The DZIF Clinical Trial Unit provides a platform for clinical studies, focusing on health-care associated infections at DZIF and at international level. Thereby our aims are to derive evidence for unmet medical needs in Infectious Disease, develop educational events on prevention and treatment of health-care-associated infections and improve translational research.
Antimicrobial stewardship and resistance: A meta-analysis
Antibiotic stewardship should ensure effective treatment for patients with bacterial infections. By a systematic review and meta-analysis, we will determine the effectiveness of antimicrobial stewardship interventions that aim to reduce the incidence of antimicrobial resistant colonisation and/ or infections in hospital inpatients. The focus lies on multiresistant gram positive bacteria, multidrug resistant gram negative bacteria and Clostridium difficile.
Recommendations to Optimise Reporting of Epidemiological Studies on Antimicrobial Resistance and Informing Improvement in Antimicrobial Stewardship Antimicrobial stewardship (AS) plays a pivotal role in controlling antimicrobial resistance spread among hospitalized patients, although available evidence mainly relies on non-experimental observational studies. Improving designing and reporting of these studies is critical to the application of findings to AS programmes. The implementation of the newly developed STROBE-AMS tool can be used for the study design of epidemiological studies and Antimicrobial Stewardship (AS) programme.
Gender differences in outpatient antibiotic prescribing
A systematic review and meta-analysis The overall drug prescribing in community shows a substantially difference between males and females that could not only be explained by the incidence of diseases between gender. The project includes a systematic review of the literature and, where appropriate, a meta-analysis of studies investigating prescriptions according to gender in the outpatients setting with a specific focus on different age categories and antibiotic classes.
Modelling the effect of selective digestive tract decontamination (SDD) against ESBL-producing Enterobacteriaceae on the rate of bloodstream infections (BSI) among neutropenic patients
SDD of patients colonized with ESBL-producing Enterobacteriaceae has demonstrated short-lived efficacy following administration of the decolonization regime. By a mathematical modeling, we assess whether and under which conditions, SDD can be an effective intervention method to reduce BSI among neutropenic patients in hematological wards and evaluate parameters to which the model-predicted results are more sensitive.