Das Klinikum

PD Dr. Madhumita Chatterjee

PD Dr. Madhumita Chatterjee

Akademische Mitarbeiterin-Wissenschaftlerin

Academic Staff and Scientist (Akademische Mitarbeiterin-Wissenschaftlerin),
Institute for Clinical and Experimental Transfusion Medicine

Kontakt

Telefonnummer: Novel Therapeutics In Immunothrombosis: 07071 29-81134

E-Mail-Adresse: madhumita.chatterjee@med.uni-tuebingen.de

Klinik / Institut / Zentrum

  • Thrombosis and Haemostasis
  • Cardiovascular Sciences
  • I am a cell biologist actively engaged in experimental and clinical research in Cardiovascular Science. I completed my Ph.D. in Life Sciences as a Senior research fellow of the Indian Council of Medical Research from Central Drug Research Institute, Jawaharlal Nehru University, New Delhi, India, 2008); and thereafter my Postdoctoral Diploma from Dept. of Medicine, Karolinska Institute, Stockholm, Sweden, 2011.My current research is focused on the pathophysiological functions of platelets in the cardiovascular disease. The translational approach of my research combines both fundamental experimental research and clinical investigation on the molecular mediators of thrombotic and thrombo-inflammatory platelets functions.
    German Research Foundation-GRK2816-P2 (Deutsche Forschungsgemeinschaft) Non-canonical CXCR7 signaling mechanisms in the regulation of the second messengers cGMP and cAMP in platelets and vascular cells
    https://www.rtg2816.com/project-chatterjee
    Scientia Global: https://www.scientia.global/dr-madhumita-chatterjee-professor-michael-lammerhofer-professor-tilman-schaffer-platelet-lipidomics-a-novel-approach-to-assessing-cardiovascular-risk/?doing_wp_cron=1610008973.9778549671173095703125
    Deutsches-Ärzteblatt (in German): https://www.aerzteblatt.de/archiv/197067/Lipidgehalt-in-Thrombozyten-Eine-tickende-Zeitbombe
    Vasomed (in German): https://www.der-niedergelassene-arzt.de/praxis/das-thrombozytenlipidom-ein-unentdeckt-fortschreitendes-trojanisches-pferd/96569a9f63a7ef2979233be1bcd31597/

