Institut für
Klinische Epidemiologie und angewandte Biometrie

Projekte

• VenSwitch

  Phase II study of (early) combination salvage therapy with Venetoclax and intensified Decitabine in Relapsed/Refractory AML

  Studienleitung: Prof. Dr. med. Claudia. Lengerke

• THS-PMI

  Cigarette smoke as risk factor for delayed fracture healing: THS vs conventional cigarette smoking in patients with a closed distal tibia fracture

  Prof. Dr. Andreas K. Nüssler

  Zur FIT-Datenbank

• VA-CAL

  Normal Range and Test/Re-Test Variability of Visual Acuity under different conditions of Contrast and Ambient Luminance (Tuebingen VA-CAL Test) in study participants with and without hereditary photoaversio

  Projektleitung: Dr. Torsten Straße

  Zur Studie

• IVAC-XS15-CLL01

  iVAC-XS15-CLL01: Personalized multi-peptide vaccination in combination with the TLR1/2 ligand XS15 in CLL patients undergoing BTK-inhibitor-based regimes

  Projektleitung: Prof. Dr. med. Juliane Walz

  Zur Studie

• Ketamin

  Pharmacologic treatment augmentation in chronic depression

  Projektleitung Dr. med. Kathrin Eckstein

  Zur Studie

• MultiPill-Exercise

  Implementation and evaluation of an individualized physical exercise promotion program in people with manifested risk factors for multimorbidity (MultiPill-Exercise): a study protocol for a pragmatic randomized controlled trial.

  Projktleitung: Prof. Dr. Inga Krauß

  Zur FIT-Datenbank

• NoPICS-Kids

  Kinderintensivmedizin neu gedacht – Vermeidung von Post Intensive Care Syndrom bei kritisch kranken Kindern und deren Familien

  Projektleitung: Stephanie Joos

  Zur FIT-Datenbank

• PSMAxCD3_Prostata

  First in human study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration resistant prostate carcinoma

  Projktleitung: Prof. Dr. Helmut Salih

  Zur Studie

• REDUCT

  Web-based Mindfulness and Skills Based Distress Reduction for Cancer Patients (Reduct) - Study Protocol of a Multicentre, Randomized, Controlled Confirmatory Intervention Trial

  Studienleitung: Prof. Martin Teufel

  Zur Studie

• RIC-VS

  Neuroprotektive Wirkung der ischämische Präkonditionierung auf den N. cochlearis und den N. facialis am Beispiel der Vestibularisschwannom-Chirurgie

  Projektleitung: Prof. Constantin Roder

• TBS-AH

  Treatment of auditory hallucinations in schizophrenia with bilateral theta burst stimulation“

  Projektleitung: Prof. Dr. med. Christian Plewnia

  Zur FIT-Datenbank

• TBS-D

  Treatment of major depressive disorder with bilateral theta burst stimulation

  Projektleitung: Prof. Dr. med. Christian Plewnia

  Zur FIT-Datenbank

• 3for1

  3for1Drei Wege - Ein Ziel: Eine Studie zur Effektivität von Interventionen zur Unterstützung psychisch belasteter Arbeitsloser bei ihrer Arbeitssuche und Genesung

  Projektleitung: Dr. Michelle Flohr (Job Center Ulm)

  Link zur Studie

• Amantadin/Annes

  AmaNtadine for NeuroenhancEment in acutE patients Study: A prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES)

  Projektleitung: PD. Dr. med. Annerose Mengel

  Link zur Studie

• Amilor

  Amiloride in nephrotic syndrome (AMILOR)

  Projektleitung: Prof. Dr. Ferruh Artunc

• AML-VAC-XS15

  Multi-peptide vaccination adjuvanted with the TLR1/2 ligand XS15 in acute myeloid leukemia (AML) patients who have achieved complete remission with first line therapy

  Projektleitung: Prof. Dr. med Helmut Salih

  Zur Publikation

• AST_MOMA

  Hoch dosis-Chemotherapie und autologe Retransfusion CD34-selektionierter peripherer Blutstammzellen bei progressiver systemischer Sklerose

