Das Klinikum
Prof. Dr. med. Tamam Bakchoul
Ärztlicher Direktor
Kontakt
Telefonnummer: Sekretariat: 07071 29-81602
Faxnummer: 07071 29-5240
E-Mail-Adresse: zkt.sekretariat@med.uni-tuebingen.de
Klinik / Institut / Zentrum
Klinische Schwerpunkte
- Facharzt für Hämostaseologie
- Facharzt für Transfusionmedizin
Wissenschaftliche Tätigkeit
-
Forschungsschwerpunkte:
- Thromboinflammation - crossover of clinical perspective and underlying
pathophysiology
- Thrombopoiesis modulation
- Immune-mediated thrombosis and thrombocytopenia
- Diagnosis and treatment of bleeding disorders
- Novel approaches to platelet transfusion
Ausbildung & beruflicher Werdegang
- seit 2020Ärztlicher Direktor Institut für Klinische und Experimentelle Transfusionsmedizin (IKET)
- seit 2017Professur für Transfusionsmedizin an der Eberhard Karl Universität Tübingen
- seit 2016Ärztlicher Direktor Zentrum für Klinische Transfusionsmedizin Tübingen
- 2013-2016Oberarzt am Institut für Immunologie und Transfusionsmedizin Greifswald
- 2012-2016Juniorprofessur für Klinische Immunhämotologie und Hämostaseologie an der Universität Greiswald
- 2015Habilitations im Fach Transfusionsmedizin an der Universitätsmedizin Greifswald
- 2015Zusatz-Weiterbildung Hämostaseologie
- 2012-2016Leiter des HLA und Thrombozytenlabors im Institut für Immunologie und Transfusionsmedizin am Universitätsklinikum Gießen
- 2011Facharzt für Transfusionsmedizin
Preise & Auszeichnungen
- Alexander-Schmidt-Preis 2023
- Günther Landbeck Excellence Award
- Young Investigator Award for Bleeding Disorders of GTH
- Young Investigator Award of ISTH
- Best Abstract Award 55. DGTI
- Fritz-Schiff-Preis der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie (DGTI) für Nachwuchswissenschaftler
Publikationen
- Schwerpunkt Thromboinflammation - crossover of clinical perspective and underlying pathophysiology
- Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia. Haematologica 2023; https://pubmed.ncbi.nlm.nih.gov/37102605/
- No Correlation between Anti-PF4 and Anti-SARS-CoV-2 Antibodies after ChAdOx1 nCoV-19 Vaccination. N Engl J Med. 2021; https://pubmed.ncbi.nlm.nih.gov/34432977/
- The use of IV immunoglobulin in the treatment of vaccine-induced immune thrombotic thrombocytopenia. Blood 2021; https://pubmed.ncbi.nlm.nih.gov/34166507/
- Schwerpunkt Thrombopiesis modulation:
- Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan. Haematologica 2021; https://pubmed.ncbi.nlm.nih.gov/31857361/
- Pathophysiology of Autoimmune Thrombocytopenia: Current Insight with a Focus on Thrombopoiesis. Hamostaseologie 2019; https://pubmed.ncbi.nlm.nih.gov/30802916/
- Blood donor-derived buffy coat to produce platelets in vitro. Vox Sang 2020; https://pubmed.ncbi.nlm.nih.gov/31709567/
- Schwerpunkt Immune-mediated thrombosis and thrombocytopenia:
- Heparin-activated procoagulant platelet assay: a flow cytometry-based functional test for heparin-induced thrombocytopenia. J Thromb Haemost. 2024; https://pubmed.ncbi.nlm.nih.gov/37838242/
- Diagnostic value of antibody-induced procoagulant platelets in heparin-induced thrombocytopenia: communication from the ISTH SSC Subcommittee on Platelet Immunology. J Thromb Haemost. 2024; https://pubmed.ncbi.nlm.nih.gov/38065529/
- Cerebral venous sinus thrombosis and thrombocytopenia due to heparin-independent anti-PF4 antibodies after adenovirus infection. Haematologica 2023; https://pubmed.ncbi.nlm.nih.gov/37881869/
- The interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thrombocytopenia. Blood 2022; https://pubmed.ncbi.nlm.nih.gov/35679071/
- Upregulation of cAMP prevents antibody-mediated thrombus formation in COVID-19. 2021. Blood Advances 2022; https://pubmed.ncbi.nlm.nih.gov/34753174/
- Antibody-induced procoagulant platelets in severe COVID-19 infection. Blood 2021; https://pubmed.ncbi.nlm.nih.gov/33512415/
- Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia. Haematologica 2021; https://pubmed.ncbi.nlm.nih.gov/34011137/
- Assessment of human platelet survival in the NOD/SCID mouse model: technical considerations. Transfusion 2016; https://pubmed.ncbi.nlm.nih.gov/27086568/
- Schwerpunkt Diagnosis and treatment of bleeding disorders:
- Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia. Front Immunol. 2023; https://pubmed.ncbi.nlm.nih.gov/37275917/
- Diagnosis of Platelet Function Disorders: A Challenge for Laboratories. Hamostaseologie 2022; https://pubmed.ncbi.nlm.nih.gov/35196730/
- Standardization of Light Transmission Aggregometry for Diagnosis of Platelet Disorders: An Inter-Laboratory External Quality Assessment. Thromb Haemost. 2019; https://pubmed.ncbi.nlm.nih.gov/31154663/
- Recessive grey platelet-like syndrome with unaffected erythropoiesis in the absence of the splice isoform GFI1B-p37. Haematologica 2017; https://pubmed.ncbi.nlm.nih.gov/28550182/
- Schwerpunkt Novel approaches to platelet transfuion:
- Inhibition of GPIb-α-mediated apoptosis signaling enables cold storage of platelets. Haematologica 2023; https://pubmed.ncbi.nlm.nih.gov/37345472/
- Cold storage of platelets in additive solution: the impact of residual plasma in apheresis platelet concentrates. Haematologica 2019; https://pubmed.ncbi.nlm.nih.gov/30115655/
- Publikationen
Veranstaltungen / Vorlesungen
- Pflichtveranstaltung Humanmedizin "Transfusionsmedizin"
- Wahlfachpflichtfach "Transfusionsmedizin und Hämostaseologie"
Mitgliedschaften
- GTH, Vorstand
- DGTI (Vorstand)
- SSC Co-Chair
- ASH Member
- ISBT Member
- DFG Fachkollegium
- Weiterbildungsbefugter für Transfusionsmedizin und Haemostaseologie