M3 Lecture Series
Prof. Dr. Michael Trauner: "Leveraging bile acid signaling to target inflammation in the gut-liver axis and beyond"
Michael Trauner, M.D., Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicne III, Medical University of Vienna
Abstract:
In addition to their detergent properties bile acids (BAs) have signaling functions which play a central role in the regulation of hepatic metabolism as well as inflammation, fibrosis, and carcinogenesis. In addition, BAs shape the gut microbial flora and have immunomodulatory signaling effects on inflammatory pathways and immune cell function. As such, BA metabolism has emerged as a key determinant of immune homeostasis due to its profound effects on T cells and other cells of the innate and adaptive immune system. Disruption of BA transport, metabolism and physiological signaling function via dedicated receptors (e.g., FXR, TGR5) contribute to the pathogenesis and progression of a wide range of liver diseases including cholestatic disorders and metabolic dysfunction-associated steatotic liver disease (MASLD) as well as hepatocellular and cholangiocellular carcinoma. BA-targeted approaches may represent new therapeutic opportunities for a range of liver diseases as well as gastrointestinal disorders along the gut–liver axis and beyond.
If you can’t be there in person, you may join via Zoom:
https://med-uni-tuebingen-de.zoom-x.de/j/67987928634?pwd=ZlRoQmJ0THVOVXRvdkFlQUpIdTZRQT09
Meeting-ID: 679 8792 8634
Kenncode: 547088
