Das Klinikum

PD Dr. rer. nat. Monika Schütz

PD Dr. rer. nat. Monika Schütz

Wissenschaftliche Mitarbeiterin, Arbeitsgruppenleiterin


Telefonnummer: 07071 29-81527

E-Mail-Adresse: monika.schuetz@med.uni-tuebingen.de

  • Med. Mikrobiologie
  • Forschung zur Biogenese von Autotransporter-Adhäsinen Gram-negativer Pathogene,
    Entwicklung neuer Therapeutika zur Behandlung multiresistenter Gram-negativer Pathogene
    Resistenzmechanismen und -entwicklung
  • 2000Studium der Biologie an der Universität Würzburg, Abschluss Diplom-Biologin
  • 2005Promotion an der Universität Würzburg zum Dr. rer. nat.
  • seit 2005Mitarbeiterin am Institut für Medizinische Mikrobiologie und Hygiene
  • 2009Nachwuchsgruppenleiterin
  • 2005-2014Wissenschaftliche Leitung der IZKF (Interdisziplinäres Zentrum für Klinische Forschung)-Serviceeinheit für Laser Capture Microdissection
  • 2019Habilitation
  • seit 04/2022in Weiterbildung zur Fachmikrobiologin
  • aktuellArbeitsgruppenleiterin am Institut für Medizinische Mikrobiologie und Hygiene/Interfakultären Institut für Mikrobiologie und Infektionsmedizin Tübingen (IMIT)
  • 2019 Förderpreis der Deutschen Gesellschaft für Hygiene und Mikrobiologie
  • Lührs, H., R. Hock, J. Schauber, M. Weihrauch, M. Harrer, R. Melcher, W. Scheppach, M. Bustin, and T. Menzel. 2002. Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cells. Int J Cancer 97:567-573.
  • Harrer, M., H. Lührs, M. Bustin, U. Scheer, and R. Hock. 2004. Dynamic interaction of HMGA1a proteins with chromatin. J Cell Sci 117:3459-3471.
  • Hock, R., F. Witte, J. Brocher, M. Schütz, and U. Scheer. 2006. Expression of HMGA2 variants during oogenesis and early embryogenesis of Xenopus laevis. Eur J Cell Biol 85:519-528.
  • Grosskinsky, U.*, M. Schütz*, M. Fritz, Y. Schmid, M. C. Lamparter, P. Szczesny, A. N. Lupas, I. B. Autenrieth, and D. Linke. 2007. A conserved glycine residue of trimeric autotransporter domains plays a key role in Yersinia adhesin A autotransport. J Bacteriol 189:9011-9019.
  • Köberle, M., A. Klein-Günther, M. Schütz, M. Fritz, S. Berchtold, E. Tolosa, I. B. Autenrieth, and E. Bohn. 2009. Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model. PLoS Pathog 5:e1000551.
  • Cornejo Castro, E. M., J. Waak, S. S. Weber, F. C. Fiesel, P. Oberhettinger, M. Schütz, I. B. Autenrieth, W. Springer, and P. J. Kahle. 2010. Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. J Neural Transm 117:599-604.
  • Lehr, U.*, M. Schütz*#, P. Oberhettinger, F. Ruiz-Perez, J. W. Donald, T. Palmer, D. Linke, I. R. Henderson, and I. B. Autenrieth. 2010. C-terminal amino acid residues of the trimeric autotransporter adhesin YadA of Yersinia enterocolitica are decisive for its recognition and assembly by BamA. Mol Microbiol 78:932-946.
  • Schulz, M. M., M. G. Buschner, R. Leidig, H. D. Wehner, P. Fritz, K. Habig, M. Bonin, M. Schütz, T. Shiozawa, and F. Wehner. 2010. A new approach to the investigation of sexual offenses-cytoskeleton analysis reveals the origin of cells found on forensic swabs. J Forensic Sci 55: 492-498.
  • Schütz, M. #, E. M. Weiss, M. Schindler, T. Hallström, P. F. Zipfel, D. Linke, and I. B. Autenrieth. 2010. Trimer stability of YadA is critical for virulence of Yersinia enterocolitica. Infect Immun 78:2677-2690.
