iFIT Dinstiguished Lecture Series with Leila Akkari, PhD
Unveiling Myeloid Cell Diversity in the Cancer Ecosystem
On behalf of the iFIT spokespersons Lars Zender, Juliane Walz and Bernd Pichler, it is our pleasure to inform you about and invite you to the next episode of our iFIT Distinguished Lecture Series 2025 that will take place
on Monday, October 20th at 12:30 pm (CEST)
at N3 Lecture Hall (Hörsaalzentrum Morgenstelle, Auf der Morgenstelle 16 , 72076 Tübingen).
Our guest speaker, Leila Akkari, PhD (Netherlands Cancer Institute, Netherlands) will give a talk on
“Unveiling Myeloid Cell Diversity in the Cancer Ecosystem”.
Tumors growing in metabolically-challenged environments are particularly reliant on cancer cells and immune cell metabolic cross-talk to satisfy their high metabolic needs. However, the intricacies of this metabolic interplay and the consequences on immune cell subsets diversity and function remain largely unexplored. The Akkari lab interrogated the heterogeneity of the tumor microenvironment using multi-omics analyses in preclinical brain and liver cancer mouse models and patient datasets and identified metabolically-rewired tumor-associated macrophage (TAM), myeloid cells and regulatory T cell subpopulations fueling cancer progression and resistance to standard of care and immunotherapies. The work of the Akkari lab reveals the dynamic evolution of specific immune cell compartment and resist to therapies, with potential for exploiting these vulnerabilities therapeutically.
As a special feature of this program, iFIT will sponsor free lunch packages! (First come, first serve)
All members of the University Hospital and University of Tübingen are invited to participate!
We look forward to this Dinstguished Lecture and to see you there!
