Das Klinikum

PD Dr. Julia Schulze-Hentrich

PD Dr. Julia Schulze-Hentrich

Research Group Leader

PhD Genetics, UBC Vancouver, Canada
Diplom Biologin, FSU Jena, Germany
1. Staatsexamen Lehramt Gymnasien, FSU Jena, Germany

Kontakt

Telefonnummer: 07071 29-72276

Faxnummer: 07071-29-5228

E-Mail-Adresse: julia.schulze-hentrich@med.uni-tuebingen.de

Klinik / Institut / Zentrum

  • Epigenomics
  • Parkinson's disease
  • Huntington's disease
  • Gene-Environment Interactions
  • Computational Biology
  • Parkinson’s disease (PD), like related neurodegenerative disorders, occurs from a presumed but still largely enigmatic interplay of genetic predispositions, age-related processes, and environmental factors. Increasing evidence points to the epigenome at the nexus between genes and the environment playing a key role in that process. Drawing on genome-wide sequencing technologies, we investigate environment-driven modulations of the epigenome in animal models, cell lines, and human samples of PD to better understand the unfolding of the disease along the gene-environment axis.
  • since 2016Research Group Leader at the Institute of Medical Genetics and Applied Genomics, Tübingen; supported by a grant of the Faculty of Medicine for excellence of young scientists to establish their own research group
  • 08/2014 – 08/2108Independent 4-year Research Grant for Excellent Female Researchers in the post- doctoral academic qualification stage (Margarete von Wrangell habilitation program) awarded by the Ministry of Science, Research and the Arts Baden- Württemberg and the European Social Fund
  • 09/2011 – 07/2014Principle Investigator (DFG Eigene Stelle) for a 3-year project at the Institute of Medical Genetics and Applied Genomics, Tübingen
  • 10/2010 – 07/2011Postdoctoral Fellow, University of British Columbia, Vancouver, Canada Human Early Learning Partnership (HELP) Program
  • 01/2006 – 10/2010Ph.D. Student in Genetics, University of British Columbia, Vancouver, Canada
  • 07/2005 – 08/2005Visiting Researcher, Tokyo Institute of Technology, Yokohama, Japan
  • 07/2004 – 05/2005Visiting Researcher, University of California, Berkeley, USA
  • 10/2000 – 12/2005Studies in Biology (M.Sc. and B.Sc. equivalent), Friedrich-Schiller University, Jena and Georg-August University, Göttingen
  • Maria Gräfin von Linden-Award of the Association of Female Scientists in Baden-Württemberg for best scientific lecture and didactic aptitude (11/2015)
  • DAAD award for researchers returning to Germany after studying abroad (10/2010)
  • Graduate scholarship, Child and Family Research Institute, Canada (10/2008 – 10/2010)
  • German Academic Exchange Service (DAAD) Graduate Student Fellowship (04/2007 – 04/2008)
  • Travel award, Child and Family Research Institute, Canada (06/2006)
  • Graduate Entrance Scholarship, University of British Columbia, Canada (01/2006)
  • Fellowship from the German Academic Scholarship Foundation (Studienstiftung) for undergraduate students (03/2003 – 02/2006)
  • Schaffner SL, Wassouf Z, Lazaro D, Xylaki M, Gladish N, Lin DTS, MacIsaac J, Ramadori K, Schulze-Hentrich JM, Outeiro TF, Kobor MS. Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways. bioRxiv. https://doi.org/10.1101/2021.06.12.448150
  • Haas E, Incebacak RD, Hentrich T, Maringer Y, Schmidt T, Zimmermann F, Casadei N, Mills JD, Aronica E, Riess O, Schulze-Hentrich JM, Hübener-Schmid J. A novel SCA3 knock-in mouse model mimics the human SCA3 disease phenotype including neuropathological, behavioral, and transcriptional abnormalities. bioRxiv. doi: https://doi.org/10.1101/2020.02.28.968024
