Das Klinikum

Dr. Veronika Leiss

Dr. Veronika Leiss

Wissenschaftliche Mitarbeiterin

Wissenschaftlicher Schwerpunkt
Die biologische Bedeutung von G-Proteinen für metabolische und kardiovaskuläre Prozesse.

Kontakt

Telefonnummer: 07071 29-72273

E-Mail-Adresse: veronika.leiss@uni-tuebingen.de

Klinik / Institut / Zentrum

  • 2010 - aktuellWissenschaftliche Mitarbeiterin im Labor von Prof. Dr. Dr. Bernd Nürnberg, Leiter der Abteilung für Pharmakologie, experimentelle Therapie und Toxikologie
  • 2009Postdoc im Labor von Prof. Dr. Franz Hofmann, Leiter des Instituts für Pharmakologie und Toxikologie, Technische Universität München
  • 2005 - 2008Doktorandin im Labor von Prof. Dr. Franz Hofmann, Leiter des Instituts für Pharmakologie und Toxikologie, Technische Universität München
  • 2000 - 2005Studium der Biologie an der Technischen Universität München (Diplom)
  • 2000allgemeine Hochschulreife, Michaeligymnasium München
  • Leiss V., Piekorz R.P., Vega S.C., Jacoby C., Flögel U., Pexa K., Schrader J., Pichler B.J., Beer-Hammer S., Nürnberg B. (2022) Data on common carotid artery occlusion inducing focalized stroke lesions after Pertussis toxin injection. Data Brief. 46:108851. doi: 10.1016/j.dib.2022.108851. PMID: 36624761; PMCID: PMC9823129.
  • Granja T.F., Köhler D., Leiss V., Eggstein C., Nürnberg B., Rosenberger P., Beer-Hammer S. (2022) Platelets and the Cybernetic Regulation of Ischemic Inflammatory Responses through PNC Formation Regulated by Extracellular Nucleotide Metabolism and Signaling. Cells.11(19):3009. doi: 10.3390/cells11193009. PMID: 36230973; PMCID: PMC9561997.
  • Castaneda-Vega S., Beer-Hammer S., Leiss V., Napieczyńska H., Vuozzo M., Schmid A.M., Zeng H., He Y., Kohlhofer U., Gonzalez-Menendez I., Quintanilla-Martinez L., Hempel J.M., Gollasch M., Yu X., Pichler B.J., Nürnberg B. (2022) Cerebrovascular Gi Proteins Protect Against Brain Hypoperfusion and Collateral Failure in Cerebral Ischemia. Mol Imaging Biol. doi: 10.1007/s11307-022-01764-8.
  • Leiss V., Reisinger E., Speidel A., Beer-Hammer S., Nürnberg B. (2021) Analyses of Gnai3-iresGFP reporter mice reveal unknown Gαi3 expression sites. Sci Rep. 11(1):14271. doi: 10.1038/s41598-021-93591-0. PMID: 34253772; PMCID: PMC8275620.
  • Leiss V., Schönsiegel A., Gnad T., Kerner J., Kaur J., Sartorius T., Machann J., Schick F., Birnbaumer L., Häring H.U., Pfeifer A., Nürnberg B. (2020) Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity. Mol Metab. 40, 101029. doi: 10.1016/j.molmet.2020.101029
  • Vega S.C., Leiss V., Piekorz R., Calaminus C., Pexa K., Vuozzo M., Schmid A.M., Devanathan V., Kesenheimer C., Pichler B.J., Beer-Hammer S., Nürnberg B. (2020) Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin. J Mol Med (Berl). 98, 97-110
  • Kolahian S., Leiss V., Nürnberg B. (2019) Diabetic lung disease: fact or fiction? Rev Endocr Metab Disord. 20, 303-319
  • Cao H., Qadri S.M., Lang E., Pelzl L., Umbach A.T., Leiss V., Birnbaumer L., Nürnberg B., Pieske B., Voelkl J., Gawaz M., Bissinger R., Lang F. (2018) Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets. Physiol Rep. 6, e13841. doi: 10.14814/phy2.13841
  • Brink T., Leiss V., Siegert P., Jehle D., Ebner J.K., Schwan C., Shymanets A., Wiese S., Nürnberg B., Hensel M., Aktories K., Orth J.H.C. (2018) Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins. PLoS Pathog. 13, e1007248. doi: 10.1371/journal.ppat.1007248
  • Beer-Hammer S., Lee S.C., Mauriac S.A., Leiss V., Groh I.A.M., Novakovic A., Piekorz R.P., Bucher K., Chen C., Ni K., Singer W., Harasztosi C., Schimmang T., Zimmermann U., Pfeffer K., Birnbaumer L., Forge A., Montcouquiol M., Knipper M., Nürnberg B., Rüttiger L. (2018) Gαi proteins are indispensable for hearing. Cell. Physiol. Biochem. 47, 1509-1532
  • Illison J., Tian L., McClafferty H., Werno M., Chamberlain L.H., Leiss V., Sassmann A., Offermanns S., Ruth P., Shipston M.J., Lukowski R. (2016) Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels. Diabetes. 65, 3621-3635
  • Keller K., Maass M., Dizayee S., Leiss V., Annala S., Köth J., Seemann W.K., Müller-Ehmsen J., Mohr K., Nürnberg B., Engelhardt S., Herzig S., Birnbaumer L., Matthes J. (2015) Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice. Cardiovasc Res. 108, 348 356
  • Leiss V., Flockerzie K., Novakovic A., Rath M., Schönsiegel A., Birnbaumer L., Schürmann A., Harteneck C., Nürnberg B. (2014) Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gαi2. Am J Physiol Endocrinol Metab. 307, E800-812
  • Zhang Q., Chibalina M.V., Bengtsson M., Groschner L.N., Ramracheya R., Rorsman N.J., Leiss V., Nassar M.A., Welling A., Gribble F.M., Reimann F., Hofmann F., Wood J.N., Ashcroft F.M., Rorsman P. (2014) Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. J Physiol. 592, 4677-4696
  • Leiss V., Illison J., Domes K., Hofmann F., Lukowski R. (2014) Expression of cGMP-dependent protein kinase type I in mature white adipocytes. Biochem Biophys Res Commun. 12, 151-156
  • Minetti G.C., Feige J.N., Bombard F., Heier A., Morvan F., Nürnberg B., Leiss V., Birnbaumer L., Glass D.J., Fornaro M. (2014) Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation. Mol Cell Biol. 34, 619-630
  • Leiss V., Friebe A., Welling A., Hofmann F., Lukowski R. (2011) Cyclic GMP kinase I modulates glucagon release from pancreatic α-cells. Diabetes. 60, 148-156
  • Lukowski R., Rybalkin S.D., Loga F., Leiss V., Beavo J.A., Hofmann F. (2010) Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proc Natl Acad Sci U S A. 23, 5646-5651
  • Vignali S.*, Leiss V.*, Karl R., Hofmann F., Welling A. (2006) Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J Physiol. 572, 691-706
  • Mitglied der Deutschen Gesellschaft für Pharmakologie (DGP)