Das Klinikum
Prof. Dr. med. Peter Lang
Stellvertretender ärztlicher Direktor Abteilung I, Bereichsleiter Stammzelltransplantation
Kontakt
Telefonnummer: 07071 29-85770
Faxnummer: 07071 29-5481
E-Mail-Adresse: peter.lang@med.uni-tuebingen.de
Klinik / Institut / Zentrum
Klinische Schwerpunkte
- Pädiatrische Hämatologie / Onkologie, Stammzelltransplantation, Immuntherapie
Zur Person
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Clinical and Research interests
Stem cell transplantation and ex vivo graft manipulation procedures: •CD34 selection, •T cell depletion strategies, •transfer of antigen specific T cells) Immunotherapy: • Antibody-based immunotherapy • Peptide vaccination • Adoptive transfer of T cells and NK cells • Clinical studies. • Our research focusses on the development and improvement of new and existing immunotherapeutic approaches for both hematological malignancies and solid tumors in pediatric patients. Of special interest is the translation into the clinical setting, reflected by a broad range of clinical studies. Currently, our antibody-based studies include antibodies fused to stimulating cytokines (immunocytokines) and a tri-specific antibody construct directed against tumor antigens like CD276 (B7-H3), GD2 or CD33/123, both recruiting effector NK cells to elicit ADCC. A bi-specific construct engaging effector T cells is under investigation as well. Furthermore, in an investigator-initiated trial (NCT02258815) which is currently continued in the form of a registry, we are evaluating the addition of an anti-GD2 antibody post-alloHSCT in patients with relapsed neuroblastoma. This approach significantly increased EFS in neuroblastoma patients. Another study which involves an optimized anti-CD19 mAb for treatment of BCP-ALL, was recently initiated. Within a compassionate use program at our institution this antibody has already proven to significantly reduce MRD after haploHSCT. In our IVAC-ALL-1 study in relapsed ALL patients, patient-individualized peptide vaccines were used to stimulate T cells. Subsequent immunomonitoring revealed immunogenicity of selected peptides and induction of specific T cell responses in these patients. Based on these promising results and analogous to our study, the IVAC-RCC trial was recently initiated in Heilbronn for which we will perform immunomonitoring of T cell responses. Furthermore, we are evaluating the use of autologous transgenic T cells designed to specifically target CMV, ADV and EBV antigens. An adoptive transfer of such T cells might be of great importance during immune reconstitution in the post autoHSCT setting which is commonly characterized with an increased risk for reactivation of latent viral infections.
Wissenschaftliche Tätigkeit
- Stem cell transplantation and ex vivo graft manipulation procedures: •CD34 selection, •T cell depletion strategies, •transfer of antigen specific T cells)
- Immunotherapy: • Antibody-based approaches (neuroblastoma, leukemia) • Peptide vaccination • Adoptive transfer of T cells and NK cells • Clinical studies.
- h-index: 52
- impact factor (cumulative): 1589
- Total number of publications: 256
Ausbildung & beruflicher Werdegang
- 1999 – 2009Senior physician (Specialist for Pediatric Hematology/Oncology)
- 2005 – presentMedical director of the laboratory for graft engineering and immunophenotyping, University Children’s Hospital Tübingen
- 2009 – presentAssociate Professor and head of the Pediatric stem cell transplantation unit, University Children’s Hospital Tübingen.
- 2012 – 03/2021Deputy medical Director of the Department of General Pediatrics and Hematology/ Oncology, University Children’s Hospital Tübingen.
- 04/2021 – 04/23Acting Medical Director of the Department of General Pediatrics and Hematology/ Oncology, University Children’s Hospital Tübingen
- 04/23-presentDeputy medical Director of the Department of General Pediatrics and Hematology/ Oncology, head of stem cell transplantation unit
Publikationen
- Arendt AM, Heubach F, Maier CP, Giardino S, Jung G, Kowalewski E, Rabsteyn A, Amorelli G, Seitz C, Schlegel P, Handgretinger R, Lang P. Targeting GD2 after allogeneic SCT: effector cell composition defines the optimal use of ch14.18 and the bispecific antibody construct NG-CU (GD2-CD3). (2023) Cancer Immunol Immunother. 72, 3813-24.
- Heinz AT, Calkoen FGJ, Derbich A, Miltner L, Seitz C, Doering M, Braun C, Atar D, Schumm M, Heubach F, Arendt AM, Schulz A, Schuster FR, Meisel R, Strahm B, Finke J, Heineking B, Stetter S, Silling G, Stachel D, Gruhn B, Debatin KM, Foell J, Schulte JH, Woessmann W, Mauz-Körholz C, Tischer J, Feuchtinger T, Handgretinger R, Lang P. Automated production of specific T cells for treatment of refractory viral infections after allogeneic stem cell transplantation. Haematologica. 108, 2080-90
- Eichholz T, Doring M, Giardino S, Gruhn B, Seitz C, Flaadt T, Schwinger W, Ebinger M, Holzer U, Mezger M, Teltschik HM, Sparber-Sauer M, Koscielniak E, Abele M, Handgretinger R, Lang P. Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas. (2023) Front Oncol. 13, 1064190.
- Flaadt T, Ladenstein RL, Ebinger M, Lode HN, Arnardottir HB, Poetschger U, Schwinger W, Meisel R, Schuster FR, Doring M, Ambros PF, Queudeville M, Fuchs J, Warmann SW, Schafer J, Seitz C, Schlegel P, Brecht IB, Holzer U, Feuchtinger T, Simon T, Schulte JH, Eggert A, Teltschik HM, Illhardt T, Handgretinger R, Lang P. Anti-GD2 Antibody Dinutuximab Beta and Low-Dose Interleukin 2 After Haploidentical Stem-Cell Transplantation in Patients With Relapsed Neuroblastoma: A Multicenter, Phase I/II Trial. (2023) J Clin Oncol. JCO2201630.
- Handgretinger R, Lang P. Could (should) we abandon total body irradiation for conditioning in children with leukemia. (2022) Blood Rev. 56, 100966
- Handgretinger R, Arendt AM, Maier CP, Lang P. Ex vivo and in vivo T-cell depletion in allogeneic transplantation: towards less or non-cytotoxic conditioning regimens. (2022) Expert Rev Clin Immunol. 18, 1285-96
- Maier C, Heubach F, Herrmann S, Kummerle P, Arendt A, Rabsteyn A, Fey GH, Peipp M, Lengerke C, Bethge W, Handgretinger R, Lang P. Effective lysis of MOLM-13 and AML blasts by triplebody spm-2 (cd123-16-33) in combination with subsets of nk cells. (2022) Bone Marrow Transplant. 57, 336-7.
- Bethge WA, Eyrich M, Mielke S, Meisel R, Niederwieser D, Schlegel PG, Schulz A, Greil J, Bunjes D, Brecht A, Kuball J, Schumm M, Vucinic V, Wiesneth M, Bonig H, Westinga K, Biedermann S, Holtkamp S, Karitzky S, Malchow M, Siewert C, Handgretinger R, Lang P. Results of a multicenter phase I/II trial of TCRalphabeta and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients. (2022) Bone Marrow Transplant. 57, 423-30
- Seitz, C. M., Eyrich, M., Greil, J., Schlegel, P., Feuchtinger, T., Bader, P., Ebinger, M., Schwarze, C. P., Schlegel, P. G., Schumm, M., Handgretinger, R. and Lang, P. (2018) Favorable immune recovery and low rate of GvHD in children transplanted with partially T cell-depleted PBSC grafts. Bone Marrow Transplant.
- Thiel U, Schober SJ, Ranft A, Gassmann H, Jabar S, Gall K, von Lüttichau I, Wawer A, Koscielniak E, Diaz MA, Ussowicz M, Kazantsev I, Afanasyev B, Merker M, Klingebiel T, Prete A, Gruhn B, Bader P, Jürgens H, Dirksen U, Handgretinger R, Burdach S, Lang P. (2021) No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease. Bone Marrow Transplant doi: 10.1038/s41409-020-01200-x
- Lang P, Eichholz T, Bakchoul T, Streiter M, Petrasch M, Bösmüller H, Klein R, Rabsteyn A, Lang AM, Adams C, Klingel K, Gessner M, Rosenberger P, Ruef P, Handgretinger R. (2020) Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients. J Pediatric Infect Dis Soc. 9(5):622-625. doi: 10.1093/jpids/piaa117.
