Address: Calwerstr. 7
72076 Tübingen

E-mail address: face@​med.​uni-​tuebingen.​de

frontend.sr-only_#{element.icon}: +49 7071 29-83799

About us

About us

The Center for Cleft Lip and Palate and Craniofacial Malformations (ZLKGKF) is one of the larger specialty centers of the Center for Rare Diseases (ZSE). The departments of oral and maxillofacial surgery, orthodontics, pediatric neurosurgery and neonatology have joined forces here to ensure optimal care for patients with the corresponding clinical pictures. In this context, other specialties such as prenatal medicine, neuropediatrics, anesthesiology, ophthalmology and otolaryngology, phoniatrics and pediatric audiology, radiology, general dentistry, and medical genetics are regularly consulted.

Information flyer about the center


E-mail address: face@​med.​uni-​tuebingen.​de

Assigner guides:

Lea Longerich

+49 7071 29-62570

Dr. Ann-Cathrine Neukamm

+49 7071 29-62371

Margret Fritz

+49 7071 29-84742

For inquiries and registrations please fill out the registration form and send it to us. We will contact you as soon as possible.

Registration form
Contact person for referring physicians

European Reference Center

(European Reference Network, ERN-CRANIO)

The Tübingen Center for Cleft Lip and Palate/Craniofacial Malformations has received certification from the European Commission as a European Reference Network (ERN-CRANIO) in 2022.

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Board of Directors

Portrait of Prof. Dr. Christian F. Poets

Prof. Dr. Christian F. Poets

Medical Director of the Department of Pediatrics IV (Neonatology)


Portrait photo

Prof. Dr. Dr. Michael Krimmel

Deputy Director
Managing Senior Physician Clinic and Polyclinic for Oral and Maxillofacial Surgery


Portrait of Prof. Dr. Bernd Koos

Prof. Dr. Bernd Koos

Medical Director of the Polyclinic of Orthodontics


Prof. Dr. Dr. Bernd Lethaus

Medical Director of the Clinic and Polyclinic for Oral and Maxillofacial Surgery


Portrait of Prof. Dr. Martin Schuhmann

Prof. Dr. Martin Schuhmann

Head of ped. neurosurgery, peripheral nerve surgery


Portrait of Maximilian Nägele

Maximilian Nägele

Commercial Director of the University Hospital for Pediatrics and Adolescent Medicine


How we help

When families should contact us

Affected families can contact our center at any time with questions or concerns, regardless of the child's age. The treatment of infantile facial malformations is particularly promising if it begins in the first days after birth.

What patients can expect at our center

After birth, children are initially cared for in the Department of Neonatology at the Children's Hospital. Here, the growth-accompanying therapy by orthodontics already begins. For most malformations, this includes a treatment with a palatal plate. Depending on the malformation, other special disciplines such as oral and maxillofacial surgery and pediatric neurosurgery are already involved in neonatology. If necessary, the children are also supported by specialists from the fields of ear, nose and throat medicine, ophthalmology and human genetics at the University Hospital of Tübingen.

We fully integrate the parents into the treatment so that they can continue the therapy with their child at home. This includes the independent change of palatal plates, instructions for feeding the children as well as early functional therapy procedures. Continued care for those affected is ensured through our interdisciplinary collaboration at the center into adulthood.

We know that the psychological burden on the affected parents is great. That is why our psychosocial service is available to parents with advice and support - even after discharge from the hospital.

Disease patterns

Disease patterns

Under the respective clinical pictures you will find further information as well as contact details for making appointments and directions to the outpatient clinics and clinics treating the patients. Our center is made up of the specialist disciplines of oral and maxillofacial surgery, orthodontics, neonatology and neurosurgery.

Father and baby with cleft lip and palate

Cleft lip and palate (LKG)

LKG is one of the most common congenital malformations. This malformation therefore requires therapy, which is explained in more detail below.

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Baby drinks milk from a bottle

Robin sequence

Every year, about 80 children in Germany are affected. The therapy concept in Tübingen is carried out using a palatal plate, which leads to an improvement in breathing.

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Baby with Down syndrome

Down syndrome

More than half of the children show obstructions of the airways during sleep. One of the most important treatment concepts is the so-called orofacial regulation therapy.

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Father with sleeping baby


Craniosynostosis is premature ossification of one or more cranial sutures associated with a growth disorder of the cranial skeleton.