  • Doppler, K., A. Lindner, W. Schütz, M. Schütz, and A. Bornemann. 2011. Gain and loss of extracellular molecules in sporadic inclusion body myositis and polymyositis--a proteomics-based study. Brain Pathol 22:32-40.
  • Müller, J. E., D. Papic, T. Ulrich, I. Grin, M. Schütz, P. Oberhettinger, J. Tommassen, D. Linke, K. S. Dimmer, I. B. Autenrieth, and D. Rapaport. 2011. Mitochondria can recognize and assemble fragments of a beta-barrel structure. Mol Biol Cell 22:1638-1647.
  • Oberhettinger, P., M. Schütz, G. Raddatz, H. Keller, I. B. Autenrieth, and D. Linke. 2011. The sequence of the pYV virulence plasmid from Yersinia enterocolitica strain WA-314 biogroup 1B serotype O:8. Plasmid 65:20-24.
  • Höring, S., M. Schütz, I. B. Autenrieth, and S. Gröbner. 2012. Lysozyme facilitates adherence of Enterococcus faecium to host cells and induction of necrotic cell death. Microbes Infect 14:554-62.
  • Schindler M.K.-H.*, M. Schütz*#, M.C. Mühlenkamp, S.H.M. Rooijakkers, T. Hallström, P.F. Zipfel, I.B. Autenrieth. 2012. Yersinia enterocolitica YadA mediates complement evasion by recruitment and inactivation of C3b. J Immunol 189:4900-8.
  • P. Oberhettinger*, M. Schütz*#, N. Heinz, J.C. Leo, J. Berger, I.B. Autenrieth, D. Linke# 2012. Intimin and invasin export their C-terminus to the bacterial cell surface using an inverse mechanism compared to classical autotransport. PLoS One 7:e47069.
  • Grin, I., Hartmann, M. D., Sauer, G., Hernandez Alvarez, B., Schütz, M., Madlung, J., Macek, B., Felipe-Lopez, A., Hensel, M., Lupas, A. & Linke, D. (2013). A Trimeric Lipoprotein assists in Trimeric Autotransporter Biogenesis in Enterobacteria. J Biol Chem. doi: 10.1074/jbc.M113.513275 jbc.M113.513275
  • Albrecht, R., M. Schütz, P. Oberhettinger, M. Faulstich, I. Bermejo, T. Rudel, K. Diederichs and K. Zeth. 2014 Crystal Structure of BamA, an Essential Factor of Outer Membrane Protein Biogenesis. Acta Cryst. D
  • Ulrich, T., P. Oberhettinger, M. Schütz, K. Holzer, A. S. Ramms, D. Linke, I. B. Autenrieth, and D. Rapaport. 2014. Evolutionary Conservation in Biogenesis of beta‐Barrel Proteins Allows Mitochondria to Assemble a Functional Bacterial Trimeric Autotransporter Protein. J Biol Chem. 289:29457‐70.
  • Leo, J. C., P. Oberhettinger, M. Chaubey, M. Schütz, D. Kühner, U. Bertsche, H. Schwarz, F. Götz, I. B. Autenrieth, M. Coles, and D. Linke. 2014. The Intimin periplasmic domain mediates dimerisation and binding to peptidoglycan. Mol Microbiol. 95:80‐100.
  • Oberhettinger, P., J. C. Leo, D. Linke, I. B. Autenrieth, and M. S. Schütz#. 2015. The Inverse Autotransporter Intimin Exports its Passenger Domain via a Hairpin Intermediate. J Biol Chem. 290:1837‐49.
  • Keller, B.*, M. Mühlenkamp, E. Deuschle, A. Siegfried, S. Mössner, J. Schade, T. Griesinger, N. Katava, C. Braunsdorf, B. Fehrenbacher, L. F. Jiménez‐Soto, M. Schaller, R. Haas, H. Genth, S. F. Retta, H. Meyer, R. T. Böttcher, R. Zent, M. Schütz*, I. B. Autenrieth*, and E. Bohn*. Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell Micro.2015. doi: 10.1111/cmi.12429.