- Schlegel P, Lang AM, Matela M, Horrer A, Schilling A, Jochner A, Wiedenmann M, Seitz C, Doring M, Feuchtinger T, Heubach F, Rabsteyn A, Handgretinger R, Lang P. (2019) Ex vivo expansion of autologous, donor-derived NK-, gammadeltaT-, and cytokine induced killer (CIK) cells post haploidentical hematopoietic stem cell transplantation results in increased antitumor activity. Bone Marrow Transplant. 54 (Suppl 2):727-32.
- llhardt, T., Toporski, J., Feuchtinger, T., Turkiewicz, D., Teltschik, H. M., Ebinger, M., Schwarze, C. P., Holzer, U., Lode, H. N., Albert, M. H., Gruhn, B., Urban, C., Dykes, J. H., Teuffel, O., Schumm, M., Handgretinger, R. and Lang, P. (2018) Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma. Biol Blood Marrow Transplant. 24, 1005-1012
- Mainardi, C., Ebinger, M., Enkel, S., Feuchtinger, T., Teltschik, H. M., Eyrich, M., Schumm, M., Rabsteyn, A., Schlegel, P., Seitz, C., Schwarze, C. P., Muller, I., Greil, J., Bader, P., Schlegel, P. G., Martin, D., Holzer, U., Doring, M., Handgretinger, R. and Lang, P. (2018) CD34(+) selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation. Br J Haematol. 180, 90-99
- Teltschik, H. M., Heinzelmann, F., Gruhn, B., Feuchtinger, T., Schlegel, P., Schumm, M., Kremens, B., Muller, I., Ebinger, M., Schwarze, C. P., Ottinger, H., Zips, D., Handgretinger, R. and Lang, P. (2016) Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients. Br J Haematol. 175, 115-122.
- Seidel, U. J., Schlegel, P., Grosse-Hovest, L., Hofmann, M., Aulwurm, S., Pyz, E., Schuster, F. R., Meisel, R., Ebinger, M., Feuchtinger, T., Teltschik, H. M., Witte, K. E., Schwarze, C. P., Rammensee, H. G., Handgretinger, R., Jung, G. and Lang, P. (2016) Reduction of Minimal Residual Disease in Pediatric B-lineage Acute Lymphoblastic Leukemia by an Fc-optimized CD19 Antibody. Mol Ther. 24, 1634-1643
- Lang, P., Feuchtinger, T., Teltschik, HM., Schwinger, W., Schlegel, P., Pfeiffer, M., Schumm, M., Lang, AM., Lang, B., Schwarze, CP., Ebinger, M., Urban, C., Handgretinger, R.(2015) Improved immune recovery after transplantation of TCRαβ/CD19-depleted allografts from haploidentical donors in pediatric patients. Bone Marrow Transplant. 50 Suppl 2, 6-10
- Schlegel, P., Feuchtinger, T., Nitschke-Gérard, C., Seidel, UJ., Lang, AM., Kyzirakos, C., Teltschik, HM., Ebinger, M., Schumm, M., Koscielniak, E., Handgretinger, R., Lang, P. (2015) Favorable NK cell activity after haploidentical hematopoietic stem cell transplantation in stage IV relapsed Ewing's sarcoma patients. Bone Marrow Transplant. 50 Suppl 2, 72-6.