  Projektleitung: Dr. Jörg Henes

  Link zum Abstract

• Atticus

  Apixabam for treatment of embolic stroke of undertermined source

  Projektleitung: Prof. Geisler

  Link zum Abstract

• BICOxCD28

  First in human study to evaluate the safety, tolerability and preliminary efficacy of the combination of a bispecific costimulator (BiCo) with EndoglinxCD28 specificity (BiCo-1) in men with metastatic castration resistant prostate cancer

• BOSS-Front 2

  Brain oscillation-synchronized stimulation of the frontal cortex: Randomized controlled trial comparing the therapeutic effectiveness of frontal theta-oscillation synchronized repetitive TMS with standard TMS therapy in major depressive disorder

  Projektleitung: Prof. Dr. med. Fallgatter

  Zur Studie

• BOSS-Stroke

  Brain-oscillation-synchronized stimulation to enhance motor recovery in early subacute stroke (BOSS-STROKE): A randomized controlled double-blind three arm parallel-group exploratory trial comparing personalized, nonpersonalized and sham repetitive transcranial magnetic stimulation

  Projektleitung: Prof. Dr. Ulf Ziemann

  Zur FIT-Datenbank

• B-pVAC

  B-pVAC-SARS-CoV-2: Phase I/II multicenter safety and immunogenicity trial of multi-peptide vaccination to prevent COVID-19 infection in adults with Bcell/antibody deficiency

  Projektleitung: Prof. Dr. Juliane Walz

  Zur Projektseite

• CAO/ARO/AIO 16

  Organ preservation in locally advanced rectal cancer by radiochemotherapy followed by consolidation chemotherapy. A prospective phase II pilot trial of the German Rectal Cancer Study Group

  Projektleitung: Dr. Cihan Gani

  Zur Projektseite

• CART-AID

  An open-label phase II, multicentre, interventional single-arm basket trial of MBCART19.1 in patients with relapsed/refractory autoimmune disease

  Projektleitung: Dr. med Ann Christin Pecher

• CCC Integrativ

  Implementierung eines sektorenübergreifenden, interprofessionellen Programms zur ev idenzbasierten Beratung zu Komplementärer Medizin und Pflege (KMP) an den vier Comprehensive Cancer Centers in Baden-Württemberg (CCC – Integrativ)

  Projektleitung: Prof. Dr. Stefanie Joos CCC

  Zur Studie

• CD45

  A multi-center phase I/II trial of memory T cell donor lymphocyte infusions after transplantation of CliniMACS TCRα/β and CD19 depleted stem cell grafts from haploidentical donors for hematopoietic cell transplantation

  Projektleitung: Prof. Dr. Bethge Wolfgang

• CD8-PET

  Early detection of side effects in patients with metastatic melanoma receiving immune checkpoint inhibitor therapy by investigation of the CD8+ immune infiltrate using [89Zr]Zr-DfIAB22M2C-PET

  Projektleitung: Prof. Dr. Christian la Fougére

  Zur Studie

• CEPIC

  Confirmatory study on the effectiveness of a new, precise needle-free injection technology in a preclinical in vivo model of cell therapy for urinary incontinence (Cepic)

  Studienleitung: Prof. Dr. Wilheim Aicher

  Zur Studie

• CNGA3 colBri

  Safety and efficacy of a bilateral single subretinal injection of rAAV.hCNGA3 in adult and minor patients with CNGA3-linked achromatopsia investigated in a randomized, wait list controlled, observer-masked trial

  Projektleitung: Prof. Dr. Katarina Singl

  Zur Studie

• COCOON

  Coaching for coping in patients diagnosed with aglioblastoma or astrocytoma CNS WHO grade 4 and their caregivers and its association with compliance to TTField

  Projektleitung: Prof. Dr. Mirjam Renovan

• DECODE-VRL

  Multizentrische Implementierung und klinische Validierung einer standardisierten, innovativen molekularbiologischen Diagnostik für das VitreoRetinale Lymphom

