Das Klinikum

PD Dr. Dr. Sebastian Hoefert

PD Dr. Dr. Sebastian Hoefert

Oberarzt

Kontakt

Telefonnummer: 07071 29-86174

Faxnummer: 07071 29-3481

E-Mail-Adresse: sebastian.hoefert@med.uni-tuebingen.de

  • 2010Medical Trainee bei Prof. Dr. Ivo Pitanguy, Clinic and Santa Casa of the Misericordia General Hospital Department of Plastic and Reconstructive Surgery of the Pontifical Catholic University of Rio de Janeiro und dem Carlos Chargas Post-Graduate Medical Institute
  • 1998Plastische Operationen (Lippen-, Kiefer- und Gaumenspalten) mit dem Komitee Ärzte für die Dritte Welt, Frankfurt und R.O.S.A.S., Dumaguete, Negros, Philippinen
  • 2023- presentOberarzt in der Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Tübingen (Prof. Dr. Dr. B. Lethaus)
  • 2010- 2023Oberarzt in der Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Tübingen (Prof. Dr. Dr. S. Reinert)
  • 2005-2010Assistenzarzt, Funktionsoberarzt, Oberarzt und Leitender Oberarzt in der Klinik für Mund-, Kiefer- und Gesichtschirurgie, Knappschaftskrankenhaus Recklinghausen (Prof. Dr. Dr. H. Eufinger)
  • 2002–2004Arzt im Praktikum und Assistenzarzt in der Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Zentrum für Zahn- Mund- und Kieferkrankheiten des Universitätsklinikums Tübingen (Prof. Dr. Dr. S. Reinert)
  • 1997–1998Arzt im Praktikum in der Klinik für Mund-, Kiefer- und Gesichtschirurgie, Knappschaftskrankenhaus Bochum-Langendreer (Prof. Dr. Dr. E. Machtens)
  • 1998-2002Studium der Zahnmedizin, Universität Tübingen
  • 1990-1997Studium der Medizin, Ruhr-Universität Bochum
  • 2019 Vortragspreis AG-Kiefer, Bad Homburg (Arbeitsgruppenleiter)
  • 2018 Vortragspreis AG-Kiefer, Bad Homburg (Arbeitsgruppenleiter)
  • 2016 Publikationspreis der BG-Unfallklinik Tübingen
  • 2016 Vortragspreis AKOPOM, Bad Homburg (Arbeitsgruppenleiter)
  • 2015 Vortragspreis AG-Kiefer, Bad Homburg (Arbeitsgruppenleiter)
  • 2012 Vortragspreis DGPro, Hamburg
  • 2009 Nachwuchspreis 22. Symposiums des Deutschen Interdisziplinären Arbeitskreises Lippen-Kiefer-Gaumenspalten/Kraniofaziale Anomalien, Mainz
  • Kämmerer PW, Tribius S, Cohrs L, Engler G, Ettl T, Freier K, Frerich B,Ghanaati S, Gosau M, Haim D, Hartmann S, Heiland M, Herbst M, Hoefert S,Hoffmann J, Hölzle F, Howaldt HP, Kreutzer K, Leonhardt H, Lutz R, Moergel M,Modabber A, Neff A, Pietzka S, Rau A, Reichert TE, Smeets R, Sproll C, StellerD, Wiltfang J, Wolff KD, Kronfeld K, Al-Nawas B. Adjuvant Radiotherapy inPatients with Squamous Cell Carcinoma of the Oral Cavity or Oropharynx andSolitary Ipsilateral Lymph Node Metastasis (pN1)-A Prospective MulticentricCohort Study. Cancers (Basel). 2023 Mar 18;15(6):1833. doi:10.3390/cancers15061833. PMID: 36980719; PMCID: PMC10047283.
  • Reinert CP, Pfannenberg C, Dittmann H, Gückel B, la Fougère C, Nikolaou K,Hoefert S. [18F]Fluoride Positron-Emission Tomography (PET) and [18F]FDG PET forAssessment of Osteomyelitis of the Jaw in Comparison to Computed Tomography (CT)and Magnetic Resonance Imaging (MRI): A Prospective PET/CT and PET/MRI PilotStudy. J Clin Med. 2022 Jul 10;11(14):3998. doi: 10.3390/jcm11143998. PMID:35887762; PMCID: PMC9323701.
