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Prof. Ayola Akim Adegnika

Prof. Ayola Akim Adegnika

Direktor CERMEL

Kontakt

Telefonnummer: 07071 29-83449

E-Mail-Adresse: a.a.adegnika@medizin.uni-tuebingen.de

  • 2017Professor in Immunology, of the Concours Africain et Malgache des Enseignements Supérieurs (CAMES)
  • 2016Full Professor of Immuno-Epidemiology clinical of Tropical Medicine University of Tübingen, DE
  • 2014Master of Science (MSc), Epidemiology, at LSHTM in London, UK
  • 2012Grade of Assistant Professor in Immunology, of the Concours Africain et Malgache des Enseignements Supérieurs (CAMES)
  • 2010Post graduate in Epidemiology at LSHTM in London, UK
  • 2008Doctorate degree, PhD in Sciences at the University of Tübingen, DE
  • 2002Doctorate degree, MD in Medicine at the University of Libreville, GA
  • Nguyen TT, Nzigou Mombo B, Lalremruata A, Koehne E, Zoleko Manego R, Dimessa Mbadinga LB, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Velavan TP, Ramharter M, Mordmüller B, Mombo-Ngoma G. DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon. Malar J. 2019 Oct 2;18(1):336. doi: 10.1186/s12936-019-2972-y
  • Mebius MM, Adegnika AA, Zinsou JF, Agobe JCD, Honkpehedji YJ, Yazdanbakhsh M, van Dam GJ, Corstjens PLAM, Tielens AGM, de Groot PG, Urbanus RT, van Hellemond JJ. Haemostatic changes in urogenital schistosomiasis haematobium: a case-control study in Gabonese schoolchildren J Helminthol. 2019 Sep 10:1-6. doi: 10.1017/S0022149X19000798. [Epub ahead of print] PMID: 31500673
  • Dejon-Agobe JC, Ateba-Ngoa U, Lalremruata A, Homoet A, Engelhorn J, Paterne Nouatin O, Edoa JR, Fernandes JF, Esen M, Mouwenda YD, Betouke Ongwe EM, Massinga-Loembe M, Hoffman SL, Sim BKL, Theisen M, Kremsner PG, Adegnika AA, Lell B, Mordmüller B.Controlled human malaria infection of healthy lifelong malaria-exposed adults to assess safety, immunogenicity and efficacy of the asexual blood stage malaria vaccine candidate GMZ2. Clin Infect Dis. 2018 Dec 18. doi: 10.1093/cid/ciy1087.
  • Dejon-Agobé JC, Zinsou JF, Honkpehedji YJ, Ateba-Ngoa U, Edoa JR, Adegbite BR, Mombo-Ngoma G, Agnandji ST, Ramharter M, Kremsner PG, Lell B, Grobusch MP, Adegnika AA. Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon. PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006663.
  • Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F, Mischlinger J, Flohr L, Kim J, Cattaneo C, Hutchinson D, Duparc S, Joerg M, Velavan TP, Lell B, Ramharter M, Adegnika AA, Mordmüller B, Kremsner PG. Efficacy and safety of fosmidomycin-piperaquine as non-artemisinin-based combination therapy for uncomplicated falciparum malaria - A single-arm, age-de-escalation proof of concept study in Gabon. Clin Infect Dis. Clin Infect Dis. 2018 Jun 1;66(12):1823-1830.
  • Lell B, Mordmüller B, Dejon Agobe JC, Honkpehedji J, Zinsou J, Mengue JB, Loembe MM, AdegnikaAA, Held J, Lalremruata A, Nguyen TT, Esen M, Kc N, Ruben AJ, Chakravarty S, Lee Sim BK, Billingsley P, James E, Richie TL, Hoffman SL, Kremsner PG. Impact of Sickle Cell Trait and Naturally Acquired Immunity on Uncomplicated Malaria after Controlled Human Malaria Infection in Adults in Gabon. Am J Trop Med Hyg. 2018 Feb;98(2):508-515. doi: 10.4269/ajtmh.17-0343.
  • Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H. Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity. 2017 Dec 19;47(6):1197-1209.e10. doi: 10.1016/j.immuni.2017.11.00.
  • Agnandji ST, Fernandes JF, Bache EB, Obiang Mba RM, Brosnahan JS, Kabwende L, Pitzinger P, Staarink P, Massinga-Loembe M, Krähling V, Biedenkopf N, Fehling SK, Strecker T, Clark DJ, Staines HM, Hooper JW, Silvera P, Moorthy V, Kieny MP, Adegnika AA, Grobusch MP, Becker S, Ramharter M, Mordmüller B, Lell B; VEBCON Consortium, Krishna S, Kremsner PG. Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial. PLoS Med. 2017 Oct 6;14(10):e1002402. doi: 10.1371/journal.pmed.1002402. eCollection 2017 Oct.
  • Nguetse CN, Adegnika AA, Agbenyega T, Ogutu BR, Krishna S, Kremsner PG, Velavan TP. Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. Malar J. 2017 May 23;16(1):217. doi: 10.1186/s12936-017-1868-y.
