General psychiatry and psychotherapy with outpatient clinic

• Relationship between functional connectivity of different resting state dynamics and other state markers of the autonomic nervous system.
• Investigation of markers with respect to disease-relevant information (Collaboration with Catherine E. Chang, Stanford, CA, USA).

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DTI and cortical thickness measurements to investigate aberrant structural, histological, functional and metabolic markers in depressed patients.

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Combining magnetic resonance spectroscopy (MRS) and fMRI to compare interindividual variation in fMRI markers with changes in concentrations of GABA, glutamate, or glutamine.

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• Application of parallel real-time EEG-fMRI to alter brain dynamics through specific modulation of subnetworks.
• Training focused attention, mindfulness, self-observation in meditation, and EMG signatures of mimic expressions as treatment alternatives to neuropsychopharmacology and psychotherapy

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Investigating pathologically altered processing of internal and external stimuli in affective disorders in the context of functional network changes in the brain (Collaboration with Michael Breakspear, Brisbane, Queensland, Australia).

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Analysis of functional activations and connectivity to study neurobiological differences at the level of neuronal circuitry (collaboration with Birgit Abler and Heiko Graf, University of Ulm)

Identification of biomarkers from resting-state fMRI prior to the initiation of pharmacotherapy that contain information about the individual vulnerability to develop side effects

Involvement of brain networks - via integration or interaction with other functional systems - in the generation of stable concepts of the internal and external world, and the integration of such information at the subjective level.

Use of parallel EEG-fMRI to discriminate sub-processes of cognitive-affective regulation by means of erotic image stimuli (collaboration with Harold Mouras, Amiens, France)

• Measurement of task-related activations of the substructures of thalamus and basal ganglia
• Investigation of the relevance of cortico-striato-thalamo-cortical connections for cognitive and affective processing

Identification of markers of clinical change and predictors of treatment outcome based on glutamatergic modulation of synaptic plasticity by NMDA antagonists such as ketamine.

• Optimization and standardization of imaging protocols to ensure sufficient data quality and robust control of potential confounders
• Development of methodological approaches for the processing of large data sets with respect to physiological noise