  • Deuschle, E., B. Keller, A. Siegfried, B. Manncke, T. Spaeth, M. Köberle, D. Drechsler-Hake, J. Reber, R. T. Böttcher, S. E. Autenrieth, I. B. Autenrieth, E. Bohn*, and M. Schütz*. 2015. Role of beta1 integrins and bacterial adhesins for Yop injection into leukocytes in Yersinia enterocolitica systemic mouse infection. Int J Med Microbiol. doi:10.1016/j.ijmm.2015.12.001
  • Willmann, M., M. El-Hadidi, D. H. Huson, M. Schütz, C. Weidenmaier, I. B. Autenrieth, and S. Peter. 2015. Antibiotic Selection Pressure Determination through Sequence-Based Metagenomics. Antimicrobial agents and chemotherapy 59: 7335-7345.
  • Wiehr, S., P. Warnke, A. M. Rolle, M. Schütz, P. Oberhettinger, U. Kohlhofer, L. Quintanilla-Martinez, A. Maurer, C. Thornton, F. Boschetti, G. Reischl, I. B. Autenrieth, B. J. Pichler and S. E. Autenrieth. 2016. "New pathogen-specific immunoPET/MR tracer for molecular imaging of a systemic bacterial infection." Oncotarget 7(10): 10990-11001.
  • Drechsler-Hake, D., H. Alamir, J. Hahn, M. Gunter, S. Wagner, M. Schütz, E. Bohn, K. Schenke-Layland, F. Pisano, P. Dersch, I. B. Autenrieth and S. E. Autenrieth. 2016. Mononuclear phagocytes contribute to intestinal invasion and dissemination of Yersinia enterocolitica. Int J Med Microbiol 306(6): 357-366.
  • Curkic, I., M. Schütz, P. Oberhettinger, M. Diard, M. Claassen, D. Linke and W. D. Hardt. 2016. Epitope-Tagged Autotransporters as Single-Cell Reporters for Gene Expression by a Salmonella Typhimurium wbaP Mutant. PLoS One 11(5): e0154828.
  • Leo, J. C., P. Oberhettinger, S. Yoshimoto, D. B. Udatha, J. P. Morth, M. Schütz, K. Hori and D. Linke 2016. "Secretion of the Intimin Passenger Domain Is Driven by Protein Folding." J Biol Chem 291(38): 20096-20112.
  • Pfitzner A.K., N. Steblau, T. Ulrich, P. Oberhettinger, I.B. Autenrieth, M. Schütz, and Doron Rapaport. 2016. Mitochondrial-bacterial hybrids of BamA/Tob55 suggest variable requirements for the membrane integration of β-barrel proteins. Scientific Reports Article number: 39053, doi:10.1038/srep39053.
  • Mühlenkamp, M. C., T. Hallström, I. B. Autenrieth, E. Bohn, D. Linke, J. Rinker, K. Riesbeck, B. Singh, J. C. Leo, S. Hammerschmidt, P. F. Zipfel and M. S. Schütz 2017. Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction. J Innate Immun 9(1): 33-51.
  • Weirich, J., C. Bräutigam, M. Mühlenkamp, M. Franz-Wachtel, B. Macek, I. Meuskens, M. Skurnik, K. Leskinen, E. Bohn, I. Autenrieth and M. Schütz# (2017). "Identifying components required for OMP biogenesis as novel targets for antiinfective drugs." Virulence: 1-20.
  • Gerst F., B.A. Jaghutriz, H. Staiger, A.M. Schulte, E. Lorza-Gil, G. Kaiser, M. Panse, S. Haug, M. Heni, M. Schütz, M. Stadion, A. Schürmann, F. Marzetta, M. Ibberson, B. Sipos, F. Fend, T. Fleming, P.P. Nawroth, A. Königsrainer, S. Nadalin, S. Wagner, A. Peter, A. Fritsche, D. Richter, M. Solimena, H.-U. Häring, S. Ullrich and Robert Wagner (2018). "The Expression of Aldolase B in Islets is Negatively Associated with Insulin Secretion in Humans." The Journal of Clinical Endocrinology & Metabolism (accepted manuscript).
  • Mühlenkamp M., P. Oberhettinger, J.C. Leo, D. Linke & M. Schütz#. YadA beauty & beast. 2015. Int J Med Microbiol. 305(2):252‐8. doi: 10.1016/j.ijmm.2014.12.008.
  • Leo, J. C., P. Oberhettinger, M. Schütz, and D. Linke. The inverse autotransporter family: Intimin, invasin and related proteins. 2015. Int J Med Microbiol pii: S1438‐4221(14)00170‐2. doi: 10.1016/j.ijmm.2014.12.011.