- Lang, P., Teltschik, H. M., Feuchtinger, T., Muller, I., Pfeiffer, M., Schumm, M., Ebinger, M., Schwarze, C. P., Gruhn, B., Schrauder, A., Albert, M. H., Greil, J., Urban, C. and Handgretinger, R. (2014) Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia. Br J Haematol. 165, 688-698
- Illhardt, T., Ebinger, M., Schwarze, C. P., Feuchtinger, T., Furtwangler, R., Schlegel, P. G., Klingebiel, T., Greil, J., Beck, J. F., Handgretinger, R. and Lang, P. (2014) Children with Relapsed or Refractory Nephroblastoma: Favorable Long-term Survival after High-dose Chemotherapy and Autologous Stem Cell Transplantation. Klin Padiatr. 226, 351-356
- Seidel, U. J., Vogt, F., Grosse-Hovest, L., Jung, G., Handgretinger, R. and Lang, P. (2014) γδ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity with CD19 Antibodies Assessed by an Impedance-Based Label-Free Real-Time Cytotoxicity Assay. Front Immunol. 5, 618
- Pfeiffer, MM., Burow, H., Schleicher, S., Handgretinger, R., Lang, P. (2013) Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia. Front Oncol.3,99
- Seidel, UJ., Schlegel, P., Lang, P. (2013) Natural killer cell mediated antibody-dependent cellular cytotoxicity in tumor immunotherapy with therapeutic antibodies. Front Immunol. 4; 76
- Pfeiffer, M., Schumm, M., Müller, I., Handgretinger, R., Lang, P. (2012) IL-15-stimulated CD3/CD19-depleted stem-cell boosts in relapsed pediatric patients after haploidentical SCT Leukemia 26, 2435-9.
- Pfeiffer, M., Feuchtinger, T., Teltschik, HM., Schumm, M., Müller, I., Handgretinger, R., Lang, P. (2010) Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children. Haematologica. 95, 1381-1388
- Feuchtinger, T., Richard, C., Joachim, S., Scheible, M.H., Schumm, M., Hamprecht, K., Martin, D., Jahn, G., Handgretinger, R., and Lang, P. (2008) Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation. J.Immunother. 31, 199-206
- Lang, P., Barbin,K., Feuchtinger,T., Greil,J., Peipp,M., Zunino,S.J., Pfeiffer,M., Handgretinger,R., Niethammer,D. and Fey,G.H. (2004) Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effectors from pediatric patients transplanted with T cell depleted allografts. Blood, 15; 3982-3985
- Lang, P., Handgretinger,R., Niethammer,D., Schlegel,P.G., Schumm,M., Greil,J., Bader,P., Engel,C., Scheel-Walter,H., Eyrich,M. and Klingebiel,T. (2003) Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia. Blood, 101, 1630-1636
- Schlegel, P., Teltschik, HM., Pfeiffer, M., Handgretinger, R., Schumm, M., Koscielniak, E., Feuchtinger, T., Klingebiel, T., Bader, P., Schlegel, PG., Greil, J., Lang, P. (2011) Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children. Best Pract Res Clin Haematol. 24, 443-52.
- Lang, P., Pfeiffer, M., Teltschik, HM., Pflugrad, U., Feuchtinger, T., Ebinger, M., Klingebiel, T., Bader, P., Schlegel, P-G., Beck, J., Greil, J., Handgretinger, R. (2011) Natural Killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors. Best Pract Res Clin Haematol. 24, 403-11.
- Feuchtinger, T., Opherk, K., Bicanic, O., Schumm, M., Grigoleit, GU., Hamprecht, K., Jahn, G., Handgretinger, R. and Lang, P. (2010) Dendritic cell vaccination in an allogeneic stem cell recipient receiving a transplant from a human cytomegalovirus (HCMV)-seronegative donor: induction of a HCMV-specific T(helper) cell response. Cytotherapy., 12, 945-950.
- Rettinger, E., Schumm, M., Pfeiffer, M., Kuçi, S., Willasch, A., Handgretinger, R., Niethammer, D., Lang, P. (2010) Identification and selective depletion of alloreactive T-cells for adoptive immunotherapy. Lab Hematol. 16, 8-22.
