Current projects
- Dr. Justin Antony Selvaraj (Junior Group Leader)
Hematopoietic stem cell gene therapy with Cas9 mRNA and AAV6 vector in metachromatic leukodystrophy - Andrés Lamsfus Calle (cand. Dr. rer. nat.)
Gene correction of human β-thalassemic hematopoietic stem cells using CRISPR/Cas9 mechanism - Alberto Daniel Moreno (cand. Dr. rer. nat.)
Comparative analysis of lentiviral gene transfer approaches designed to promote fetal hemoglobin production for the treatment of β-hemoglobinopathies - Guillermo Ureña Bailén (cand. Dr. rer. nat.) CRISPR/Cas9-boosted improvements in CAR-T and CAR-NK cell-based immunotherapy for cancer treatment
- Jennifer Rottenberger (MTA)
Antibody optimization in CHO-S cells using CRISPR/Cas9 gene editing for enhanced anti-tumor activity
Safety and Tolerability of donor-specific Mesenchymal Stem Cells in Pediatric Liver Transplantation by Living Donation (Cooperation with Dr. Hartleiff, Tübingen) - Yujuan Hou (cand. MD PhD) Using CRISPR/Cas9 system for the treatment of immunodeficiencies
- Janani Raju (cand. Dr. rer. nat., funded by Prof. Schöls / Dr. Hayer, Klinik für Neurologie Tübingen) Towards CRISPR/Cas-based gene therapy in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: generating the optimal guide RNA
- Luise Luib (cand. Dr. med.)
Etablierung eines Verfahrens zur Früherkennung von ALL-Rezidiven mittels MRD-Bestimmung durch digitale PCR bei Patienten nach anti-CD19-Antikörpertherapie - Marie Katz (cand. Dr. med.)
Lack of association between the presence of SUFU polymorphism rs17114808 and development of acute GvHD after hematopoietic stem cell transplantation
Completed master and doctoral theses
- Laura Eichler (cand. Dr. med. 2020)
Retrospektive Analyse zur Untersuchung der Bedeutung von genetischen Markern in Chitinasegenen bei der Zystischen Fibrose - Guillermo Ureña Bailén (Master Mol. Med. 2019)
Generation of efficient CAR-T cells using CRISPR/Cas9 system - Janani Raju (Master Mol. Med. 2019)
Optimization of CRISPR/Cas9 system for autologous hematopoietic stem cell transplantation - Merve Kaftancıoğlu (Master Mol. Med. 2019)
Hematopoietic stem cell gene therapy with Cas9 mRNA and AAV6 vector in metachromatic leukodystrophy - Darina Siegmund (Dr. rer. nat. 2018)
Functional assessment of myeloid-derived suppressor cells, mesenchymal stromal cells, and regulatory T cells for the control of T-cell function: implications for graft-versus-host disease - Matthias Firnkorn (Dr. med. 2018)
Zusammenhang zwischen dem KIR-Rezeptorprofil und dem Auftreten akuter lymphoblastischer Leukämien im Kindesalter - Sibylle Schmidt (Dr. med. 2016)
Der Einfluss der SNPs rs4077515 des CARD9-Gens und rs3816527 des PTX3-Gens auf die Lungenerkrankung der Zystische Fibrose - Johanna Huber (Dr. med. 2015)
Die Bedeutung der KIR-Rezeptoren bei Morbus Crohn und Colitis ulcerosa - Sebastian Michaelis (Dr. med. 2015)
Die klinische Relevanz der KIR Rezeptoren bei haploidenter hämatopoietischer Stammzelltransplantation - Katrin Mörth (Dr. med. 2015)
Mesenchymale Stromazellen als Therapie bei steroidrefraktärer akuter und chronischer Graft-versus-Host-Disease bei pädiatrischen Patienten nach hämatopoetischer Stammzelltransplantation