Das Klinikum

Frau Sarah-Maria Trenz

Frau Sarah-Maria Trenz

PhD candidate

Insertion of Legionella’s TMD-effectors into host cell membranes

Kontakt

Telefonnummer: 07071 29-85773

E-Mail-Adresse: sarah-maria.trenz@med.uni-tuebingen.de

Klinik / Institut / Zentrum

  • Insertion of Legionella’s TMD-effectors into host cell membranes

    In my research I am investigating the infection of macrophages by the intracellular pathogen Legionella pneumophila on a molecular level. To survive within phagocytic host cells Legionella secretes a large repertoire of effector proteins via its Type IV secretion system (Dot/Icm). I am specifically interested in effector proteins harboring hydrophobic transmembrane domains (TMDs) necessary for the integration into host cell membranes. The focus of my project is to uncover the mechanisms TMD-effectors use to correctly target and insert into membranes of the eukaryotic host.

  • October 2014 - 2017Bachelor Biology, University of Erlangen
  • October 2017 - 2018Scientific assistant in Cell biology, University of Erlangen
  • October 2018 - March 2021Master Molecular Cell Biology and Immunology, University of Tübingen
  • March 2021 - 2024PhD candidate at the Institut for Medical Microbiology und Hygiene, AG Wagner
  • Steinle H, Weber J, Stoppelkamp S, Große-Berkenbusch K, Golombek S, Weber M, Canak-Ipek T, Trenz SM, Schlensak C, Avci-Adali M. Delivery of synthetic mRNAs for tissue regeneration. Adv Drug Deliv Rev. 2021 Dec;179:114007. doi: 10.1016/j.addr.2021.114007. Epub 2021 Oct 26. PMID: 34710530.
  • Publikationen
  • Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM)