Metabolomics & Systems Medicine

Our research focus is metabolomics and systems medicine by application of advanced analytical techniques within preclinical and clinical research. For that we have specialized in chromatography, mass spectrometry and NMR spectroscopy and the use of metabolomics and lipidomics for systems biology and personalized medicine. Our expertise covers the complete workflow from sample preparation to analytical data acquisition, including QC measures, until statistical evaluation. The methodology of the lab ranges from ex-vivo tissue, feces/stool and cell culture investigations under application of two-phase extraction SOPs for polar and lipid metabolites until quantitative analysis of murine and human biofluids such as serum, urine and CSF. Using established SOPs and assays we are involved in a wide range of research projects in the realms of cancer, neurology, immunology, metabolic disorders and cardiovascular diseases.

Dr. Christoph Trautwein

Dr. Christoph Trautwein

Head of Core Facility Metabolomics, Research Group Leader WSIC/M3

Publications: ORCID Profile

Publications: Web of Science

Personenprofil: Mehr zur Person

Christoph Trautwein finished his first degree at the University Stuttgart in 2006 as environmental engineer (Dipl.-Ing.) where he specialized in analytical chemistry and environmental microbiology. Awarded with a scholarship from the German Environmental Agency (DBU) he started his PhD in 2007 at the University of Freiburg in collaboration with the University Hospital Freiburg. Herein he investigated the microbial degradation and distribution of drugs in the aquatic environment using chromatography coupled with ion trap and triple quadrupole mass spectrometry. Fascinated by the potential use of advanced analytical chemistry within clinical resaerch, he started a second career in Molecular Medicine at the same time. Christoph Trautweil obtained his doctor title in 2012 (Dr. rer. nat.) and graduated in 2014 as Dipl. mol. med. at the University of Freiburg. In order to expand his analytical knowledge towards NMR spectroscopy, he was working from 2015-2016 at the Karlsruhe Institute for Technology (KIT) as postdoc for NMR based metabolomics. In 2017, he joined the WSIC at the University Hospital Tübingen and since then build up the research field of preclinical and clinical metabolomics including a magnitude of internal and external collaborations. Since 2019 he is heading his own research group supported by the WSIC foundation and proper 3rd party funding. Currently he is in process of finalizing his habilitation and assembling the new metabolomics core facility at the M3 center equipped with latest ion mobility mass spectrometry and MALDI-2 technology.

Christoph Trautwein steht vor einem Laborgerät
Dr. Christoph Trautwein – Metabolomics & Systems Medicine.
Dr. Jannik Sprengel

Dr. Jannik Sprengel

Akademischer Mitarbeiter, Core Facility Metabolomics

Publications: Researchgate

Publications: ORCID

Publications: Publications

Personenprofil: Mehr zur Person

Dr. Laimdota Zizmare

Dr. Laimdota Zizmare

Akademische Mitarbeiterin

Publications: ORCID

Publications: ResearchGate

Publications: Google Scholar

Personenprofil: Mehr zur Person

Herr Denis Andrei Ispan

Herr Denis Andrei Ispan

Core Facility Metabolomics, Akademische Mitarbeiter

Publications: Publications

Personenprofil: Mehr zur Person

Frau Sisi Deng

Frau Sisi Deng

Core Facility Metabolomics, Akademische Mitarbeiterin

Publications: ResearchGate

Publications: ORCID Profile

Personenprofil: Mehr zur Person

Teamfoto
Our research team
ex-vivo tissue
feces/stool and cell culture investigations
two-phase
extraction SOPs for polar and lipid metabolites
analysis
of murine and human biofluids

Selected publications

  • Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle
     
    Yiyi Chen, Laimdota Zizmare, Victor Calbiague, Lan Wang, Shirley Yu, Fritz W Herberg, Oliver Schmachtenberg, Francois Paquet-Durand, Christoph Trautwein
    https://pubmed.ncbi.nlm.nih.gov/38739438/
  • Quantitative Metabolomics and Lipoprotein Analysis of PDAC Patients Suggests Serum Marker Categories for Pancreatic Function, Pancreatectomy, Cancer Metabolism, and Systemic Disturbances
     
    Gyuntae Bae, Georgy Berezhnoy , Alejandra Flores, Claire Cannet, Hartmut Schäfer, Marc H Dahlke, Patrick Michl, Markus W Löffler, Alfred Königsrainer, Christoph Trautwein
     https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00611
  • Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake
     
    Qianlu Yang, Sisi Deng, Heike Preibsch, Tim-Colin Schade, André Koch, Georgy Berezhnoy, Laimdota Zizmare, Anna Fische, Brigitte Gückel, Annette Staebler, Andreas D Hartkopf , Bernd J Pichler, Christian la Fougère, Markus Hahn, Irina Bonzheim, Konstantin Nikolaou, Christoph Trautwein
     https://pubmed.ncbi.nlm.nih.gov/38332687/
  • A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
     
    Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Nogayhan Seymen, Pierluigi Ramadori, Vera Joerke, Laimdota Zizmare, David Aicher, Indresh K Gopalsamy, Winnie Fong, Jan Kosla, Enrico Focaccia, Xin Li, Suhail Yousuf, Tjeerd Sijmonsma, Mohammad Rahbari, Katharina S Kommoss, Adrian Billeter, Sandra Prokosch, Ulrike Rothermel, Florian Mueller, Jenny Hetzer, Danijela Heide, Benjamin Schinkel, Tim Machauer, Bernd Pichler, Nisar P Malek, Thomas Longerich, Susanne Roth, Adam J Rose, Johannes Schwenck, Christoph Trautwein, Mohammad M Karimi, Mathias Heikenwälder
     https://pubmed.ncbi.nlm.nih.gov/38718791/
  • Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD+ pathway and SIRT1 activation
     
    Caterina Lonati, Georgy Berezhnoy , Nathan Lawler, Reika Masuda, Aditi Kulkarni, Samuele Sala, Philipp Nitschke, Laimdota Zizmare, Daniele Bucci, Claire Cannet, Hartmut Schäfer, Yogesh Singh, Nicola Gray, Samantha Lodge, Jeremy Nicholson, Uta Merle, Julien Wist, Christoph Trautwein
    https://pubmed.ncbi.nlm.nih.gov/37955280/
  • Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients
     
    Samuele Sala, Philipp Nitschke, Reika Masuda, Nicola Gray, Nathan G Lawler, James M Wood, Joshua N Buckler, Georgy Berezhnoy, Jose Bolaños, Berin A Boughton, Caterina Lonati, Titus Rössler, Yogesh Singh, Ian D Wilson, Samantha Lodge, Aude-Claire Morillon, Ruey Leng Loo, Drew Hall, Luke Whiley, Gary B Evans, Tyler L Grove, Steven C Almo, Lawrence D Harris, Elaine Holmes, Uta Merle, Christoph Trautwein, Jeremy K Nicholson, Julien Wist
     https://pubmed.ncbi.nlm.nih.gov/38310443/