Metastatic disease remains the leading cause of cancer-related deaths worldwide, accounting for over 90% of fatalities. Unfortunately, there is still a significant lack of therapies specifically targeting the process of metastasis. Our research group leverages state-of-the-art high-throughput sequencing technologies to investigate the impact of post-transcriptional gene regulation mediated by microRNAs (miRNAs) and RNA-binding proteins (RBPs) on the development of metastases. We employ cutting-edge techniques in molecular research to elucidate the intricate mechanisms of metastasis in both cellular and murine models. Our primary objective is to identify both cell-intrinsic (autonomous) and cell-extrinsic (nonautonomous) mechanisms involved in post-transcriptional gene regulation in the process of metastasis (See Fig.). By translating our newly acquired knowledge into clinical practice, we aim to facilitate the development of innovative therapies to effectively target the formation of metastatic spread.
Post-transcriptional control in metastasis
Head of the research group
Publikationen: Pubklikationen
Biosketch
Dr. Missios holds a degree in Human Medicine from the University of Ulm, Germany, where he completed his state examination in November 2012. Under the supervision of Karl Lenhard Rudolph he pursued his MD-Ph.D. studies and graduated with honors (summa cum laude) in May 2015. From 2013 to 2015. Dr. Missios completed his Residency in Internal Medicine at the University Hospital Tuebingen. Next, he joined George Q. Daley’s lab at the Stem Cell Program, Boston Children's Hospital, Harvard Medical School in Boston, MA, USA. His postdoctoral training went from 2015 to 2019. In 2019, he returned to Tuebingen as a Group leader in the field of Posttranscriptional control in advanced malignancy. Concurrently, he served as a clinical fellow in the Department of Internal Medicine I of the University Clinic Tuebingen. He successfully competed his Fellowship in Internal Medicine with a specialization in Gastroenterology and Gastrointestinal Oncology at the University Hospital Tuebingen in February 2023. Apart from his research, he assumes clinical duties as an attending physician at the oncology day clinic.
Co-affiliations
miRNAs
post-transcriptional gene regulation mediated by microRNAs
metastasis
in cellular and murine models
RBPs
RNA-binding proteins
Selected publications
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2021
LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy
Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee AS, Dominguez D, Ting DT, Daley GQ. LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy.
J Clin Invest. 2021 Nov 15;131(22):e145142. https://doi.org/10.1172/jci145142 -
2021
Das molekulare Tumorboard [The molecular tumor board]
Missios P, Beha J, Bitzer M, Malek NP. Das molekulare Tumorboard [The molecular tumor board].
Chirurg. 2021 Nov;92(11):1011-1015. German. https://doi.org/10.1007/s00104-021-01487-6 -
2021
Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma
Bitzer M, Spahn S, Babaei S, Horger M, Singer S, Schulze-Osthoff K, Missios P, Gatidis S, Nann D, Mattern S, Scheble V, Nikolaou K, Armeanu-Ebinger S, Schulze M, Schroeder C, Biskup S, Beha J, Claassen M, Ruhm K, Poso A, Malek NP. Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma.
NPJ Precis Oncol. 2021 Sep 3;5(1):80. https://doi.org/10.1038/s41698-021-00220-0 -
2021
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer
Eser PÖ, Paranal RM, Son J, Ivanova E, Kuang Y, Haikala HM, To C, Okoro JJ, Dholakia KH, Choi J, Eum Y, Ogino A, Missios P, Ercan D, Xu M, Poitras MJ, Wang S, Ngo K, Dills M, Yanagita M, Lopez T, Lin M, Tsai J, Floch N, Chambers ES, Heng J, Anjum R, Santucci AD, Michael K, Schuller AG, Cross D, Smith PD, Oxnard GR, Barbie DA, Sholl LM, Bahcall M, Palakurthi S, Gokhale PC, Paweletz CP, Daley GQ, Jänne PA. Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer.
Sci Transl Med. 2021 Sep;13(609):eabb3738. doi: 10.1126/scitranslmed.abb3738. Epub 2021 Sep 1. PMID: 34516823; PMCID: PMC8627689.
https://doi.org/10.1126/scitranslmed.abb3738 -
2020
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors
Tao T, Shi H, Mariani L, Abraham BJ, Durbin AD, Zimmerman MW, Powers JT, Missios P, Ross KN, Perez-Atayde AR, Bulyk ML, Young RA, Daley GQ, Look AT. LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16516-16526. doi: 10.1073/pnas.1922692117. Epub 2020 Jun 29. PMID: 32601179; PMCID: PMC7368283. https://doi.org/10.1073/pnas.1922692117 -
2020
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
Franses JW, Philipp J, Missios P, Bhan I, Liu A, Yashaswini C, Tai E, Zhu H, Ligorio M, Nicholson B, Tassoni EM, Desai N, Kulkarni AS, Szabolcs A, Hong TS, Liss AS, Fernandez-Del Castillo C, Ryan DP, Maheswaran S, Haber DA, Daley GQ, Ting DT. Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target.
Nat Commun. 2020 Jul 3;11(1):3303. https://doi.org/10.1038/s41467-020-17150-3 -
2019
The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia
Rowe RG, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, Yermalovich A, Barragan J, Mathieu R, Jha DK, Fleming MD, North TE, Daley GQ. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia.
J Exp Med. 2019 Mar 4;216(3):527-538. doi: 10.1084/jem.20181765. Epub 2019 Feb 6. PMID: 30728174; PMCID: PMC6400531. https://doi.org/10.1084/jem.20181765 -
2014
Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice
Missios P, Zhou Y, Guachalla LM, von Figura G, Wegner A, Chakkarappan SR, Binz T, Gompf A, Hartleben G, Burkhalter MD, Wulff V, Günes C, Sattler RW, Song Z, Illig T, Klaus S, Böhm BO, Wenz T, Hiller K, Rudolph KL. Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.
Nat Commun. 2014 Sep 18;5:4924. https://doi.org/10.1038/ncomms5924