Das Klinikum
Dr. rer. nat. Perihan Mir
Wissenschaftliche Leitung Hämatologische Diagnostik
Kontakt
Telefonnummer: 07071 29-80647
E-Mail-Adresse: perihan.mir@med.uni-tuebingen.de
Klinik / Institut / Zentrum
Ausbildung & beruflicher Werdegang
- 01/2021 - heuteWissenschaftliche Leitung Hämatologische Diagnostik
- 01/2020 - 12/2020Postdoc im Labor für Translationale Onkologie - AG Skokowa
- 08/2015 - 12/2019Doktorarbeit im Labor für Translationale Onkologie - AG Skokowa
- 10/2014 - 05/2015Master of Science im Labor für Molekulare Medizin - AG Schulze-Osthoff
- 02/2012 - 08/2012Bachelor of Science im Labor für Entwicklungsbiologie - AG Lengerke
- 10/2009 - 05/2015Studium Biochemie
Preise & Auszeichnungen
- Best Abstract Award & Best of DGHO 'Translational Medicine', 2019
- ASH Abstract Achievement Award, 2019
- ASH Abstract Achievement Award, 2018
- ASH Abstract Achievement Award, 2017
- Young Investigator's Award & Best of DGHO 'Translational Research', 2013
Publikationen
- P. Mir, M. Ritter, K. Welte, J. Skokowa and M. Klimiankou, ‘Gene Knockout in Hematopoietic Stem and Progenitor Cells Followed by Granulocytic Differentiation’, RNA Interference and CRISPR Technologies, Methods in Molecular Biology, vol. 2115, p. 455-469,February 2020; DOI: 10.1007/978-1-0716-0290-4_26
- P. Mir, M. Klimiankou, B. Findik, K. Haehnel, S. Mellor-Heineke, C.Zeidler, J. Skokowa, K. Welte, ‘New insights into the pathomechanism of cyclic neutropenia’, Annals of the New York Academy of Science, January 2020; DOI: 10.1111/nyas.14309
- B. H. Alvarez*, J. Skokowa*, M. Coles* , P. Mir, L. Weidmann, K. W. Rogers, K. Welte, A. Lupas, P. Müller, M. ElGamacy, ‘Design of novel granulopoietic proteins by topological rescaffolding’, December 2020, PLOS Biology; DOI: 10.1371/journal.pbio.3000919
- B. Dannenmann, A. Zahabi, P. Mir, B. Oswald, R. Bernhard, M.Klimiankou, T. Morishima, K. Schulze-Osthoff, C. Zeidler, L. Kanz, N.Lachmann, T. Moritz, K. Welte and J. Skokowa, ‘Human iPSC-based model of severe congenital neutropenia reveals elevated UPR andDNA damage in CD34+ cells preceding leukemic transformation’,Experimental Hematology, vol. 71, p. 51-60, January 2019; DOI: 10.1016/j.exphem.2018.12.006
- M. Nasri*, P. Mir*, B. Dannenmann, D. Amend, T. Skroblyn, Y. Xu, K.Schulze-Osthoff, M. Klimiankou, K. Welte and J. Skokowa,‘Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response’, Blood Advances, vol. 3, no. 1, p. 63-71, January 2019; DOI: 10.1182/bloodadvances.2017015511
- M. Nasri, M. Ritter*, P. Mir*, B. Dannenmann*, N. Aghaallaei, D.Amend, V. Makaryan, Y. Xu, B. Fletcher, R. Bernhard, I. Steiert, K.Hähnel, J. Berger, I. Koch, B. Sailer, K. Hipp C. Zeidler, M.Klimiankou, B. Bajoghli, D. C. Dale, K. Welte and J. Skokowa,‘CRISPR/Cas9 mediated ELANE knockout enables neutrophilicmaturation of primary hematopoietic stem and progenitor cells andinduced pluripotent stem cells of severe congenital neutropeniapatients’, Haematologica, vol. 105, no. 3, p. 598-609, June 2019; DOI: 10.3324/haematol.2019.221804
- T. Schaefer*, H. Wang*, P. Mir, M. Konantz, T. Pereboom, B. Merz, T.Fehm, S. Perner, O. Rothfuss, L. Kanz, K. Schulze-Osthoff, C.Lengerke. „Molecular and functional interactions between AKT andSOX2 in breast carcinoma", Oncotarget 2016; DOI: 10.18632/oncotarget.6183
- C. Koch, B. Samareh, T. Morishima, P. Mir , L. Kanz, C. Zeidler, J. Skokowa, K. Welte, 'GM-CSF treatment is not effective in congenital neutropenia patients due to its inability to activate NAMPT signaling', Annals of Hematology, December 2016, DOI: 10.1007/s00277-016-2894-5
- Publikationen