- Feuchtinger, T., Pfeiffer, M., Pfaffle, A., Teltschik, H.M., Wernet, D., Schumm, M., Lotfi, R., Handgretinger, R., and Lang, P. (2009) Cytolytic activity of NK cell clones against acute childhood precursor-B-cell leukaemia is influenced by HLA class I expression on blasts and the differential KIR phenotype of NK clones. Bone Marrow Transplant 43, 875-881
- Lang, P. and Handgretinger, R. (2008) Haploidentical SCT in children: an update and future perspectives. Bone Marrow Transplant. 42 Suppl 2, S54-S59
- Handgretinger, R. and Lang, P. (2008) The history and future prospective of haplo-identical stem cell transplantation. Cytotherapy 10, 443-451
- Lang, P., Mueller, I., Greil, J., Bader, P., Schumm, M., Pfeiffer, M., Hoelle, W., Klingebiel, T., Heinzelmann, F., Belka, C., Schlegel, P.G., Kremens, B., Woessmann, W., and Handgretinger, R. (2008) Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients. Blood Cells Mol Dis 40, 33-39
- Handgretinger, R., Chen, X., Pfeiffer, M., Mueller, I., Feuchtinger, T., Hale, G.A., and Lang, P. (2007) Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation. Ann.N.Y.Acad.Sci. 1106, 279-289
- Pfeiffer, M., Schumm, M., Feuchtinger, T., Dietz, K., Handgretinger, R., and Lang, P. (2007) Intensity of HLA class I expression and KIR-mismatch determine NK-cell mediated lysis of leukaemic blasts from children with acute lymphatic leukaemia. Br.J.Haematol. 138, 97-100
- Schumm, M., Feuchtinger, T., Pfeiffer, M., Hoelle, W., Bethge, W., Ebinger, M., Kuci, S., Handgretinger, R., and Lang, P. (2007) Flow cytometry with anti HLA-antibodies: a simple but highly sensitive method for monitoring chimerism and minimal residual disease after HLA-mismatched stem cell transplantation. Bone Marrow Transplant 39, 767-773
- Feuchtinger T, Matthes-Martin S, Richard C, Lion T, Fuhrer M, Hamprecht K, Handgretinger R, Peters C, Schuster FR, Beck R, Schumm M, Lotfi R, Jahn G, and Lang P. (2006) Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 134;64-76
- Lang, P., Pfeiffer, M., Muller, I., Schumm, M., Ebinger, M., Koscielniak, E., Feuchtinger, T., Foll, J., Martin, D., and Handgretinger, R. (2006) Haploidentical stem cell transplantation in patients with pediatric solid tumors: preliminary results of a pilot study and analysis of graft versus tumor effects. Klin.Padiatr. 218, 321-326
- Schumm, M., Handgretinger, R., Pfeiffer, M., Feuchtinger, T., Kuci, S., Faul, C., Vogel, W., Bethge, W., and Lang, P. (2006) Determination of residual T- and B-cell content after immunomagnetic depletion: proposal for flow cytometric analysis and results from 103 separations. Cytotherapy. 8, 465-472
- Feuchtinger, T., Lucke, J., Hamprecht, K., Richard, C., Handgretinger, R., Schumm, M., Greil, J., Bock, T., Niethammer, D., and Lang, P. (2005) Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation. Br.J.Haematol. 128, 503-509
- Feuchtinger, T., Richard, C., Pfeiffer, M., Neuhauser, F., Lucke, J., Handgretinger, R., Greil, J., Bader, P., Klingebiel, T., Schlegel, P.G., Jahn, G., Niethammer, D., and Lang, P. (2005) Adenoviral infections after transplantation of positive selected stem cells from haploidentical donors in children: an update. Klin.Padiatr. 217, 339-344
- Lang, P., Greil J., Bader P., Schumm M., Handgretinger R., Klingebiel T., Schlegel P.G., Beck J.F., Scheel-Walter H.G. and Niethammer D. (2005) Bearbeitung und Transplantation hämatopoetischer Stammzellen. Ergebnisse und klinischer Nutzen der Stammzellaufreinigung von alternativen Spendern für die allogene Transplantation im Kindesalter. Monatsschrift Kinderheilkd. 153,954-964
- Lang, P., Niethammer, D., Bader, P., and Greil, J. (2005) Comment on ‘CD34+ selected hematopoietic stem cell (HSC) not preceded by any immunosuppressive therapy as effective treatment of graft failure' - G Milone et al. Bone Marrow Transplant. 35, 522
