Medizinische Klinik
Innere Medizin VII
Institut für Tropenmedizin, Reisemedizin, Humanparasitologie

The main focus of this research group is the evolutionary ecology and epidemiology of infectious diseases, such as malaria, dengue and various bacterial infections. We are particularly interested in multi-scale host-pathogen interactions and how these affect infection pathologies, pathogen evolution and disease incidence across time and space. For this we employ a wide variety of mathematical and computational techniques, from individual-based and population-level modelling to advanced statistical methods and machine learning for the analyses of complex datasets.

• Andrade CM, Fleckenstein H, Thomson-Luque R, Doumbo S, Lima NF, Anderson C, Hibbert J, Hopp CS, Tran TM, Li S, Niangaly M, Cisse H, Doumtabe D, Skinner J, Sturdevant D, Ricklefs S, Virtaneva K, Asghar M, Homann MV, Turner L, Martins J, Allman EL, N'Dri ME, Winkler V, Llinás M, Lavazec C, Martens C, Färnert A, Kayentao K, Ongoiba A, Lavstsen T, Osório NS, Otto TD, Recker M, Traore B, Crompton PD, Portugal S. Increased circulation time of Plasmodium falciparumunderlies persistent asymptomatic infection in the dry season. Nat Med. 2020 Dec;26(12):1929-1940. doi: 10.1038/s41591-020-1084-0
• Bediako Y, Adams R, Reid AJ, Valletta JJ, Ndungu FM, Sodenkamp J, Mwacharo J, Ngoi JM, Kimani D, Kai O, Wambua J, Nyangweso G, de Villiers EP, Sanders M, Lotkowska ME, Lin JW, Manni S, Addy JWG, Recker M, Newbold C, Berriman M, Bejon P, Marsh K, Langhorne J. Repeated clinical malaria episodes are associated with modification of the immune system in children. BMC Med. 2019 Mar 13;17(1):60. doi: 10.1186/s12916-019-1292-yHolding T, Valletta JJ, Recker M. Multiscale Immune Selection and the Transmission-Diversity Feedback in Antigenically Diverse Pathogen Systems. Am Nat. 2018 Dec;192(6):E189-E201. doi: 10.1086/69953
• Lourenço J, Maia de Lima M, Faria NR, Walker A, Kraemer MU, Villabona-Arenas CJ, Lambert B, Marques de Cerqueira E, Pybus OG, Alcantara LC, Recker M. Epidemiological and ecological determinants of Zika virus transmission in an urban setting. Elife. 2017 Sep 9;6:e29820. doi: 10.7554/eLife.29820
• Flasche S, Jit M, Rodríguez-Barraquer I, Coudeville L, Recker M, Koelle K, Milne G, Hladish TJ, Perkins TA, Cummings DA, Dorigatti I, Laydon DJ, España G, Kelso J, Longini I, Lourenco J, Pearson CA, Reiner RC, Mier-Y-Terán-Romero L, Vannice K, Ferguson N. The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study. PLoS Med. 2016 Nov 29;13(11):e1002181. doi: 10.1371/journal.pmed.1002181
• Recker M, Laabei M, Toleman MS, Reuter S, Saunderson RB, Blane B, Török ME, Ouadi K, Stevens E, Yokoyama M, Steventon J, Thompson L, Milne G, Bayliss S, Bacon L, Peacock SJ, Massey RC. Clonal differences in Staphylococcus aureus bacteraemia-associated mortality. Nat Microbiol. 2017 Oct;2(10):1381-1388. doi: 10.1038/s41564-017-0001-x
• Laabei M, Recker M, Rudkin JK, Aldeljawi M, Gulay Z, Sloan TJ, Williams P, Endres JL, Bayles KW, Fey PD, Yajjala VK, Widhelm T, Hawkins E, Lewis K, Parfett S, Scowen L, Peacock SJ, Holden M, Wilson D, Read TD, van den Elsen J, Priest NK, Feil EJ, Hurst LD, Josefsson E, Massey RC. Predicting the virulence of MRSA from its genome sequence. Genome Res. 2014 May;24(5):839-49. doi: 10.1101/gr.165415.113
  

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