New Science Advances paper by the group of Julia Sbierski-Kind

We are excited to share our new paper in Science Advances, which highlights how type 2 and type 3 lymphocytes interact with fibroblast niches to shape liver repair and fibrosis. Combining mouse models of liver injury with advanced three-dimensional imaging and spatial transcriptomics, we uncovered a spatially organized cellular network in which type 2 lymphocytes help restrain pro-fibrotic type 3 immune responses, thereby balancing beneficial tissue repair with pathological scarring. Our findings identify a previously unrecognized immune–stromal communication circuit that can protect against fibrosis but, when disrupted, contributes to chronic liver disease. This work offers new insight into the cellular organization of tissue remodeling and may help guide future therapeutic strategies for liver fibrosis.

Reference:

• Julia Sbierski-Kind et al., Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches.Sci. Adv.12,eaea6805(2026). https://doi.org/10.1126/sciadv.aea6805