The issue how tumors evade the immune system and why immune cells fail to control tumor progression are questions which fascinate scientific researchers for many years. The Ca2+/NFAT signaling pathway, which is the focus of our scientific interest, was identified to play an important role in tumor cell biology acting as tumor suppressor as well as oncogene in a large variety of tumor entities. Furthermore, it tightly regulates activation and proliferation of immune cells, thereby also modulating recognition of tumor cells.
Our work is aimed to elucidate the role of NFAT transcription factors in the context of the
- molecular mechanisms regulating NK cell reactivity
- immunosurveillance of CLL and resistance to NK cell mediated killing
- modulation of leukemic cell recognition by immune cells