  • Zurek B, Ellwanger K, Vissers LELM, Schüle R, Synofzik M, Töpf A, de Voer RM, Laurie S, Matalonga L, Gilissen C, Ossowski S, 't Hoen PAC, Vitobello A, Schulze-Hentrich JM, Riess O, Brunner HG, Brookes AJ, Rath A, Bonne G, Gumus G, Verloes A, Hoogerbrugge N, Evangelista T, Harmuth T, Swertz M, Spalding D, Hoischen A, Beltran S, Graessner H; Solve-RD consortium. Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases. Eur J Hum Genet. 2021 Jun 1. doi: 10.1038/s41431-021-00859-0.
  • Hentrich T, Koch A, Weber N, Kilzheimer A, Burkhardt S, Rall K, Casadei N, Kohlbacher O, Riess O, Schulze-Hentrich JM, Brucker SY*. The endometrial transcription landscape of MRKH syndrome. Front Cell Dev Biol. 2020 Sep 24;8:572281. doi: 10.3389/fcell.2020.572281.
  • Hentrich T, Wassouf Z, Ehrhardt C, Haas E, Mills JD, Aronica E, Outeiro TF, Hübener-Schmid J, Riess O, Casadei N, Schulze-Hentrich JM. Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients. Aging (Albany NY). 2020 Oct 5;12(19):18889-18906. doi: 10.18632/aging.103935.
  • Secker KA , Bruns L, Keppeler H, Jeong J, Hentrich T, Schulze-Hentrich JM, Mankel B, Fend F, Schneidawind D, Schneidawind C. Only Hematopoietic Stem and Progenitor Cells From Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations. Cancers (Basel). 2020 Jun 7;12(6):E1487.
  • Secker KA, Bloechl B, Keppeler H, Duerr-Stoerzer S, Schmid H, Schneidawind D, Jeong J, Hentrich T, Schulze-Hentrich JM, Schneidawind C. MAT2A as Key Regulator and Therapeutic Target in MLLr Leukemogenesis. Cancers (Basel). 2020 May 24;12(5):1342.
  • Cheng F, Walter M, Wassouf Z, Hentrich T, Casadei N, Schulze-Hentrich JM, Barbuti P, Krueger R, Riess O, Grundmann-Hauser K, Ott T. Unraveling Molecular Mechanisms of THAP1 Missense Mutations in DYT6 Dystonia. J Mol Neurosci. 2020 Feb 28.
  • Singh Y, El-Hadidi M, Matthes J, Wassouf Z, Schulze-Hentrich JM, Kohlhofer U, Quintanilla-Martinez de Fend L, Huson D, Riess O, Casadei N. Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinson’s disease. Front Neurosci. 2019, Oct 15;13:1032
  • Secker KA, Keppeler H, Duerr-Stoerzer S, Schmid H, Schneidawind D, Hentrich T, Schulze-Hentrich JM, Mankel B, Fend F, Schneidawind C. Inhibition of DOT1L and PRMT5 promote synergistic anti-tumor activity in a human MLL leukemia model induced by CRISPR/Cas9. Oncogene. 2019 Aug 15.
  • Yu-Taeger L, Ott T, Bonsi P, Tomczak C, Wassouf Z, Martella G, Sciamanna G, Imbriani P, Ponterio G, Tassone A, Schulze-Hentrich JM, Goodchild R, Riess O, Pisani A, Grundmann-Hauser K, Nguyen HP. Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia. Neurobiol Dis. 2020 Feb;134:104634.
  • Wassouf Z, Hentrich T, Casadei N, Jaumann M, Knipper M, Riess O, Schulze-Hentrich JM. Distinct Stress Response and Altered Striatal Transcriptome in Alpha-Synuclein Overexpressing Mice. Front. Neurosci., 10 January 2019 | https://doi.org/10.3389/fnins.2018.01033
  • Hentrich T, Wassouf Z, Riess O, Schulze-Hentrich JM. SNCA overexpression disturbs hippocampal gene expression trajectories in midlife. Aging (Albany NY). 2018 Dec 13. https://doi.org/10.18632/aging.101691
  • Paiva I, Jain G, Gotovac Jerčić K, Hentrich T, Kerimoglu C, Pinho R, Szegő EM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser AE, Lingor P, Schulze-Hentrich JM, Borovečki F, Fischer A, Outeiro TF.Transcriptional deregulation and ER-Golgi impairment in models of Parkinson's disease. Neurobiol Dis. 2018 Nov;119:121-135.