  Projektleitung: PD. Dr. Vinodh Kakkassery

  Zur FIT-Datenbank

• DESENSITIZE PD

  Intestinale Levodopa + Entacapone Therapie (Lecigon®) zur Unterstützung der dopaminergen Desensitivierung bei der Parkinson-Krankheit

  Projektleitung: Prof. Dr. Daniel Weiß

• DNPM

  Deutsches Netzwerk für Personalisierte Medizin

  Projektleitung: Prof. Dr. Malek

  Zur Fit-Datenbank

• Dysphagie

  Oral transport, penetration, and aspiration in Parkinson’s disease: Clinical and mechanistic insights from a randomized controlled trial on subthalamic and nigral stimulation

  Projektleitung: Prof. Dr. Daniel Weiß

• EARLY-TMS

  Repetitive transcranial magnetic stimulation (rTMS) as an early intervention in Major Depressive Disorder (MDD) compared to antidepressant selective serotonin reuptake inhibitor (SSRI) medication (Early-TMS)

  Projektleitung: Prof. Dr. med. Christian Plewnia

• EDITH

  Evaluation of a digital treatment platform (CDSS) for outpatient and transectoral care for epilepsy patients: EDITH (Epilepsie richtig Diagnostizieren und Therapieren)

  Projektleitung: Dr. Josua Kegele

• ELIEO

  Early versus Late Initiation of ECMO Trial (ELIEO-Trial)

  Projektleitung: Prof. Dr. Peter Rosenberger

• FLYSYN

  First in man study to evaluate the safety, tolerability and preliminary efficacy of theFc-optimized FLT3 antibody FLYSYN for the treatment of acute myeloid leukemiapatients with minimal residual disease

  Projektleitung: Prof. Dr. Helmut Salih

  Zur Studie

• Fusion-VAC22

  FusionVAC22_01: DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocellular carcinoma and other tumor entities carrying the oncogenic driver fusion

  Projektleitung: Prof. Dr. Helmut Salih

  Zur Publikation

• Fusion-VAC22_02

  FusionVAC22_02: DNAJB1-PRKACA fusion transcript-based peptide vaccine for fibrolamellar hepatocellular carcinoma patients and other tumor entities carrying the oncogenic driver fusion

  Projektleitung: Prof. Juliane Walz

• Gliom-XS15

  GLIO-XS15 Multi peptide vaccination with Pam3Cys-GDPKHPKSF (XS15) as an immunomodulator in addition to standard postoperative radiation therapy and temozolomide chemotherapy in newly diagnosed HLA-A2-positive MGMT-methylated glioblastoma

  Projektleitung: Prof. Ghazaleh Tabatabai

  Zur Pressemitteilung

• HY133

  A randomized double-blind placebo-controlled first-in-man single-dose and multiple dose study to evaluate the safety, tolerability and efficacy of a recombinant chimeric bacteriophage endolysin HY-133 with an extended phase to evaluate effects of the nasal microbiome

  Projektleitung: Dr. Sebastian Volc

  Zur Pressemitteilung

• IAV Protective Microspheres

  T cell vaccination of AAD mice against influenza virus infection with biodegradable PLGA microspheres

  Projektleitung: Prof. Planz

  Zur FIT-Datenbank

• IMPRO

  Improved Management of Patients with Recent-Onset Stable Chest Pain (IMPRO)

  Projektleitung: Prof. Marc Dewey

• iMRI-ALA

  Impact of iMRI on the extent of resection in patients with newly diagnosed glioblastomas - A prospective multicenter parallel group clinical trial

  Projektleitung: Prof. Constantin Roder

  Zur Publikation

• IT-PD1

  Intrathecal application of PD-1 antibody in metastatic solid tumors with leptomeningeal disease

  Projektleitung: Prof. Ghazaleh Tabatabai

• IVAC-CLL-01

  iVAC-CLL01: Patient-individualized peptide vaccination after first line therapy of CLL

  Projektleitung: Prof. Dr. Helmut Salih

  Zur Studie