  • Klein, K., M.S. Sonnabend, L. Frank, K. Leibiger, M. Franz-Wachtel, B. Macek, T. Trunk, J.C. Leo, I.B. Autenrieth, M. Schütz, and E. Bohn, Deprivation of the Periplasmic Chaperone SurA Reduces Virulence and Restores Antibiotic Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa. Front Microbiol, 2019. 10: p. 100. DOI: 10.3389/fmicb.2019.00100.
  • Hahn, J., M. Günter, J. Schuhmacher, K. Bieber, S. Pöschel, M. Schütz, B. Engelhardt, H. Oster, C. Sina, T. Lange, and S.E. Autenrieth, Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice. Brain Behav Immun, 2020. 87: p. 329-338. DOI: 10.1016/j.bbi.2020.01.001.
  • Sonnabend, M.S., K. Klein, S. Beier, A. Angelov, R. Kluj, C. Mayer, C. Gross, K. Hofmeister, A. Beuttner, M. Willmann, S. Peter, P. Oberhettinger, A. Schmidt, I.B. Autenrieth, M. Schütz, and E. Bohn, Identification of Drug Resistance Determinants in a Clinical Isolate of Pseudomonas aeruginosa by High-Density Transposon Mutagenesis. Antimicrob Agents Chemother, 2020. 64(3). DOI: 10.1128/AAC.01771-19.
  • Rooke, J.L., C. Icke, T.J. Wells, A.E. Rossiter, D.F. Browning, F.C. Morris, J.C. Leo, M.S. Schütz, I.B. Autenrieth, A.F. Cunningham, D. Linke, and I.R. Henderson, BamA and BamD Are Essential for the Secretion of Trimeric Autotransporter Adhesins. Front Microbiol, 2021. 12: p. 628879. DOI: 10.3389/fmicb.2021.628879.
  • Birkle, K., F. Renschler, A. Angelov, G. Wilharm, M. Franz-Wachtel, B. Macek, E. Bohn, E. Weber, J. Müller, L. Friedrich, and M. Schütz, An Unprecedented Tolerance to Deletion of the Periplasmic Chaperones SurA, Skp, and DegP in the Nosocomial Pathogen Acinetobacter baumannii. J Bacteriol, 2022. 204(10): p. e0005422. DOI: 10.1128/jb.00054-22.
  • Geissert, J.K., E. Bohn, R. Mostolizadeh, A. Dräger, I.B. Autenrieth, S. Beier, O. Deusch, A. Renz, M. Eichner, and M.S. Schütz, A Computational Model of Bacterial Population Dynamics in Gastrointestinal Yersinia enterocolitica Infections in Mice. Biology (Basel), 2022. 11(2). DOI: 10.3390/biology11020297.
  • Eggers, O., F.A. Renschler, L.A. Michalek, N. Wackler, E. Walter, F. Smollich, K. Klein, M.S. Sonnabend, V. Egle, A. Angelov, C. Engesser, M. Borisova, C. Mayer, M. Schütz, and E. Bohn, YgfB increases beta-lactam resistance in Pseudomonas aeruginosa by counteracting AlpA-mediated ampDh3 expression. Commun Biol, 2023. 6(1): p. 254. DOI: 10.1038/s42003-023-04609-4.
  • Publikationen
  • WPV Praktische Infektiologie: Diagnostik, Therapie, Forschung für Studierende der Humanmedizin
  • W5 Grundlagen der Infektionsbiologie für Studierende der Biologie, Molekularen Medizin, Biochemie
  • Modul: Grundlagen der Infektionsbiologie Teilveranstaltung Vorlesung für Studierende der Biologie, Molekularen Medizin, Biochemie
  • W-Schiene: Mechanismen der Pathogenität von Mikroorganismen für Studierende der Biologie
  • Laborpraktikum Infektionsbiologie für Studierende der Biologie, Molekularen Medizin, Biochemie
  • TüREX
  • Bachelor- und Masterarbeiten (Biologie, Biochemie, Mol. Medizin), Doktorarbeiten (Dr. med., Dr. rer. nat.)
  • DGHM Fachgruppe Mikrobielle Pathogenität