  • Mombo-Ngoma G, Honkpehedji J, Basra A, Mackanga JR, Zoleko RM, Zinsou J, Agobe JC, Lell B, Matsiegui PB, Gonzales R, Agnandji ST, Yazdanbakhsh M, Menendez C, Kremsner PG, Adegnika AA, Ramharter M. Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon., Int J Parasitol. 2016 Dec 18. pii: S0020-7519(16)30270-3. doi: 10.1016/j.ijpara.2016.11.001.
  • Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FJ, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-Wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium. A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms N Engl J Med. 2016 Jun 23;374(25):2453-2464.
  • de Jong SE, Selman MH, Adegnika AA, Amoah AS, van Riet E, Kruize YC, Raynes JG, Rodriguez A, Boakye D, von Mutius E, Knulst AC, Genuneit J, Cooper PJ, Hokke CH, Wuhrer M, Yazdanbakhsh M. IgG1 Fc N-glycan galactosylation as a biomarker for immune activation. Sci Rep. 2016 Jun 16;6:28207. doi: 10.1038/srep28207.
  • Kremsner PG, Adegnika AA, Hounkpatin AB, Zinsou JF, Taylor TE, Chimalizeni Y, Liomba A, Kombila M, Bouyou-Akotet MK, Mawili Mboumba DP, Agbenyega T, Ansong D, Sylverken J, Ogutu BR, Otieno GA, Wangwe A, Bojang KA, Okomo U, Sanya-Isijola F, Newton CR, Njuguna P, Kazungu M, Kerb R, Geditz M, Schwab M, Velavan TP, Nguetse C, Köhler C, Issifou S, Bolte S, Engleitner T, Mordmüller B, Krishna S. Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial. PLoS Med. 2016 Jan 12;13(1):e1001938. doi: 10.1371/journal.pmed.1001938.
  • Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe - Preliminary Report. N Engl J Med. 2015 Apr 1.
  • Ateba-Ngoa U, Adegnika AA, Zinsou JF, Kassa Kassa RF, Smits H, Massinga-Loembe M, Mordmüller B, Kremsner PG, Yazdanbakhsh M. Cytokine and chemokine profile of the innate and adaptive imm AAune response of schistosoma haematobium and plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon. Malar J. 2015 Feb 25;14:94. doi: 10.1186/s12936-015-0608-4.
  • Ateba-Ngoa U, Mombo-Ngoma G, Zettlmeissl E, van der Vlugt LE, de Jong S, Matsiegui PB, Ramharter M, Kremsner PG, Yazdanbakhsh M, Adegnika AA. CD4+CD25hiFOXP3+ Cells in Cord Blood of Neonates Born from Filaria Infected Mother Are Negatively Associated with CD4+Tbet+ and CD4+RORγt+ T Cells. PLoS One. 2014 Dec 22;9(12):e114630.
  • Adegnika AA, Zinsou JF, Issifou S, Ateba-Ngoa U, Kassa RF, Feugap EN, Honkpehedji YJ, Dejon Agobe JC, Kenguele HM, Massinga-Loembe M, Agnandji ST, Mordmüller B, Ramharter M, Yazdanbakhsh M, Kremsner PG, Lell B. Randomized, Controlled, Assessor-Blind Clinical Trial To Assess the Efficacy of Single- versus Repeated-Dose Albendazole To Treat Ascaris lumbricoides, Trichuris trichiura, and Hookworm Infection. Antimicrob Agents Chemother. 2014 May;58(5):2535-40.
  • AA Adegnika, C Köhler, ST Agnandji, SK Chai, L Labuda, LP Breitling D Schonkeren, E Weerdenburg, S Issifou, AJF Luty, PG Kremsner and M Yazdanbakhsh Pregnancy-associated malaria affects cord blood TLR ligand-induced cytokine responses. J Infect Dis. 2008 Sep 15;198(6):928-36.
  • AA Adegnika, ST Agnandji, SK Chai, M Ramharter, L Breitling, E Kendjo, S Issifou, M Yazdanbakhsh, M Kombila, P G Kremsner. Increased prevalence to intestinal helminth infection during pregnancy in a Sub-Saharan African community. Wien Klin Wochenschr. 2007 dec; 119(23-24):712-716.
  • AA Adegnika, JJ Verweij, ST Agnandji, SK Chai, L Breitling, M Ramharter, M Frolich, S Issifou, PG Kremsner, and M Yazdanbakhsh. Microscopic and sub-microscopic Plasmodium falciparum infection, but not inflammation caused by infection, is associated with low birth weight, Am. J. Trop. Med. Hyg. 2006 75 (5) 798-803.
  • Adegnika AA, Kremsner PG. Epidemiology of malaria and helminth interaction: a review from 2001 to 2011. Curr Opin HIV AIDS. 2012 May;7(3):221-4. Review.
  • Zur vollständigen Publikationsliste
  • Deutsches Zentrum für Infektionsforschung (DZIF)
  • German Society of Infectious Diseases, DGI,
  • Central Africa Network of Excellence (CANTAM)
  • Severe Malaria in African Children (SMAC)
  • African Research Network for Neglected Tropical Diseases (ARNTD)
  • Société Africaine de Parasitologie (SOAP)
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