  • Wassouf Z, Hentrich T, Samer S, Rotermund C, Kahle PJ, Ehrlich I, Riess O, Casadei N, Schulze-Hentrich JM. Environmental enrichment prevents transcriptional disturbances induced by alpha-synuclein overexpression. Front Cell Neurosci. 2018 doi: 10.3389/fncel.2018.00112
  • Novati A, Hentrich T, Wassouf Z, Weber JJ, Yu-Taeger L, Déglon N, Nguyen HP*, Schulze-Hentrich JM*. Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease. Sci Rep. 2018 Apr 11;8(1):5803.
  • Sugeno N, Jäckel S, Voigt A, Wassouf Z, Schulze-Hentrich JM, Kahle PJ. 𝛼-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses. Sci Rep. 2016 Nov 3;6:36328.
  • Rossetto D, Cramet M, Wang AY, Steunou AL, Lacoste N, Schulze JM, Côté V, Monnet-Saksouk J, Piquet S, Nourani A, Kobor MS, Côté J. Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling. EMBO J. 2014 Jun 17;33(12):1397-415.
  • Maltby VE, Martin BJ, Brind'Amour J, Chruscicki AT, McBurney KL, Schulze JM, Johnson IJ, Hills M, Hentrich T, Kobor MS, Lorincz MC, Howe LJ. Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae. PNAS. 2012 Nov 6;109(45):18505-10.
  • Maltby VE, Martin BJ, Schulze JM, Johnson I, Hentrich T, Sharma A, Kobor MS, Howe L. Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin. Mol Cell Biol. 2012 Sep;32(17):3479-85.
  • Hentrich T, Schulze JM, Emberly E, Kobor MS. CHROMATRA: a Galaxy tool for visualizing genome-wide chromatin signatures. Bioinformatics. 2012 Mar 1;28(5):717-8.
  • Schulze JM*, Hentrich T*, Nakanishi S, Gupta A, Emberly E, Shilatifard A, Kobor MS. Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123. Genes Dev. 2011 Nov 1;25(21):2242-7.
  • Lenstra TL, Benschop JJ, Kim T, Schulze JM, Brabers NA, Margaritis T, van de Pasch LA, van Heesch SA, Brok MO, Groot Koerkamp MJ, Ko CW, van Leenen D, Sameith K, van Hooff SR, Lijnzaad P, Kemmeren P, Hentrich T, Kobor MS, Buratowski S, Holstege FC. The specificity and topology of chromatin interaction pathways in yeast. Mol Cell. 2011 May 20;42(4):536-49.
  • Takahashi YH*, Schulze JM*, Jackson J, Hentrich T, Seidel C, Jaspersen SL, Kobor MS, Shilatifard A. Dot1 and histone H3K79 methylation in natural telomeric and HM silencing. Mol Cell. 2011 Apr 8;42(1):118-26.
  • Schulze JM, Kane CM, Ruiz-Manzano A. The YEATS domain of Taf14 in Saccharomyces cerevisiae has a negative impact on cell growth. Mol Genet Genomics. 2010 Apr;283(4):365-80.
  • Wang AY*, Schulze JM*, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. PNAS. 2009 Dec 22;106(51):21573-8
  • Schulze JM*, Jackson J*, Nakanishi S, Gardner JM, Hentrich T, Haug J, Johnston M, Jaspersen SL, Kobor MS, Shilatifard A. Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell. 2009 Sep 11;35(5):626-41.
  • Schulze JM. Deleterious mutation in GPSM2 identified as cause for nonsyndromic deafness. Clin Genet. 2011 Jan;79(1):44-5.
  • Schulze JM*, Wang AY*, Kobor MS. Reading chromatin: insights from yeast into YEATS domain structure and function. Epigenetics. 2010 Oct 1;5(7):573-7.
  • Schulze JM. LRTOMT: a new tone in understanding the symphony of non-syndromic deafness. Clin Genet. 2009 Mar;75(3):227-9.
  • Schulze JM, Wang AY, Kobor MS. YEATS domain proteins: a diverse family with many links to chromatin modification and transcription. Biochem Cell Biol. 2009 Feb;87(1):65-75.
  • Publikationen
  • Epigenetik des Menschen (3158)
  • Epigenetics in the nervous system
  • Human- und Molekulargenetik
  • Molekulare Humangenetik
  • Grundlagen der Humangenetik
  • Journal Club