST Agnandji, SK Chai, L Labuda, LP Breitling D Schonkeren, E Weerdenburg, S Issifou, AJF Luty, PG Kremsner and M Yazdanbakhsh Pregnancy-associated malaria affects cord blood TLR ligand-induced cytokine responses. J Infect Dis. 2008 Sep 15;198(6):928-36.
  • AA Adegnika, ST Agnandji, SK Chai, M Ramharter, L Breitling, E Kendjo, S Issifou, M Yazdanbakhsh, M Kombila, P G Kremsner. Increased prevalence to intestinal helminth infection during pregnancy in a Sub-Saharan African community. Wien Klin Wochenschr. 2007 dec; 119(23-24):712-716.
  • AA Adegnika, JJ Verweij, ST Agnandji, SK Chai, L Breitling, M Ramharter, M Frolich, S Issifou, PG Kremsner, and M Yazdanbakhsh. Microscopic and sub-microscopic Plasmodium falciparum infection, but not inflammation caused by infection, is associated with low birth weight, Am. J. Trop. Med. Hyg. 2006 75 (5) 798-803.
  • Adegnika AA, Kremsner PG. Epidemiology of malaria and helminth interaction: a review from 2001 to 2011. Curr Opin HIV AIDS. 2012 May;7(3):221-4. Review.
  • Adegnika AA, de Vries SG, Zinsou FJ, Honkepehedji YJ, Dejon Agobé JC, Vodonou KG, Bikangui R, Bouyoukou Hounkpatin A, Bache EB, Massinga Loembe M, van Leeuwen R, Molemans M, Kremsner PG, Yazdanbakhsh M, Peter J Hotez P, Bottazzi ME, Li G, Bethony JM, Diemert DJ, Grobusch MP for the HookVac Consortium. Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial. The Lancet Infectious Diseases Published: September 11, 2020 DOI:https://doi.org/10.1016/S1473-3099(20)30288-7
  • Veletzky L, Hergeth J, Stelzl DR, Mischlinger J, Manego RZ, Mombo-Ngoma G, McCall MBB, Adegnika AA, Agnandji ST, Metzger WG, Matsiegui PB, Lagler H, Mordmüller B, Budke C, Ramharter M. Burden of Disease in Gabon Caused by Loiasis: A Cross-Sectional Survey. Lancet Infect Dis. 2020 Jun 22:S1473-3099(20)30256-5. doi: 10.1016/S1473-3099(20)30256-5. Online ahead of print.
  • Nouatin O, Ateba Ngoa U, Ibáñez J, Dejon-Agobe JC, Mordmüller B, Edoa JR, Mougeni F, Brückner S, Bouyoukou Hounkpatin A, Esen M, Theisen M, Moutairou K, Hoffman SL, Issifou S, Luty AJF, Loembe MM, Agnandji ST, Lell B, Kremsner PG, Adegnika AA. Effect of immune regulatory pathways after immunization with GMZ2 malaria vaccine candidate in healthy lifelong malaria-exposed adults. Vaccine. 2020 May 5. pii: S0264-410X(20)30540-5. doi: 10.1016/j.vaccine.2020.04.046
  • 38. Kreidenweiss A, Trauner F, Rodi M, Koehne E, Held J, Wyndorps L, Manouana GP, McCall M, Adegnika AA, Lalremruata A, Kremsner PG, Fendel R, Sandri TL. Monitoring the threatened utility of malaria rapid diagnostic tests by novel high-throughput detection of Plasmodium falciparum hrp2 and hrp3 deletions: A cross-sectional, diagnostic accuracy study.EBioMedicine. 2019 Nov 21. pii: S2352-3964(19)30723-6. doi: 10.1016/j.ebiom.2019.10.048.
  • Lalremruata A, Nguyen TT, McCall MBB, Mombo-Ngoma G, Agnandji ST, Adegnika AA, Lell B, Ramharter M, Hoffman SL, Kremsner PG, Mordmüller B. Recombinase polymerase amplification and lateral flow assay for ultrasensitive detection of low-density Plasmodium falciparum infection from controlled human malaria infection studies and naturally acquired infections. J Clin Microbiol. 2020 Feb 26. pii: JCM.01879-19. doi: 10.1128/JCM.01879-19.
  • Manouana GP, Nguema-Moure PA, Mbong Ngwese M, Bock CT, Kremsner PG, Borrmann S, Eibach D, Mordmüller B, Velavan TP, Niendorf S, Adegnika AA. Genetic Diversity of Enteric. Viruses in Children under Five Years Old in Gabon. Viruses. 2021 Mar 24;13(4):545. doi: 10.3390/v13040545.
  • Publikationen
  • Deutsches Zentrum für Infektionsforschung (DZIF)
  • German Society of Infectious Diseases, DGI,
  • Central Africa Network of Excellence (CANTAM)
  • Severe Malaria in African Children (SMAC)
  • African Research Network for Neglected Tropical Diseases (ARNTD)
  • Société Africaine de Parasitologie (SOAP)