Das Klinikum

Dr. rer. nat. Niels Niethard

Dr. rer. nat. Niels Niethard

Hertie Network of Excellence in Clinical Neuroscience Fellow

My research focus is how sleep serves as a brain state that renormalizes certain set points to maintain the organism’s homeostatic balance.

Kontakt

Telefonnummer: 07071 29-88915

E-Mail-Adresse: niels.niethard@uni-tuebingen.de

Klinik / Institut / Zentrum

  • The idea that the main function of sleep is to maintain the organism’s homeostatic balance is at the center of my research into the dynamics of the sleeping brain and their functional significance. I have extensively studied how sleep affects the brain’s excitation-inhibition balance and, thereby, contributes to synaptic plasticity. To this end, I have investigated brain structure and function on multiple levels, ranging from single cells and synapses studied with in vivo two-photon imaging to the system level of brain network function assessed with electrophysiology and behavioral approaches.
  • Lendner, Niethard, Mander, vSchalkwijk, Schuh-Hofer, Schmidt, Knight, Born, Walker, Lin, Helfrich (2023). Human REM sleep recalibrates neural activity in support of memory formation. Science Advances
  • Niethard N, Hallschmid M (2023). A sweet spot for the sleeping brain: Linking human sleep physiology and glucoregulation. Cell Reports Medicine
  • S Brodt, M Inostroza, N Niethard, J Born (2023). Sleep—A brain-state serving systems memory consolidation. Neuron
  • Niethard N (2023). Aging impairs the temporal clustering of sleep spindles. SLEEP
  • Sawangjit A, Harkotte M, Oyanedel CN, Niethard N, Born J, InostrozaM (2022). Two distinct ways to form long-term object recognition memory during sleep and wakefulness. PNAS
  • Niethard N, Brodt S, Born J (2021). Cell-type specific dynamics of calcium activity in cortical circuits over the course of slow wave sleep and rapid eye movement sleep. Journal of Neuroscience
  • Oyanedel C, Durán E, Niethard N, Inostroza M, Born J (2020) Temporal associations between sleep slow oscillations, spindles and ripples. European Journal of Neuroscience
  • Niethard N, Born J (2020) A Backup of Hippocampal Spatial Code outside the Hippocampus? New Light on Systems Memory Consolidation. Neuron
  • Sawangjit A, Oyanedel C, Niethard N, Born J, Inostroza M (2020) Deepened sleep makes hippocampal spatial memory more persistent. Neurobiol Learn Mem
  • Klinzing J, Niethard N, Born J (2019) Mechanisms of systems memory consolidation during sleep. Nature Neuroscience
  • Puentes-Mestril C, Roach J, Niethard N, Zochowski M, Aton S (2019) How rhythms of the brain tune memory and synaptic plasticity. Sleep
  • Niethard N and Born J (2019). Back to baseline: Sleep recalibrates synapses. Nature Neuroscience
  • Niethard N, Ngo HV, Ehrlich I, Born J (2018). Cortical circuit activity underlying sleep slow oscillations and spindles. PNAS
  • Sawangjit A, Oyanedel CN, Niethard N, Salazar C, Born J, Inostroza M (2018). The hippocampus is crucial for forming non-hippocampal long-term memory during sleep. Nature
  • Duran E, Oyanedel CN, Niethard N, Inostroza M, Born J (2018) Sleep stage dynamics in neocortex and hippocampus. Sleep
  • Niethard N, Burgalossi A, Born J (2017). Plasticity during sleep is linked to specific regulation of cortical circuit activity. Frontiers in neural circuits
  • Niethard N, Hasegawa M, Itokazu T, Oyanedel CN, Born J, Sato TR (2016). Sleep-stage-specific regulation of cortical excitation and inhibition. Current Biology.
  • Publikationen