  • Reinert CP, Pfannenberg C, Gatidis S, la Fougère C, Nikolaou K, Hoefert S.<sup>18</sup>F-Fluoride PET/CT Imaging of Medication-Related Osteonecrosis ofthe Jaw in Conservative Treatment-A Case Report. Front Oncol. 2021 Jul1;11:700397. doi: 10.3389/fonc.2021.700397. PMID: 34277447; PMCID: PMC8281890.
  • Schoenhof R, Munz A, Yuan A, ElAyouti A, Boesmueller H, Blumenstock G,Reinert S, Hoefert S. Microarchitecture of medication-related osteonecrosis ofthe jaw (MRONJ); a retrospective micro-CT and morphometric analysis. JCraniomaxillofac Surg. 2021 Jun;49(6):508-517. doi: 10.1016/j.jcms.2021.02.018.Epub 2021 Mar 2. PMID: 33707134.
  • Valentin A, Goetz M, Hetzel J, Reinert S, Hoefert S. Routine panendoscopy inoral squamous cell cancer patients: mandatory or facultative? Clin OralInvestig. 2021 Mar;25(3):1245-1254. doi: 10.1007/s00784-020-03429-8. Epub 2020Jul 1. PMID: 32607829; PMCID: PMC7878265.
  • Yuan A, Munz A, Reinert S, Hoefert S. Histologic analysis of medication-related osteonecrosis of the jaw compared with antiresorptive-exposed bone andother infectious, inflammatory, and necrotic jaw diseases. Oral Surg Oral MedOral Pathol Oral Radiol. 2020 Feb;129(2):133-140. doi:10.1016/j.oooo.2019.08.018. Epub 2019 Sep 3. PMID: 31606424.
  • Weise H, Naros A, Weise C, Reinert S, Hoefert S. Severe odontogenicinfections with septic progress - a constant and increasing challenge: aretrospective analysis. BMC Oral Health. 2019 Aug 2;19(1):173. doi:10.1186/s12903-019-0866-6. PMID: 31375095; PMCID: PMC6679486.
  • Yuan A, Munz A, Reinert S, Hoefert S. Gingival fibroblasts and medication-related osteonecrosis of the jaw: Results by real-time and wound healingin vitro assays. J Craniomaxillofac Surg. 2019 Sep;47(9):1464-1474. doi:10.1016/j.jcms.2019.06.004. Epub 2019 Jun 8. PMID: 31327558.
  • Naros A, Weise H, Tilsen F, Hoefert S, Naros G, Krimmel M, Reinert S,Polligkeit J. Three-dimensional accuracy of mandibular reconstruction bypatient-specific pre-bent reconstruction plates using an "in-house" 3D-printer.J Craniomaxillofac Surg. 2018 Sep;46(9):1645-1651. doi:10.1016/j.jcms.2018.05.047. Epub 2018 Jun 1. PMID: 29983306.
  • Weise H, Naros A, Blumenstock G, Krimmel M, Hoefert S, Kluba S, Hofer S,Reinert S. Donor site morbidity of the anterolateral thigh flap. JCraniomaxillofac Surg. 2017 Dec;45(12):2105-2108. doi:10.1016/j.jcms.2017.09.022. Epub 2017 Sep 30. PMID: 29108918.
  • Hoefert S, Yuan A, Munz A, Grimm M, Elayouti A, Reinert S. Clinical courseand therapeutic outcomes of operatively and non-operatively managed patientswith denosumab-related osteonecrosis of the jaw (DRONJ). J CraniomaxillofacSurg. 2017 Apr;45(4):570-578. doi: 10.1016/j.jcms.2017.01.013. Epub 2017 Jan 25.PMID: 28238559.
  • Kloth C, Hoefert S, Fischborn T, Schraml C. Dentogener Fokus als Ursache füreine nekrotisierende Fasziitis [Dentogene Focus as a Rare Cause of NecrotizingFasciitis]. Dtsch Med Wochenschr. 2017 Feb;142(3):212-215. German. doi:10.1055/s-0042-121849. Epub 2017 Feb 10. PMID: 28187489.