- Lang, P., Schumm, M., Greil, J., Bader, P., Klingebiel, T., Muller, I., Feuchtinger, T., Pfeiffer, M., Schlegel, P.G., Niethammer, D., and Handgretinger, R. (2005) A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study. Klin.Padiatr. 217, 334-338
- Pfeiffer, M., Stanjevic, S., Feuchtinger, T., Greil, J., Handgretinger, R., Barbin, K., Jung, G., Martin, D., Niethammer, D., and Lang, P. (2005) Rituximab mediates in vitro antileukemic activity in pediatric patients after allogeneic transplantation. Bone Marrow Transplant 36, 91-97
- Lang P., Greil J., Bader P., Handgretinger R., Klingebiel T., Schumm M, Schlegel PG, Feuchtinger T., Pfeiffer M., Scheel-Walter H., Fuhrer M., Martin D., and Niethammer D. (2004) Long-term outcome after haploidentical stem cell transplantation in children. Blood Cell Mol Dis. 33, 281-287
- Lang, P., Bader,P., Schumm,M., Feuchtinger,T., Einsele,H., Führer,M., Weinstock,C., Handgretinger,R., Kuci,S., Martin,D., Niethammer,D. and Greil,J. (2004) Transplantation of a combination of CD133+ and CD34+ selected progenitor cells from alternative donors. Br.J.Haematol., 124, 72-79
- Lang, P., Griesinger A., Hamprecht K., Feuchtinger T., Schumm M., Neuhäuser F., Greil J., Martin D., Handgretinger R. and Niethammer D. (2004) Antiviral activity against CMV-infected fibroblasts in pediatric patients transplanted with CD34+-selected allografts from alternative donors. Human Immunology, 65, 423-431.
- Lang, P., Handgretinger,R., Greil,J., Bader,P., Schumm,M., Klingebiel,T. and Niethammer,D. (2004) Transplantation of CD34+ enriched allografts in children with nonmalignant diseases: does graft manipulation necessarily result in high incidence of graft failure? Bone Marrow Transplant., 33, 125-126. Correspondence
- Lang, P., Klingebiel,T., Bader,P., Greil,J., Schumm,M., Schlegel,P.G., Eyrich,M., Mueller-Weihrich,S., Niethammer,D. and Handgretinger,R. (2004) Transplantation of highly purified peripheral-blood CD34+ progenitor cells from related and unrelated donors in children with non-malignant diseases. Bone Marrow Transplant., 33, 25-32.
- Lang, P., Klingebiel,T., Schumm,M., Handgretinger,R., Greil,J., Beck,J.F., Niethammer,D. and Bader,P. (2004) Correction of persistent thrombocytopenia by a boost of CD133+ selected stem cells in a patient transplanted for Wiskott-Aldrich syndrome 10 years ago. Bone Marrow Transplant., 33, 879-80. Correspondence
- Lang, P., Pfeiffer,M., Handgretinger,R., Schumm,M., Demirdelen,B., Stanojevic,S., Klingebiel,T., Köhl,U., Kuci,S. and Niethammer,D. (2002) Clinical scale isolation of T cell-depleted CD56+ donor lymphocytes in children. Bone Marrow Transplant., 29, 497-502.
- Lang, P., Schumm,M., Taylor,G., Klingebiel,T., Neu,S., Geiselhart,A., Kuci,S., Niethammer,D. and Handgretinger,R. (1999) Clinical scale isolation of highly purified peripheral CD34+progenitors for autologous and allogeneic transplantation in children. Bone Marrow Transplant., 24, 583-589.
- Lang, P., Klein,R., Becker,E.W. and Berg,P.A. (1992) Distribution of the PBC-specific- (M2) and the naturally-occurring mitochondrial antigen- (NOMAg) systems in plants. Clin.Exp.Immunol., 90, 509-516.
- Lang, P., Huenecke, S., Pfeiffer, M., Handgretinger, R. and Koehl, U. (2010) Natural killer cells in leukemia and tumor therapy. Monatsschr. Kinderh. 158, 223-226.
- A complete list of publications can be viewed on publons.com by clicking on this link
Mitgliedschaften
- ALL-SZT Forum 2012
- Cooperative CWS-Studie
- SAA-Studie
- SIOP-EN (Société internationale d’oncologie pédiatrique, Neuroblastoma subgroup)
- NHL-BFM
- GPOH (Gesellschaft für pädiatrische Onkologie und Hämatologie)
- DGKJ (Deutsche Gesellschaft für Kinder- und Jugendmedizin)
- EBMT-PDWP (European Group for Blood and Marrow Transplantation, Working Party for Pediatric Diseases)