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Interdisciplinary cooperation of all necessary specialists

Because important functions such as breathing, nutrition, speech and hearing are also impaired in infantile facial malformations, all the necessary specialists from different disciplines work together in our centre: Initially, it is primarily the paediatricians of neonatology and the orthodontists, then the oral and maxillofacial surgeons, supported if necessary by radiologists (magnetic resonance imaging and computer tomography), ENT specialists, ophthalmologists, neurosurgeons and human geneticists.

Interdisciplinary Conferences

Every Wednesday

an interdisciplinary consultation takes place in the Department of Oral and Maxillofacial Surgery.

Research and teaching

  • Effert J., Uhlig S., Wiechers C, Quante M., Poets C.F., Schulz M.C., Reinert S., Krimmel M., Koos B., Weise C. (2023) Prospective evaluation of children with Robin sequence following Tübingen palatal plate therapy. Journal of Clinical Medicine 12, 448. https://doi.org/10.3390/jcm12020448

  • Naros A, Schulz M, Finke H, Reinert S, Krimmel M. (2023) Autologous Tooth Transplantation in Craniofacial Malformations. Cleft Palate Craniofac J. 2023 Apr 24:10556656231170997. doi: 10.1177/10556656231170997

  • Wiechers C, Uhlig S, Poets A, Weise C, Naros A, Krimmel M, Koos B, Poets CF, Quante M. (2023) Sleep and neurocognitive outcome in primary school children with Robin Sequence. Sleep. 2023 May 10;46(5):zsac317. doi: 10.1093/sleep/zsac317

  • Kluba S, Reinert S, Krimmel M. (2023) Single-dose versus prolonged antibiotic prophylaxis for alveolar bone grafting in cleft patients. Int J Oral Maxillofac Surg. May;52(5):564-568. doi: 10.1016/j.ijom.2022.10.002

  • Naros A, Naros CH, Awad D, Krimmel M, Kluba S (2023) Antibiotic prophylaxis and surgical site infections in orthognathic surgery – a retrospective analysis. BMC Oral Health 25;23(1):688. doi: 10.1186/s12903-023-03391-3

  • Effert J, Wiechers C, Kreutzer K, Poets CF, Schulz MC, Krimmel M, Aretxabaleta M, Finke H, Koos B, Weise C. (2023) Retrospective evaluation of the orthodontic treatment needs in primary school children with Robin sequence following Tübingen palatal plate therapy in infancy. J Craniomaxillofac Surg. 2023 Sep;51(9):528-535. doi: 10.1016/j.jcms.2023.06.004. Epub 2023 Jul 7. PMID: 37460350

  • Hurth H, Zipfel J, Kerscher SR, Decker K, Haas-Lude K, Krimmel M, Neunhoeffer F, Schuhmann MU. (2023) Intracranial Pressure, Autoregulation, and Cerebral Perfusion in Infants With Nonsyndromic Craniosynostosis at the Time of Surgical Correction. Neurosurgery. 2023 Dec 13. doi: 10.1227/neu.0000000000002797. Online ahead of print. PMID: 38088557

  • Knechtel A, Weismann C, Poets CF. (2023) Caring for Infants with Robin Sequence Treated with the Tübingen Palatal Plate: A Review of Personal Practice. Children (Basel). 2023 Sep 29;10(10):1628. doi: 10.3390/children10101628.

  • Oechsle AL, Wiechers C, Abadie V, Abel F, Breugem C, Poets CF. (2023) Study protocol for a multicenter, multinational, observational registry of epidemiology, treatment and outcome of patients with Robin sequence. Head and Face Medicine. 2023 May 20;19(1):20. doi: 10.1186/s13005-023-00364-3.

  • Weismann C, Lehmann M, Aretxabaleta M, Koos B, Schulz MC. (2023) Maxillary canine position of patients with non-syndromic craniofacial disorder: a retrospective evaluation of panoramic radiographs. Head and Face Medicine. 2023 Oct 9;19(1):44. doi: 10.1186/s13005-023-00390-1

  • Schmidt M, Slavicek G, Slavicek F, Schulz MC, Aretxabaleta M, Effert J, Koos B, Weise C. (2023) Masticatory Efficiency in Orthodontic Patients with Craniofacial Disorder. Int. J Environ Res Public Health. 2023 Feb 28;20(5):4324. doi: 10.3390/ijerph20054324

  • Sullivan NAT, Smit JA, Lachkar N, Logjes RJH, Kruisinga FH, Reinert S, Persson M, Davies G, Breugem CC (2023) Differences in analysis and treatment of upper airway obstruction in Robin sequence across different countries in Europe. Eur J Pediatr 182(3): 1271-1280, 10.1007/s00431-022-04781-5

Further links

Certificates and Associations

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