  • Lotter O, Hoefert S, Micheel M, Gonser P, Schaller HE, Rothenberger J.Analyse von Fallpauschalen und deren versorgungsrelevante Effekte in derpostbariatrischen Wiederherstellungschirurgie [Analysis of Diagnosis RelatedGroups and their Impact on Health Care in Post Massive Weight Loss Surgery].Handchir Mikrochir Plast Chir. 2016 Aug;48(4):226-32. German. doi:10.1055/s-0042-110568. Epub 2016 Aug 22. PMID: 27547931.
  • Grimm M, Biegner T, Teriete P, Hoefert S, Krimmel M, Munz A, Reinert S.Estrogen and Progesterone hormone receptor expression in oral cavity cancer. MedOral Patol Oral Cir Bucal. 2016 Sep 1;21(5):e554-8. doi: 10.4317/medoral.21182.PMID: 27475696; PMCID: PMC5005091.
  • Grimm M, Rieth J, Hoefert S, Krimmel M, Rieth S, Teriete P, Kluba S, BiegnerT, Munz A, Reinert S. Standardized pretreatment inflammatory laboratory markersand calculated ratios in patients with oral squamous cell carcinoma. Eur ArchOtorhinolaryngol. 2016 Oct;273(10):3371-84. doi: 10.1007/s00405-016-3950-4. Epub2016 Feb 29. PMID: 26926692.
  • Grimm M, Hoefert S, Krimmel M, Biegner T, Feyen O, Teriete P, Reinert S.Monitoring carcinogenesis in a case of oral squamous cell carcinoma using apanel of new metabolic blood biomarkers as liquid biopsies. Oral MaxillofacSurg. 2016 Sep;20(3):295-302. doi: 10.1007/s10006-016-0549-2. Epub 2016 Feb 13.PMID: 26875085.
  • Hoefert S, Sade Hoefert C, Munz A, Schmitz I, Grimm M, Yuan A, Northoff H,Reinert S, Alexander D. Effect of bisphosphonates on macrophagic THP-1 cellsurvival in bisphosphonate-related osteonecrosis of the jaw (BRONJ). Oral SurgOral Med Oral Pathol Oral Radiol. 2016 Mar;121(3):222-32. doi:10.1016/j.oooo.2015.10.008. Epub 2015 Oct 22. PMID: 26725718.
  • Grimm M, Krimmel M, Hoefert S, Kraut W, Calgéer B, Biegner T, Teriete P,Munz A, Reinert S. Monitoring a 'metabolic shift' after surgical resection oforal squamous cell carcinomas by serum lactate dehydrogenase. J Oral Pathol Med.2016 May;45(5):346-55. doi: 10.1111/jop.12374. Epub 2015 Sep 25. PMID: 26403591.
  • Hoefert S, Sade Hoefert C, Munz A, Northoff H, Yuan A, Reichenmiller K,Reinert S, Grimm M. Altered macrophagic THP-1 cell phagocytosis and migration inbisphosphonate-related osteonecrosis of the jaw (BRONJ). Clin Oral Investig.2016 Jun;20(5):1043-54. doi: 10.1007/s00784-015-1584-3. Epub 2015 Sep 9. PMID:26349768.
  • Grimm M, Kraut W, Hoefert S, Krimmel M, Biegner T, Teriete P, Cetindis M,Polligkeit J, Kluba S, Munz A, Reinert S. Evaluation of a biomarker based bloodtest for monitoring surgical resection of oral squamous cell carcinomas. ClinOral Investig. 2016 Mar;20(2):329-38. doi: 10.1007/s00784-015-1518-0. Epub 2015Jul 8. PMID: 26153867.
  • Hoefert S, Hoefert CS, Albert M, Munz A, Grimm M, Northoff H, Reinert S,Alexander D. Zoledronate but not denosumab suppresses macrophagicdifferentiation of THP-1 cells. An aetiologic model of bisphosphonate-relatedosteonecrosis of the jaw (BRONJ). Clin Oral Investig. 2015 Jul;19(6):1307-18.doi: 10.1007/s00784-014-1358-3. Epub 2014 Nov 21. PMID: 25411080.
  • Lotter O, Townley WA, Gonser P, Schaller HE, Hoefert S. Reimbursement forreconstruction by tissue transfer-a European comparison. BMC Health Serv Res.2014 Sep 24;14:427. doi: 10.1186/1472-6963-14-427. PMID: 25248968; PMCID:PMC4263045.
