Das Klinikum

Dr.rer.nat. Natalia Ruetalo Buschinger

Dr.rer.nat. Natalia Ruetalo Buschinger

Akad. Mitarbeiterin

Postdoktorandin, Sektion Molekulare Virologie

Kontakt

Telefonnummer: 07071 29-85482

E-Mail-Adresse: Natalia.Ruetalo-Buschinger@med.uni-tuebingen.de

  • Characterization and optimization of small compounds which display antiviral activity agains flavivirus.
  • SARS-CoV-2: antiviral research and characterization of antibody immune response in Covid-19 patients.
  • 2018 - PresentPostdoc position, Molecular Virology, AG Schindler, Tübingen
  • 2012 - 2017PhD in Biochemistry, Max Planck Institute, Tübingen
  • 2008 - 2012Master in Molecular Biology, Uruguay
  • 2004 - 2008Bachelor in Molecular Biology, Uruguay
  • Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science. 2021 Jan 12:eabe6230. doi: 10.1126/science.abe6230. Epub ahead of print. PMID: 33436526.
  • Flehmig B, Schindler M, Ruetalo N, Businger R, Bayer M, Haage A, Kirchner T, Klingel K, Normann A, Pridzun L, Tougianidou D, Ranke MB. Persisting Neutralizing Activity to SARS-CoV-2 over Months in Sera of COVID-19 Patients. Viruses. 2020 Nov 27;12(12):E1357. doi: 10.3390/v12121357. PMID: 33260809.
  • Böffert R, Businger R, Preiß H, Ehmann D, Truffault V, Simon C, Ruetalo N, Hamprecht K, Müller P, Wehkamp J, Schindler M. The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus. Antiviral Res. 2020 May;177:104779. doi: 10.1016/j.antiviral.2020.104779. Epub 2020 Mar 21. PMID: 32209394.
  • Ruetalo N, Anders S, Stollmaier C, Jäckl M, Schütz-Stoffregen MC, Stefan N, Wolf C, Wiesner S. (2019). The WW1 domain enhances auto-inhibition in Smurf ubiquitin ligases. J Mol Biol. In press. doi:10.1016/j.jmb.2019.09.018
  • Mari S*, Ruetalo N*, Maspero E, Stoffregen MC, Pasqualato S, Polo S, WiesnerS. (2014). Structural and Functional Framework for the Autoinhibition ofNedd4-Family Ubiquitin Ligases. Structure 22 (11): 1639–1649. doi:10.1016/j.str.2014.09.006. * Co-first author.
  • Trajtenberg F, Albanesi D, Ruétalo N, Botti H, Mechaly AE, Nieves M, AguilarPS, Cybulski L, Larrieux N, de Mendoza D, Buschiazzo A. (2014). Allosteric activation of bacterial response regulators: the role of the cognate histidinekinase beyond phosphorylation. Mbio. 5: (6). doi:10.1128/mBio.02105-14.
  • Trajtenberg F, Graña M, Ruétalo N, Botti H & Buschiazzo, A. (2010). Structuraland enzymatic insights into the ATP-binding and autophosphorylationmechanism of a sensor histidine kinase. J Biol Chem. 285(32):24892-903.doi/10.1074/jbc.M110.147843
  • Cancela M, Ruétalo N, Delloca N, DaSilvaE, Smircich P, Rinaldi G, Roche L,Carmona C, Alvarez-Valin F, Zaha A, Tort JF. (2010). Survey of transcriptsexpressed by the invasive juvenile stage of the liver fluke Fasciola hepática.BMC Genomics 11 (1): 227. doi:10.1186/1471-2164-11-227.