    German Research Foundation-SFB-TR240-A08 (Deutsche Forschungsgemeinschaft) Regulation of the platelet lipidome and its implications in thrombo-inflammation. https://gepris.dfg.de/gepris/person/269514124?language=en
    https://gepris.dfg.de/gepris/projekt/406423272
    German Heart Research Foundation, DSHF F/22/17 (Deutsche Stiftung für Herzforschung), for the project ‘Pro-thrombotic and Pro-inflammatory Effects of soluble Junctional adhesion molecule-A: implications for Coronary Artery Disease’. https://www.dshf.de/projekte.php
    German Research Foundation DFG-KFO274-TP1 (Deutsche Forschungsgemeinschaft) for the project: Interaction of platelet-derived inflammatory mediators and their receptors CXCR4 and CXCR7 in regulating platelet function and inflammation. https://gepris.dfg.de/gepris/projekt/208666583
  • Regulatory molecular mechanisms governing immunothrombotic adversities in heparin-induced thrombocytopenia: validation of novel therapeutic strategies
  • 07.02.2024Habilitation: Habilitation thesis: “Atypical chemokine receptor 3 (ACKR3/CXCR7) modulates thrombotic and thrombo-inflammatory platelet functions” in the subject area Experimental Medicine, from the Medical Faculty of Eberhard Karls University Tübingen.
  • 1.1.25-presentGroup leader Institute for Clinical and Experimental Transfusion Medicine
  • 1.7.22-31.12.2024Group Leader Principal Investigator DFG-RTG/GRK2816, Dept. of Pharmacology, Experimental Therapy and Toxicology
  • 2012-June 2022Principal Investigator DFG-TR240:A08, DSHF F/22/17 (Deutsche Stiftung für Herzforschung), Memeber of TUEPIC adn associated researcher DFG-KFO274-TP1, Dept. of Cardiology and Angiology
  • 2009-2011Postdoctoral Diploma, Karolinska Institute, Stockholm, Sweden
  • 2003-2008PhD, Central Drug Research Institute, India
  • Bakchoul T and Chatterjee M. Lipid signatures of immunothrombosis: insights from VITT (Commentary on Beyond Platelet Activation: Dysregulated Lipid Metabolism in Defining Risk and Pathophysiology of VITT’ by Stevens et al.) Research and Practice in Thrombosis and Haemostasis 2025
  • Guan T, Emschermann F, Schories C, Groga-Bada P, Martus P, Borst O, Gawaz M, Geisler T, Rath D, Chatterjee M.Platelet SR-PSOX/CXCL16–CXCR6 Axis Influences Thrombotic Propensity and Prognosis in Coronary Artery Disease. Int. J. Mol. Sci. 2022; 23:11066.
  • Rath D, Rapp V, Schwartz J, Winter S, Emschermann F, Arnold D, Rheinlaender J, Büttcher M, Strebl M, Braun M, Altgelt K, Petersen Uribe A, Schories C, Canjuga D, Schaeffeler E, Borst O, Schäffer T, Langer H, Stehle T, Schwab M, Geisler T, Gawaz M, Chatterjee M.Homophilic interaction between Transmembrane-JAM-A and soluble JAM-A regulates thrombo-inflammation. JACC- Basic to Translational Science. 2022. 2022;7: 445-461.
  • Chatterjee M. GPIIb/IIIa commanded platelet patrol. Blood in press 2022. Editorial Blood . 2022 Jul 14;140(2):81-83. doi: 10.1182/blood.2022016697.
  • Cebo M, Dittrich K, Manke MC, Rheinlaender J, von Eysmondt H, Ferreirós N, Sudman J, Witte A, Pelzl L, Borst O, Rath D, Bakchoul T, Gawaz M, Schäffer TE, Lämmerhofer M, Chatterjee M. Platelet Chemokine Receptor ACKR3/CXCR7 Favors Anti-platelet Lipids over an Atherothrombotic Lipidome and Regulates Thrombo-inflammation. Blood. 2022 Mar 17;139(11):1722-1742.
  • Rath D, Rapp V, Schwartz J, Winter S, Emschermann F, Arnold D, Rheinlaender J, Büttcher M, Strebl M, Braun M, Altgelt K, Petersen Uribe A, Schories C, Canjuga D, Schaeffeler E, Borst O, Schäffer T, Langer H, Stehle T, Schwab M, Geisler T, Gawaz M, Chatterjee M. Homophilic interaction between Transmembrane-JAM-A and soluble JAM-A regulates thrombo-inflammation. JACC- Basic to Translational Science. 2022. 2022;7: 445-461.
  • Chatterjee M, Rath D, Schlotterbeck J, Rheinlaender J, Walker-Allgaier B, Alnaggar N, Zdanyte M, Müller I, Borst O, Geisler T, Schäffer TE, Lämmerhofer M, Gawaz M. Regulation of oxidized platelet lipidome: implications for coronary artery disease. Eur. Heart J. 2017; 38:1993-2005.
  • Chatterjee M. Atypical roles of the Chemokine Receptor ACKR3/CXCR7 in platelet Pathophysiology.Cells. 2022 Jan 9;11(2):213. doi: 10.3390/cells11020213.
  • Chatterjee M. Platelet Lipidome: dismantling the ‘Trojan horse’ in the bloodstream. J. Thromb. Hemost. 2020; 18:543-557.
  • Chatterjee M, Borst O, Walker B, Fotinos A, Vogel S, Seizer P, Mack A, Alampour-Rajabi S, Rath D, Geisler T, Lang F, Langer HF, Bernhagen J, Gawaz M. Macrophage migration inhibitory factor limits activation-induced apoptosis of platelets via CXCR7-dependent Akt signaling. Circ. Res. 2014; 115: 939-49.
  • Chatterjee M, Seizer P, Borst O, Schönberger T, Mack A, Geisler T, Langer HF, May AE, Vogel S, Lang F, Gawaz M. SDF-1α induces differential trafficking of CXCR4-CXCR7 involving cyclophilin A, CXCR7 ubiquitination and promotes platelet survival. FASEB J. 2014; 28:2864-78.
  • Chatterjee M, von Ungern-Sternberg S, Seizer P, Schlegel F, Büttcher M, Sindhu NA, Müller S, Mack A, Gawaz M. Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4-CXCR7. Cell Death Dis. 2015; 19: 6: e1989.
  • Publikationen