  • Hoefert S, Schmitz I, Weichert F, Gaspar M, Eufinger H. Macrophages andbisphosphonate-related osteonecrosis of the jaw (BRONJ): evidence of localimmunosuppression of macrophages in contrast to other infectious jaw diseases.Clin Oral Investig. 2015 Mar;19(2):497-508. doi: 10.1007/s00784-014-1273-7. Epub2014 Jun 24. PMID: 24957986.
  • Hoefert S, Grimm M, Sharghi F, Geist A, Krimmel M, Reinert S. Atraumatictooth extraction in patients taking bisphosphonates: a review of literature andexperience with three cases. Oral Maxillofac Surg. 2014 Sep;18(3):341-9. doi:10.1007/s10006-014-0452-7. Epub 2014 May 15. PMID: 24827755.
  • Hoefert S. The evolution of mouth gags. Presentation of a new modificateddenhart mouth gag. J Maxillofac Oral Surg. 2013 Dec;12(4):475-9. doi:10.1007/s12663-012-0417-z. Epub 2012 Aug 29. PMID: 24431892; PMCID: PMC3847009.
  • Grimm M, Renz C, Munz A, Hoefert S, Krimmel M, Reinert S. Co-expression ofCD44+/RANKL+ tumor cells in the carcinogenesis of oral squamous cell carcinoma.Odontology. 2015 Jan;103(1):36-49. doi: 10.1007/s10266-013-0133-2. Epub 2013 Aug25. PMID: 23979059.
  • Lotter O, Stahl S, Townley WA, Hoefert S, Eberhard Schaller H, Amr A.Reimbursement for tissue reconstruction by pedicled and free flaps across fiveEuropean countries. The importance of autologous breast reconstruction. MinervaChir. 2013 Apr;68(2):129-37. PMID: 23612226.
  • Grimm M, Hoefert S, Luz O, Reinert S, Polligkeit J. Transketolase-likeprotein 1 expression in recurrent oral squamous cell carcinoma after curativeresection: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013Sep;116(3):e173-8. doi: 10.1016/j.oooo.2011.12.022. Epub 2012 Jul 21. PMID:22819458.
  • Grimm M, Krimmel M, Polligkeit J, Alexander D, Munz A, Kluba S, Keutel C,Hoffmann J, Reinert S, Hoefert S. ABCB5 expression and cancer stem cellhypothesis in oral squamous cell carcinoma. Eur J Cancer. 2012Nov;48(17):3186-97. doi: 10.1016/j.ejca.2012.05.027. Epub 2012 Jul 10. PMID:22784549.
  • Grimm M, Krimmel M, Alexander D, Munz A, Kluba S, Keutel C, Hoffmann J,Polligkeit J, Reinert S, Hoefert S. Prognostic value of histamine H1 receptorexpression in oral squamous cell carcinoma. Clin Oral Investig. 2013Apr;17(3):949-55. doi: 10.1007/s00784-012-0784-3. Epub 2012 Jul 11. PMID:22782258.
  • Grimm M, Henopp T, Hoefert S, Schaefer F, Kluba S, Krimmel M, Reinert S.Multiple osteolytic lesions of intraosseous adenoid cystic carcinoma in themandible mimicking apical periodontitis. Int Endod J. 2012 Dec;45(12):1156-64.doi: 10.1111/j.1365-2591.2012.02079.x. Epub 2012 Jun 20. PMID: 22712721.
  • Lotter O, Amr A, Jaminet P, Hoefert S, Schaller HE, Stahl S.Fallpauschalenentwicklung in der rekonstruktiven Mammachirurgie [Development ofDRGs in reconstructive breast surgery]. Handchir Mikrochir Plast Chir. 2012Apr;44(2):112-7. German. doi: 10.1055/s-0032-1306362. Epub 2012 Apr 11. PMID:22495963.
  • Hoefert S, Eufinger H. Relevance of a prolonged preoperative antibioticregime in the treatment of bisphosphonate-related osteonecrosis of the jaw. JOral Maxillofac Surg. 2011 Feb;69(2):362-80. doi: 10.1016/j.joms.2010.06.200.Epub 2010 Dec 3. PMID: 21122968.
  • Hoefert S, Eufinger H. Sunitinib may raise the risk of bisphosphonate-related osteonecrosis of the jaw: presentation of three cases. Oral Surg OralMed Oral Pathol Oral Radiol Endod. 2010 Oct;110(4):463-9. doi:10.1016/j.tripleo.2010.04.049. Epub 2010 Aug 9. PMID: 20692189.
