General psychiatry and psychotherapy with outpatient clinic

("Neurobiology of Cognition" Laboratory; NoCo-Lab)

The Neurobiology of Cognition Laboratory (NoCo-Lab) investigates the neurobiological basis of cognitive performance and its alteration by aging and by psychiatric and neurological diseases.

Research topics

• A central focus of our research concerns the self-perception of one's own actions ("sense of agency") and its alteration in schizophrenia and other psychiatric and neurological disorders.
• Another focus is on the limits of cognitive capacity, namely in decision making ("agony of choice"), in action planning, and in working memory.
• Our basic research should also contribute to the development of new strategies to counteract disease-related impairments in cognitive performance.

Method spectrum

Our spectrum of methods includes behavioral experiments, including the measurement of eye and body movements, as well as functional imaging (fMRI).

Key publications

• Reutskaja E* Lindner A* Nagel R Andersen RA Camerer CF (2018) Choice overload reduces neural signatures of choice set value in dorsal striatum and anterior cingulate cortex. Nature Human Behaviour, 2: 925-935.
• Höller-Wallscheid MS Thier P Pomper JK Lindner A (2017) Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age. Proceedings of the National Academy of Sciences USA, 114,5: E830-E839.
• Synofzik M Thier P Leube DT Schlotterbeck P Lindner A (2010) Misattributions of agency in schizophrenia are based on imprecise predictions about the sensory consequences of one's actions Brain 133, 1, 262-271.
• Lindner A Thier P Kircher TT Haarmeier T Leube DT (2005) Disorders of agency in schizophrenia correlate with an inability to compensate for the sensory consequences of actions. Current Biology 15, 12, 1119-1124.