iFIT Lunch & Learn Session with Prof. Dr. Lisa Sevenich
Harness metabolic checkpoints for improved immune-targeted therapy against brain metastasis
On behalf of the iFIT spokespersons Lars Zender, Juliane Walz and Bernd Pichler, it is our pleasure to inform you about and invite you to the next episode of our iFIT Lunch & Learn 2025 that will take place
on Wednesday, September 17th at 12:00 pm (CEST)
at Big Lecture Hall 210 in the CRONA Clinics.
Our speaker and member, Prof. Dr. Lisa Sevenich (Hertie Institute for Clinical Brain Research, Tübingen) will give a talk on
“Harness metabolic checkpoints for improved immune-targeted therapy against brain metastasis”.
Brain metastases represent a significant clinical challenge that necessitates the development of novel and effective therapeutic options. Our goal is to develop immune-targeted therapies specifically designed to overcome tissue-specific limitations to treatment success. We employ a wide range of ex vivo and in vivo experimental models of brain metastases, along with patient samples, to characterize the highly specialized tumor-immune microenvironment associated with brain metastases. Utilizing multiomics approaches combined with mechanistic studies, we aim to dissect the disease-associated functions of immune subpopulations. This insight provides a scientific rationale for combination trials. In my talk, I will summarize our findings regarding the challenges and opportunities of tumor-associated macrophage therapy and T cell-directed immunotherapy in combination with radiotherapy. A particular focus will be placed on immunometabolism and immunometabolism-targeting approaches as novel therapeutic avenues that allow for the simultaneous modulation of the myeloid and lymphoid compartments, thereby preventing the rapid induction of adaptive resistance mechanisms that can hinder the reactivation of anti-cancer immunity.
As a special feature of this program, iFIT will sponsor free lunch packages! (First come, first serve)
All members of the University Hospital and University of Tübingen are invited to participate!
We look forward to this Seminar Series session and to see you there!