  • Hoefert CS, Bacher M, Herberts T, Krimmel M, Reinert S, Hoefert S, Göz G.Implementing a superimposition and measurement model for 3D sagittal analysis oftherapy-induced changes in facial soft tissue: a pilot study. J Orofac Orthop.2010 May;71(3):221-34. English, German. doi: 10.1007/s00056-010-9932-z. Epub2010 May 26. PMID: 20503004.
  • Hoefert S, Schmitz I, Tannapfel A, Eufinger H. Importance of microcracks inetiology of bisphosphonate-related osteonecrosis of the jaw: a possiblepathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jawbased on scanning electron microscopy findings. Clin Oral Investig. 2010Jun;14(3):271-84. doi: 10.1007/s00784-009-0300-6. Epub 2009 Jun 18. PMID:19536569.
  • Linkeschova K, Hoefert S, Wierich W, Eufinger H. Seltener Fall einerZahnwurzelinfiltration durch ein metastasierendes malignes Melanom der Mundhöhle[Rare case of an infiltration and invasion of a dental root by a mucosalmelanoma of the oral cavity]. Mund Kiefer Gesichtschir. 2007 Dec;11(6):345-8.German. doi: 10.1007/s10006-007-0076-2. Epub 2007 Sep 29. PMID: 17906880.
  • Hoefert S, Eufinger H. Kieferknochennekrosen als mögliche unerwünschteWirkung von Bisphosphonaten [Osteonecrosis of the jaws as a possible adverseeffect of the use of bisphosphonates]. Mund Kiefer Gesichtschir. 2005Jul;9(4):233-8. German. doi: 10.1007/s10006-005-0624-6. PMID: 16395774.
  • Hoefert S, Bloch T, Wierich W, Eufinger H. Seltene Entität einesmakroskopisch sichtbaren Tumorzapfens eines Plattenepithelkarzinoms in dengrossen Kopf-Hals-Venen [Rare entity of a macroscopically visible tumor cone ofsquamous cell carcinoma in the greater veins of the head and neck]. Mund KieferGesichtschir. 2006 Jan;10(1):46-9. German. doi: 10.1007/s10006-005-0660-2. PMID:16362394.
  • Hoefert S, Eufinger H. Nekrosen der Kieferknochen unterBisphosphonattherapie [Necrosis of the jaws under bisphosphonate therapy].Orthopade. 2006 Feb;35(2):204, 206-9. German. doi: 10.1007/s00132-005-0901-y.PMID: 16344954.
  • Hoefert S, Schilling E, Philippou S, Eufinger H. Amyloidose der Zunge alsdiagnostisch richtungsweisende Manifestation des Plasmozytoms [Amyloidosis ofthe tongue as a possible diagnostic manifestation of plasmacytoma]. Mund KieferGesichtschir. 1999 Jan;3(1):46-9. German. doi: 10.1007/s100060050093. PMID:10077969.
  • Hoefert S, Lotter O. Change in reimbursement and costs in German oncologicalhead and neck surgery over the last decade: ablative tongue cancer surgery andreconstruction with split-thickness skin graft vs. microvascular radial forearmflap. Clin Oral Investig. 2018 May;22(4):1741-1750. doi:10.1007/s00784-017-2269-x. Epub 2017 Nov 9. PMID: 29124365.
  • Hoefert S, Taier R. Mechanical stress in plates for bridging reconstructionmandibular defects and purposes of double plate reinforcement. JCraniomaxillofac Surg. 2018 May;46(5):785-794. doi: 10.1016/j.jcms.2018.01.016.Epub 2018 Feb 2. PMID: 29567342.
  • Hoefert S, Yuan A, Munz A, Grimm M, Elayouti A, Reinert S. Clinical courseand therapeutic outcomes of operatively and non-operatively managed patientswith denosumab-related osteonecrosis of the jaw (DRONJ). J CraniomaxillofacSurg. 2017 Apr;45(4):570-578. doi: 10.1016/j.jcms.2017.01.013. Epub 2017 Jan 25.PMID: 28238559.
  • Publikationen
  • DGZMK
  • DOG e.V.
  • AKWiDGMKG
  • DGMKG
  • AGOKi
  • AKOPOM
  • EACMFS